PR domain containing 16, also known as PRDM16, is a protein which in humans is encoded by the PRDM16 gene. (wikipedia.org)
We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. (bioseek.eu)
Furthermore, brown fat programming of mesenchymal stem cells by PRDM-BF1-RIZ1 homologous domain containing 16 (Prdm16), was associated with a dramatic reduction of p107 levels. (mitophysiology.org)
Adipose10
PRDM16 acts as a transcription coregulator that controls the development of brown adipocytes in brown adipose tissue. (wikipedia.org)
Previously, this coregulator was believed to be present only in brown adipose tissue, but more recent studies have shown that PRDM16 is highly expressed in subcutaneous white adipose tissue as well. (wikipedia.org)
PRDM16 is highly enriched in brown adipose cells as compared to white adipose cells, and plays a role in these thermogenic processes in brown adipose tissue. (wikipedia.org)
PRDM16 activates brown fat cell identity and can control the determination of brown adipose fate. (wikipedia.org)
A knock-out of PRDM16 in mice shows a loss of brown cell characteristics, showing that PRDM16 activity is important in determining brown adipose fate. (wikipedia.org)
The presence of PRDM16 in adipose tissue causes a significant up-regulation of thermogenic genes, such as UCP-1 and CIDEA, resulting in thermogenic heat production. (wikipedia.org)
Recent research has shown that PRDM16 is present in subcutaneous white adipose tissue. (wikipedia.org)
The activity of PRDM16 in white adipose tissue leads to the production of brown fat-like adipocytes within white adipose tissue, called beige cells (also called brite cells). (wikipedia.org)
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. (scielo.br)
Adipose tissue expression of UCP1 and PRDM16 genes and their association with postprandial triglyceride metabolism and glucose intolerance. (cdc.gov)
Genes4
The study found that the presence of PRDM16 in subcutaneous WAT leads to a significant up-regulation of brown-fat selective genes UCP-1, CIDEA, and PPARGC1A. (wikipedia.org)
Finally, Prdm16-deficient brown fat displays an abnormal morphology, reduced thermogenic gene expression and elevated expression of muscle-specific genes. (bioseek.eu)
Notably, the sustained expression of p107 blocked the ability of Prdm16 to induce brown fat genes. (mitophysiology.org)
Scientists led by Brigham and Women's Hospital (BWH), of Harvard Medical School in Boston, Massachusetts, US, identified "single-nucleotide polymorphisms" or "SNPs" in the genes PRDM16, TRPM8 and LRP1, and showed that each alters the risk for migraines by 10 to 15 percent. (health32.com)
Modulation1
Or, perhaps only a specific type of modulation of PRDM16 would result in a "natural" weight loss. (the-scientist.com)
Protein4
In mice, the levels of PRDM16 within WAT, specifically anterior subcutaneous WAT and inguinal subcutaneous WAT, is about 50% that of interscapular BAT, both in protein expression and in mRNA quantity. (wikipedia.org)
PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue. (taconic.com)
To elucidate functional characteristics of these N-terminal residues, we compared the protein interactomes of the full-length and ΔPR isoforms of PRDM3 and its closely related paralog, PRDM16. (rcsb.org)
The article quotes work by Bruce Spiegelman showing that selectively disabling beige fat in mice by targeting the protein PRDM16, which is found only in these cells, leaving the white and brown fat intact leads to animals with severe metabolic dysfunction - obesity, insulin resistance and fatty livers. (drsharma.ca)
Indeed, Prdm16 directly suppressed p107 transcription via promoter binding. (mitophysiology.org)
Skeletal1
PRDM16 controls a brown fat/skeletal muscle switch. (bioseek.eu)
Expression3
Transgenic aP2-PRDM16 mice were used in a study to observe the effects of PRDM16 expression in WAT. (wikipedia.org)
Expression of PRDM16 has also been shown to protect against high-fat diet induced weight gain. (wikipedia.org)
Conversely, ectopic expression of PRDM16 in myoblasts induces their differentiation into brown fat cells. (bioseek.eu)
Mice2
s experiment with aP2-PRDM16 transgenic mice and wild type mice showed that transgenic mice eating a 60% high-fat diet had significantly less weight gain than wild type mice on the same diet. (wikipedia.org)
If human WAT expresses PRDM16 as in mice, this WAT could be a potential target for stimulating energy expenditure and combating obesity. (wikipedia.org)
Cells1
PRDM16 controls the cell fate between muscle and brown fat cells. (wikipedia.org)
Brown4
Loss of PRDM16 from brown fat precursors causes a loss of brown fat characteristics and promotes muscle differentiation. (wikipedia.org)
PRDM16 stimulates brown adipogenesis by binding to PPAR-gamma (peroxisome-proliferator-activated receptor-gamma) and activating its transcriptional function. (bioseek.eu)
Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis. (bioseek.eu)
In "The skinny fat ," 1 Bruce Spiegelman tells us he is working with the Broad Institute to screen every FDA-approved drug for possible effects on a "brown-fat molecule," PRDM16, reasoning that drugs that act on this molecule might also trigger weight loss. (the-scientist.com)
Significant2
Wouldn't it be smart to determine whether any of these FDA-approved drugs are associated with significant weight loss before starting the screening campaign at the molecular level for PRDM16? (the-scientist.com)
For example, say you find a drug that indeed modulates PRDM16 in a bioassay but is not associated with significant weight loss in patients using the drug. (the-scientist.com)
UCP13
Although recent studies indicate that epicardial adipose tissue expresses brown fat-like genes, such as PGC1α, UCP1 and PRDM16, the association of these genes with type 2 diabetes mellitus (DM2) in coronary artery disease (CAD) remains unknown. (biomedcentral.com)
PGC1α, UCP1, and PRDM16 mRNAs expression levels were measured by real-time PCR in epicardial and thoracic subcutaneous adipose tissue from 44 CAD patients (22 with DM2 [CAD-DM2] and 22 without DM2 [CAD-NDM2]) and 23 non-CAD patients (NCAD). (biomedcentral.com)
Therefore, our main objective was to evaluate the expression of PGC1α, UCP1 and PRDM16 mRNAs in EAT contiguous with CAD in patients with and without DM2. (biomedcentral.com)
Transcriptional3
PRDM16 is a transcriptional cofactor and histone methyltransferase, playing a critical role in maintaining hematopoietic stem cells, and MLL fusion-induced leukemogenesis. (nih.gov)
CG10348, the fly orthologue of transcriptional regulator PRDM16. (cancerindex.org)
15. Transcriptional control of brown fat determination by PRDM16. (nih.gov)
Adipose tissue6
PRDM16 acts as a transcription coregulator that controls the development of brown adipocytes in brown adipose tissue. (wikipedia.org)
Previously, this coregulator was believed to be present only in brown adipose tissue, but more recent studies have shown that PRDM16 is highly expressed in subcutaneous white adipose tissue as well. (wikipedia.org)
PRDM16 is highly enriched in brown adipose cells as compared to white adipose cells, and plays a role in these thermogenic processes in brown adipose tissue. (wikipedia.org)
The presence of PRDM16 in adipose tissue causes a significant up-regulation of thermogenic genes, such as UCP-1 and CIDEA, resulting in thermogenic heat production. (wikipedia.org)
Recent research has shown that PRDM16 is present in subcutaneous white adipose tissue. (wikipedia.org)
The activity of PRDM16 in white adipose tissue leads to the production of brown fat-like adipocytes within white adipose tissue, called beige cells (also called brite cells). (wikipedia.org)
Histone methyltransferase1
4. study the potential tumor suppressor role of a new member of the histone methyltransferase family, PRDM16, that was recently isolated in the applicant's laboratory. (nih.gov)
Subcutaneous2
In mice, the levels of PRDM16 within WAT, specifically anterior subcutaneous WAT and inguinal subcutaneous WAT, is about 50% that of interscapular BAT, both in protein expression and in mRNA quantity. (wikipedia.org)
The study found that the presence of PRDM16 in subcutaneous WAT leads to a significant up-regulation of brown-fat selective genes UCP-1, CIDEA, and PPARGC1A. (wikipedia.org)
Adipogenesis2
C57/BL6 mice were treated with the β3-adrenergic agonist, CL316243, resulting in reduced expression of genes related to de novo adipogenesis (RIP140, p107, PRDM16, CtBP) and increased expression of genes associated with WAT to BAT transdifferentiation (C/EBPβ, cyclooxygenase-2). (nih.gov)
Our results point to Mef2 and miR-133 as central upstream regulators of Prdm16 and hence of brown adipogenesis in response to cold exposure in BAT and SAT. (unige.ch)
Obesity1
If human WAT expresses PRDM16 as in mice, this WAT could be a potential target for stimulating energy expenditure and combating obesity. (wikipedia.org)
Determination2
PRDM16 activates brown fat cell identity and can control the determination of brown adipose fate. (wikipedia.org)
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. (nih.gov)
Gene therapy1
Correction of X-linked Chronic Granulomatous Disease by Gene Therapy, Augmented by Insertional Activation of MDS1-EVI1, PRDM16 or SETBP1. (medscape.com)
Brown fat2
PRDM16 controls the cell fate between muscle and brown fat cells. (wikipedia.org)
Loss of PRDM16 from brown fat precursors causes a loss of brown fat characteristics and promotes muscle differentiation. (wikipedia.org)
Found1
Subsequently, PRDM16 was found to be over-expressed in ATRT samples and knockdown of PRDM16 in SMARCB1-deficient rhabdoid tumor cells reduced proliferation. (cancerindex.org)
Family1
PRDM16 is one of the PRDM proteins family. (biomasswars.com)