Prazosin alpha 2 adrenergic receptors. Medical search. Frequent questions

The alpha 1-agonist methoxamine and the alpha 1-antagonist prazosin were injected into the DPT of freely moving, unanaesthetized cats. (nih.gov)
See also receptor antagonist) alpha-2 receptors. (wikipedia.org)
All effects were antagonized by the alpha 1-adrenoceptor antagonist prazosin (0.1 microM), indicating receptor-mediated effects. (aspetjournals.org)
Alpha-receptor antagonist medications potentially interfere with iris muscle dilation, resulting in difficult lens removal and possibly increasing complications. (urotoday.com)
Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. (lgmpharma.com)
Such effect was completely reversed both by the opioid receptor antagonist naloxone and by the unselective muscarinic receptor antagonist atropine. (researchgate.net)
The phenylephrine studies were repeated in seven hypertensive patients during treatment with prazosin, an alpha 1 adrenergic antagonist. (ox.ac.uk)
These include the alpha-2 adrenergic agonists clonidine and guanfacine, the nonselective beta-adrenergic agent propranolol, and most promising prazosin, which is an alpha-1 adrenergic receptor antagonist that blocks the actions of NE on alpha-1 receptors(Petrakis, 2016). (duepapers.net)
Tamsulosin is an alpha-1 receptor antagonist [ 2 ]. (kratom.org)
and an angiotensin II receptor antagonist (used for blood pressure control), losartan (Cozaar). (raynauds.co.in)
The stimulating effect of NE on the TRH secretion was abolished by icv antagonist of adrenergic alpha2-receptor, yohimbine (40 nmol/L). (nel.edu)
A beta-2 selective adrenergic antagonist. (lookformedical.com)
A widely used non-cardioselective beta-adrenergic antagonist. (lookformedical.com)
Cirazoline is a full agonist at the α 1A adrenergic receptor , a partial agonist at both the α 1B and α 1D adrenergic receptors, [1] and a nonselective antagonist to the α 2 adrenergic receptor . (wikipedia.org)
Phentolamine is an alpha-adrenergic receptor antagonist. (empowerpharmacy.com)

Agonists of alpha-2 receptors in the vascular smooth muscle lead to vasoconstriction. (wikipedia.org)
However, in clinical practice drugs applied intravenously that are agonists of alpha-2 receptors such as clonidine lead to powerful vasodilation, which causes a decrease in blood pressure by presynaptic activation of the receptors in the sympathetic ganglia. (wikipedia.org)
Usage of beta-2 receptor agonists as hypotensive agents is less widespread due to adverse effects such as unnecessary bronchodilation in lungs and increase in blood sugar levels. (wikipedia.org)
Cooling augmented contractions evoked by the alpha 2-adrenergic agonists B-HT 920 and UK 14304 but did not affect responses to the full alpha 1-adrenergic agonist phenylephrine. (johnshopkins.edu)
Therefore, cooling reduces alpha 1-adrenergic responsiveness in canine cutaneous veins, but in the case of full alpha 1-adrenergic agonists such as norepinephrine and phenylephrine the inhibitory effect of cooling is buffered by an alpha 1-adrenoceptor reserve. (johnshopkins.edu)
It is unclear whether this is caused by structural changes in the arterial wall or by hyperresponsiveness of vascular smooth muscle to endogenous alpha adrenergic agonists. (ox.ac.uk)
This indicates that small doses of prazosin (1-2 mg) cause significant in vivo shifts in the dose-response relationship of alpha adrenergic agonists. (ox.ac.uk)
Specific antagonists and agonists of alpha(2)-adrenoceptors were employed for the characterization of alpha(2)-adrenoceptors involved in the autoregulation of depolarization-evoked release of norepinephrine in the pig pineal. (nel.edu)
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. (lookformedical.com)
Alpha-2 agonists often have a sedating effect and are commonly used as anesthesia enhancers in surgery, as well as in treatment of drug or alcohol dependence . (wikipedia.org)

The main endogenous agonist of these cell receptors is norepinephrine (NE). (wikipedia.org)
However, the contractions evoked by the partial alpha 1-adrenergic agonist St 587 were virtually abolished by cooling. (johnshopkins.edu)
In contrast, a selective α-adrenergic agonist phenylephrine, elicited greater contractions both in the aged body and trigone than those in young rats. (scirp.org)
Using the dorsal hand vein compliance technique we compared the changes in diameter of superficial veins in response to phenylephrine, an alpha 1 adrenergic receptor agonist, and to nitroglycerin, a venorelaxant, in patients with essential hypertension and in normotensive subjects. (ox.ac.uk)
Kratom is an alpha-2 adrenergic receptor agonist [ 1 ]. (kratom.org)
In the human prostate, Prazosin antagonizes phenylephrine (alpha1 agonist)-induced contractions, in vitro , and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate. (pharmacycode.com)
Studies in normal human subjects have shown that Prazosin competitively antagonized the pressor effects of phenylephrine (an alpha1 agonist) and the systolic pressor effect of norepinephrine. (pharmacycode.com)
The aim of the study was to ascertain whether rilmenidine, a second generation imidazoline-alpha-2-adrenoreceptor agonist, is able to increase analgesic effects of ibuprofen in the writhing test in mice. (nel.edu)
The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. (lookformedical.com)

Antagonists of alpha-1 receptors (doxazosin, prazosin) cause vasodilation (a decrease in vascular smooth muscle tone with increase of vessel diameter and decrease of the blood pressure). (wikipedia.org)
This level of risk was subsequently confirmed and was thereafter described with all currently used alpha-1 adrenergic receptor antagonists [3,4,5,6]. (urotoday.com)
The FDA considers the risk for IFIS to be a class effect for alpha-1 adrenergic receptor antagonists [8,9]. (urotoday.com)
The dorsal hand vein compliance technique is useful in detecting systemic effects of alpha adrenergic antagonists. (ox.ac.uk)
There is some evidence that Angiotensin II receptor antagonists (often Losartan) reduce frequency and severity of attacks, and possibly better than nifedipine. (raynauds.co.in)
Results from using an in vitro tissue bath technique indicated that propranolol and preferential beta(2)-adrenoceptor antagonists (ICI-118,551 and butoxamine), in a concentration-dependent manner, blocked the relaxation induced by nicotine (100 microM) without affecting the relaxation elicited by transmural nerve stimulation (TNS, 8 Hz). (lookformedical.com)

Cooling (from 37 to 24 degrees C) augmented contractions to norepinephrine under control conditions and after alpha 1-adrenergic blockade (prazosin) but not following alpha 2-adrenergic blockade (rauwolscine). (johnshopkins.edu)
With norepinephrine, this permits the potentiating effect of cooling on the alpha 2-adrenergic component of the response to predominate. (johnshopkins.edu)
Norepinephrine released from adrenergic nerve endings, relaxes bladder body by increasing intracellular cAMP via β-adrenergic receptors widely expressed in the bladder body, and contracts bladder base and proximal urethra via α-adrenergic receptors to prevent premature bladder emptying. (scirp.org)
Beta-blockers inhibit the action of epinephrine and norepinephrine on beta-adrenergic receptors , decreasing heart rate and cardiac output. (pharmacologymentor.com)
[2] "Norepinephrine" is also the international nonproprietary name given to the drug . (wikipedia.org)
Regardless of how and where it is released, norepinephrine acts on target cells by binding to and activating adrenergic receptors located on the cell surface. (wikipedia.org)

The agents used include alpha-adrenergic blockers, 5-alpha-reductase inhibitors, and various combinations. (medscape.com)
The advantage of prazosin over nonselective alpha-adrenergic blockers includes a lower incidence of adverse effects. (medscape.com)
The "intra-operative floppy iris syndrome" cataract surgery complication has been reported in men using alpha-blockers. (urotoday.com)
The risk of complicated cataract surgery was 14.9% in patients using alpha-blockers, approximately 50% higher than those not receiving this medication (9.5%) (p=0.003). (urotoday.com)
Except in special conditions, vasodilators and alpha- and beta-blockers are 3rd-line drugs, which if needed should be used after consultation with a specialist. (msdmanuals.com)
Prazosin is thought to produce alpha-adrenergic blockade in a different way from the classical alpha-blockers phenoxybenzamine and phentolamine.2 The unusual side effects of prazosin, frequency of micturition and incontinence of urine, have been attributed to this alpha-blocking action.5 We now consider priapism a potential hazard of treatment with prazosin. (erowid.org)
Losartan belongs to the class of medications called angiotensin II receptor blockers . (medbroadcast.com)
Alpha-blockers antagonize alpha-1 adrenergic receptors in vascular smooth muscle, causing vasodilation and reduced peripheral vascular resistance. (pharmacologymentor.com)
Alpha Receptor Blockers: prozosin (Minipres) or doxazosin (Cardura). (raynauds.co.in)
Alpha-1 adrenergic blockers such as prazosin can be used to control Raynaud's vasospasms under supervision of a health care provider. (raynauds.co.in)
For instance, non-depolarising neuromuscular blockers like d-tubocurarine, pancuronium, vecuronium, atracurium and depolarising neuromuscular blocker like suxamethonium all act on nicotinic acetylcholine receptors (nAChR) which are of ionotropic receptors. (egpat.com)
Two classes of drugs that should never be used during pregnancy are ACE inhibitors and angiotensin II receptor blockers. (cardiohow.com)
Thiazide diuretics (such as HCTZ) or calcium channel blockers are recommended first, along with the possibility of adding a second drug from the ACE inhibitor or angiotensin II receptor blocker class. (cardiohow.com)
Along with a diuretic, some calcium channel blockers, ACE inhibitors and angiotensin II receptor blockers may also be good choices. (cardiohow.com)
In the United Kingdom, the June 2006 "Hypertension: management of hypertension in adults in primary care" [6] guideline of the National Institute for Health and Clinical Excellence , downgraded the role of beta-blockers due to their risk of provoking type 2 diabetes . (wikidoc.org)
Despite lowering blood pressure, alpha blockers have significantly poorer endpoint outcomes than other antihypertensives, and are no longer recommended as a first-line choice in the treatment of hypertension. (wikidoc.org)
Beta blockers , which counter some of the effects of noradrenaline by blocking their receptors, are frequently used to treat glaucoma , migraine , and a range of cardiovascular problems. (wikipedia.org)
Alpha blockers , which counter a different set of noradrenaline effects, are used to treat several cardiovascular and psychiatric conditions. (wikipedia.org)

Prazosin (10(-8) M) shifted the concentration-response curves to phenylephrine and UK 14,304 to the right, but did not shift the concentration-response curves to clonidine and oxymetazoline. (aspetjournals.org)
Pretreatment with chlorethylclonidine, which selectively alkylates the alpha-1B subtype, did not affect the Emax value of phenylephrine-induced contractions, but significantly shifted the curve to the right. (aspetjournals.org)
Moreover, following partial irreversible blockade of the alpha 1-adrenoceptors with phenoxybenzamine, cooling also reduced the contractions evoked by phenylephrine. (johnshopkins.edu)
In order to elucidate the mechanism of functional changes in aged rat urinary bladder, we studied the influence of senescence on, 1) the α-adrenergic contractile response to phenylephrine in the urinary bladder body and trigone, 2) the muscarinic contractile response to carbachol in the body and trigone. (scirp.org)
The mean dose ratio of the shift in phenylephrine ED50 (ED50 during prazosin therapy/ED50 before prazosin therapy) was 6.1. (ox.ac.uk)

The prazosin was stopped, and his blood pressure was controlled with propranolol, triamterene, and hydrochlorothiazide. (erowid.org)

Tamsulosin, a sulfamoylphenethylamine-derivative alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH). (lgmpharma.com)
Tamsulosin is an alpha-adrenergic blocker used to treat benign prostatic hyperplasia and ureteric stones. (kratom.org)
Prazosin is an alpha-adrenergic blocking agent used to treat hypertension and benign prostatic hyperplasia. (pharmacycode.com)

Phenoxybenzamine is a nonselective alpha-adrenergic receptor blocker that antagonizes both alpha-1 and alpha-2 receptors. (medscape.com)

It inhibits postsynaptic alpha-adrenergic receptors, resulting in vasodilation of veins and arterioles and a decrease in total peripheral resistance and blood pressure. (medscape.com)
This drug, the first of a new class of antihypertensive agents, interferes with alpha-adrenergic function at the postsynaptic level. (erowid.org)
These results show no evidence for a generalized change in alpha adrenergic responsiveness in hypertension and support the concept that increased blood pressure responses to alpha adrenergic stimulation in hypertensives are due to structural and geometric changes in the arterial wall rather than to an increased responsiveness of postsynaptic alpha adrenergic receptors. (ox.ac.uk)

For example, epinephrine binds to the β2 receptor on bronchial muscle which then activates adenylyl cyclase system releasing cAMP. (egpat.com)

Vascular smooth muscle is innervated primarily by the sympathetic nervous system through adrenergic receptors (adrenoceptors). (wikipedia.org)
The adrenergic receptors exert opposite physiologic effects in the vascular smooth muscle under activation: alpha-1 receptors. (wikipedia.org)
Under NE binding alpha-1 receptors cause vasoconstriction (contraction of the vascular smooth muscle cells decreasing the diameter of the vessels). (wikipedia.org)
This presynaptic effect is predominant and completely overrides the vasoconstrictive effect of the alpha-2 receptors in the vascular smooth muscle. (wikipedia.org)
Agonism of beta-2 receptors causes vasodilation and low blood pressure (i.e. the effect is opposite of the one resulting from activation of alpha-1 and alpha-2 receptors in the vascular smooth muscle cells). (wikipedia.org)
However, unlike these drugs, tamsulosin has a higher affinity for the alpha-1A- adrenergic receptors, which are located in vascular smooth muscle. (lgmpharma.com)
The antihypertensive effect of Prazosin results from a decrease in systemic vascular resistance and the parent compound Prazosin is primarily responsible for the antihypertensive activity. (pharmacycode.com)

Alpha adrenergic blockade during prazosin therapy. (ox.ac.uk)
People with normal or low BP would invoke compensation by the sympathetic nervous system in response to alpha blockade. (hypothes.is)

Terazosin is a quinazoline compound that counteracts alpha1-induced adrenergic contractions of bladder neck, facilitating urinary flow in the presence of BPH. (medscape.com)
The drug is commercially available in a racemic mixture of 2 isomers, and is pharmacologically related to doxazocin, prazosin, and terazosin. (lgmpharma.com)

Because of availability of longer-acting, once-daily selective agents, however, the clinical utility of prazosin for BPH has been reduced. (medscape.com)
Accordingly, Prazosin is a selective inhibitor of the alpha1 subtype of alpha adrenergic receptors. (pharmacycode.com)

ARBs selectively block the binding of angiotensin II to its receptor, leading to vasodilation and reduced aldosterone secretion. (pharmacologymentor.com)

When the active metabolites of kratom bind to these receptors, they cause vasoconstriction, papillary constriction, and constriction of smooth muscles in the genitourinary tract. (kratom.org)
It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. (lookformedical.com)

Prazosin is currently approved for the treatment of hypertension. (medscape.com)

Prazosin improves urinary flow rate and frequency of micturition. (medscape.com)

In previous studies we investigated the role of beta- and alpha 2-adrenergic receptors through local microinjections of various drugs into the dorsal pontine tegmentum (DPT) of the cat. (nih.gov)
Drugs can bind to the various protein targets among which G-protein coupled receptors (GPCR) hold their flagship. (egpat.com)
Then, can we include all drugs acting on receptors into the list? (egpat.com)
Few of the drugs act on receptor coupled with ion channels again not fall into the list. (egpat.com)
These receptors, commonly called as ionotropic receptors, are not GPCR hence all drugs acting on these should be properly differentiated. (egpat.com)
Similar is the case with many drugs acting on these receptors. (egpat.com)
Angiotensin II receptor blocker valsartan (Diovan) at the forefront of drugs for high blood pressure. (cardiohow.com)
Drugs that bind to and block the activation of ADRENERGIC BETA-2 RECEPTORS. (lookformedical.com)
Drugs that selectively bind to and activate beta-adrenergic receptors. (lookformedical.com)
For reasons that are still unclear, some Alpha-2 drugs, such as guanfacine , have also been shown to be effective in the treatment of anxiety disorders and ADHD . (wikipedia.org)

Contraction linked to 5-HT(1B/1D) receptor stimulation in the rabbit renal artery can be explained by an influx of external Ca(2+) through voltage-dependent Ca(2+) channels and sensitization of the contractile myofilaments to existing levels of Ca(2+), with no release of Ca(2+) from intracellular stores. (ox.ac.uk)
Existence and alpha 1-adrenergic stimulation of inositol polyphosphates in mammalian heart. (aspetjournals.org)
1,4,5-IP3 (significant at 10 microM) and both IP4 isomers (significant at 1 microM) increased after alpha-adrenoceptor stimulation, whereas 1,3,4,5,6-IP5 and IP6 remained unaffected. (aspetjournals.org)
Increased inositol polyphosphate turnover may be involved in the mechanism(s) whereby alpha 1-adrenoceptor stimulation produces an increase in myocardial force of contraction. (aspetjournals.org)
In order to elucidate the mechanisms of age-related changes in urinary bladder function, we studied the influence of aging on the contractile response to muscarinic and α-adrenergic stimulation, and on the binding characteristics of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB) to muscarinic cholinoceptors, in addition to histological examination in rat urinary bladder. (scirp.org)
We revealed that the muscarinic receptor-mediated response was not affected by aging, while the contractile response to α-adrenergic stimulation was significantly augmented in both bladder body and trigone. (scirp.org)
[4] [5] However, in preliminary studies, through stimulation of α 2 adrenoceptors, working memory is comparatively improved. (wikipedia.org)

Alfuzosin is an alpha-1 blocker of adrenoreceptors in the prostate. (medscape.com)
It is an alpha-adrenergic blocker specifically targeted to alpha-1 receptors. (medscape.com)
Alpha-blocker medications are the first line of therapy for men with these urinary symptoms. (urotoday.com)
To assess the frequency of cataract surgery complications arising from alpha-blocker therapy in a large patient population. (urotoday.com)
If possible, alpha blocker medications should be discontinued prior to eye surgery in older patients. (urotoday.com)
As alpha-blocker medications are the first line of therapy for men with LUTS, these reports of IFIS led the Food and Drug Administration, American Urological Association, American Academy of Ophthalmology, and American Society of Cataract and Refractive Surgery to issue statements alerting physicians and patients to potential difficulties during cataract surgery in patients using alpha-1 blocker therapy [7,8,9]. (urotoday.com)
The purpose of this study was to assess the impact of alpha-blocker therapy on complications during cataract surgery in a large patient population. (urotoday.com)
Several randomized controlled trials have found that the alpha-1 blocker prazosin is effective in reducing symptoms of posttraumatic stress disorder (PTSD) among active-duty soldiers(Roundup, 2017). (duepapers.net)
Tamsulosin is an alpha-adrenergic receptor blocker. (kratom.org)

Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. (lgmpharma.com)

Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra. (aspetjournals.org)
Pharmacological characterization of alpha(2)adrenoceptors mediating this process. (nel.edu)

A study published in 2005 described a new clinical entity, the "intra-operative floppy iris syndrome" (IFIS), and suggested that this syndrome was associated with tamsulosin, a drug used widely for the treatment of lower urinary tract symptoms (LUTS) due to benign prostate enlargement [2]. (urotoday.com)
Studies show that tamsulosin has about 12 times greater affinity for alpha-1 adrenergic receptors in the prostate than those in the aorta, which may result in a reduced incidence of adverse cardiovascular effects. (lgmpharma.com)
Thus, because kratom and tamsulosin have opposite effects mediated by the alpha-adrenergic receptors, they will become ineffective if combined. (kratom.org)
Kratom and tamsulosin act via alpha-adrenergic receptors. (kratom.org)

Central adrenergic system may play a stimulating role through alpha2-receptor in the acute hypoxia-modulating TRH release from rat hypothalamus. (nel.edu)

Presynaptic beta(2)-adrenoceptors mediate nicotine-induced NOergic neurogenic dilation in porcine basilar arteries. (lookformedical.com)

Acetylcholine released from cholinergic nerve endings, contracts the smooth muscle of bladder body via activation of muscarinic receptors to cause voiding. (scirp.org)
The muscarinic receptor-mediated contraction of smooth muscle is induced by activation of protein kinase C and by increased intracellular Ca 2+ . (scirp.org)
All muscarinic acetylcholine receptors are G-protein coupled receptors present at various locations such as CNS, heart, many smooth muscles and exocrine glands. (egpat.com)

The residual contraction was abolished by the putative receptor operated channel inhibitor, SKF 96365 (2 microM). (ox.ac.uk)
Imatinib is a 2-phenyl amino pyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. (keralapharmacist.com)
2 3 Phentolamine also has been used to treat hypertensive crisis associated with monoamine oxidase inhibitor (MAOI) therapy and in combination with papaverine to treat erectile dysfunction (ED). 1 According to ED treatment guidelines, oral phosphodiesterase type 5 (PDE5) inhibitors are considered first-line therapy. (empowerpharmacy.com)

The drug acts by blocking alpha-1 adrenergic receptors in the genitourinary tract's and relaxing the muscles, especially the bladder's detrusor muscles and prostatic muscles, allowing easy passage of urine through the urethra. (kratom.org)

This is a combination product that contains 2 medications used to lower high blood pressure (hypertension), losartan and hydrochlorothiazide. (medbroadcast.com)

Relaxation is produced by blocking alpha-1 adrenoreceptors in the bladder neck and prostate. (medscape.com)
Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men. (lgmpharma.com)
The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS. (lookformedical.com)

Cooling and alpha 1- and alpha 2-adrenergic responses in cutaneous veins: role of receptor reserve. (johnshopkins.edu)
Experiments were designed to determine the effects of cooling on alpha 1- and alpha 2-adrenergic responses in isolated canine cutaneous veins. (johnshopkins.edu)

Indoramin improves urine flow rates by blocking alpha-1 adrenoreceptors in the bladder neck and prostate, thus relaxing smooth muscle in those sites. (medscape.com)

Cytokines and other factors produced by cells of the immune system can cross the blood-brain barrier to induce the release of neurotransmitters and hormones from the brain and pituitary, leading to several central nervous system (CNS)-dependent responses such as sleep, depression, thermogenesis, and anorexia [2-4]. (brainimmune.com)
The beta-3 adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS. (lookformedical.com)

The usual recommended starting dose for this medication is 3.125 mg 2 times daily in order to allow the body to get used to it. (medbroadcast.com)
If you miss more than 2 doses in a row, contact your doctor for instructions on restarting the medication. (medbroadcast.com)

The pharmacological characteristics of alpha-1 and alpha-2 adrenergic receptors in young (6 month) and old (4.5-5 year) female rabbit urethra were studied using isolated muscle bath techniques. (aspetjournals.org)
On the other hand, adrenergic activity is inhibited in this phase, leading to relax proximal urethra for voiding. (scirp.org)

These experiments suggest that cooling augments alpha 2-adrenergic responsiveness without affecting alpha 1-adrenergic responsiveness. (johnshopkins.edu)

One of two major pharmacologically defined classes of adrenergic receptors. (lookformedical.com)

Prazosin improves urine flow rates by relaxing smooth muscle. (medscape.com)
During the phase of urine storage, adrenergic nerves mainly play a crucial role [3,4]. (scirp.org)

In intact arterial segments, 1 nM - 10 microM 5-HT failed to induce contraction or increase the fura-2 fluorescence ratio (in the presence of 1 microM ketanserin and prazosin to block 5-HT(2) and alpha(1)-adrenergic receptors, respectively). (ox.ac.uk)

Receptor interactions of imidazolines. (wikipedia.org)

The α 1 adrenergic receptor stimulates phosphatidylinositol turnover and increased diacylglycerol activates protein kinase C, while increased inositoltrisphosphate mobilize Ca 2+ to cause smooth muscle contraction. (scirp.org)

People who take rauwolscine should stop at least 2 weeks before surgery. (webmd.com)

Results of double-labeling studies indicated that beta(2)-adrenoceptor immunoreactivities and NADPH diaphorase reactivities were colocalized in the same nerve fibers in basilar and middle cerebral arteries. (lookformedical.com)

Alpha 1-adrenergic coronary constriction during exercise and ischemia. (unthsc.edu)

These effects were prevented by the subsequent injection of prazosin. (nih.gov)
On the other hand, the injection into the DPT of prazosin alone produced scarce or inconsistent effects on the sleep/waking cycle. (nih.gov)
This would counteract the depressant effects of adrenergic antagonism. (hypothes.is)

Do not take 2 doses within 6 hours of one another. (medbroadcast.com)

Anatomy26

Organisms15

Diseases4

Chemicals and Drugs158

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Psychiatry and Psychology1

Phenomena and Processes36

Information Science3

Antagonist15

Agonists10

Agonist9

Antagonists6

Norepinephrine6

Blockers18

Phenylephrine5

Propranolol1

Benign Prostatic H3

Nonselective1

Postsynaptic3

Epinephrine1

Vascular7

Blockade2

Terazosin2

Selective2

Vasodilation1

Vasoconstriction2

Treatment of hypertension1

Frequency of micturition1

Drugs10

Stimulation7

Blocker9

Alpha1 Receptors1

Characterization of alpha2

Tamsulosin4

Alpha2 Receptor1

Presynaptic1

Muscarinic3

Inhibitor3

Genitourinary1

Losartan1

Relaxation3

Veins2

Prostate1

Thermogenesis2

Medication2

Urethra2

Responsiveness1

Pharmacologically1

Urine2

MicroM1

Interactions1

Stimulates1

Rauwolscine1

Nerve1

Coronary1

Effects3

Doses1