Statins are also found in the combination medications Advicor® (lovastatin + niacin), Caduet® (atorvastatin + amlodipine) and Vytorin™ (simvastatin + ezetimibe). (drhendesi.com)
Some commonly used statins include: atorvastatin (Lipitor), simvastatin (Zocor), or lovastatin (Mevacor). (rxfacts.org)
A sol-gel Carbowax 20 M/3-[(3-Cholamidopropyl) dimethyl ammonio]-1-propanesulfonate composite sorbent-based capsule phase microextraction device has been fabricated and characterized for the determination of four statins (pravastatin, rosuvastatin, pitavastatin, and atorvastatin) in human urine. (bvsalud.org)
Lovastatin1
Herein, a microextraction method was reported based on the liquid-solid phase transition of benzoic acid to quantify two statins, namely lovastatin and simvastatin in authentic human urine. (bvsalud.org)
Cholestyramine2
Two other types of medicines that lower cholesterol levels are bile acid sequestrants, such as colesevelam, cholestyramine, and colestipol, and nicotinic acid (niacin). (uhhospitals.org)
Novo Cholamine (Cholestyramine) resin belongs to the class of medications known as bile acid sequestrants. (pocketpills.com)
Known as bile acid sequestrants1
This class of LDL-lowering drugs, also known as bile acid sequestrants or bile acid-binding drugs, works in the intestines by promoting increased disposal of cholesterol. (drhendesi.com)
Pitavastatin1
Finally, the method's applicability was demonstrated in the determination of the statins in authentic human urine after oral administration of pitavastatin and rosuvastatin-containing tablets. (bvsalud.org)
Statins2
For those who have a bad reaction to statins or when statins do not lower cholesterol enough, other medications, such as ezetimibe, niacin, fibrates, or bile acid sequestrants, may be combined with statins. (rxfacts.org)
Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)
Fibric acid3
Another class of lipid-lowering agents is fibric acid derivatives, which primarily target triglyceride levels. (pharmaoffer.com)
By activating PPAR-alpha, fibric acid derivatives enhance the breakdown of triglycerides and increase the elimination of fatty acids from the bloodstream. (pharmaoffer.com)
These medicines include bempedoic acid, bile acid sequestrants, fibric acid derivatives, and nicotinic acid (niacin). (healthwise.net)
Niacin1
Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. (medscape.com)
Bind to bile acids2
a class of hyperlipidemia agents that bind to bile acids in the gastrointestinal tract. (ashp.org)
These agents bind to bile acids in the intestine, preventing their reabsorption. (pharmaoffer.com)
Inhibitors1
Use of simvastatin is contraindicated in medications that are strong inhibitors of cytochrome P450 activity (such as cyclosporine, ketoconazole, diltiazem, ciprofloxacin or amiodarone), and dose adjustments are appropriate for its use with other agents that inhibit CYP 3A4. (nih.gov)
Ezetimibe1
Simvastatin is also available as a fixed combination with ezetimibe under the brand name Vytorin. (nih.gov)
Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg. the recommended dose is 5 to 80 mg daily based upon tolerability and lipid levels. (nih.gov)
Steroid hormones2
In addition to its importance within cells, cholesterol is an important component in the hormonal systems of the body to manufacture bile acids, steroid hormones, and vitamin D. In vertebrates, it is formed predominantly in the liver. (natural-homeremedies.com)
Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid and vitamin D. Elevated levels of cholesterol in the blood, especially when bound to low-density lipoprotein (LDL, often referred to as "bad cholesterol"), may increase the risk of cardiovascular disease. (wikipedia.org)
Intestines2
Bile acid sequestrants or bile acid resin drugs work inside your intestines to manage cholesterol levels, as they attach to bile from the liver to stop it from being absorbed back into the blood. (chestercountycheese.org)
It works by binding to cholesterol-like substances called bile acids in the intestines and preventing them from being absorbed into the body. (pocketpills.com)
Fatty acids1
a lipid that is the storage form of fatty acids, used as an energy source. (ashp.org)
a lipid used in the production of hormones, bile salts, and cell membranes that contributes to atherosclerotic plaque formation when levels are high. (ashp.org)
Additionally, bile acid sequestrants are often used as lipid-lowering agents. (pharmaoffer.com)
Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
But in view of the wide use of simvastatin, clinically apparent liver injury is exceeding rare and is estimated to occur in 1 per 100,000 patient years of exposure. (nih.gov)
Simvastatin is metabolized to some extent in the liver (via CYP 3A4) and is excreted in bile. (nih.gov)
Medicines1
These medicines bind to bile, so they can't be used during digestion. (drhendesi.com)
Folic acid2
High homocysteine can be treated with folic acid. (adam.com)
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas. (nih.gov)
Vitamin1
By reducing fat absorption, bile acid sequestrants tend to reduce absorption and assimilation of vitamin A and other fat-soluble nutrients. (interactionsguide.com)
Increases2
Coadministration with these agents may cause increases in simvastatin levels and potentiate its hepatic or muscle toxicity. (nih.gov)
Through the interaction with the phospholipid fatty-acid chains, cholesterol increases membrane packing, which both alters membrane fluidity and maintains membrane integrity so that animal cells do not need to build cell walls (like plants and most bacteria). (wikipedia.org)
Levels1
Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)
In several studies, ALT elevations were no more frequent in patients taking 10 and 20 mg of simvastatin daily than in placebo recipients. (nih.gov)