• The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance. (nih.gov)
  • It is readily soluble in chloroform and methanol, but practically insoluble in water. (wikipedia.org)
  • Metformin hydrochloride is a white to off-white crystalline powder that is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. (themedidex.com)
  • It is soluble in water, very slightly soluble in alcohol, and practically insoluble in chloroform. (salvavidaspharmaceutical.com)
  • There is little difference in relative bioavailability when nifedipine capsules are given orally and either swallowed whole, bitten and swallowed, or bitten and held sublingually. (nih.gov)
  • Patients with hepatic impairment (liver cirrhosis) have a longer disposition half-life and higher bioavailability of nifedipine than healthy volunteers. (nih.gov)
  • Among all newly discovered chemical entities about 40% drugs are lipophilic and these drugs are rejected by the pharmaceutical industry and will never benefit a patient because of its poor bioavailability due to low water solubility and/or cell membrane permeability. (scialert.net)
  • White, odorless, crystalline powder that is stable in air and practically insoluble in water. (medscape.com)
  • White, odorless, crystalline powder largely insoluble in water. (medscape.com)
  • Solubility: practically insoluble in water, freely soluble in acetone, in alcohol and in methylene chloride. (china.cn)
  • The combinatorial chemistry and high throughput screening increases the solubility of poorly water soluble compounds. (scialert.net)
  • Hence, poor aqueous solubility has become the leading hurdle for formulation, and scientists are concerned in improving oral delivery of insoluble drug candidates. (dovepress.com)
  • The elimination half-life of nifedipine administered as nifedipine extended-release tablet is approximately 7 hours in contrast to the known 2 hour elimination half-life of nifedipine administered as an immediate-release capsule. (nih.gov)
  • Nifedipine extended-release tablets are an extended-release tablet dosage form of the calcium channel blocker nifedipine. (nih.gov)
  • Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. (nih.gov)
  • Nifedipine selectively inhibits calcium ion influx across the cell membrane of vascular smooth muscle and cardiac muscle without altering serum calcium concentrations. (nih.gov)
  • The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (nih.gov)
  • The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. (nih.gov)
  • Nifedipine is an antianginal drug belonging to a class of pharmacological agents, the calcium channel blockers. (nih.gov)
  • This unloading of the heart reduces myocardial energy consumption and oxygen requirements and probably accounts for the effectiveness of nifedipine in chronic stable angina. (nih.gov)
  • After ingestion of nifedipine extended-release tablets under fasting conditions, plasma concentrations peak at about 2.5 to 5 hours with a second small peak or shoulder evident at approximately 6 to 12 hours post dose. (nih.gov)
  • The usual starting dose of FORTAMET (metformin hydrochloride) Extended-Release Tablets is 1000 mg taken with a full glass of water once daily with the evening meal, although 500 mg may be utilized when clinically appropriate. (themedidex.com)
  • Nifedipine is completely absorbed after oral administration. (nih.gov)
  • Nifedipine is rapidly and fully absorbed after oral administration. (nih.gov)
  • Water is the solvent of choice for liquid pharmaceutical formulations. (scialert.net)
  • Nanosuspensions consist of stabilized submicron sized crystalline drug particles in liquid medium, usually water. (dovepress.com)
  • Nifedipine extended-release tablets contain 30 mg of nifedipine for once-a-day oral administration. (nih.gov)
  • Nifedipine capsules are formulated as soft gelatin capsules for oral administration each containing 10 mg nifedipine. (nih.gov)
  • Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. (nih.gov)
  • Three 30 mg nifedipine extended-release tablets, however, result in substantially higher C max values than those after a single 90 mg nifedipine extended-release tablet. (nih.gov)
  • Nifedipine is extensively converted to inactive metabolites and approximately 80 percent of nifedipine and metabolites are eliminated via the kidneys. (nih.gov)
  • The combinatorial screening programs employed by the pharmaceutical companies identified that about 40% of active New Chemical Entities (NCEs) are poorly water soluble. (scialert.net)
  • Rajebahadur M, Zia H, Nues A, Lee C. Mechanistic study of solubility enhancement of nifedipine using vitamin E TPGS or solutol HS-15. (innovareacademics.in)
  • The resulting differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), and dissolution test data indicate that the resulting composites are amorphous at 1:15 API: polymer ratios for PVP and 1:5 for Soluplus®, which ensures the solubility of GML-3 in purified water and maintaining the supercritical state in solution. (bvsalud.org)
  • Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. (healthyplace.com)
  • Clotrimazole is a colourless, crystalline, weakly alkaline substance, melting point 141°- 145°C, soluble in acetone, chloroform and ethanol and practically insoluble in water. (pdfdrugs.com)
  • Tamsulosin hydrochloride is a white crystalline powder that melts with decomposition at approximately 230°C. It is sparingly soluble in water and methanol, slightly soluble in glacial acetic acid and ethanol, and practically insoluble in ether. (rxlist.com)
  • Fluconazole is a white to off-white crystalline powder, which is sparingly soluble in water and saline. (pdfdrugs.com)
  • Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. (nih.gov)
  • Orange-red powder, practically insoluble in water, soluble in warm ethanol (96 per cent), soluble in alkaline solutions. (forexsanity.com)
  • Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle. (nih.gov)
  • Nifedipine selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without altering serum calcium concentrations. (nih.gov)
  • The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (nih.gov)
  • The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. (nih.gov)
  • Nifedipine extended-release tablets are designed to provide nifedipine at an approximately constant rate over 24 hours. (nih.gov)
  • Nifedipine extended-release tablets depends for its action on the existence of an osmotic gradient between the contents of the bi-layer core and fluid in the gastrointestinal tract. (nih.gov)
  • Nifedipine extended-release tablets contain 30 mg of nifedipine for once-a-day oral administration. (nih.gov)
  • Nifedipine extended-release tablets meet USP Dissolution Test 4 (using first derivative UV spectrophotometry at 245 nm for sample analysis). (nih.gov)
  • After ingestion of nifedipine extended-release tablets under fasting conditions, plasma concentrations peak at about 2.5 to 5 hours with a second small peak or shoulder evident at approximately 6 to 12 hours post dose. (nih.gov)
  • Two 30 mg nifedipine extended-release tablets may be interchanged with a 60 mg nifedipine extended-release tablet. (nih.gov)
  • Three 30 mg nifedipine extended-release tablets, however, result in substantially higher C values than those after a single 90 mg nifedipine extended-release tablet. (nih.gov)
  • Adalat CC tablets contain either: 30, 60, or 90 mg of nifedipine for once-a-day oral administration. (nih.gov)
  • Nifedipine extended-release tablet is formulated as a once-a-day controlled-release tablet for oral administration to provide 30, 60, or 90 mg of nifedipine. (nih.gov)
  • Nifedipine extended-release tablet is similar in appearance to a conventional tablet. (nih.gov)