Reduces arterial blood prChloroformBioavailabilityCrystalline powderMethylene chlorideSolubilityVerapamilCapsuleCalciumStableDoseAbsorbed after oral administrationLiquidOralYellowHigherPlasmaApproximatelyActiveSolubilityFreely solubleAcetoneSoluble in waterEthanolInfluxTabletsDrugsExtended-releaseWarm
Reduces arterial blood pr1
- The mechanism by which nifedipine reduces arterial blood pressure involves peripheral arterial vasodilatation and, consequently, a reduction in peripheral vascular resistance. (nih.gov)
Chloroform3
- It is readily soluble in chloroform and methanol, but practically insoluble in water. (wikipedia.org)
- Metformin hydrochloride is a white to off-white crystalline powder that is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. (themedidex.com)
- It is soluble in water, very slightly soluble in alcohol, and practically insoluble in chloroform. (salvavidaspharmaceutical.com)
Bioavailability3
- There is little difference in relative bioavailability when nifedipine capsules are given orally and either swallowed whole, bitten and swallowed, or bitten and held sublingually. (nih.gov)
- Patients with hepatic impairment (liver cirrhosis) have a longer disposition half-life and higher bioavailability of nifedipine than healthy volunteers. (nih.gov)
- Among all newly discovered chemical entities about 40% drugs are lipophilic and these drugs are rejected by the pharmaceutical industry and will never benefit a patient because of its poor bioavailability due to low water solubility and/or cell membrane permeability. (scialert.net)
Crystalline powder2
- White, odorless, crystalline powder that is stable in air and practically insoluble in water. (medscape.com)
- White, odorless, crystalline powder largely insoluble in water. (medscape.com)
Methylene chloride1
Solubility2
- The combinatorial chemistry and high throughput screening increases the solubility of poorly water soluble compounds. (scialert.net)
- Hence, poor aqueous solubility has become the leading hurdle for formulation, and scientists are concerned in improving oral delivery of insoluble drug candidates. (dovepress.com)
Verapamil1
- and nondihydropyridine (eg, verapamil) and dihydropyridine (eg, nifedipine) calcium channel blockers. (medscape.com)
Capsule1
- The elimination half-life of nifedipine administered as nifedipine extended-release tablet is approximately 7 hours in contrast to the known 2 hour elimination half-life of nifedipine administered as an immediate-release capsule. (nih.gov)
Calcium6
- Nifedipine extended-release tablets are an extended-release tablet dosage form of the calcium channel blocker nifedipine. (nih.gov)
- Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. (nih.gov)
- Nifedipine selectively inhibits calcium ion influx across the cell membrane of vascular smooth muscle and cardiac muscle without altering serum calcium concentrations. (nih.gov)
- The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (nih.gov)
- The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. (nih.gov)
- Nifedipine is an antianginal drug belonging to a class of pharmacological agents, the calcium channel blockers. (nih.gov)
Stable1
- This unloading of the heart reduces myocardial energy consumption and oxygen requirements and probably accounts for the effectiveness of nifedipine in chronic stable angina. (nih.gov)
Dose2
- After ingestion of nifedipine extended-release tablets under fasting conditions, plasma concentrations peak at about 2.5 to 5 hours with a second small peak or shoulder evident at approximately 6 to 12 hours post dose. (nih.gov)
- The usual starting dose of FORTAMET (metformin hydrochloride) Extended-Release Tablets is 1000 mg taken with a full glass of water once daily with the evening meal, although 500 mg may be utilized when clinically appropriate. (themedidex.com)
Absorbed after oral administration2
Liquid2
- Water is the solvent of choice for liquid pharmaceutical formulations. (scialert.net)
- Nanosuspensions consist of stabilized submicron sized crystalline drug particles in liquid medium, usually water. (dovepress.com)
Oral2
- Nifedipine extended-release tablets contain 30 mg of nifedipine for once-a-day oral administration. (nih.gov)
- Nifedipine capsules are formulated as soft gelatin capsules for oral administration each containing 10 mg nifedipine. (nih.gov)
Yellow1
Higher1
- Three 30 mg nifedipine extended-release tablets, however, result in substantially higher C max values than those after a single 90 mg nifedipine extended-release tablet. (nih.gov)
Plasma1
- The half-life of nifedipine in plasma is approximately two hours. (nih.gov)
Approximately1
- Nifedipine is extensively converted to inactive metabolites and approximately 80 percent of nifedipine and metabolites are eliminated via the kidneys. (nih.gov)
Active1
- The combinatorial screening programs employed by the pharmaceutical companies identified that about 40% of active New Chemical Entities (NCEs) are poorly water soluble. (scialert.net)
Solubility2
- Rajebahadur M, Zia H, Nues A, Lee C. Mechanistic study of solubility enhancement of nifedipine using vitamin E TPGS or solutol HS-15. (innovareacademics.in)
- The resulting differential scanning calorimetry (DSC), powder X-ray diffractometry (PXRD), and dissolution test data indicate that the resulting composites are amorphous at 1:15 API: polymer ratios for PVP and 1:5 for Soluplus®, which ensures the solubility of GML-3 in purified water and maintaining the supercritical state in solution. (bvsalud.org)
Freely soluble1
- Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. (healthyplace.com)
Acetone1
- Clotrimazole is a colourless, crystalline, weakly alkaline substance, melting point 141°- 145°C, soluble in acetone, chloroform and ethanol and practically insoluble in water. (pdfdrugs.com)
Soluble in water2
- Tamsulosin hydrochloride is a white crystalline powder that melts with decomposition at approximately 230°C. It is sparingly soluble in water and methanol, slightly soluble in glacial acetic acid and ethanol, and practically insoluble in ether. (rxlist.com)
- Fluconazole is a white to off-white crystalline powder, which is sparingly soluble in water and saline. (pdfdrugs.com)
Ethanol2
- Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. (nih.gov)
- Orange-red powder, practically insoluble in water, soluble in warm ethanol (96 per cent), soluble in alkaline solutions. (forexsanity.com)
Influx4
- Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle. (nih.gov)
- Nifedipine selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without altering serum calcium concentrations. (nih.gov)
- The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (nih.gov)
- The reduction in calcium influx by nifedipine causes arterial vasodilation and decreased peripheral vascular resistance which results in reduced arterial blood pressure. (nih.gov)
Tablets8
- Nifedipine extended-release tablets are designed to provide nifedipine at an approximately constant rate over 24 hours. (nih.gov)
- Nifedipine extended-release tablets depends for its action on the existence of an osmotic gradient between the contents of the bi-layer core and fluid in the gastrointestinal tract. (nih.gov)
- Nifedipine extended-release tablets contain 30 mg of nifedipine for once-a-day oral administration. (nih.gov)
- Nifedipine extended-release tablets meet USP Dissolution Test 4 (using first derivative UV spectrophotometry at 245 nm for sample analysis). (nih.gov)
- After ingestion of nifedipine extended-release tablets under fasting conditions, plasma concentrations peak at about 2.5 to 5 hours with a second small peak or shoulder evident at approximately 6 to 12 hours post dose. (nih.gov)
- Two 30 mg nifedipine extended-release tablets may be interchanged with a 60 mg nifedipine extended-release tablet. (nih.gov)
- Three 30 mg nifedipine extended-release tablets, however, result in substantially higher C values than those after a single 90 mg nifedipine extended-release tablet. (nih.gov)
- Adalat CC tablets contain either: 30, 60, or 90 mg of nifedipine for once-a-day oral administration. (nih.gov)
Drugs1
- Novel drug delivery technologies for insoluble drugs. (innovareacademics.in)
Extended-release2
- Nifedipine extended-release tablet is formulated as a once-a-day controlled-release tablet for oral administration to provide 30, 60, or 90 mg of nifedipine. (nih.gov)
- Nifedipine extended-release tablet is similar in appearance to a conventional tablet. (nih.gov)
Warm1
- Warm water can be used, but not hot water. (shreejipharmainternational.com)