• Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. (sigmaaldrich.com)
  • PPARs are ligand-activated transcription factors belonging to the steroid, thyroid and retinoid nuclear receptor superfamily. (unich.it)
  • With the involvement of PPARs in many diverse metabolic pathways there is great clinical interest in the potential utility of PPAR ligands for the treatment of cancer, inflammation, psoriasis, atherosclerosis, dyslipidaemia, neurological disorders, obesity and diabetes. (sigmaaldrich.com)
  • In fact, PPAR agonists - which help activate PPARs - are one class of new diabetes drugs. (stumptuous.com)
  • Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. (antibodies-online.com)
  • Crypto PPARs Soft Capsules can be consumed every day or sometimes just by people in good health who do not have any health problems. (crypto.com.my)
  • Crypto PPARs Soft Capsules have proven to be very instrumental in helping the healing process of chronic diseases. (crypto.com.my)
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  • Many compounds are known agonists at multiple PPARs with different isoform selectivities. (sigmaaldrich.com)
  • Furthermore, in vitro PPARs transactivation assays on these 3- or 4-alkoxy substituted phenoxy derivatives afforded six compounds. (oncotarget.com)
  • PPARs are nuclear receptor proteins, which means basically that they're proteins that are active within a cell, and their job is to regulate the expression of genes. (stumptuous.com)
  • Simply Nature Sciences brings together the Synergistic power of natural PPARs (from Cryptomonadales) and Resveratrol (from Red Grape Skin) to bring you the very Best in natural cellular care. (ournoblelife.com)
  • The activation of PPARs can exert an anti-inflammatory effect with inhibition of pro-inflammatory cytokines and a decrease in cell recruitment. (usda.gov)
  • In this study we analyzed the expression of PPARs and of their heterodimeric partners, RXRs, in embryonic rat cortical neurons during their in vitro maturation. (unich.it)
  • Our results demonstrate the presence of PPARs alpha, beta/delta and gamma and of RXRs beta and gamma. (unich.it)
  • PPARs are also expressed in muscle and exert pleiotropic specialised responses upon activation by their ligands. (frailty.net)
  • PPARs do a bunch of things, including regulating fatty acid storage and glucose metabolism. (stumptuous.com)
  • PPARs have a highly conserved DNA binding domain (region C) and a diverse ligand-independent activation domain (region A/B) which can confer constitutive activity on the receptor. (sigmaaldrich.com)
  • Here, we review the studies that provide insight into the important regulatory roles of PPARs in T-cell activation, survival, proliferation, differentiation, and autoimmune disease. (molcells.org)
  • Different isotypes of PPARs (alpha, beta/delta and gamma) have distinct physiological functions depending on their different ligand activation profiles and tissue distribution. (unich.it)
  • This agent increases plasma catabolism and the clearance of TG-rich particles by lipoprotein lipase induction and the suppression of the hepatic production of apo C-III through the activation of PPARs. (medscape.com)
  • PPARs regulate genes that are involved in development, metabolism, inflammation, and many cellular processes in different organs. (frailty.net)
  • PPARs play an important role in many cellular functions including lipid metabolism, cell proliferation, differentiation, adipogenesis and inflammatory signalling. (sigmaaldrich.com)
  • The PPARs are pivotal for the modulation of many of the pathogeneses mentioned above. (frailty.net)
  • Le tissu adipeux sécrète, en effet, une grande variété de molécules biologiquement actives agissant pour prévenir l'accumulation délétère de lipides et la modulation de l'insulinorésistance. (erudit.org)
  • Interactions and binding stability from the docking analysis and 20 ns molecular dynamic simulations confirmed the representative compounds to be suitable and plausible for PPARs pockets. (oncotarget.com)
  • The above-mentioned results demonstrated that the compounds may be used as reference for further optimization for enhanced PPARs activities and wide safety range. (oncotarget.com)
  • New insights into the role of PPARs. (unil.ch)
  • This review discusses the role of adipokines and PPARs with regard to hepatic energy metabolism and progression of NAFLD. (wjgnet.com)
  • And just like Marge and your wages, PPARs can affect some of the major functions of your cells. (stumptuous.com)
  • PPARs have been found to interact with a number of endogenous lipids and drugs for the treatment of human metabolic diseases. (sigmaaldrich.com)
  • Is There a Future for PPARs in the Treatment of Neuropsychiatric Disorders? (mdpi.com)
  • Suppose that the setpparparam command sets the OpenBoot PROM environment variables and then the poweron -a command starts multiple physical partitions (PPARs) simultaneously. (fujitsu.com)
  • Side note: PPARs are one of the reasons that your genetic "blueprint" is not your destiny. (stumptuous.com)
  • PPARs And Their Use In Improving Health And Wellness! (bodybuilding.com)
  • Manickam R, Duszka K, Wahli W. PPARs and Microbiota in Skeletal Muscle Health and Wasting. (frailty.net)