RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARα activation, resulting in increased Apoa2 mRNA expression. (elifesciences.org)
The increase in liver weights was due to activation of PPARα and peroxisome proliferation. (elifesciences.org)
Peroxisome proliferator-activated receptors (PPARs, including alpha, beta and gamma subtypes) and their agonists have a protective role in treatment of central nervous system (CNS) diseases. (biomedcentral.com)
The pSG5-puro plasmid pSG5-human GAL4-hPPAR alpha-puromycin enables to express the DNA binding domain of the yeast activator GAL4 (GAL4 DBD) followed by the ligand binding domain of the human peroxisome proliferator activated receptor receptor alpha hPPAR alpha LBD. (inserm-transfert.com)
The PPAR/RXR dimer then binds to a peroxisome proliferators-response element (Staels and Fruchart 2005), a DNA-specific sequence of which many types exist. (bodybuilding.com)
One of the mediators of the positive metabolic effects of endurance exercise is peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). (mrsupps.com)
The present study examined the combined effects of an antihypertensive (S-Amlodipine) and an insulin-sensitizing agent, peroxisome proliferator-activated receptor (PPAR) agonists (Pioglitazone and Ragaglitazar), on cardiovascular risk factors in aged diabetic and insulin-resistant Zucker fa/fa rats. (biomedcentral.com)
Lately we reported that several semi-volatile compounds (SVOCs) were competitive ligands for human peroxisome proliferator-activated nuclear receptor gamma (PPAR= 0. (sciencepop.org)
The pharmacodynamics of ALT-801, a GLP-1/glucagon receptor dual agonist optimized for NASH and weight loss, were compared to semaglutide (GLP-1 receptor agonist) and elafibranor (peroxisome proliferator-activated receptor, PPAR-α/δ, agonist) in a biopsy-confirmed, diet-induced obese (DIO) mouse model of NASH (DIO-NASH). (researchsquare.com)
Agonist3
Rosiglitazone (0.8, 2.4 and 7.2 mg/kg), a selective PPAR- gamma agonist, was injected intraperitoneally at 1 h before GCIRI. (biomedcentral.com)
Rosiglitazone, a PPAR-gamma agonist, plays a protective role in hippocampal neuron damage of GCIRI rats by inhibiting the oxidative stress response and inflammation. (biomedcentral.com)
This suggests that use of a PPAR-alpha agonist may be beneficial in aiding fat loss . (bodybuilding.com)
Antagonism1
The activation or antagonism of PPAR-gamma did not affect the expression of PPAR-alpha or -beta, indicating that the three subtypes of PPARs act in independent pathways in the CNS. (biomedcentral.com)
Gamma3
The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with agonists or antagonists of PPAR-gamma. (biomedcentral.com)
The expression changes of PPAR-alpha, -beta and -gamma at mRNA and protein levels were detected by RT-PCR and western blotting. (biomedcentral.com)
PPAR-gamma agonists, also known as thiazolidinediones (TZDs), such as Pioglitazone and Rosiglitazone increase insulin sensitivity, reduce levels of blood glucose, insulin and triglycerides with a concomitant reduction in BP and improvement in endothelial function [ 8 , 9 ]. (biomedcentral.com)
Rosiglitazone1
After treatment with rosiglitazone or GW9662, no significant change in PPAR-alpha or -beta expression was detected. (biomedcentral.com)
Activator1
Taken together, these results demonstrate that curcumin is a PPARα activator and may affect expression levels of proteins involved in amyloid deposition to influence amyloidosis and metabolism in a complex manner. (elifesciences.org)
Isoforms1
There are three different PPAR isoforms, each of which have a distinct action when activated. (bodybuilding.com)
Hepatic1
In addition to the change in plasma fatty acid levels, hepatic apoA-I andapoA-II are increased by PPAR-alpha activation, which improves cholesterol levels by increasing HDL levels (Chinetti et al. (bodybuilding.com)
Nuclear1
Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3). (wikipedia.org)
Inflammation1
Study endpoints included body and liver weight, liver and plasma total cholesterol and triglycerides, plasma aminotransferases, histological analysis of liver steatosis, inflammation (galectin-3) and fibrosis (collagen type 1 alpha 1), and evaluation of individual animal changes in composite Non-alcoholic Fatty Liver Disease Activity Score (NAS) and fibrosis stage. (researchsquare.com)
Liver3
Liver X receptor alpha has been shown to interact with EDF1 and Small heterodimer partner. (wikipedia.org)
PPAR-alpha activation increases the expression of lipoprotein lipase and apolipoprotein A-V (apoA-V) while simultaneously decreasing expression of apoC-III in the liver, which decreases VLDL particles and lowering plasma triglycerides in chylomicrons (Staels and Fruchart 2005). (bodybuilding.com)
Natural regulators of brown and beige fat include external conditions like cold temperatures, and exercise, as well as internal mechanisms like thyroid hormones, beta-adrenergic hormones, retinoids, PPARγ and PPARα agonists, and the liver X receptor. (mrsupps.com)
Transcriptional1
However ligand binding does not necessarily indicate agonism of the receptor leading to transcriptional events. (sciencepop.org)
Partial1
The results suggest that a combination of PPAR agonists and S-Amlodipine has partial benefits in improving the cardiovascular risk factors such as reduction in triglyceride levels, associated with chronic type 2 diabetes, and therefore may be utilized as an approach for addressing some of these devastating metabolic syndrome complications. (biomedcentral.com)
Adipose1
These cells enable to measure the PPAR alpha activity of environmental (water, sediments), human (blood, urine adipose tissue) or food (water, vegetables, meat) samples. (inserm-transfert.com)
Expression3
Restoration of LXR-alpha expression/function within a psoriatic lesion may help to switch the transition from psoriatic to symptomless skin. (wikipedia.org)
the contents of IL-1, IL-6, IL-10 and TNF-alpha, and the NF- kappa B expression were measured by enzyme-linked immunosorbent assay (ELISA) and immunohistochemical staining. (biomedcentral.com)
The MDA, IL-1, IL-6, IL-10, TNF-alpha content and expression of PPARs increased significantly, but the SOD activity and NF-kappa B expression were weakened in the hippocampus. (biomedcentral.com)
Gene1
This gene encodesthe E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of thePDH complex. (biobender.com)
Beta1
The E1 enzyme is a heterotetramer of two alpha and two beta subunits. (biobender.com)
Chemicals1
Chemicals that KSHV K8 alpha antibody were previously identified as possible PPARligands were tested here for PPARactivation using environmentally relevant house dust samples could be of more value in estimating real-world exposure and possible health effects. (sciencepop.org)
Treatment1
PPAR-alpha agonists in the form of fibrates have been in use for the treatment of dyslipidemia [ 10 ]. (biomedcentral.com)
Cells1
HG5LN GAL4-hPPAR alpha cells were generated by transfection of HG5LN cells with the plasmid pSG5-GAL4-human PPAR alpha-puromycin. (inserm-transfert.com)
PPAR-γ agonists such as rosiglitazone and pioglitazone are used in clinical practice for the treatment of diabetes, and there is some evidence that pioglitazone may have positive effects on cardiovascular complications by virtue of its favorable effects on lipid profiles. (medscape.com)
Given the prevalence of lipid abnormalities in patients with diabetes, dual PPAR-α/γ agonists (glitazars) could potentially benefit patients with diabetes. (medscape.com)
This study demonstrates that GW0742 treatment has a prominent anti-inflammatory effect in 5XFAD mice and suggests that PPARδ agonists may have therapeutic utility in treating AD. (nih.gov)
As such, evidence suggests the potential synergistic benefit of combining PPAR agonists, cannabinoids and antioxidants as a novel approach for treating chronic pain. (accurateclinic.com)
This supplement is directed at suppressing these driving forces in chronic pain with the inclusion of pan-PPAR (peroxisome proliferator-activated receptor) agonists that modulates key metabolic and inflammatory pathways, cannabinoids that act through the ECS and other botanical antioxidants and terpenes. (accurateclinic.com)
Ligands3
Here, we tested the ability of modeling approaches to predict the effect of diverse PPARα ligands on receptor activity using Cos7 cells transiently transfected with a full length human PPARα (hPPARα) expression construct and a peroxisome proliferator response element-driven luciferase reporter. (nih.gov)
We studied binding of ligands from different wines to the peroxisome proliferator-activated receptor γ (PPARγ), a key factor in glucose and lipid metabolism. (indexindex.com)
The ameliorating effects of red wine on metabolic diseases may be partially explained by the presence of PPARγ ligands. (indexindex.com)
Receptor7
Predicting the effects of per- and polyfluoroalkyl substance mixtures on peroxisome proliferator-activated receptor alpha activity in vitro. (nih.gov)
Animal toxicity studies and human epidemiology indicate that PFAS may act through shared mechanisms including activation of peroxisome proliferator activated receptor α (PPARα). (nih.gov)
Liver X receptor alpha (LXR-alpha) is a nuclear receptor protein that in humans is encoded by the NR1H3 gene (nuclear receptor subfamily 1, group H, member 3). (wikipedia.org)
Liver X receptor alpha has been shown to interact with EDF1 and Small heterodimer partner. (wikipedia.org)
11. Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. (nih.gov)
Peroxisome proliferator activator receptor δ (PPARδ) is a transcription factor with potent anti-inflammatory activation properties and PPARδ agonism leads to reduction in brain Aβ levels in 5XFAD mice. (nih.gov)
Given that cannabis terpenes demonstrate direct agonism at CB1 receptor," the authors contend, "THC-terpene effects are beyond the classical definition of entourage. (cbdreview.info)
Rosiglitazone2
They had an affinity to PPARγ similar to that of the standard pharmaceutical agent rosiglitazone, which is used for the treatment of type 2 diabetes. (indexindex.com)
All of the red wines had affinities for PPARγ equivalent to concentrations of rosiglitazone ranging from 52-521 μM. (indexindex.com)
PPARs1
Previous studies have elucidated the functions and mechanism of ppars in muscle, mainly contain pparγ-glut1/glut4/insulin sensitivity-glucose utilization. (saunaabc.com)
Lipid1
LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. (nih.gov)
Glucose1
Interplay of adiponectin, TNFα and insulin on gene expression, glucose uptake and PPARγ, AKT and TOR pathways in rainbow trout cultured adipocytes. (geneticsmr.com)
Pathways1
Consequently, upon ligand binding, activation of DAMP/PAMP receptors and NLR family pyrin domain containing 3 (NLRP3) inflammasome pathways promote the production of pro-inflammatory cytokines, including tumor necrosis factor alpha (TNFα), IL-1β, IL-6, and IL-18, contributing to cardiac injury ( Fairweather, 2007 ). (frontiersin.org)
Dual1
If ongoing studies confirm the theoretical benefit and safety of dual PPAR-α/γ agonism, aleglitazar may become the first therapy demonstrated to reduce macrovascular complications in patients with diabetes. (medscape.com)
Activation1
This study was carried out to elucidate the involvement of microglial activation in the PPARδ-mediated reduction of Aβ burden and subsequent outcome to neuronal survival in a 5XFAD mouse model of AD. (nih.gov)