Potentially sensitive biological processes. Medical search. Frequent questions

The biologics formulation development process includes proven methods to address the unique challenges associated with dealing with living organisms. (ascendiapharma.com)
In the life science industry where biological life or living organisms are at play, it is vital to maintain utmost hygiene along with superior indoor air quality. (camfil.com)

These processes include those of the potentially present pathogens and the food itself. (fooddocs.com)
It is critical for your air filtration system to contain all of these potentially harmful airborne pathogens. (camfil.com)
The inadequate availability of biological reference materials for these pathogens poses a genuine obstacle in pursuit of these objectives, and the lack of a comprehensive and equitable framework for developing reference materials is a weakness. (cdc.gov)
We outline the need for internationally standardized biological materials for high-threat pathogens as a core element of global health security. (cdc.gov)

Molecule size - Biological molecules range from 3000 atoms to 25,000+ atoms, making them larger than small molecules. (ascendiapharma.com)
Metabolomics is a rapidly evolving omics science that focuses on the comprehensive analysis of small molecules (metabolites) within biological samples. (alliedacademies.org)
While previous studies have focused on releasing molecules that activate biological events, little has been done in the area of regulating the inhibition of biological processes. (uga.edu)
In fact, studies have shown that dogs are capable of detecting scent molecules at concentrations that are as low as parts per trillion, making their sense of smell up to 100,000 times more sensitive than ours. (can-dogs.com)
In the biological sciences the suffix -omics is used to refer to the study of large sets of biological molecules. (who.int)
Through various omic technologies it is now possible to interrogate large sets of biological molecules. (who.int)

It incorporates a spectrum of "omics" technologies (genomics, proteomics, epigenomics, etc.) and molecular imaging, to generate computational algorithms and quantitative models that shed light on mechanisms underlying the cancer process and predict response to intervention. (wikipedia.org)
The Cancer Genome Atlas data collection Computational algorithms to extract drivers of cancer progression from existing datasets Statistical and mechanistic modeling of signaling networks Quantitative modeling of cancer evolutionary processes Mathematical modeling of cancer cell population growth Mathematical modeling of cellular responses to therapeutic intervention Mathematical modeling of cancer metabolism The practice of Cancer Systems Biology requires close physical integration between scientists with diverse backgrounds. (wikipedia.org)
It allows us essentially to turn the beautiful 3-D pictures of mitochondria we can get from cryo-ET into sensitive, quantitative measurements-which we can potentially use to help identify the detailed mechanisms of diseases, for example," Barad says. (scripps.edu)
Mechanistic approaches, incorporating quantitative information on functional traits, can potentially predict species- and population-specific responses that result from the cumulative impacts of small-scale processes acting at the organismal level, and can be used to infer population-level dynamics and inform natural resources management. (frontiersin.org)
Immunoassays such as ELISAs or molecular methods such as quantitative PCR can be used to quantify biological materials, but these assays are subject to inherent variability between test instances and different laboratories, and require the use of reference preparations to generate a quantitative output ( 2 ). (cdc.gov)
Our data suggest that with the selection of sensitive candidate species, the Mn/Ca proxy has potential to be further developed for quantitative oxygen reconstructions in the low-oxygen range. (lu.se)

Complex biochemical tasks can thus be processed in a fashion similar to that of a traditional biological laboratory on a miniature scale," explained Dr Pipper. (medicalxpress.com)
An increasing number of magnetic particle-based biochemical kits are commercially available to process cells, RNA, DNA and proteins. (medicalxpress.com)
This approach provides a holistic view of the dynamic biochemical processes occurring within an organism and offers valuable insights into metabolic pathways and their perturbations under various disease conditions[ 2 ]. (alliedacademies.org)
We designed sensitive, in vivo, cell-based assays to measure receptor activation and in vitro biochemical assays to measure the ability of candidate hormones to bind directly to the receptors, or to modulate important features of receptor biology such as interaction with coactivator and corepressor proteins. (uci.edu)

Zinc ion, as biologically important metal ions, plays a vital biological role in various pathophysiologic processes, such as gene expression, cell apoptosis, enzymatic adjustment, and neurotransmission, because of its structural properties [ 1 - 3 ]. (hindawi.com)
Biological expressions of social inequality refers to how people literally embody and biologically express experiences of economic and social inequality, from in utero to death, thereby producing social inequalities in health across a wide spectrum of outcomes. (bmj.com)
1 6 The construct of "biological expressions of social inequality" thus stands in contrast with biologically deterministic formulations that cast biological processes and traits tautologically invoked to define membership in subordinate versus dominant groups (for example, skin colour or biological sex) as explanations for social inequalities in health. (bmj.com)
We explore potential biologically controlled mechanisms that could potentially explain this species-specific response. (lu.se)

To address if certain elements can serve as biosignatures, we pair petrographic/mineralogical approaches with high-resolution sampling for analysing trace elements as well as redox-sensitive elements and their stable isotopes. (europlanet-society.org)
Bottom-water oxygen conditions determine redox regime and availability of redox-sensitive trace elements such as manganese, which in turn may be recorded by manganese-to-calcium ratios (Mn/Ca) in biogenic calcium carbonates (e.g., benthic foraminifera tests). (lu.se)

We offer a selection of recent papers on a variety of topics from the Journal of Biological Chemistry , the Journal of Lipid Research and Molecular & Cellular Proteomics . (asbmb.org)
The results of their research were reported in the Journal of Biological Chemistry . (asbmb.org)
The study , published in the Journal of Biological Chemistry , is a step forward in creating precision medicine approaches to diabetes prevention and treatment. (asbmb.org)
This technique , presented in the Journal of Biological Chemistry , offers a simple means of identifying EGFR variants that potentially drive cancerous activity and merit further investigation. (asbmb.org)
In a study in the Journal of Biological Chemistry , researchers in the U.K. biochemically and structurally characterized a protein that might protect nitrogenases from oxygen inactivation. (asbmb.org)

NGS tests are potentially sensitive to interference by reagents or biological materials that are not effectively removed during the nucleic acid extraction process. (fabricgenomics.com)
These WHO IRPs, composed of international reference standards and other reference materials ( Table 1 ), provide a common set of reagents that are used to ensure the quality of biological assays and medicines globally. (cdc.gov)

Single-cell elemental analysis by triple-quadrupole ICP-MS is emerging as a selective, highly sensitive, and potentially high-throughput technique for the study of constitutive elements, and uptake of metallodrugs (or metal-containing nanomaterials) in single cells. (chromatographyonline.com)
On the basis of USGS studies and other recent work, a better understanding is emerging of mercury distribution, ongoing transport, transformation processes, and the extent of biological uptake in areas affected by historical gold mining. (usgs.gov)
Biologic uptake: the process by which the transfer of substances from the environment to plants, animals, and humans occurs. (cdc.gov)

Our novel naturalistic observation approach incorporates the Electronically Activated Recorder (EAR), as well as surveys, daily diaries, biological measures (including diurnal cortisol, inflammatory markers and gene expression), and clinical asthma evaluations. (grantome.com)
These processes require coordinated gene expression and are regulated by a large and diverse group of inter- and intracellular signaling pathways mediated by an equally diverse group of hormones and hormone receptors. (uci.edu)

Quantum information processing harnesses the fundamental properties of quantum mechanics to offer new possibilities in secure communication and cryptography. (timebusinessnews.com)
Single cells represent a fundamental biological unit. (justia.com)
They can diffuse from a source and penetrate to a target within tissues making them ideal candidates for developmental signals and an important model system to study the role of regulated transcription in fundamental biological processes. (uci.edu)

The main principle behind cold food storage and the ideal freezer temperature is to slow down any biological process around the food, including that of spoilage bacteria. (fooddocs.com)
Your average cleaning products will not be sufficient in these Trauma Cleanup situations, and will likely leave behind biohazard residue that can potentially spread bacteria and disease. (mastertechmold.com)

Often, manipulations are carried out on all parts of a sample, but researchers have learned that much of biological function is dependent on the specific location of a particular event. (uga.edu)
Research and defence , where researchers manipulate highly dangerous biological, chemical and radioactive materials that must be contained to avoid a dramatic outbreak. (camfil.com)
The HST researchers built their "biological Legos" by encapsulating cells within a polymer called polyethylene glycol (PEG), which has many medical uses. (nanowerk.com)
Other researchers have developed a technique called organ printing to create complex 3-D tissues, but that process requires a robotic machine that is not in widespread use. (nanowerk.com)

Complexity - Sugars, proteins, nucleic acids, and combinations of these substances can make-up a biological drug. (ascendiapharma.com)
The studies examined reported variability in soil and climate, and the complexity of soil processes contributed to the absence of clear findings. (ac.be)

Following the absorption of a poison or toxicant, biological changes in the body are the result of the toxicodynamics of the particular poison or toxicant. (cdc.gov)
This strategy allows us to identify compounds with potentially unusual fractionation and absorption properties. (uci.edu)

Sheep are by far the most sensitive livestock species to copper. (okstate.edu)
However, most current forecasting approaches do not incorporate species-specific, process-based biological information, which limits their ability to inform actionable strategies. (frontiersin.org)
The results are part of a special issue of the journal Biological Conservation on use of environmental DNA to inform conservation and management of aquatic species. (usgs.gov)
The results from this study indicate that eDNA detection methods are an effective way to determine the distribution of Chinook across a large area and can potentially be used to document the arrival of migratory species, like Pacific salmon, or colonization of streams following habitat restoration or reintroduction efforts," said Laramie. (usgs.gov)
Our work will help improve sampling strategies for eDNA monitoring of sensitive and invasive species," said Strickler. (usgs.gov)
However, biological influences on Mn incorporation (e.g., species-specific Mn fractionation, ontogeny, living and calcification depths) are still poorly constrained. (lu.se)

Biological formulation development involves discovering solutions for the most bioactive, native protein delivery. (ascendiapharma.com)
Chemical pathology, also known as clinical biochemistry or clinical chemistry, is a crucial discipline in medical diagnostics that involves the analysis of biological fluids and tissues to assess health and detect disease. (alliedacademies.org)
Another example of a process the new method can help clarify involves the role of protein synthesis in the development of an organism. (uga.edu)

The overarching goal of this longitudinal project?Asthma in the Lives of Families Today (ALOFT)?is to identify the behavioral and biological pathways through which family social environments ?get under the skin? (grantome.com)
Circulation pathways of biological samples between different sections of the laboratory--These pathways should be assessed for the purpose of minimizing contamination risks. (who.int)

Early Disease Detection: Metabolomics may enable the detection of disease at an early stage, even before symptoms become apparent, potentially improving patient outcomes and reducing healthcare costs. (alliedacademies.org)
When drug shortages occur, healthcare providers (HCPs) often must ration drugs, cancel or delay treatments, or utilize alternative drugs that may be less efficacious and/or are associated with increased risk of adverse outcomes, potentially impacting patient care. (gabi-journal.net)

In the current application, the team attached a light-sensitive molecule called a chromophore to a bioactive molecule called an effector through a single covalent bond that inactivates the bioactive molecule. (uga.edu)

Confocal and multiphoton imaging techniques are still the methods of choice for performing sophisticated studies on biological samples. (leica-microsystems.com)
and changes in methods of food processing, distribution and consumer habits have reaffirmed that infectious disease events in one country are potentially a concern for the entire world. (who.int)

Isolating specific biological and psychological processes in families that potentially contribute to, or buffer, asthma morbidity will foster future ?bench to bedside? (grantome.com)
1 2 6 Core to social epidemiology, this construct of "biological expressions of social inequality" has been evident in epidemiological thought-albeit not always explicitly named as such-since the discipline's emergence in the early 19th century, as exemplified by early pathbreaking research (for example, conducted by Louis René Villermé (1782-1863)) on socioeconomic gradients in-and effects of poverty on-mortality, morbidity, and height. (bmj.com)

It is required by all animals for a variety of important biological processes. (okstate.edu)
This includes the bends of the inner membrane and the gaps between membranes-all potentially useful markers of important mitochondrial and cellular events. (scripps.edu)
It is important to note that the purpose of cognitive interviewing is not to obtain survey data generalizable to a larger population, but rather to examine question response processes and to characterize potential response problems. (cdc.gov)
The new method, which uses so-called "caged compounds" that can be turned on with light, could lead to more intricate studies of such important but poorly understood processes, such as protein synthesis in nerve synapses. (uga.edu)
Such sensitive biohazard cleanups require professional help, so it is important to consult a professional Trauma Cleanup company in South Toms River, NJ, 08757 to get the job done. (mastertechmold.com)
On the contrary there is extensive evidence that fluoride can interfere with many important biological processes. (fluoridealert.org)
We have taken an integrated approach toward understanding the role of orphan steroid receptors in important biological processes. (uci.edu)
As many suppliers of generic drugs may begin to produce biosimilars in the future, the issue of biological drug shortages may become an important consideration. (gabi-journal.net)

Recent years have seen strong research efforts on the lipid component of biological membranes. (lu.se)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)

14 ] investigated selective and sensitive "turn-on" fluorescent Zn 2+ sensors based on di- and tripyrrins with readily modulated emission wavelengths. (hindawi.com)

Further, clustering of these genes resulted in six clusters with themes in synaptic transmission, signal transduction, metabolic process, and apoptosis, which provided an intuitional view on the major molecular functions of the genes. (hindawi.com)

This can help to define search criteria for potentially habitable environments on other terrestrial planets. (europlanet-society.org)
In sensitive environments like pharmaceutical and biopharma facilities with high biosafety levels, both people and the environment risk higher exposure to toxic materials. (camfil.com)

These are deeply sensitive questions that have profound implications for so many lives. (nothingwavering.org)

In my talk, I will show you some examples how such biological cues influence the dynamic properties of membranes. (lu.se)

Cancer systems biology therefore adopts a holistic view of cancer aimed at integrating its many biological scales, including genetics, signaling networks, epigenetics, cellular behavior, mechanical properties, histology, clinical manifestations and epidemiology. (wikipedia.org)
Our ongoing project aims to elucidate how cells recognize temperature or cellular events caused by the temperature changes and control the expression of DESAT1 to adapt the cellular processes and behaviors," Umeda said. (asbmb.org)

Since 1947, the provision of WHO reference materials has played a vital role in the translation of laboratory science into worldwide clinical practice and has been delivered through the WHO Expert Committee on Biological Standardization, WHO collaborating centers, and various state and nonstate partners. (cdc.gov)
Ensuring quality and safety during laboratory processes is a major concern for laboratory managers. (who.int)
Sample processing areas--Here, samples are centrifuged, as needed, allocated for different examinations, and dispersed to the appropriate sections of the laboratory for analysis. (who.int)

Clean air plays an imperative role in the life science, healthcare and pharmaceutical process chain. (camfil.com)

Ensuring that approved biological medicines are available for adequate patient care through normal operations and during periods of supply shortages requires leveraging financial, technological and human resources. (gabi-journal.net)

The Expert Committee on Biological Standardization meets annually to establish detailed recommendations and guidelines for manufacturing, licensing, and control of complex biological materials, including blood products, vaccines, and related in vitro diagnostic tests, and to maintain a catalog of IRPs to be distributed globally as required. (cdc.gov)

A receptor population, such as people potentially or actually exposed. (cdc.gov)

To improve spatial coverage, some reconstructions include proxies that may be more sensitive to precipitation than to temperature, in which case statistical techniques are used to infer the temperature signal, exploiting the spatial relationship between temperature and precipitation. (nationalacademies.org)
The potential applications of quantum technology are vast and include quantum computing, quantum information processing, quantum sensing, quantum simulation, and more. (timebusinessnews.com)
The devices may further include auxiliary chambers integrated with the cell capture chamber for subsequent processing and assaying of the contents of a captured cell. (justia.com)

Analysis of the compositional variation in living cells is essential for understanding biological processes. (chromatographyonline.com)
In their report on February 14, 2023, in the Journal of Cell Biology , the scientists described a set of techniques that enables the imaging and quantification of even subtle structural changes inside mitochondria, and the correlation of those changes with other processes ongoing in cells. (scripps.edu)
In biological terms this arrangement of the retina is said to be inverted because the visual cells are oriented so that their sensory ends are directed away from incident light (Figure 1). (answersingenesis.org)
Microfluidic devices are provided for trapping, isolating, and processing single cells. (justia.com)
However, the vast majority of biological knowledge has emerged as a consequence of studying cell populations and not individual cells. (justia.com)
The likelihood of drug shortages may be increased for biological medicines, which are produced in living cells, require complex manufacturing processes and rigorous regulatory compliance, and are sensitive to storage and handling conditions. (gabi-journal.net)

Burge remarked that a single inhaled ragweed pollen grain can produce symptoms in a sensitive person. (cdc.gov)

Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. (wikipedia.org)
Athens, Ga. - Proteins are the puzzle-pieces of life, involved in how organisms grow and flourish, but studying their complex biological processes in living systems has been extremely difficult. (uga.edu)

12 ] also synthesized and evaluated two new ratiometric chemosensors for the quantification of potentially toxic free Zn 2+ ions in aqueous solutions. (hindawi.com)
understand the basics of safety and biosafety management issues when working with toxic chemicals, biological samples, physical hazards, and when interacting with patients. (who.int)

Part 1: Soil biological and chemical (phosphorus and nitrogen) properties. (ac.be)
To reduce agriculture's dependence on fertilizer, scientists seek to enhance the ability of plants to provide for themselves through nitrogen fixation, a process that converts nitrogen from the air into ammonia. (asbmb.org)

This manuscript highlights critical supply chain parameters that HCPs should consider when evaluating a manufacturer's ability to maintain and deliver a continuous supply of biological medicines. (gabi-journal.net)

Among these nanostructured materials, core-shell Fe 3 O 4 @SiO 2 NPs have been widely favored in biological and environmental applications [ 19 - 21 ]. (hindawi.com)
PPE that is appropriate for various types of patient interactions and effectively covers personal clothing and skin likely to be soiled with blood, saliva, or other potentially infectious materials (OPIM) should be available. (cdc.gov)
The concept of biological standardization and the use of biological reference materials has existed since the turn of the 20th century after simultaneous discovery of diphtheria antitoxin by von Behring and Roux ( 3 , 4 ). (cdc.gov)
Circulation paths should be designed in such a way that contact between the public and biological materials can occur only in the rooms where patient samples are collected. (who.int)

Whether biological changes occur in response to exposure depends on how much of a poison or toxicant dose a person has been exposed to and how much he or she has subsequently absorbed. (cdc.gov)
In addition to epidemics that occur naturally, outbreaks might result from intentional or accidental release of biological agents. (who.int)

Insulin resistance caused by fat depletion, known as lipodystrophy, is rare but has become a focus of research, including studies of associations between accumulation of fats stored in muscle, known as intramyocellular lipids, and insulin-resistant or insulin-sensitive states. (asbmb.org)

Every validation process should start with a very specific "statement of use" that will aid in determining the samples that should be used for validation. (fabricgenomics.com)
Target organs are those that are sensitive to that specific poison or toxicant. (cdc.gov)
Using samples from this site, this project compares between chemically- and microbially influenced carbonate precipitation to further explore if trace element behaviour is related to biological processes, and if specific elements can be used as potential biosignatures. (europlanet-society.org)
Generally speaking, there are few research tools available that are location-specific, so the new method adds a potentially powerful tool for scientists. (uga.edu)

Gomez Fernandez and Khademhosseini used this method to build tubes that could function as capillaries, potentially helping to overcome one of the most persistent problems with engineered organs - lack of an immediate blood supply. (nanowerk.com)

In the study, Grotjahn's team put together a computational toolkit to process imaging data from a microscopy technique called cryo-electron tomography (cryo-ET)-which essentially images biological samples in three dimensions, using electrons instead of light. (scripps.edu)

Biologics tend to be heat sensitive and susceptible to microbial contamination. (ascendiapharma.com)

growth of ice crystals to form snow ('ice crystal process'), which may rime to form graupel/hail or may fall out as 'cold' precipitation. (lu.se)
We have predicted the separate contributions of precipitation from the two processes in our existing high-resolution model of clouds. (lu.se)
We have discovered that the ice crystal process produces most of the precipitation at middle latitudes, but that the warm rain process prevails in the tropics. (lu.se)

While sheep do require a small amount of copper in their diets, providing them almost any feed that isn't labelled for sheep is potentially dangerous. (okstate.edu)
Although these systems provide a high-throughput qPCR readout, they do not address the front end sample preparation and require single cell isolation by FACS or micropipette followed by off-chip processing and pre-amplification of starting template prior to analysis. (justia.com)
Trauma scenes often contain sensitive contaminates that require specialized cleaning and disposal. (mastertechmold.com)
Not a single biological process has been shown to require fluoride. (fluoridealert.org)

The term hypoxia is used to describe biological situations where insufficient levels of oxygen exist. (mdpi.com)

Biomarkers are characteristics that can be objectively measured and used as an indicator of normal biological processes, disease processes, or pharmacologic responses to a therapy. (medscape.com)

In the life sciences, pharmaceutical and biopharma facilities have their own special air quality requirements with one thing in common: keeping workers, equipment and processes safe. (camfil.com)

We envision that our droplet-based system will be an attractive diagnostic platform, especially for decentralized environmental, biological or medical testing," said Dr Pipper. (medicalxpress.com)
The technology is highly sensitive to environmental disturbances, which can cause errors in computations. (timebusinessnews.com)

In so far as people are simultaneously social and biological organisms, is any biological process ever expressed devoid of social context? (bmj.com)

It is because of this unique market position that many pharmaceutical companies are developing biological drugs. (ascendiapharma.com)

The tunnels also provided a protected environment for sluices and a way to discharge processed sediments (placer tailings) to adjacent waterways. (usgs.gov)
eDNA is the DNA that animals release into the environment through normal biological processes from sources such as feces, mucous, skin, hair, and carcasses. (usgs.gov)

These techniques visualize typical structures or dynamic processes in biological samples and depend on existing autofluorescent matter in the specimen or the availability of suitable fluorescent dyes. (leica-microsystems.com)
over Raman spectroscopy and first applications on biological samples [ 2 ]. (leica-microsystems.com)

With increasing processing and starch exposure, the risk of grain overload or rumen acidosis increases. (okstate.edu)

Anatomy15

Organisms15

Diseases5

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes94

Disciplines and Occupations17

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture6

Information Science31

Health Care10

Living organisms2

Pathogens4

Molecules6

Quantitative6

Biochemical4

Biologically4

Redox-sensitive2

Journal of Biolog5

Reagents2

Uptake3

Gene expression2

Fundamental3

Bacteria2

Researchers4

Complexity2

Absorption2

Species6

Involves3

Pathways2

Outcomes2

Molecule1

Methods2

Morbidity2

Important8

Lipid2

Selective1

Apoptosis1

Environments2

Implications1

Examples1

Cellular2

Laboratory3

Healthcare1

Ensuring1

Vaccines1

Receptor1

Include3

Cells6

Symptoms1

Complex2

Toxic2

Nitrogen2

Medicines1

Materials4

Occur2

Insulin resistance1

Specific4

Organs1

Electrons1

Microbial1

Precipitation3

Require4

Oxygen1

Responses1

Sciences1

Environmental2

Simultaneously1

Pharmaceutical1

Environment2

Samples2

Exposure1