• This case offers an example of acute drug-induced liver injury occurring after a dosage increase of duloxetine. (psychiatrist.com)
  • [ 1 ] while acetaminophen toxicity is the main cause of drug-induced liver injury in the United States. (medscape.com)
  • Inhibiting gap junctions in liver cells could provide a feasible strategy to preventing drug-induced liver injury (DILI), investigators claim. (genengnews.com)
  • Drug-induced liver injury is the most common cause of acute liver failure in the U.S, as well as the most frequently cited reason for abandoning candidate drug compounds early in development, or withdrawing approved medicines from the market. (genengnews.com)
  • Unfortunately, there are currently no specific treatment strategies for preventing drug-induced liver injury. (genengnews.com)
  • Deeper understanding of drug-induced liver injury (DILI) mechanisms is the goal of an international team of experts from the Prospective European Drug-induced Liver Injury Network (PRO-EURO DILI Network), who met on March 9 and 10 at the Institute of Physics of the Academy of Sciences of the Czech Republic. (fzu.cz)
  • Drug-induced liver injury should be considered in any acute liver injury or jaundice without evidence of biliary obstruction. (bsg.org.uk)
  • Idiosyncratic drug-induced liver injury (DILI) is an unpredictable type of liver injury following exposure to medication within the recommended dose which is distinctive from liver injury caused by drug overdosage, commonly caused by paracetamol overdose (POD). (bsg.org.uk)
  • Physicians must be vigilant in identifying drug-related liver injury because early detection can decrease the severity of hepatotoxicity if the drug is discontinued. (medscape.com)
  • The manifestations of drug-induced hepatotoxicity are highly variable, ranging from asymptomatic elevation of liver enzymes to fulminant hepatic failure. (medscape.com)
  • Within the PRO-EURO DILI Network there are five working groups dealing, for example, with the standardization of approaches to the diagnosis of drug-induced liver damage, the assessment of the hepatotoxicity potential of individual drugs and their interaction or trying to contribute to better decision-making by regulatory bodies related to DILI. (fzu.cz)
  • The TP-induced hepatotoxicity increased by twofold when CYP activity was blocked by 1-aminobenzotriazole , suggesting that CYP and P-gp may both contribute to the detoxification of TP in the SCRH model. (curehunter.com)
  • Our results for the first time demonstrated that in addition to CYP-mediated metabolism, P-gp also plays an important role in the disposition of TP and TP-induced hepatotoxicity. (curehunter.com)
  • APAP administration in rats induced a significant rise in biochemical parameters such as aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), lacatate dehydrogenase (LDH), and serum alkaline phosphatase (SALP). (jru-b.com)
  • This study is carried out on Wistar rats to evaluate the hepatoprotective activity of Argemone mexicana L aerial part extracts against CCL_4 induced acute liver damages. (airitilibrary.com)
  • Hepatic fibrosis in rats was induced by the intra-peritoneal injection of NDEA (10 mlkg −1 b.wt. (nature.com)
  • PGJ abrogates liver fibrosis instigated by NDEA in Wistar rats by declining oxidative stress via regulation of Nrf2 and NFκB. (nature.com)
  • Researchers in Serbia found that diabetic lab rats orally administered with the probiotic Lactobacillus paraplantarum BGCG11 experienced a reduced level of DNA damage in the liver and kidney, compared to control rats that didn't receive probiotics. (nutraingredients-usa.com)
  • Their aim was to assess the potential beneficial in vivo ​ effect of the probiotic L. paraplantarum ​ BGCG11 on diabetic complications in the liver and kidneys in diabetes-induced rats. (nutraingredients-usa.com)
  • "We studied the changes in redox metabolism through monitoring antioxidant enzyme activities, the level of cell injury by examining DNA damage and activation of the prosurvival Akt kinase as well as the degree of tissue damage through the activation of the fibrotic process in the liver and kidneys of diabetic rats," ​ they wrote. (nutraingredients-usa.com)
  • They found that rats that were supplemented with the probiotic, either before or both before and after diabetes was induced, experienced antidiabetogenic and anti-inflammatory activities at the systemic and tissue levels. (nutraingredients-usa.com)
  • Additionally, rats in the supplementation group exhibited decreased hyperglycemia and reduced DNA damage in the liver and kidney. (nutraingredients-usa.com)
  • This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
  • Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). (researchgate.net)
  • The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. (researchgate.net)
  • The Food and Drug Administration (FDA) concluded that the overall risk of liver toxicity from pemoline outweighs the benefits. (medscape.com)
  • A preventive or therapeutic strategy against DILI could thus have implications both for the safer use of already marketed drugs, the development of new treatments for a range of diseases, and the potential salvage of otherwise promising drug candidates that have demonstrated hepatic toxicity. (genengnews.com)
  • Their paper is titled "Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure. (genengnews.com)
  • In the future, we would like to contribute to the creation of a realistic and regulatory authority-approved liver model on which possible drug toxicity could be investigated," said Oleg Lunov, head of the Laboratory of Biophysics, where drug-induced liver damage is researched at FZU. (fzu.cz)
  • Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model. (curehunter.com)
  • Discontinue JUXTAPID for clinically significant liver toxicity ( 2.4 , 5.1 ). (drugs.com)
  • The next phase of the research will therefore be examining and scaling samples of damaged liver so that it were possible to determine in advance who who is at risk of suffering from DILI when administered a particular drug. (fzu.cz)
  • Liver biopsy and HLA genotyping can help clinical management by differentiating DILI from AIH and excluding DILI secondary to certain drugs. (bsg.org.uk)
  • DILI usually occurs after a latency period ranges from few days to months post-exposure compared to a period from hours to days in liver injury due to overdose. (bsg.org.uk)
  • Following a large national audit in the UK of 881 consecutive patients admitted with jaundice, where a biliary obstruction was ruled out by imaging, idiosyncratic DILI was the second most common cause of liver injury (15% of cases) after alcoholic liver disease (2). (bsg.org.uk)
  • DILI can progress to acute liver failure (ALF) accounting to 7-15% of total ALF cases (3). (bsg.org.uk)
  • The pattern of DILI is based on the earliest identified liver chemistry elevations above the upper limit of normality (ULN) that fit DILI criteria and defined using R-value where R = (ALT/ULN)/(ALP/ULN). (bsg.org.uk)
  • Mortality/ liver transplant rates exceed 10% in DILI patients with hepatocellular injury and jaundice (5, 6). (bsg.org.uk)
  • The outcome is worse when acute liver failure develops in DILI than that in paracetamol overdose. (bsg.org.uk)
  • Induced Liver of inflammation: C-reactive protein within reference range, and a urinary level of 26 mg/dL. (cdc.gov)
  • Here we show that inflammation, fatty liver and dysregulated metabolism are hallmarks of systemically affected livers in mouse models and in patients with extrahepatic metastasis. (nature.com)
  • Previous work by the MIT/MGH and Rutgers team, along with independent research, has demonstrated a link between liver inflammation and the hepatic gap junctions that enable direct intercellular communication between coupled cells in the liver. (genengnews.com)
  • Initial in vivo studies demonstrated that mice deficient in Cx32, the primary gap junction protein in the liver, were far less susceptible than wild-type mice to actual liver damage and inflammation caused by treatment with the hepatotoxin thioacetamide (TAA). (genengnews.com)
  • In other words, the beneficial bacteria "overwhelm intestinal inflammation," ​reducing the activity of common toxins that damage the liver and kidneys among diabetic populations. (nutraingredients-usa.com)
  • "These findings may be relevant with regard to the therapeutic potential of probiotic in treating the diabetic condition but also in the management of other pathological states associated with redox metabolism imbalance, inflammation and fibrosis," ​ the researchers argued. (nutraingredients-usa.com)
  • Chronic alcohol use impairs not only gut and liver functions, but also multi-organ interactions, leading to persistent systemic inflammation and ultimately, to organ damage. (wjgnet.com)
  • The team also observed that reprogrammed livers have high levels of inflammation, marked by elevated level of tumor necrosis factor-α (TNF-α), and low levels of drug-metabolizing enzymes called cytochrome P450, which break down potentially toxic molecules, including many drug molecules. (sciencemission.com)
  • The present study aimed to investigate the potential hepatoprotective effects of diosmetin on hydrogen peroxide (H2O2)‑induced oxidative damage in L02 cells and attempted to evaluate the role of the nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response element pathway in this process. (spandidos-publications.com)
  • Conversely, diosmetin (20‑40 µM) significantly reversed the damaging effects of H2O2, which indicated that diosmetin may exhibit potent hepatoprotective potential against H2O2‑induced oxidative damage. (spandidos-publications.com)
  • These results demonstrate that resveratrol could significantly scavenge reactive oxygen species, inhibit As 2 O 3 -induced oxidative damage, and significantly attenuate the accumulation of arsenic in renal tissues by facilitating As 2 O 3 metabolism. (springer.com)
  • More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. (medscape.com)
  • Nowday's liver disorders due to exposure of different types of drug/chemical molecules are common. (jru-b.com)
  • The key step within assignment of the hazard-specific SK is the determination of the hazard potential of the substance, or its potential for causing adverse health effects as a result of skin exposure. (cdc.gov)
  • Chen SC, Chen CC, Kuo CY, Huang CH, Lin CH, Lu ZY, Chen YY, Lee HS, Wong RH (2012) Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes. (springer.com)
  • In vitro exposure of BEAS-2B bronchial epithelial cells and A549 alveolar adenocarcinoma cells results in cytotoxicity, increased oxidative stress, increased intracellular [Ca2 + ], decreased mitochondrial membrane potential, and interleukin (IL)-8 production. (dovepress.com)
  • exposure results in cytotoxicity, oxidative stress, intracellular Ca2 + flux, decreased mitochondrial membrane potential, and production of IL-1β and chemokine CXCL9. (dovepress.com)
  • We also observed fatty liver and decreased cytochrome P450 expression at diagnosis in tumour-free livers of patients with pancreatic cancer who later developed extrahepatic metastasis, highlighting the clinical relevance of our findings. (nature.com)
  • It is induced by c-Myc oncogene and plays an important role in anchorage independent growth of cancer cells (metastasis). (wikipedia.org)
  • MTDH is therefore a potential therapeutic target for enhancing chemotherapy and reducing metastasis. (wikipedia.org)
  • It has been established by recent studies that pomegranate derived products abrogate chemically induced tumors of lung, skin, breast and colon and it also abates the metastasis of xenografted lung and prostrate tumors in rodents 13 . (nature.com)
  • CAIRO5 is the first randomized controlled phase III trial in which the currently most effective systemic regimens were compared in defined subgroups of patients with initially unresectable colorectal cancer liver metastasis, as defined by a liver expert panel. (ascopost.com)
  • Panitumumab significantly increased response rate and depth of response, which, however, did not translate into an increased local treatment rate of liver metastasis. (ascopost.com)
  • Considering the results of previous anti-EGFR trials, the data and overall survival should be weighted before we can draw a final conclusion about the use of anti-EEGR therapy in patients with initially unresectable colorectal cancer liver metastasis and their-left sided and RAS/BRAF wild-type tumor. (ascopost.com)
  • This subsequently induces cancer cell growth, proliferation and metastasis. (amrita.edu)
  • One of our more striking observations was that this EVP-induced fatty liver condition did not co-occur with liver metastases, suggesting that causing fatty liver and preparing the liver for metastasis are distinct strategies that cancers use to manipulate liver function," said a co-first author. (sciencemission.com)
  • The fatty acid cargo of tumour EVPs-particularly palmitic acid-induced secretion of tumour necrosis factor (TNF) by Kupffer cells, generating a pro-inflammatory microenvironment, suppressing fatty acid metabolism and oxidative phosphorylation, and promoting fatty liver formation. (nature.com)
  • Fig. 5: Tumour EVPs suppress liver drug metabolism and enhance chemotoxicity. (nature.com)
  • The liver is the primary organ involved in xenobiotic metabolism and is a major target organ for chemicals and drugs. (scialert.net)
  • The present study aimed to investigate the effect of resveratrol on As 2 O 3 -induced nephrotoxicity and arsenic metabolism. (springer.com)
  • Secondary metabolites are organic molecules of low molecular weight, biosynthesized by any living being using a wide range of biosynthetic pathways, known as secondary metabolism. (mdpi.com)
  • Notably, Kupffer cell ablation or TNF blockade markedly decreased tumour-induced fatty liver generation. (nature.com)
  • Our results reveal how tumour-derived EVPs dysregulate hepatic function and their targetable potential, alongside TNF inhibition, for preventing fatty liver formation and enhancing the efficacy of chemotherapy. (nature.com)
  • Fig. 3: Uptake of tumour-derived EVPs by Kupffer cells induces fatty liver formation. (nature.com)
  • Fig. 4: Palmitic acid in tumour EVPs induces TNF secretion from Kupffer cells and promotes fatty liver generation. (nature.com)
  • The study's key finding is that these tumors induce accumulation of fat molecules in liver cells, consequently reprogramming the liver in a way that resembles the obesity- and alcohol-related condition known as fatty liver disease. (sciencemission.com)
  • When taken up by liver-resident immune cells called Kupffer cells, the fatty acid cargo triggers the production TNF-α, which consequently drives fatty liver formation. (sciencemission.com)
  • The scientists suspect that the fatty liver condition benefits cancers in part by turning the liver into a lipid-based source of energy to fuel cancer growth. (sciencemission.com)
  • Aqueous extract of Artemisia capillaris improves non-alcoholic fatty liver and obesity in mice induced by high-fat diet. (bvsalud.org)
  • Non-alcoholic fatty liver disease ( NAFLD ) is one of the most common chronic liver diseases and is a nutritional metabolic disease . (bvsalud.org)
  • Although the researchers principally used animal models of cancers in the study, they observed similar changes in the livers of newly diagnosed pancreatic cancer patients who later developed non-liver metastases. (sciencemission.com)
  • Pancreatic histopathology slides demonstrated that stevia extract did not induce any increase in the number of β-cells. (researchgate.net)
  • Scopolin alleviated oleic acid-induced lipid accumulation and downregulation of SIRT1 activity in HepG2 cells, and these beneficial effects of scopolin were abolished in the presence of SIRT1 inhibitor. (elsevierpure.com)
  • We see in liver cells not only an abnormal accumulation of fat but also a shift away from the normal processing of lipids, so that the lipids that are being produced are more advantageous to the cancer," said the other co-senior author. (sciencemission.com)
  • WAC promoted the phosphorylation levels of PI3K/AKT and AMPK in liver and HepG2 cells of NAFLD mice , inhibited SREBP-1c expression, reduced TG and lipogenesis , and decreased lipid accumulation. (bvsalud.org)
  • Aniline induces methemoglobinemia, which impairs the delivery of oxygen to tissues. (cdc.gov)
  • For example, treatment of hepatitis C, a common viral infection and a cause of liver cirrhosis, with pegylated interferon plus ribavirin is complicated by hemolytic anemia induced by ribavirin. (cdc.gov)
  • Metabolomics data derived from livers of PBS-injected control and B16F10 tumour-bearing mice (Supplementary Table 1 ) have been deposited at Figshare ( https://doi.org/10.6084/m9.figshare.22233187 ). (nature.com)
  • Metabolomics data derived from livers of PBS-injected control and K7M2 tumour-bearing mice (Supplementary Table 2 ) have been deposited at Figshare ( https://doi.org/10.6084/m9.figshare.22233253 ). (nature.com)
  • Lipidomics data derived from livers of PBS-injected control and B16F10 tumour-bearing mice (Supplementary Table 3 ) have been deposited at Figshare ( https://doi.org/10.6084/m9.figshare.22233265 ). (nature.com)
  • Lipidomics data derived from livers of PBS-injected control and K7M2 tumour-bearing mice (Supplementary Table 4 ) have been deposited at Figshare ( https://doi.org/10.6084/m9.figshare.22233274 ). (nature.com)
  • Gap junction protein inhibitor protects mice from death and liver damage after hepatotoxic drug challenge. (genengnews.com)
  • Their experiments demonstrated that treating mice with a small molecule inhibitor that specifically target the hepatic gap junction protein connexion 32 (Cx32) provides significant protection against liver damage and death resulting from subsequent or simultaneous challenge with known hepatotoxic drugs such as acetaminophen. (genengnews.com)
  • The spatial patterns of liver injury in the TAA-treated wild-type mice led the authors to postulate that gap junction communication between cells might promote the propagation and amplification of an injury signal after TAA treatment. (genengnews.com)
  • While the livers of TAA-treated wild-type mice exhibited intense focal regions of reactive oxygen species (ROS) activity, those of Cx32−/− mice showed compara-tively little activity. (genengnews.com)
  • The present study aimed to investigate whether scopolin exhibits beneficial effects on high-fat diet (HFD)-induced hepatic steatosis in mice. (elsevierpure.com)
  • Mice administered 0.02% scopolin for 8 weeks exhibited improved phenotypes of HFD-induced hepatic steatosis along with increased hepatic SIRT1 activity and protein expression. (elsevierpure.com)
  • In addition, mice in which the receptor gene for TNFα has been knocked out are resistant to alcohol-induced liver injury[ 5 ]. (wjgnet.com)
  • The purpose of this study was to investigate the protective effect of GLP-2 on Dextran sulfate sodium (DSS) -induced UC in mice and its potential mechanism. (researchsquare.com)
  • Leiser SF and Miller RA: Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice. (spandidos-publications.com)
  • Yan B, Ma Z, Shi S, Hu Y, Ma T, Rong G and Yang J: Sulforaphane prevents bleomycin-induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2-related factor-2 activation. (spandidos-publications.com)
  • Title : Investigations of immunotoxicity and allergic potential induced by topical application of triclosan in mice Personal Author(s) : Anderson, Stacey E.;Meade, B. Jean;Long, Carrie M.;Lukomska, Ewa;Marshall, Nikki B. (cdc.gov)
  • In vivo experiments were performed using HFD-fed ( high fat diet ) C57BL/6 mice to induce NAFLD model, and in vitro experiments were performed using oleic acid to induce HepG2 cells to construct NAFLD cell model. (bvsalud.org)
  • WAC was able to reverse the elevation of serum lipid levels induced by high-fat diet in mice . (bvsalud.org)
  • June 25, 2022 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics that target specific viral diseases, today announced the presentation of new clinical and pre-clinical data from its proprietary compounds at the European Association for the Study of the Liver (EASL) International Liver Congress™ (ILC). (biospace.com)
  • Humans with variants of pro- and anti-inflammatory cytokine genes show increased susceptibility to alcoholic liver disease[ 2 ]. (wjgnet.com)
  • Taiwanofungus camphoratus (synonym Antrodia camphorata ) is a widely used medicinal fungus in the folk medicine of Taiwan with several pharmacological features such as anti-inflammatory, liver protection, antihypertensive, and antioxidative activities. (hindawi.com)
  • Furthermore, iHepSCs showed anti-inflammatory and anti-fibrotic effects in CCl 4 -induced liver fibrosis. (figshare.com)
  • Hepatic steatosis associated with JUXTAPID may be a risk factor for progressive liver disease, including steatohepatitis and cirrhosis ( 5.1 ). (drugs.com)
  • The objective of the present study was to evaluate the protective effects of Sharbat-e-Deenar (SD) against acetaminophen (APAP, paracetamol) induced liver damage. (jru-b.com)
  • The damaging effects on the liver of some marketed drugs, such as acetaminophen (paracetamol), also limits their dosage. (genengnews.com)
  • Liver fibrosis is a serious health concern which leads to liver diseases such as cirrhosis and primary liver cancer having a worldwide mortality of approximately 1.5 million deaths per year 23 . (nature.com)
  • Cirrhosis is defined histologically as a diffuse hepatic process characterized by fibrosis and conversion of the normal liver architecture into structurally abnormal nodules. (medscape.com)
  • The progression of liver injury to cirrhosis may occur over several weeks to years. (medscape.com)
  • Specific medical therapies may be applied to many liver diseases in an effort to diminish symptoms and to prevent or forestall the development of cirrhosis. (medscape.com)
  • Cadenas S, Barja G (1999) Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO 3 . (springer.com)
  • In the United States, approximately 2000 cases of acute liver failure occur annually and drugs account for over 50% of them (39% are due to acetaminophen, 13% are idiosyncratic reactions due to other medications). (medscape.com)
  • Duloxetine is generally well tolerated, but can potentially elevate liver enzymes and in rare cases cause liver damage. (psychiatrist.com)
  • Monomicrobial enzymes were increased (glutamate highly suspect for metastatic spread of liver abscesses caused by Klebsiella pyruvate transaminase 112 U/L, as- an unknown tumor. (cdc.gov)
  • Uncommon: Pancreatitis (dose related, less common in children than adults), increased liver enzymes, and retinal depigmentation. (cdc.gov)
  • Unusual (more severe): Pancreatitis (primarily seen in children with advanced HIV infection receiving multiple other medications), peripheral neuropathy, decreased neutrophil count, and increased liver enzymes. (cdc.gov)
  • Other: Increased liver enzymes. (cdc.gov)
  • The degree of elevation of liver enzymes does not accurately reflect the severity of the liver injury or predict clinical outcome. (bsg.org.uk)
  • Notably, tumour EVP education enhanced side effects of chemotherapy, including bone marrow suppression and cardiotoxicity, suggesting that metabolic reprogramming of the liver by tumour-derived EVPs may limit chemotherapy tolerance in patients with cancer. (nature.com)
  • These results together suggested that TCEE is a potential ingredient for developing an integrated chemotherapy for human liver cancer. (hindawi.com)
  • Chemotherapy agents such as doxorubicin, cisplatin, and 5-fluorouracil are the primary choices for treating liver cancer cases but the response rate and overall survival remained poor [ 3 , 4 ]. (hindawi.com)
  • THOUSAND OAKS, Calif.--(BUSINESS WIRE)--March 27, 2006--Amgen (NASDAQ:AMGN), the world's largest biotechnology company, today announced the U.S. Food and Drug Administration (FDA) has approved every-three-week dosing of Aranesp(R) (darbepoetin alfa) for the treatment of chemotherapy-induced anemia (low red blood cell count) in patients with non-myeloid malignancies. (amgen.com)
  • Amgen developed Aranesp to provide cancer patients with a long-acting and effective means to treat chemotherapy-induced anemia, a common side effect of chemotherapy," said Willard Dere, M.D., chief medical officer and senior vice president of Global Development at Amgen. (amgen.com)
  • Patients with chemotherapy-induced anemia were randomized to receive 500 mcg of Aranesp every three weeks (n=353) or 2.25 mcg/kg (n=352) administered weekly for up to 15 weeks. (amgen.com)
  • More than half of chemotherapy patients report that fatigue, a common symptom of anemia, affects their daily lives more than any other side effect of treatment, including nausea, pain and depression. (amgen.com)
  • We identified tumour-derived extracellular vesicles and particles (EVPs) as crucial mediators of cancer-induced hepatic reprogramming, which could be reversed by reducing tumour EVP secretion via depletion of Rab27a . (nature.com)
  • After STAT3 activation, nuclear factor (NF) -κB enter the nucleus, bind to the promoter of the target gene, and induce pro-inflammatory mediators such as InducibleNitric Oxide Synthase (iNOS) , Cyclooxygenase-2 (COX-2) , Tumor necrosis factor-α (TNF-α) and Interleukin-6 (IL-6) ,to reactivate the JAK/STAT3 pathway, thus forming a malignant pro-inflammatory cycle[6]. (researchsquare.com)
  • The boxed warning emphasizes the risk for severe liver injury and acute liver failure, which may be fatal. (medscape.com)
  • Patients developing features of acute liver failure (jaundice, encephalopathy, ascites, and coagulopathy) should be referred urgently to a liver transplant centre. (bsg.org.uk)
  • Intraperitoneal administration induces neurological effects. (dovepress.com)
  • MTDH knockdown by artificial microRNA interference functions as a potential tumor suppressor in breast cancer. (wikipedia.org)
  • An alcohol-induced increase of tumor necrosis factor (TNF) α, a pro-inflammatory cytokine, in the mouse brain is closely linked to neurodegeneration[ 4 ]. (wjgnet.com)
  • Marinde J.G. Bond, PhD Candidate , of the University Medical Center, Utrecht, discusses phase III findings from the CAIRO5 study of the Dutch Colorectal Cancer Group, the first such trial in defined subgroups of patients with initially unresectable colorectal cancer liver metastases and left-sided and RAS/BRAF V600E wild-type tumor. (ascopost.com)
  • There are also crucial molecules involved in immune cell function, but their production is altered in these fatty livers, hinting that this condition may also weakens anti-tumor immunity," said the other co-senior author. (sciencemission.com)
  • The researchers were able to mitigate these systemic effects of tumors on the livers by implementing strategies such as blocking tumor-EVP release, inhibiting the packaging of palmitic acid into tumor EVPs, suppressing TNF-α activity, or eliminating Kupffer cells in the experimental animal models. (sciencemission.com)
  • The researchers are further investigating the potential of implementing these strategies in human patients to block these remote effects of tumors on the liver, and exploring the possibility of utilizing the detection of palmitic acid in tumor EVPs circulating in the blood as a potential warning sign of advanced cancer. (sciencemission.com)
  • The investigators moved on to think about evaluating the therapeutic potential of pharmacologically inhibiting Cx32, using 2-aminoethoxy-dipenyl-borate (2APB), a compound previously shown to transiently inhibit Cx32 gap junctions in vitro, and which they confirmed was specific to the Cx32 gap junction protein. (genengnews.com)
  • In the new study, the researchers uncovered a different set of liver changes caused by distant cancer cells which they observed in animal models of bone, skin and breast cancer that metastasize to other organs but not to the liver. (sciencemission.com)
  • Antibodies that recognize extracellular epitopes and can thus label iGluRs on living neurons are important tools for the study of receptor localization and dynamics. (jneurosci.org)
  • Scopolin resulted in increased deacetylation of sterol regulatory element-binding protein 1c with subsequent downregulation of lipogenic genes, and enhanced deacetylation of protein peroxisome proliferator-activated receptor-3 coactivator 1α with upregulation of fatty acid oxidation genes in livers. (elsevierpure.com)
  • The hepatoprotective effect of SD was also confirmed by the histopathological examination and comet assay of liver tissue. (jru-b.com)
  • Hu Y, Wang S, Wang A, Lin L, Chen M and Wang Y: Antioxidant and hepatoprotective effect of Penthorum chinense Pursh extract against t-BHP-induced liver damage in L02 cells. (spandidos-publications.com)
  • Therefore, directly converting iHepSCs from somatic cells may facilitate the development of patient-specific cell-based therapy for chronic liver damage. (figshare.com)
  • Tang W, Jiang YF, Ponnusamy M and Diallo M: Role of Nrf2 in chronic liver disease. (spandidos-publications.com)
  • The new clinical data for AB-729, our RNAi therapeutic, continues to support its development as a potential cornerstone agent for the treatment of chronic hepatitis B (cHBV) infection. (biospace.com)
  • Also, DM induced histopathological alterations such as cytoplasmic vacuolization and degeneration in nuclei, congestion, an enlargement of the blood vessels and lymphocytes infiltration in the liver. (scialert.net)
  • The results showed that co-treatment of vitE and vitC protected guinea pigs from DM-induced biochemical and histopathological changes. (scialert.net)
  • Histopathological observations by H&E, M&T, picro-sirius and ultra-structural scrutiny by SEM and TEM indicated liver damage and increase in COX2 and α-SMA by NDEA which was successfully rectified by the supplementation of PGJ. (nature.com)
  • The present study tested whether TRVP4 also contributes to neuropathic pain, using a rat model of Taxol-induced painful peripheral neuropathy. (jneurosci.org)
  • Similarly, significant increase in Lipid Peroxidation (LPO) level while induced significant decreases in the activities of liver Catalase (CAT) and Glutathione-S-Transferase (GST). (scialert.net)
  • Our findings show that tumors can lead to significant systemic complications including liver disease, but also suggest that these complications can be addressed with future treatments," said the study co-senior author. (sciencemission.com)
  • The researchers traced this liver reprogramming to EVPs that are released by the distant tumors and carry fatty acids, especially palmitic acid. (sciencemission.com)
  • Laboratory markers of liver function were measured before, during, and after duloxetine-induced liver injury. (psychiatrist.com)
  • A dose increase appears to have resulted in rapid autonomic dysfunction and liver injury. (psychiatrist.com)
  • Drugs are an important cause of liver injury. (medscape.com)
  • Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug, and one-third of all drugs withdrawn from the market are withdrawn for liver injury. (medscape.com)
  • Between 1998 and 2000, the US Food and Drug Administration (FDA) has recommended withdrawal of 2 drugs from the market for causing severe liver injury: bromfenac and troglitazone. (medscape.com)
  • The results revealed that H2O2 induced notable injury to L02 cells, as demonstrated by decreased cell viability, increased lactate dehydrogenase release, apoptotic rate and intracellular ROS production, and by the loss of MMP. (spandidos-publications.com)
  • Human users of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) users may be at risk of developing MDMA-induced neuronal injury. (erowid.org)
  • Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. (medscape.com)
  • In the last few years, the US Food and Drug Administration (FDA) has withdrawn 2 drugs from the market for causing severe liver injury: bromfenac and troglitazone. (medscape.com)
  • Charles Swanton, PhD , of The Francis Crick Institute, discusses a newly discovered mechanism of action for air pollution-induced non-small cell lung cancer in which particles linked to climate change appear to promote cancerous changes. (ascopost.com)
  • The finding might pave the way for new potential approaches to lung cancer prevention and treatment (Abstract LBA1). (ascopost.com)
  • Chen CJ, Chen CW, Wu MM, Kuo TL (1992) Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. (springer.com)
  • Flow cytometry and inverted fluorescence microscope were used to measure the intracellular reactive oxygen species (ROS) and mitochondrial membrane potential (MMP). (spandidos-publications.com)
  • Moderate or severe hepatic impairment or active liver disease including unexplained persistent abnormal liver function tests ( 4 ). (drugs.com)
  • Scientists can use these new imaging techniques to clarify the potential for reversing cerebellar damage in recovered alcoholics and to explore a new topic: the role of cerebellar damage in cognitive impairment. (nih.gov)
  • Resveratrol is a well-known polyphenolic compound that is reported to reduce As 2 O 3 -induced cardiotoxicity. (springer.com)
  • This study demonstrates that Oct4 and Hnf4α -induced HepSCs show typical hepatic and biliary functionality in vitro . (figshare.com)
  • Expression of cell cycle inhibitors, P21 and P27, and activation of apoptosis executer enzyme, caspase-3, were also induced by TCEE. (hindawi.com)
  • Since hepatic stem cells (HepSCs) possess self-renewal and bipotency with the capacity to differentiate into both hepatocytes and cholangiocytes, they have therapeutic potential for treating liver disease. (figshare.com)
  • Baur JA, Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. (springer.com)
  • Fig. 1: Remote primary tumours induce metabolic dysfunction in the liver. (nature.com)
  • Fig. 2: Tumour-derived EVPs induce liver metabolic dysfunction. (nature.com)
  • In contrast to the results for BEAS-2B and A549 cells, in RKO colon carcinoma cells ZnO NPs and not Zn2 + induce cytotoxicity and mitochondrial dysfunction. (dovepress.com)
  • Using these antibodies, in conjunction with GluR2-specific and synaptophysin antibodies, we have directly localized and quantified surface-expressed native AMPA and NMDA receptors on cultured living hippocampal neurons during development. (jneurosci.org)
  • In the final assembly area 9 of 103 workers had abnormal serum liver enzyme concentrations. (cdc.gov)
  • Glucagon-like peptide-2 (GLP-2) is a newly discovered enteral nutrition factor, but its efficacy and potential mechanism of action on UC have not been fully elucidated. (researchsquare.com)
  • Despite various documented roles of PGJ, there are no studies on antifibrotic potential in NDEA-induced mammalian liver fibrotic model. (nature.com)
  • These findings point towards pomegranate as a potential and efficacious therapeutic agent against liver fibrosis. (nature.com)
  • Now, it is high time that work should be done on these lines to garner the potential of pomegranate in order to cure liver fibrosis. (nature.com)
  • Here, we investigated the therapeutic effects of induced HepSCs (iHepSCs) on a carbon tetrachloride (CCl 4 )-induced liver fibrosis model. (figshare.com)
  • It also presents the therapeutic effect of iHepSCs in liver fibrosis. (figshare.com)
  • They thus postulated that liver-specific gap junction inhibitors might act to protect the liver if they could be co-formulated with hepatotoxic drugs. (genengnews.com)
  • Thus, the modulation of canalicular P-gp has a potential to cause drug-drug interaction between TP and the coadministered P-gp inhibitors or inducers in the clinic. (curehunter.com)
  • These 2 cases of community- male medical doctor with no history of woman with type-2 diabetes, who was acquired K. pneumoniae serotype K1 serious medical conditions, who sud- hospitalized for epigastric pain and fa- and K2 liver abscesses with metastatic denly experienced fever up to 40°C, tigue. (cdc.gov)
  • doxorubicin decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)