Cell Line, TumorMolecular Targeted TherapySignal TransductionCell ProliferationGene Expression Regulation, NeoplasticRNA, Small InterferingApoptosisGene Knockdown TechniquesRNA InterferenceDisease Models, AnimalGene Expression ProfilingMice, Inbred C57BLMice, KnockoutBlotting, WesternImmunohistochemistryUp-RegulationReverse Transcriptase Polymerase Chain ReactionCell MovementRNA, MessengerAntineoplastic AgentsTumor Markers, BiologicalNeoplasm InvasivenessCells, CulturedMicroRNAsCell SurvivalMice, NudeOligonucleotide Array Sequence AnalysisDrug Delivery SystemsXenograft Model Antitumor AssaysGene Expression RegulationMice, TransgenicEnzyme InhibitorsPhosphorylationInflammationNeoplasmsDown-RegulationDisease ProgressionProtein Kinase InhibitorsGene SilencingCell Growth ProcessesMutationGene ExpressionProto-Oncogene Proteins c-aktBreast NeoplasmsReal-Time Polymerase Chain ReactionModels, BiologicalMice, SCIDPrognosisDrug Resistance, NeoplasmCell Transformation, NeoplasticNeoplastic Stem CellsTissue Array AnalysisCell LineNeoplasm MetastasisHEK293 CellsNF-kappa BDrug DesignNeoplasm ProteinsTransfectionEnzyme ActivationCell CycleProtein BindingProtein-Serine-Threonine KinasesPiperazinesNeovascularization, PathologicTumor Cells, CulturedMice, Inbred BALB CCell DeathPyrimidinesTOR Serine-Threonine KinasesImmunoprecipitationPancreatic NeoplasmsTranscription FactorsFlow CytometryProto-Oncogene ProteinsTransplantation, HeterologousEndothelial CellsCytokinesMice, Inbred NODNeurodegenerative DiseasesReceptors, G-Protein-CoupledCarcinomaHeterocyclic Compounds, 3-RingIndolesPhosphatidylinositol 3-KinasesPhenotypeFibrosisTumor BurdenOxidative StressLung NeoplasmsProstatic NeoplasmsBrain NeoplasmsReactive Oxygen SpeciesBenzamidesExtracellular Signal-Regulated MAP KinasesOvarian NeoplasmsMembrane ProteinsCell Cycle CheckpointsTumor Necrosis Factor-alphaMAP Kinase Signaling System