Drug DesignDrug DiscoveryDrug InteractionsDrug Evaluation, PreclinicalCellulose, OxidizedDrug Delivery SystemsPharmaceutical PreparationsDrug TherapyDrug-Related Side Effects and Adverse ReactionsTrypanosoma brucei bruceiProtozoan ProteinsDrug CarriersMolecular StructureModels, MolecularAntiprotozoal AgentsCrystallography, X-RayEnzyme InhibitorsChemistry, PharmaceuticalMolecular Sequence DataGenes, EssentialAmino Acid SequenceSmall Molecule LibrariesTrypanosomaTrypanosomiasisMethenyltetrahydrofolate CyclohydrolaseTrypanocidal AgentsTrypanosomiasis, AfricanInhibitory Concentration 50Genome, ProtozoanTrypanosoma cruziCatalytic DomainLeishmania majorMolecular Targeted TherapyMolecular Docking SimulationMycobacterium tuberculosisAntineoplastic AgentsLigandsDisease Models, AnimalGenes, ProtozoanComputational BiologyCell Line, TumorStructure-Activity RelationshipAnthelminticsMetabolic Networks and PathwaysBinding SitesPlasmodium falciparumHigh-Throughput Screening AssaysProtein BindingSignal TransductionProteomePhytotherapyNanostructuresKineticsDose-Response Relationship, DrugCell ProliferationStructural Homology, ProteinGene Expression ProfilingHelminth ProteinsSubstrate SpecificitySystems BiologyPurinesGenomicsRNA InterferenceNeoplasmsSequence Homology, Amino AcidRecombinant ProteinsBacterial ProteinsProteomicsProtein Interaction MappingProtease InhibitorsProtein Structure, TertiaryAntimalarialsCell LineSequence AlignmentProtein ConformationMutationMicrosomes, LiverPeptidesMolecular Dynamics SimulationCytochrome P-450 Enzyme SystemCell SurvivalApoptosisModels, BiologicalAntitubercular AgentsAnti-Bacterial AgentsProtein Kinase InhibitorsPhylogenyProteinsCloning, MolecularAntifungal AgentsSulfonamidesComputer SimulationDatabases, ProteinAntiviral AgentsInternetSolubilityGene Expression Regulation, NeoplasticSoftwareCells, CulturedMice, Knockout