• Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. (nih.gov)
  • As the transcriptional pattern was indicative for nutrient limitations, we performed fed-batch cultivations where we added the respective nutrients and compared them to non-supplemented cultures regarding cell growth, productivity and expression levels of selected biomarker genes. (biomedcentral.com)
  • Transcriptional analysis of P. pastoris fed-batch cultivations led to the identification of nutrient limitations in the later phases, and respective biomarker genes for indication of limitations. (biomedcentral.com)
  • The biomarker genes are versatily applicable to media and process optimization approaches, where tailor-made solutions are envisioned. (biomedcentral.com)
  • Two subgroups of cytosolic GSTs have been characterized based upon their interaction with glutathione: the Y-GST group, which uses a tyrosine residue to activate glutathione, and the S/C-GST, which instead uses serine or cysteine residues. (wikipedia.org)
  • However, because receptor antagonists have aerosol formulations and possible antiproliferative activity, they may also have potential, particularly in the lung, where topical application of such formulations is feasible. (aacrjournals.org)
  • The findings of the present study provided insight into the molecular mechanisms underlying ferruginol-induced apoptosis in non-small cell lung cancer (NSCLC) cells, indicating that this compound may be a potential candidate drug for anti-NSCLC. (jove.com)
  • Here, utilizing the WS MSC model, we tested the potential rescuing effect with a group of compounds which have been reported with "anti-aging" or "longevity-promoting" activity from different model organisms. (springer.com)