Potential binding sites. Medical search. Frequent questions

In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. (wikipedia.org)
The knowledge about DNA-binding residues, binding specificity and binding affinity helps to not only understand the recognition mechanism of protein-DNA complex, but also give clues for protein function annotation. (nature.com)
Although several approaches have been proposed in the literature to model the DNA-binding specificity of TFs, they still have some limitations. (biorxiv.org)
The parasite ACBP is shown to have a different ligand-binding pocket, leading to an acyl-CoA binding specificity different from that of bovine ACBP. (rcsb.org)
These, together with measured binding-specificity differences, suggest that there is a potential for the design of molecules that might selectively block the acyl-CoA binding site. (rcsb.org)
2012 ), generalizing the observation that hotspot localization is determined by the DNA-binding specificity of the zinc finger array (Grey et al. (springer.com)
Therefore, the potential for drug compounds to be carried by this nucleotide complex requires further research with respect to binding affinity, solubility, toxicology, and specificity with other analogues. (proteopedia.org)

Several experimental techniques have been proposed to identify the DNA-binding sites and investigate the interaction modes between proteins and DNAs. (nature.com)
There is an urgent need for computational tools that can rapidly and reliably identify DNA-binding sites in DNA-binding proteins. (nature.com)
Binding sites of other proteins which are similar to the binding site of the target protein can offer hints for possible side effects of a new drug prior to clinical studies. (uni-marburg.de)
Moreover, binding site comparisons are used as an idea generator for bioisosteric replacements of individual functional groups of the newly developed drug and to unravel the function of hitherto orphan proteins. (uni-marburg.de)
The structural comparison of binding sites is especially useful when applied on distantly related proteins as a comparison solely based on the amino acid sequence is not sufficient in such cases. (uni-marburg.de)
The Automatic Search for Ligand Binding Sites in Proteins of Known Three-dimensional Structure Using only Geometric Criteria. (uni-marburg.de)
Identifying ligand-binding sites on proteins is key to understanding how the protein functions and finding new drugs. (drugdiscoverynews.com)
As they report in the Journal of Chemical Information and Modeling , the researchers started with X-ray structures of proteins bound by drugs or druglike ligands, the latter defined by 14 molecular descriptors. (drugdiscoverynews.com)
Using the Alpha Site Finder function of MOE , they identified concavities in the proteins' surfaces and characterized the composition of amino acids in these concavities, as well as more general placement on protein surfaces. (drugdiscoverynews.com)
The researchers then tested their PLB index on a collection of 756 proteins, identifying 15,232 potential binding sites. (drugdiscoverynews.com)
Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
DSB sites are preferentially located within chromatin loops, while several proteins that are required for DSB formation (Rec114, Mei4, and Mer2) localize on the chromosome axis (Blat et al. (springer.com)
DNA meth-ylation represses transcription by interfering with transcription factor binding and indirectly by recruiting methyl-CpG-binding proteins and reducing chromatin remodeling activities ( 12 ). (spandidos-publications.com)
We have tested and validated the ability of HDPBL to detect pockets in proteins that bind to hydrophobic ligands, polar ligands and charged small probes as well as to characterize the environment of membrane proteins. (arxiv.org)
Evaluation of different methods to calculated reduction potentials for heme proteins. (lu.se)
The specific binding of small molecules (ligands) to proteins is the basis for many biological functions, such as signalling and enzyme activity. (lu.se)

How to Measure the Similarity Between Protein Ligand-binding Sites. (uni-marburg.de)
A simple and fuzzy method to align and compare druggable ligand-binding sites. (uni-marburg.de)
When they looked at the highest scoring concavities on a given protein, they found 79% represented known ligand binding sites. (drugdiscoverynews.com)
The PLB index would also be useful for identifying ligand-binding sites on novel target molecules with unknown ligands. (drugdiscoverynews.com)
In the blood vascular system, human serum albumin (HSA) is a vital globular transport protein with potential multiple ligand binding sites. (researchgate.net)

Allosteric binding induces conformational changes that may increase the protein's affinity for substrate. (wikipedia.org)
Conversely, allosteric binding that decreases the protein's affinity for substrate is negative modulation. (wikipedia.org)
Understanding protein-DNA binding affinity is still a mystery for many transcription factors (TFs). (biorxiv.org)
Radioligand binding studies show that ibogaine binds with low micromolar (μM) affinity to a number of molecular targets in nervous tissue, resulting in a complex pharmacology (16- 27). (erowid.org)
Thus, the interaction of ibogaine with μM-affinity binding sites may be functionally relevant in vivo. (erowid.org)
Characterizing the binding affinity of compounds to HSA is ess. (researchgate.net)

There are three main locations where ion ligands bind to the oligonucleotide/drug complex. (proteopedia.org)
This is particularly troublesome if the two ligands bind in slightly different conformations, or if the protein itself adopts different conformations in the two cases, as illustrated in the figure below. (lu.se)

Competitive inhibitors compete with substrate to bind to free enzymes at active sites and thus impede the production of the enzyme-substrate complex upon binding. (wikipedia.org)
Uncompetitive inhibitors, alternatively, bind concurrently with substrate at active sites. (wikipedia.org)
Lastly, mixed inhibitors are able to bind to both the free enzyme and the enzyme-substrate complex. (wikipedia.org)
However, in contrast to competitive and uncompetitive inhibitors, mixed inhibitors bind to the allosteric site. (wikipedia.org)
Substrates, transition states, and products can bind to the active site, as well as any competitive inhibitors. (wikipedia.org)
2010. Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates . (ub.edu)
2010. Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents . (ub.edu)
Several HSP70 inhibitors have been reported, but because the majority have poor physicochemical properties and for many the exact mode of action is poorly understood, more detailed mechanistic and structural insight into ligand-binding to HSP70s is urgently needed. (rcsb.org)
Here we describe the first comprehensive fragment-based inhibitor exploration of an HSP70 enzyme, which yielded an amino-quinazoline fragment that was elaborated to a novel ATP binding site ligand with different physicochemical properties to known adenosine-based HSP70 inhibitors. (rcsb.org)

Binding sites incur functional changes in a number of contexts, including enzyme catalysis, molecular pathway signaling, homeostatic regulation, and physiological function. (wikipedia.org)
At the molecular level, abnormal cells that are potential cancer cells need to be "switched" to normal mode. (cancer.gov)
As CXXC1 is orthologous to Saccharomyces cerevisiae Spp1 that links DSB sites to the DSB machinery on the chromosome axis, we propose that these molecular interactions involved in the regulation of meiotic DSB formation are conserved in mouse meiosis. (springer.com)
It involves two series of molecular dynamics (MD) simulations in which the ligand is artificially transformed to another ligand, for which the binding free energy is known. (lu.se)

Active site residues of hexokinase allow for stabilization of the glucose molecule in the active site and spur the onset of an alternative pathway of favorable interactions, decreasing the activation energy. (wikipedia.org)
Bullock and Fersht 8 have shown that mutations of DNA-binding residues, such as those on the tumor repressor protein P53, may predispose individuals to cancer. (nature.com)

Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site. (cdc.gov)
It is observed by the in silico studies that 1-NA bind at the active site of acetylcholinesterase akin to acetylcholine (ACh) with a better fitness score. (who.int)

Some of these ibogaine binding sites include sigma-2 receptors (16,17), serotonin (5-HT) and dopamine (DA) transporters (18-21), mu- and kappa-opioid receptors (21-24), and NMDA-coupled ion channels (25-27). (erowid.org)
N -(4-[ 18 F]Fluorobenzoyl)interleukin-2 ([ 18 F]FB-IL2) specifically binds to interleukin-2 receptors (IL-2R) and thus may be used to detect inflammation processes using positron emission tomography (PET). (springer.com)
This demonstration opens the door to potentially manipulating such receptors' binding sites in legumes and other organisms in the future. (lu.se)

Synthesis, Fluorine-18 Radiolabeling, and Biological Evaluation of N-((E)-4-Fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4′-halophenyl)nortropanes: Candidate Radioligands for In Vivo Imaging of the Brain Dopamine Transporter with Positron Emission Tomography. (acs.org)
Synthesis and Biological Evaluation of Bupropion Analogues as Potential Pharmacotherapies for Cocaine Addiction. (acs.org)
Our proposed approach creates TF-specific classifier models using genome-wide DNA-binding experiments and a prior biological knowledge on DNA sequences and TF binding preferences. (biorxiv.org)
Consecutive pathway and cluster analysis led to the identification of biological processes, namely processes involving binding and processing of nucleic acids, LRP1-dependent endocytosis, and exosome formation. (degruyter.com)
MicroRNAs are a kind of small noncoding RNAs, which are involved in the posttranscriptional regulation of gene expression by binding the translation section and lead to either mRNA degradation or translational inhibition and have been found to regulate crucial biological processes, including proliferation, differentiation, and apoptosis [ 10 - 12 ]. (hindawi.com)

In the context of the blood, an example of competitive binding is carbon monoxide which competes with oxygen for the active site on heme. (wikipedia.org)
In these circumstances, the binding of carbon monoxide induces a conformation change that discourages heme from binding to oxygen, resulting in carbon monoxide poisoning. (wikipedia.org)

Electric charge, steric shape and geometry of the site selectively allow for highly specific ligands to bind, activating a particular cascade of cellular interactions the protein is responsible for. (wikipedia.org)
At the catalytic binding site, several different interactions may act upon the substrate. (wikipedia.org)
An analysis of the number of binding sites in the spatial context of the target site indicates that the interactions between binding sites next to each other are important for protein-DNA recognition and their binding ability. (nature.com)
Antiepileptic drugs should be used carefully, with consideration of medication interactions and potential side effects. (medscape.com)
We present a model for the calcium-dependent regulation of TRPV1 via competitive interactions of ATP and calmodulin at the TRPV1-ARD-binding site and discuss its relationship to the C-terminal region previously implicated in interactions with PIP2 and calmodulin. (nih.gov)
This ability to strongly bind metal ions was also important for x-ray crystallographic purposes, as it enabled researchers to form crystals of the complex by relying on interactions between neighboring molecules' binding sites. (proteopedia.org)
Interactions between charges are controlled by electrostatics, while hydrophobic interactions are modeled with a Yukawa potential. (arxiv.org)

Regulatory site ligands can involve homotropic and heterotropic ligands, in which single or multiple types of molecule affects enzyme activity respectively. (wikipedia.org)
To address this problem, researchers at Astellas Pharma and Tokai University developed a new algorithm that allowed them to predict drug and druglike molecule binding. (drugdiscoverynews.com)
The fibrinolytic potential of human urine was first described in 1947, and the active molecule was named urokinase. (medscape.com)

The binding event is often, but not always, accompanied by a conformational change that alters the protein's function. (wikipedia.org)
For example, in the context of protein function, the binding of calcium to troponin in muscle cells can induce a conformational change in troponin. (wikipedia.org)
Crystal structures of amino-quinazoline ligands bound to the different conformational states of the HSP70 nucleotide binding domain highlighted the challenges of a fragment-based approach when applied to this particular flexible enzyme class with an ATP-binding site that changes shape and size during its catalytic cycle. (rcsb.org)
A problem with FEP is that the sampling of the conformational space of the ligand and binding site may be limited by high energy barriers. (lu.se)

In particular, most miRNAs bind to target sequences located within the 3'-untranslated region (3'UTR) of mRNAs, resulting in the cleavage of the target mRNAs or repression of their translation ( 13 ). (iiarjournals.org)
Finally, the created classifier models are used to scan new DNA sequences and identify potential binding sites. (biorxiv.org)

Binding to protein binding sites is most often reversible (transient and non-covalent), but can also be covalent reversible or irreversible. (wikipedia.org)
Voltage-sensitive ion channels closely regulate generation of action potentials (brief and reversible alterations of the voltage of cellular membranes). (medscape.com)
Time-activity curves could be fitted well by the Logan analysis method, indicating that the binding between [ 18 F]FB-IL2 and CD25 is reversible. (springer.com)

Further analysis of MC1R antibodies indicated that their binding sites were on extracellular domains of the receptor, were of the IgG1 subclass and, in two patients, adversely affected the function of the MC1R. (bl.uk)

These programs are utilized to screen entire libraries of molecules for a possible ligand of a binding site and to furthermore estimate in which conformation the ligand will most likely bind. (uni-marburg.de)
To date, the main prognostic factor used in clinical practice is the tumor stage, yet several molecules and genetic alterations have also been introduced as potential markers. (iiarjournals.org)
Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA molecules in the cell and plays a role in fatty acid metabolism. (rcsb.org)
Furthermore, the binding site seems to be specific to anthracene and similar molecules. (proteopedia.org)

The immunoreactivity of each of these potential autoantigens was tested in radioligand binding assays against 48 alopecia areata patient sera and was detected in 8 (16.7%), 21 (43.8%), and 10 (20.8%) patient serum samples, respectively. (bl.uk)

During the generation of action potentials, sodium ions move across the membrane through voltage-gated ion channels. (medscape.com)
In short, this DNA/Anthraquinone derivative complex provides a potential anti-cancer drug and information about the role of positively charged ions in the intercalation of the drug compound. (proteopedia.org)
The 1xcs complex also binds to metal ions in more than one location, which have been shown to be important to the drug's binding ability. (proteopedia.org)
Literature states that the variable ion gives strength to the binding of the Co(2+) ions. (proteopedia.org)

Conclusion: The current study suggests that the functional variant (rs1044129) in the miR-367 binding site of RYR3 may be a potential marker for prognosis in patients following curative surgery for CRC. (iiarjournals.org)
Additionally, the structural data revealed a potential functional role for the ATP ribose moiety in priming the protein for the formation of the ATP-bound pre-hydrolysis complex by influencing the conformation of one of the phosphate binding loops. (rcsb.org)
2010 ). PRDM9 includes several functional domains, such as a DNA-binding zinc finger array, a histone lysine methyltransferase PR/SET (PRDI-BF1 and RIZ1 homology) domain, and a Krüppel-associated box (KRAB)-related domain. (springer.com)
Our results indicate that C. carpio possesses two functional fpns with distinct expression patterns, highlighting the potential for functional divergence and expression differentiation among fpns in this species. (bvsalud.org)

Therefore, a reliable identification of DNA-binding sites in DNA-binding protein is important for protein function annotation, in silico modeling of transcription regulation and site-directed mutagenesis. (nature.com)

Mutations in the TRPV1-ARD binding site eliminate tachyphylaxis. (nih.gov)
With HyperPP fast channel inactivation, mutations are usually situated in the inner parts of transmembrane segments or in the intracellular loops affecting the docking sites for the fast inactivating particle, thus impairing fast channel inactivation leading to persistent Na + current. (medscape.com)

The firing of an action potential by an axon is accomplished through sodium channels. (medscape.com)

however, in which context chromatin states are instructive for TF binding remains mainly unknown. (nih.gov)
One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
Ketamine treatment increased the binding of NF‑κB and permissive histone H3 lysine‑4 (H3K4)m3, but caused a decrease in the repressive histone H3K27m3 and H3K36m3 on the COX‑2 promoter ranging from ‑1,522 to ‑1,331 bp as determined by a chromatin immunoprecipitation assay. (spandidos-publications.com)
The mechanism of epigenetic regulation involves the CpG site methylation of promoter regions and the modification of DNA and histones by altering chromatin structure ( 9 - 11 ). (spandidos-publications.com)

Protein inhibition by inhibitor binding may induce obstruction in pathway regulation, homeostatic regulation and physiological function. (wikipedia.org)

Restoring de novo methyltransferase activity initiates remethylation at these sites and outcompetes NRF1 binding. (nih.gov)
DNMT1 preserves the methyltransferase by binding to hemi-methylated CpG sites and methylates the cytosine on the newly synthesized strand after DNA replication, whereas DNMT3a/DNMT3b are required for the de novo genomic methylation of DNA ( 15 ). (spandidos-publications.com)

The binding of a ligand to an allosteric site of a multimeric enzyme often induces positive cooperativity, that is the binding of one substrate induces a favorable conformation change and increases the enzyme's likelihood to bind to a second substrate. (wikipedia.org)

The structure reveals a binding site that accommodates triphosphate nucleotides such as ATP, and biochemical studies demonstrate that calmodulin binds the same site. (nih.gov)
The two other ligands, shown in cyan bind four to five nucleotides away from the drug itself. (proteopedia.org)

In vitro, rCcCCL19bs could bind and aggregate A. hydrophila and Staphylococcus aureus. (bvsalud.org)

Enzymes incur catalysis by binding more strongly to transition states than substrates and products. (wikipedia.org)
Here, we have explored alternative substrates, such as 1-NA and 2-NA which might have the potential to behave as specific substrates for the detection of hemolysate cholinesterase activity on the gels. (who.int)

Few studies have been able to attribute in vivo pharmacological effects of ibogaine to activation of specific binding sites. (erowid.org)

To explore the contribution of DNA methylation to constrained TF binding, we mapped DNase-I-hypersensitive sites in murine stem cells in the presence and absence of DNA methylation. (nih.gov)
Methylation-restricted sites are enriched for TF motifs containing CpGs, especially for those of NRF1. (nih.gov)
The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)‑2 promoter via nuclear factor (NF)‑κB transcriptional regulation and elucidated its effect on the COX‑2 transcriptional expression in a ketamine‑induced ulcerative cystitis (KIC) animal model. (spandidos-publications.com)
Moreover, the CpG site methylation is mediated by DNA methyltransferases (DNMTs), which catalyze the addition of a methyl group to cytosine ( 13 , 14 ). (spandidos-publications.com)

As a result, exploring potential therapeutic target and diagnostic marker is of immense significance to the improvement of glioma sufferer's survival. (hindawi.com)
demonstrate through studies on induced pluripotent stem cell-derived cortical neurons that miR-33a is a potential therapeutic target for the treatment of SPG4-related hereditary spastic paraplegia. (portlandpress.com)

Eukaryotic transcription factors (TFs) are key determinants of gene activity, yet they bind only a fraction of their corresponding DNA sequence motifs in any given cell type. (nih.gov)

Co-administration with elbasvir (EBR) and grazoprevir (GZR) due to the potential for significant decreases in plasma concentrations of EBR and GZR (see section 4.5). (who.int)

Side reactions are also discouraged by this specific binding. (wikipedia.org)
Find support for a specific problem in the support section of our website. (mdpi.com)
Several algorithms have been developed to look for binding clefts in protein surfaces, but none of them into account a key identifier of protein-ligand binding, the clustering of specific amino acids. (drugdiscoverynews.com)
They found specific amino acids tended to be found within concavities more often than others, and they used this information to develop an index called propensity for ligand binding (PLB). (drugdiscoverynews.com)
Reference citations in some PDQ cancer information summaries may include links to external websites that are operated by individuals or organizations for the purpose of marketing or advocating the use of specific treatments or products. (cancer.gov)
The specific agonist and antagonist of SIRT1 were used to explore the potential role of SIRT1 in M1 polarization induced by PM 2.5 . (medsci.org)
Because tobacco use has declined in the United States, accompanied by a decrease in incidence of many tobacco-related cancers, researchers have suggested that the increase in oral cavity and pharynx cancers might be attributed to anatomic sites with specific cell types in which HPV DNA is often found (4,5). (cdc.gov)

What makes a dangling bond a binding site for thermal CH3 radicals? (mpg.de)

At the regulatory site, the binding of a ligand may elicit amplified or inhibited protein function. (wikipedia.org)

This role involves its DNA-binding domain, which is composed of a tandem array of zinc fingers, and PRDM9-dependent trimethylation of histone H3 at lysine 4. (springer.com)

In fact, there is speculation that the key to ibogaine s antiaddictive potential is related to the simultaneous activation of multiple neurotransmitter systems in the brain (14,15). (erowid.org)

Results: Among seven target variants, rs1044129 at the miR-367 binding site of calcium channel ryanodine receptor gene 3 (RYR3) was associated with relapse-free survival (RFS) for colon cancer patients as a recessive model in a univariate analysis. (iiarjournals.org)

Thus, we propose a hypothesis, PM 2.5 exposure induces M1 polarization and miR-146a-3p is a potential upstream regulator by targeting SIRT1. (medsci.org)

These webinars include information about the history of the program, funding for associates, an overview of the program itself, guidance on the characteristics of a quality PHAP training experience, and steps on how to apply to be a host site. (cdc.gov)

They have shown that metal sites in crystal structures are frequently photoreduced or disordered, which makes the interpretation of the structures hard. (lu.se)

In fact, the TF NRF1 occupies several thousand additional sites in the unmethylated genome, resulting in increased transcription. (nih.gov)

Enzyme binding allows for closer proximity and exclusion of substances irrelevant to the reaction. (wikipedia.org)
Upon binding to an enzyme substrate (ES) complex, an enzyme substrate inhibitor (ESI) complex is formed. (wikipedia.org)
At the active site, a substrate binds to an enzyme to induce a chemical reaction. (wikipedia.org)

In the present work, accelerated methods for the comparison of protein binding sites as well as an extended procedure for the assessment of ligand poses in protein binding sites are presented. (uni-marburg.de)
CD25 contains the main binding site for IL-2 and can be present as a transmembrane or soluble receptor. (springer.com)

Luciferase analysis was used to identify the binding site of miR-146a-3p and SIRT1. (medsci.org)

This suggests that binding of DNA-methylationsensitive TFs relies on additional determinants to induce local hypomethylation. (nih.gov)

CiMex3B up-regulates the expressions of IFN1, ISG15, MX2, as well as the expressions of inflammatory cytokines such as IL6, IL8 and TNFα in response to poly(I:C). A screening test for identifying potential targets indicated that CiMex3B is associated with TLR3 and TRIF. (bvsalud.org)

Pocketome via Comprehensive Identification and Classification of Ligand Binding Envelopes. (uni-marburg.de)
The 'Group' letters/numbers that you see throughout this web site refer to the classification of herbicides by their site of action. (weedscience.org)

In order to define which glycans may be implicated in the binding of the bacteria to the gastric mucosa in humans, we have characterized the exact pattern of glycosylation of gastric mucins. (pasteur.fr)

We describe the structure of the cytosolic ankyrin repeat domain (ARD) of TRPV1 and identify a multiligand-binding site important in regulating channel sensitivity within the TRPV1-ARD. (nih.gov)

The comparison between our proposed PDNAsite method and the existing methods indicate that PDNAsite outperforms most of the existing methods and is a useful tool for DNA-binding site identification. (nature.com)
Methods for the assessment of ligand poses in protein binding sites are also used in the early phase of drug development within docking programs. (uni-marburg.de)
Materials and Methods: Three miRNA variants and four variants in the miRNA binding sites were selected based on allelic frequencies, while their potential impact has been described in previous studies. (iiarjournals.org)
Most of the methods require a cut-off threshold in order to classify a K-mer as a binding site (BS) and finding such a threshold is usually done by handcraft rather than a science. (biorxiv.org)
Hence, the current methods do not actually capture the TF-DNA binding relationship. (biorxiv.org)
One of the most rigorous methods used to calculate binding free energies is free-energy perturbation (FEP). (lu.se)
Typically, these methods work either by increasing the effective temperature in the simulation or by artificially flattening the potential-energy landscape, as illustrated in the figure below. (lu.se)

CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. (cdc.gov)

Poisson regression models were stratified by diabetes type and included demographic and clinical factors, clinical site, and waist-to-height ratio (WHtR). (cdc.gov)

The binding site of the drug compound is one of these high electron density areas, and was a key component in it's identification. (proteopedia.org)

Based on binding potential measured by PET, the limit of detection was about 160,000 CD25-positive cells per 200 μl lesion (95 % confidence). (springer.com)

In these studies we showed that Ser275 is a key residue in the selective binding of ATP. (rcsb.org)
As the vast majority of studies have focused on the female reproductive system, a discussion of the potential impact of melatonin on human male fertility will be left for others. (frontiersin.org)
Genetic studies on HRAC Group 4 resistant Wild Radish have not been reported to the site. (weedscience.org)

Anatomy7

Organisms6

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes54

Disciplines and Occupations1

Information Science6

Specificity7

Proteins16

Ligand Binding Sites5

Affinity6

Ligands bind2

Inhibitors9

Molecular4

Residues2

Acetylcholinesterase2

Receptors3

Biological5

Heme2

Interactions7

Molecule3

Conformational4

Sequences2

Reversible3

Extracellular1

Molecules4

Radioligand1

Ions4

Functional4

Silico1

Mutations2

Sodium1

Chromatin4

Inhibition1

Methyltransferase2

Allosteric1

Nucleotides2

Vitro1

Substrates2

Vivo1

Methylation4

Therapeutic target2

Sequence1

Decreases1

Specific7

Radicals1

Regulatory1

Histone1

Simultaneous1

Gene1

Induces1

Webinars1

Crystal structures1

Genome1

Enzyme3

Present2

Analysis1

Determinants1

Targets1

Classification2

Humans1

Sensitivity1

Methods7

Accessibility1

Clinical1

Identification1

Detection1

Studies3