Potent vasodilator agent with calcium. Medical search. Frequent questions

In humans, angiotensin-converting enzyme inhibitors, a potent class of antihypertensive agents, lower blood pressure at least partially by favoring enhanced kinin accumulation in plasma and target tissues. (nature.com)

Oedema formation with the vasodilators nifedipine and diazoxide: direct local effect or sodium retention? (wikipedia.org)
The relative potency of CCBs as vasodilators varies, with dihydropyridine-type compounds, such as nifedipine, regarded as the most potent subclass, and verapamil, diltiazem, and bepridil as somewhat less potent. (medscape.com)
In vitro, several calcium antagonists (e.g., nifedipine, nisoldipine, and isradipine) bind with some selectivity to the L-type calcium channel present in blood vessels, whereas verapamil binds equally well to cardiac and vascular L-type calcium channels. (medscape.com)
Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers. (nih.gov)
Nifedipine is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle. (nih.gov)
Nifedipine selectively inhibits calcium ion influx across the cell membrane of cardiac muscle and vascular smooth muscle without altering serum calcium concentrations. (nih.gov)
Nifedipine dilates the main coronary arteries and coronary arterioles, both in normal and ischemic regions, and is a potent inhibitor of coronary artery spasm, whether spontaneous or ergonovine-induced. (nih.gov)
Nifedipine is a peripheral arterial vasodilator which acts directly on vascular smooth muscle. (nih.gov)
The binding of nifedipine to voltage-dependent and possibly receptor-operated channels in vascular smooth muscle results in an inhibition of calcium influx through these channels. (nih.gov)

Although Amiloride Hydrochloride may be used alone, its principal indication is as concurrent therapy with thiazides or more potent diuretics in order to conserve potassium during periods of vigorous diuresis and during long-term maintenance therapy. (janusinfo.se)
It may be used with more potent diuretics when a greater diuresis is required while maintaining a more balanced serum electrolyte pattern. (janusinfo.se)

Diazoxide is used as a vasodilator in the treatment of acute hypertension or malignant hypertension. (wikipedia.org)
However, because of the different binding and pharmacologic characteristics of CCBs, a rationale exists for combining different agents in this class in the management of hypertension and/or symptomatic coronary artery disease. (medscape.com)
These agents are employed in the treatment of hypertension, angina, and/or supraventricular arrhythmias. (medscape.com)
Cite this: Combination Calcium Channel Blocker Therapy in the Treatment of Hypertension - Medscape - Sep 01, 2001. (medscape.com)
Sympathetic stimulation: Such stimulation can be due to either endogenous causes (e.g., pain, fear/panic disorder), or exogenous agents (e.g., ingestion of sympathomimetic agents), both of which may cause hypertension and mental status abnormalities. (cancertherapyadvisor.com)
Vasodilators are commonly prescribed to treat hypertension (high blood pressure), angina (chest pain), and heart failure. (pharmaoffer.com)
Results of Tenax Therapeutics' Phase 2 trial of levosimendan in patients with pulmonary hypertension (PH) and heart failure with preserved ejection fraction (HFpEF) demonstrated that IV levosimendan produces potent dilation of the central and pulmonary venous circulations which translates into an improvement in exercise capacity, a discovery that forms the basis for the Phase 3 investigation of Tenax Therapeutics' potential groundbreaking therapy. (biospace.com)
Some of these agents are currently under evaluation in clinical trials for treatment of hypertension and diabetes. (frontiersin.org)
Experimental and clinical evidence implicate an imbalance between endogenous vasoconstrictor and vasodilator systems in the development and maintenance of hypertension. (nature.com)
[8] In particular, atenolol seems to be less useful in hypertension than several other agents. (wikidoc.org)
In hypertension, it is used as an adjunct to prolonged therapy with thiazides and similar agents to prevent potassium depletion. (janusinfo.se)

Adenosine is a potent vasodilator in most vascular beds, except in renal afferent arterioles and hepatic veins where it produces vasoconstriction. (globalrph.com)
Although the exact mechanism by which adenosine receptor activation relaxes vascular smooth muscle is not known, there is evidence to support both inhibition of the slow inward calcium current reducing calcium uptake, and activation of adenylate cyclase through A2 receptors in smooth muscle cells. (globalrph.com)
Another class is nitric oxide (NO) donors, which release NO, a potent vasodilator, to promote relaxation of vascular smooth muscles. (pharmaoffer.com)
Levosimendan is a unique potassium ATP channel activator and calcium sensitizer that affects the heart and vascular system through multiple mechanisms of action. (biospace.com)
The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. (nih.gov)
Stores of intracellular calcium in vascular smooth muscle are limited and thus dependent upon the influx of extracellular calcium for contraction to occur. (nih.gov)
In fact, in addition to their potent vasodilating effect, EETs have potent anti-inflammatory properties, inhibit platelet aggregation, promote fibrinolysis, and reduce vascular smooth muscle cell proliferation. (frontiersin.org)

Angiotensin I is then converted by angiotensin converting enzyme (ACE) to angiotensin II, a potent endogenous vasoconstrictor substance. (nih.gov)
ACE inhibitors inhibit the activity of Angiotensin-converting enzyme (ACE), an enzyme responsible for the conversion of angiotensin I into angiotensin II, a potent vasoconstrictor . (wikidoc.org)

Mupirocin, formerly termed pseudomonic acid A, is a novel antibacterial agent with a unique chemical structure and mode of action apart from other antibiotic agents. (drugbank.com)
It enhances antifungal and antibacterial agents when combined with them. (365healthybychoiceshop.com)
Spearmint has potent antibacterial properties that can fight even antibiotic-resistant harmful pathogens. (naturallydaily.com)

Moreover, it has been exploited for the treatment of a variety of cardiovascular diseases due to its potential antihypertensive, anti-angina, vasodilator, and cardiac depressant activities. (cysticfibrosistreatmentreport.com)
It has a specific effect on cardiac contractility by inhibiting calcium to reduce the workload of the heart. (365healthybychoiceshop.com)

19 published his findings on cortisone causing dramatic improvements in patients with rheumatoid arthritis, corticosteroids have become established as the most potent anti-inflammatory agents in the pharmacotherapy of various chronic inflammatory diseases, including asthma 20 . (ersjournals.com)

Vasodilators are a crucial subcategory of pharmaceutical Active Pharmaceutical Ingredients (APIs) that play a significant role in the management of various cardiovascular conditions. (pharmaoffer.com)
The therapeutic benefits of vasodilators extend beyond cardiovascular disorders. (pharmaoffer.com)
In conclusion, vasodilators are a vital subcategory of pharmaceutical APIs used to manage cardiovascular conditions. (pharmaoffer.com)

Diazoxide is one of the most potent openers of the K+ ATP channels present on the insulin producing beta cells of the pancreas. (wikipedia.org)
Opening these channels leads to hyperpolarization of cell membrane, a decrease in calcium influx, and a subsequently reduced release of insulin. (wikipedia.org)
Repaglinide blocks ATP-dependent potassium channels in pancreatic beta cells, thereby causing depolarization of the cell membrane and subsequent opening of calcium channels. (medindex.am)

The increased calcium influx into the pancreatic beta cells induces insulin secretion, thereby lowering blood glucose levels. (medindex.am)

Rational alternatives exist, including an ACE inhibitor/calcium channel blocker (CCB) or a dihydropyridine CCB/ b blocker combination. (medscape.com)
Several reports have demonstrated dihydropyridine derivatives as a potentiator of cystic fibrosis transmembrane conductance regulator protein, potent antimalarial agent and HIV-1 protease inhibitor. (cysticfibrosistreatmentreport.com)

Studies have demonstrated that the increase in active tension reflects an increase in cytosolic free calcium. (nih.gov)

Research shown many of these compounds to be potent anti-inflammatory, antioxidant, anti-microbial and mighty free radical scavengers. (dupischai.com)

Evidence shows that antiplatelet agents, antioxidant therapies, amino acid supplementation, angiotensin converting enzyme (ACE) inhibitors, and angiotensin-receptor blockers may be able to prevent or slow the progression of atherosclerosis. (medscape.com)
The data indicate that l-NAME and atropine-sensitive endothelial-derived NO and COX enzyme inhibitors and Ca 2+ entry blocking-mediated vasodilator effect of the extract explain its antihypertensive potential. (nih.gov)

Chewing leaves of mint freshen breath and offers micro nutrients such as calcium, potassium, magnesium, iron, dietary fiber and manganese. (philihealth.com)
Various minerals can be added to calcium and magnesium of the Myer's cocktail. (easyhealthoptions.com)

Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. (lookformedical.com)

Abortive agents are used to stop or reduce the severity of an acute attack, whereas prophylactic agents are used to reduce the frequency and intensity of individual headache exacerbations. (medscape.com)

A potent calcium channel blockader with marked vasodilator action. (ouhsc.edu)
Ten calcium channel blockers (CCBs) are currently marketed in the United States. (medscape.com)
One widely used class of vasodilators is calcium channel blockers, which prevent calcium from entering the muscle cells of blood vessels. (pharmaoffer.com)
Dihydropyridine moiety plays an important role in several calcium-channel blockers. (cysticfibrosistreatmentreport.com)
calcium channel blockers side effects erectile dysfunction This can be a frustrating and awkward issue for lots of guys, however it is also a common one. (wsscheduler.com)
Calcium channel blockers block the entry of calcium into muscle cells in artery walls. (wikidoc.org)

In animal studies, captopril did not alter the pressor responses to a number of other agents, including angiotensin II and norepinephrine, indicating specificity of action. (nih.gov)

Vasodilator drugs can be divided into selective arteriolar dilators, venous dilators, and drugs with nonselective vasodilating effects. (brainkart.com)

Kinins (bradykinin and lys-bradykinin) are endogenous vasodilators and natriuretic peptides known best for their ability to antagonize angiotensin-induced vasoconstriction and sodium retention. (nature.com)

The ubiquitous distributions of H 2 S-producing enzymes and potent chemical reactivities of H 2 S in biological systems make H 2 S unique in its ability to regulate cellular and organ functions in both health and disease. (hindawi.com)

For the treatment of low blood pressure, people use adrenergic and dopaminergic agents, such as Midodrine. (ahefv.com)

It is a vasodilator, probably related to histamine release in the cells and to prostaglandin inhibition. (365healthybychoiceshop.com)

In very mild failure a thiazide diuretic may be tried, but a loop agent such as furosemide is usually required. (brainkart.com)

In addition, each tablet contains the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, microcrystalline cellulose, sodium starch glycolate (derived from potato), starch (derived from corn), and stearic acid. (nih.gov)
PhenQ is a potent dietary supplement that blends five different ingredients into one. (healthcanal.com)

Nitroglycerin is a vasodilator drug used for the treatment of chest pain and high blood pressure It was first approved in 2000 and is currently marketed by Pfizer, and other companies, depending on the dosage form Nitroglycerin is available in various forms, including a spray form, sublingual tablet form, intravenous form, extended-release tablet form, and transdermal form. (pharmaoffer.com)
Remember that interactions which modify the effects of a drug might involve non-pharmaceuticals, non-medicinal chemical agents, and social drugs such as alcohol, marijuana, tobacco, and traditional cures, as well as certain types of food for example, grapefruit juice. (ehd.org)

In hypertensive rats under similar conditions, extract and fractions showed antihypertensive effect at same doses while aqueous fraction being more potent, exhibited 68.53 ± 4.45% fall in MAP (70 mmHg). (nih.gov)

A benzoic acid derivative belonging to the meglitinide class of antidiabetic agents. (medindex.am)
The fumarate salt form of ibutilide, a class III antiarrhythmic agent. (medindex.am)

In fact, vitamin D triggers the release of your body's own natural antimicrobial peptides against infectious agents including bacteria, viruses, fungi, and parasites. (easyhealthoptions.com)

The dosages and indications for these agents are not identical. (pdr.net)

All currently available CCBs are vasodilators and thereby reduce blood pressure. (medscape.com)
Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body. (drugbank.com)

DMSO is a powerful free radical scavenger and an effective anti-inflammatory agent. (365healthybychoiceshop.com)

Treatment should be started with a low dose of Amiloride, i.e. 5mg (1 tablet), plus a low dosage of the other diuretic agent. (janusinfo.se)
If necessary, dosage of both agents may be increased gradually until there is effective diuresis. (janusinfo.se)

Anatomy12

Organisms4

Diseases3

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes19

Antihypertensive Agents1

Nifedipine9

Diuretics2

Hypertension11

Vascular7

Vasoconstrictor2

Antibacterial3

Cardiac2

Pharmacotherapy1

Cardiovascular3

Channels3

Influx1

Inhibitor2

Cytosolic1

Compounds1

Inhibitors2

Magnesium2

Platelet1

Acute1

Channel6

Specificity1

Venous1

Sodium retention1

Enzymes1

Adrenergic1

Inhibition1

Furosemide1

Ingredients2

Drug2

Effect1

Class2

Bacteria1

Indications1

Reduce2

Free1

Dosage2