Similar to cyclopamine, which also occurs in the genus Veratrum, it is a teratogen implicated in birth defects when consumed by animals during a certain period of their gestation. (wikipedia.org)
Jervine is a potent teratogen causing birth defects in vertebrates. (wikipedia.org)
Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of the developing limbs. (elsevierpure.com)
Barely 800 chemicals are known teratogens, producing birth defects in laboratory animals, and only about twenty of these are known to cause birth defects in the human. (wnho.net)
Animal studies show that nitrazepam is converted in the gut into 7-amino-nitrazepam, a teratogen that causes birth defects and can halt a pregnancy. (bigpharmanews.com)
Additionally, testosterone is a teratogen, a substance which is known to cause severe birth defects. (crworkshops.com)
Carcinogen4
Although it is a potent liver carcinogen similar to aflatoxin B1, current knowledge suggests that it is nowhere near as widespread in its occurrence. (wikipedia.org)
It is thus considered as a potent carcinogen, mutagen, and teratogen. (wikipedia.org)
It has been suggested that sterigmatocystin is about 1/10 as potent a carcinogen as aflatoxin B1. (wikipedia.org)
Aflatoxin B1 is the most potent carcinogen and is the major mycotoxin produced by A. flavus. (mountainenvironmentals.com)
Humans2
Has nature genetically engineered the sweet potato long before humans thought of the technology, and if so, should that reassure us about GMO safety? (gmwatch.org)
A. flavus produces aflatoxins, the most toxic and potent hepato-carcinogenic natural compounds ever characterized. (mountainenvironmentals.com)
Potentially2
These results further indicate that, with UGT deficiencies, HPPH potentially is a potent mediator of phenytoin-initiated genotoxicity and embryopathy, which may be relevant to teratogenesis and other adverse effects of phenytoin. (aspetjournals.org)
The latter do not adequately address the types of effects potentially produced by pharmaceuticals, especially highly potent compounds. (cdc.gov)
Highly1
Clobetasol propionate is a highly potent topical corticosteroid that has been shown to suppress the HPA axis at doses as low as 2 g per day. (nih.gov)
Natural1
The study shows that the Agrobacterium genes got into the sweet potato by natural horizontal gene transfer (HGT). (gmwatch.org)
Control1
It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. (nih.gov)
Major1
But an international team of biologists has now found that this has occurred naturally in a major crop plant: the sweet potato. (gmwatch.org)
Effects1
These early behavioral responses were predictive for 17 specific developmental abnormalities and mortality measured at 5 dpf, often at lower (i.e., more potent) concentrations than those at which morphological effects were observed. (oregonstate.edu)