Potent estrogens catechol. Medical search. Frequent questions

Steroid hormones can be grouped into five groups by the receptors to which they bind: glucocorticoids, mineralocorticoids, androgens, estrogens, and progestogens. (absoluteastronomy.com)
Two types of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and the estrogen G protein-coupled receptor GPR30 , which is a G protein-coupled. (absoluteastronomy.com)
Estrogen receptors are found throughout the body, including the breast and uterine tissue. (uniquenutritionsolutions.com)
In addition to reducing estrogen's effects on the target tissue, tamoxifen also promotes a healthy balance in the types of estrogen receptors. (uniquenutritionsolutions.com)
There are two types of estrogen receptors - alpha and beta. (uniquenutritionsolutions.com)
Alpha estrogen receptors are often referred to as the "gas" and promote cell growth and proliferation. (uniquenutritionsolutions.com)
Beta estrogen receptors, on the other hand, are the "brakes" on cell growth. (uniquenutritionsolutions.com)
Also, these compounds can help to balance our alpha and beta estrogen receptors. (uniquenutritionsolutions.com)
It also helps create a healthy balance between the alpha and beta estrogen receptors, reducing breast cancer risk. (uniquenutritionsolutions.com)
When we have substances that affect or mimic our hormones, like xenoestrogens ("foreign estrogens" that come from things like plastics, receipt paper, pesticides, and ingredients in cosmetics and body care products), they fit into cellular receptors, but instead of signaling the cell to do something, it's like putting super glue into the keyhole. (rebelhealthtribe.com)
Oestrogen and xenoestrogens mediate critical points in carcinogenesis by binding to oestrogen receptors, whose distribution is age-, gender-, and tissue-specific. (biomedcentral.com)
The distribution of oestrogen receptors in mammalian tissues suggests that oestrogens could have a significant role in orchestrating a number of pathways in living organisms during development and adulthood. (biomedcentral.com)
Besides functioning as an antioxidant and anthelmintic , many isoflavones have been shown to interact with animal and human estrogen receptors , causing effects in the body similar to those caused by the hormone estrogen . (wikipedia.org)

It was clear to me from the research literature and smaller clinical studies that the natural hormone progesterone, when delivered topically at a physiological dose (25 mg) protects normal breast tissue from the growth promoting actions of estrogens. (zrtlab.com)
All of the drugs tested except 17␣-estradiol produced a profound slowing The nongenomic actions of estrogens are receiving a re- observation has motivated the coining of the term "estrogen newed interest. (drugstodaypdf.com)

The catechol estrogens are endogenous metabolites of estradiol and estrone and include the following compounds: 2-Hydroxylated: 2-Hydroxyestradiol 2-Hydroxyestrone 2-Hydroxyestriol 4-Hydroxylated: 4-Hydroxyestradiol 4-Hydroxyestrone 4-Hydroxyestriol The most abundant catechol estrogen in serum and urine is 2-hydroxyestrone, with 2-hydroxyestradiol and 2-hydroxyestriol also being formed, while the principal 4-hydroxy catechol estrogen, 4-hydroxyestrone, is present in only small amounts in urine. (wikipedia.org)
In addition, gene expression data implicating the oestrogen-metabolising enzyme CYP1B1 suggests a detrimental role of oestrogens or oestrogen metabolites. (ersjournals.com)
The comprehensive HuMapTM profile reports not only important markers and metabolites, but it also calculates the relationship of catechol estrogens (2OHE1, 4OHE1, and 16OHE1) representative of phase 1 detox as well as phase 2 activity of the COMT enzyme via methoxy estrogen ratios. (regeneruslabs.com)
Understanding how catechol estrogens break down as well as the rate of methylation, which renders potentially harmful metabolites inactive, can help mitigate risk and determine individualized treatment. (regeneruslabs.com)

These were the Women's Health Initiative (WHI) and Million Women's studies of women using FDA-approved estrogens and progestogens in the United States and Great Britain, respectively [1 , 2] . (zrtlab.com)

As a selective estrogen receptor modulator (SERM), tamoxifen has the ability to be an "antiestrogen" in breast tissue. (uniquenutritionsolutions.com)
Tamoxifen, a triphenylethylene-based selective estrogen-receptor modulator, is a landmark drug for the treatment of breast cancer and is also used for treating liver cancer and osteoporosis. (bvsalud.org)
ML323 is a selective and highly potent USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. (adooq.com)
GRL0617 is a potent, selective and competitive noncovalent inhibitor of SARS PLPro, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM. (adooq.com)

The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in extrahepatic tissues, and are metabolized by catechol O-methyltransferase (COMT) into methoxylated estrogens such as 2-methoxyestradiol and 4-methoxyestrone as well as by conjugation via other phase II enzymes. (wikipedia.org)
Estrogens diffuse through cell membranes, distribute themselves throughout the cell, and bind to and activate the nuclear estrogen receptor, a DNA-binding protein found in estrogen-responsive tissues. (medscape.com)
Selenium - Estrogen levels affect how selenium is distributed to various tissues in the body. (gynelogic.co.uk)
Aromatase is more active in peripheral tissues increasing estrogens in males as well as the main source of estrogens in the postmenopausal female. (regeneruslabs.com)
2000). and other molecules with estrogen activity have been widely The sites of action responsible for the rapid action of ste- studied in a variety of tissues including chromaffin cells roids are a source of controversy. (drugstodaypdf.com)

Our findings suggest that variations in oestrogens and oestrogen metabolism modify FPAH risk. (ersjournals.com)
A detrimental role for oestrogens in FPAH is supported by studies that show oestrogen is a potent mitogen of pulmonary vascular smooth muscle cells 4 . (ersjournals.com)
Thus, individuals who metabolise a larger proportion of oestrogen to 16α-OHE 1 may be at increased risk of diseases that result from both the mitogenic and genotoxic effects of oestrogens, such as breast and prostate cancers 18 . (ersjournals.com)

a cytochrome p450 family enzyme critical to oestrogen metabolism) in affected female compared with unaffected female BMPR2 mutation carriers 5 . (ersjournals.com)
Lowers aromatase (enzyme that converts testosterone to estrogen) in ovaries. (gynelogic.co.uk)
DUBs-IN-1 is a potent deubiquitinase enzyme inhibitor with IC50s of 18 uM/0.71 uM for USP7/USP8 respectively. (adooq.com)

In addition to being substrates for COMT similarly to catecholamines like dopamine, norepinephrine, and epinephrine, catechol estrogens are potent competitive inhibitors of COMT as well as of tyrosine hydroxylase, and may affect both catecholamine biosynthesis and metabolism. (wikipedia.org)
We examined genetic and metabolic markers of altered oestrogen metabolism in subjects with a BMPR2 mutation. (ersjournals.com)
Recently, our studies of BMPR2 mutation carriers implicated altered oestrogen metabolism as a key factor in the penetrance of FPAH in females. (ersjournals.com)
Our genetic and biochemical results suggest that imbalanced oestrogen metabolism may contribute to the pathogenesis of FPAH, and that further analysis of this pathway may lead to new biological markers and therapeutic treatments for all forms of PAH. (ersjournals.com)
In addition, these top 5 foods help promote healthy estrogen metabolism, reducing your risk for breast cancer. (uniquenutritionsolutions.com)
Cytochrome P450 1B1 (CYP1B1) is active in the metabolism of estrogens to reactive catechols and of different procarcinogens. (biomedcentral.com)
however, differences in the distribution of polymorphisms in key candidate genes involved in estrogen/xenobiotic metabolism might contribute to variation in breast cancer susceptibility in different populations. (biomedcentral.com)

Estrogens are intricately involved with other hormones, especially progesterone, in the processes of ovulatory menstrual cycle and pregnancy and affect release of pituitary gonadotrophins. (medscape.com)
Conclusions: In patients with HER2-positive breast cancer, tumor grade 3, estrogen receptor negativity, progesterone receptor negativity, strong HER2 positivity (score 3+), and the use of the neoadjuvant trastuzumab are associated with higher pathological complete response rates. (bvsalud.org)
Smaller studies suggested that FDA-approved oral progesterone, which was not as widely used, did not increase risk in combination with estrogen therapy. (zrtlab.com)
These results led to widescale panic among postmenopausal women using conventional estrogen and progestogen (both synthetic progestins and natural progesterone) therapies and a precipitous drop in prescriptions for these forms of HRT [1] . (zrtlab.com)
And if you were taking a progestogen to help balance the estrogen and protect against its proliferative effects, use bioidentical progesterone, not a synthetic progestin like medroxyprogesterone acetate (Provera) or other synthetic "fake" progesterone. (zrtlab.com)

Risk for estrogen-dependent diseases in relation to phthalate exposure and polymorphisms of CYP17A1 and estrogen receptor genes. (cdc.gov)
As a number of anthropogenic agents are xenoestrogens, environmental health research has focused on oestrogen receptor level disturbances and of aromatase polymorphisms. (biomedcentral.com)

Similarly to estradiol and estrone, catechol estrogens possess estrogenic activity. (wikipedia.org)
Lowers the ratio of estradiol (strong estrogen) to estrone (weaker estrogen). (gynelogic.co.uk)
Vitamin A - Helps metabolize the biologically active estrogen (estradiol) to an inactive form (estrone). (gynelogic.co.uk)

The reasons explaining their different tissue selec- translating, cannot be attributed to genomic activity (Weh- tivity and specific activity are still obscure and cannot be satisfactorily explained by the simple ␣- and ␤-estrogen re- The naturally occurring steroid 17␤-estradiol, its ␣-isomer, ceptor affinity (Nadal et al. (drugstodaypdf.com)

Under poor conditions of inactivation by phase II enzymes, catechol estrogens can undergo oxidation to reactive quinones and semiquinones, and this has been hypothesized to contribute to estrogen-induced carcinogenesis. (wikipedia.org)

Estrogen-based oral contraceptives cause B6 deficiency. (gynelogic.co.uk)

Determining the activity of aromatase can assist with understanding the root cause of lower testosterone as well as estrogen dominance. (regeneruslabs.com)

This causes a buildup of both the xenoestrogens, as well as the body's own endogenously (made by the body) produced estrogens, leading to estrogen dominance which is so common these days. (rebelhealthtribe.com)

Estrogen drug products act by regulating transcription of a limited number of genes. (medscape.com)
The activated estrogen receptor binds to specific DNA sequences or hormone-response elements, which enhances transcription of adjacent genes and, in turn, leads to the observed effects. (medscape.com)

For instance, 2-hydroxyestrone reportedly shows negligible uterotrophic effect in animals, whereas 4-hydroxy catechol estrogens show moderate changes in stimulating uterine weight. (wikipedia.org)
Catechol-O-methyltransferase polymorphism is associated with increased uterine fibroid risk in different ethnic groups. (gynelogic.co.uk)
However, when estrogen was combined with a synthetic progestin to prevent uterine cancer, the breast cancer risk increased 1.5 to 2-fold. (zrtlab.com)

5α-reductase converts testosterone into the metabolite 5α-DHT which is three times more potent than testosterone. (regeneruslabs.com)
SJB3-019A (IC50 = 0.0781 uM) was 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. (adooq.com)

16α-Hydroxyestrone Estriol (16α-hydroxyestradiol) Epiestriol (16β-hydroxyestradiol) Estrogen conjugate Lipoidal estradiol H.J. Buchsbaum (6 December 2012). (wikipedia.org)
This meant if you were to use estrogen replacement therapy (ERT) you would replace with estradiol and/or estriol, not a synthetic estrogen like ethinyl estradiol (synthetic estrogen found in birth control pills) or a conjugated horse estrogen (Premarin). (zrtlab.com)
17␤-Estradiol as well as the estrogen receptor modu- Ca2ϩ but only at micromolar concentrations, whereas nano- lators raloxifene and LY117018, but not 17␣-estradiol, inhib- molar concentrations increased the cAMP levels. (drugstodaypdf.com)

Cysteine - Prevents oxidation of estrogen into a dangerous form that causes breast cancer. (gynelogic.co.uk)
12,13 However, its catechol structure ( o -dihydroxyl structure in the B-ring) leads to pro-oxidant properties by generating ROS during its oxidation process, which may result in quinone toxicity. (rsc.org)

Estrogen alters magnesium levels throughout menstrual cycle. (gynelogic.co.uk)

In reality, it modulates or changes how the estrogen cell receptor receives the hormone estrogen. (uniquenutritionsolutions.com)
As a hormone, estrogen has various types of action. (uniquenutritionsolutions.com)

Tamoxifen is a drug often used to treat women who have had estrogen receptor-positive (ER+) breast cancer or are at high risk for breast cancer. (uniquenutritionsolutions.com)
Ramadan WS, Talaat IM, Hachim MY, Lischka A, Gemoll T, El-Awady R. The impact of CBP expression in estrogen receptor-positive breast cancer. (sharjah.ac.ae)

Nested from those subjects, a case-control study of urinary oestrogen metabolite levels (2-hydroxyoestrogen (2-OHE) and 16α-hydroxyoestrone (16α-OHE 1 )) was conducted in females (five affected mutation carriers versus six unaffected mutation carriers). (ersjournals.com)

No adequate evidence supports that estrogens are effective for nervous symptoms or depression that might occur during menopause, and they should not be used to treat these conditions. (medscape.com)

Whats more, estrogen secretion decreases with the decline of ovarian function and the arrival of menopause, which then lead to multiple organ dysfunction, such as heart disease, osteoporosis, cancer, obesity, senile dementia, and so on [7]. (edrc2013.org)

During the last decade, environmental health and oncology have shown an increasing interest in oestrogen as an evolutionary conserved molecule. (biomedcentral.com)

In comparison to proanthocyanidins (Pas) from various other resources such as for example grape seeds, apples or cranberry [7,8,9], BLPs include a basic but potent device, Epigallocatechin gallate (EGCG) as the terminal & most of their expansion units, using a mean amount of polymerization (mDP) around 6.5 [10]. (columbiagypsy.net)

Data suggest that, unlike the weak mitogen 2-OHE, 16α-OHE 1 stimulates cellular proliferation by constitutively activating the oestrogen receptor. (ersjournals.com)

2-Hydroxylated catechol estrogens are weak and possibly antiestrogenic estrogens, whereas their 4-hydroxylated counterparts are more potent in their estrogenic activity. (wikipedia.org)

Detoxifies excess estrogen via methylation pathway. (gynelogic.co.uk)

Is Tamoxifen an Anti-estrogen Drug? (uniquenutritionsolutions.com)
Tamoxifen is often referred to as an anti-estrogen drug or thought of as reducing estrogen production. (uniquenutritionsolutions.com)
Because Tamoxifen blocks the estrogen receptor, some of the side effects are related to low estrogen, like hot flashes. (uniquenutritionsolutions.com)
These compounds help improve Tamoxifen by reducing estrogen levels and safely detoxing estrogen from our bodies. (uniquenutritionsolutions.com)
Flaxseed contains lignans, a phytoestrogen that blocks the estrogen receptor, similar to what Tamoxifen does. (uniquenutritionsolutions.com)

OBJECTIVE: To assess the risk of recurrence of breast cancer associated with vaginal estrogen therapy in women diagnosed with genitourinary syndrome of menopause with a history of breast cancer using a large U.S. claims database. (bvsalud.org)
Recurrence was defined as mastectomy, radiation, chemotherapy, or secondary malignancy within 3 months to 5 years after the initiation of vaginal estrogen therapy for genitourinary syndrome of menopause. (bvsalud.org)
The control cohort included women with breast cancer without any vaginal estrogen prescriptions after genitourinary syndrome of menopause diagnosis. (bvsalud.org)

The excess of adult females suggests oestrogen as a possible disease modifier, as does a lower prevalence among pre-pubertal females compared with males 2 , 3 . (ersjournals.com)

Zinc dependent proteins metabolize estrogen. (gynelogic.co.uk)

Estrogens occur naturally in several forms. (medscape.com)

Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. (medscape.com)
Although historically oestrogen has been related to development of reproductive system, research over the last decade has confirmed its crucial role in the development and homeostasis of other organ systems. (biomedcentral.com)

Some of the side effects are due to low estrogen or estrogen being blocked at the cellular level. (uniquenutritionsolutions.com)
J.D.M. was the recipient of a fellowship from Instituto Tecnolo´gico Several second messenger routes were implicated in the de Canarias, A.M. from Spanish Ministerio de Ciencia y Tecnologı´a, and J.F.G. cellular signaling occurring upon nongenomic estrogen stim- from Consejerı´a de Educacio´n del Gobierno de Canarias. (drugstodaypdf.com)

Helps breakdown estrogen in the liver and convert it to a less toxic form. (gynelogic.co.uk)

Low levels linked to higher estrogen. (gynelogic.co.uk)

Both studies came to the same conclusion - that estrogen therapy, mostly in the form of oral conjugated equine estrogens, by itself did not significantly increase the risk of breast cancer and, to the surprise of many, was associated with a lower risk. (zrtlab.com)

Examples of a novel series of phenanthrolinones are shown to be potent competitive inhibitors of avian prolyl 4-hydroxylase, and of collagen hydroxylation, in embryonic chick tendon cells and human foreskin fibroblasts in vitro and in the oestradiol-stimulated rat uterus in vivo. (embl.de)

At the single cell level, estrogens modified the total catecholamine release with high and low affinity, re- kinetics of exocytosis at nanomolar range. (drugstodaypdf.com)

Aspartame - artificial sweetener found to be a potent neurotoxin. (custommedicine.com.au)

LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1. (adooq.com)

Anatomy3

Organisms10

Diseases2

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes11

Information Science2

Health Care1

Receptors13

Actions of estrogens2

Metabolites4

Progestogens1

Selective4

Tissues5

Oestrogens3

Enzyme3

Metabolism7

Progesterone5

Polymorphisms2

Estrone3

Steroid1

Reactive1

Oral contraceptives1

Aromatase1

Xenoestrogens1

Genes2

Uterine3

Times more potent2

Estradiol3

Oxidation2

Menstrual cycle1

Hormone estrogen2

Receptor-positive2

Metabolite1

Symptoms1

Decreases1

Evolutionary1

Epigallocatechin1

Proliferation1

Estrogenic1

Methylation1

Tamoxifen5

Menopause3

Suggests1

Proteins1

Naturally1

Reproductive2

Cellular2

Convert1

Levels1

Breast cancer1

Shown1

Cell1

Found1

Competitive1