InhibitorsProteinsPathwayProteinPathwaysInhibitorAntibodyInhibitionParoxysmal Nocturnal HemoAtypical hemolytic uremic sCascadeSelectiveInhibitsBindsCleavageTherapeuticInnate immunityInhibiting complement activationMembraneAHUSAntimicrobialSerine proteasesTherapiesRole of complementActivation of complementSystemPathogensHuman complementReceptorsInflammationEculizumabImmuneCritical mediatorMediatorComponentMechanismsBone marrowRegulatorsPhagocytosisXenotransplantationRegulatoryEffectivelyFragmentsRenalVitroDebrisDiseases
Inhibitors14
- Today, we'll take a closer look at recently approved and emerging drug therapies, such as complement inhibitors , FcRn inhibitors , and other novel therapeutics. (medscape.com)
- Why don't we start with complement inhibitors? (medscape.com)
- Complement inhibitors are relatively new, though we've known about complement at the neuromuscular junction since the 1950s, when Arthur Strauss was measuring complement levels in myasthenic patients and noted some changes. (medscape.com)
- We know that uncontrolled activation of the complement pathway is responsible for many devastating diseases, and through the development of the first two complement inhibitors - SOLIRIS and ULTOMIRIS - we have shown the transformative impact of C5 inhibition on several of these diseases," said John Orloff, M.D., Executive Vice President and Head of Research & Development at Alexion. (businesswire.com)
- Several complement inhibitors targeting various complement pathways are in clinical trials for the treatment of HSCT-TMA. (biomedcentral.com)
- Advancements in the understanding of the etiopathogenesis of aHUS paved the way for the successful development of anticomplement therapies (complement C5 inhibitors), which have revolutionized the treatment of aHUS. (jrheum.org)
- These two latter pathogenic mechanisms are the target of novel strategies of anti-complement treatments, which can be split into terminal and proximal complement inhibitors. (frontiersin.org)
- Many novel terminal complement inhibitors are now in clinical development: they all target C5 (as eculizumab), potentially paralleling the efficacy and safety profile of eculizumab. (frontiersin.org)
- Indeed, proximal inhibitors are designed to interfere with early phases of complement activation, eventually preventing C3-mediated extravascular hemolysis in addition to intravascular hemolysis. (frontiersin.org)
- Indeed, we envision a new scenario of therapeutic complement inhibition, where proximal inhibitors (either anti-C3, anti-FD or anti-FB) may prove effective for the treatment of PNH, either in monotherapy or in combination with anti-C5 agents, eventually leading to drastic improvement of hematological response. (frontiersin.org)
- InflaRx (Nasdaq:IFRX) is a clinical-stage biopharmaceutical company focused on applying its proprietary anti-C5a technology to discover and develop first-in-class, potent and specific inhibitors of C5a. (inflarx.de)
- 2017. Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication . (lsrnw.ac.uk)
- The plasma protein inhibitors are factor H and C4-binding protein, and the regulatory membrane proteins located on cell surfaces are complement receptors 1 (CR1), decay-accelerating factor (DAF), and membrane cofactor protein (MCP). (justia.com)
- To date, there are no inhibitors of complement activation used in the clinic, though certain candidates for clinical use exist, specifically, a recombinant form of complement receptor 1 known as soluble complement receptor 1 (sCR1) and a humanized monoclonal anti-C5 antibody (5G1.1-scFv). (justia.com)
Proteins8
- The complement system consists of more than 35 soluble and cell-bound proteins, 12 of which are directly involved in the complement pathways. (dadamo.com)
- Some authors propose a role for an antibody-mediated pathogenesis supported by: (1) reports that up to 30% of patients have antibodies against myelin proteins, (2) reports that there is deposition of immunoglobulin and complement in sural nerve biopsies, and (3) therapeutic response to intravenous immunoglobulins and plasma exchange. (medlink.com)
- 10 This distinction is not absolute because genetic defects in complement proteins have been identified in secondary TMA. (jrheum.org)
- To analyze the protective effects against complement-mediated cytolysis of the MCP , DAF , and CD59 human complement regulatory proteins, alone and in combination, on NIH 3T3 mouse fibroblast cells. (ectrx.org)
- One is to knock out the α-1,3-galactosyltransferase that expresses a Gal epitope, and the other is to introduce human complement regulatory proteins (hCRPs) into the pig. (ectrx.org)
- The functions of the complement proteins of innate immunity are governed by the weak interactions between the activated proteins and their regulators. (silverchair.com)
- In vivo, regulation of complement at the C3 and C5 activation steps is provided by both plasma and membrane proteins. (justia.com)
- These proteins inhibit the C3 and C5 convertases (multi-subunit proteases), by promoting dissociation of the multisubunit complexes and/or by inactivating the complexes through proteolysis (catalyzed by factor I). Several pharmacological agents that regulate or modulate complement activity have been identified by in vitro assay, but most have been shown in vivo to be of low activity or toxic. (justia.com)
Pathway14
- The agreement provides Alexion with exclusive worldwide licenses, as well as development and commercial rights, for up to four targets within the complement pathway. (businesswire.com)
- We are excited by the potential to explore different targets in the complement pathway and look forward to building on Alexion's more than 20 years of complement expertise with the development of next-generation peptide therapies in collaboration with Zealand Pharma, which may provide the opportunity to treat many additional diseases. (businesswire.com)
- Under the terms of the agreement, Alexion and Zealand will enter into an exclusive collaboration for the discovery and development of subcutaneously delivered peptide therapies directed to up to four complement pathway targets. (businesswire.com)
- Complement C3 (C3) is a core component of the complement activation pathway, and dysregulation of the complement pathway is involved in several retinal degenerative diseases. (biomedcentral.com)
- We determined that complement pathway is activated following MMS treatment, and C3 knockout (KO) increased the rate of photoreceptor cell survival and preserved visual function. (biomedcentral.com)
- Recent studies have found that inhibiting the complement activation pathway is a potential therapeutic strategy for AMD [ 22 , 23 ]. (biomedcentral.com)
- LNP023 is a first-in-class, orally administered, potent and highly selective factor B inhibitor of the alternative complement pathway. (novartis.com)
- In PNH, LNP023 acts upstream of the C5 terminal pathway, preventing not only intravascular hemolysis but also extravascular hemolysis. (novartis.com)
- In particular, the lectin pathway of complement is activated by damage-associated molecular patterns (DAMPs) on the surface of injured endothelial cells. (biomedcentral.com)
- In this article, we review the role of the complement system in HSCT-TMA pathogenesis, with a focus on the lectin pathway. (biomedcentral.com)
- Endothelial injury triggers activation of the complement system-significantly through the lectin pathway-via altered cell-surface patterns on injured endothelial cells, initiating an inflammatory response [ 7 ]. (biomedcentral.com)
- Here we discuss evidence for the role of lectin pathway activation in endothelial injury-associated complications of HSCT and how targeting complement activity may provide therapeutic benefit for patients with HSCT-TMA. (biomedcentral.com)
- Homo sapiens] C5 fragments are released from neutrophils upon their activation of the alternative complement pathway and this further amplifies neutrophil pro-inflammatory responses. (innatedb.com)
- Activation of C3 by complement pathway C3 convertases and its subsequent attachment to target surface leads to assembly of the membrane attack complex and ultimately to damage or lysis of the target cells. (justia.com)
Protein13
- Zilucoplan is a macrocyclic peptide that binds to the protein complement component 5 (C5) and inhibits its cleavage into C5a and C5b. (wikipedia.org)
- A phase 2 trial was designed that gave a signal, and then the landmark REGAIN trial was our first complement inhibitor targeting the fifth protein of the complement cascade. (medscape.com)
- C5a is a protein fragment released from complement component C5. (eaglebio.com)
- The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. (eaglebio.com)
- The complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. (jrheum.org)
- 7 - 9 A TMA is called "primary" when a genetic or acquired defect in a complement protein is identified (as in atypical hemolytic uremic syndrome [aHUS]) or "secondary" when occurring in the context of another disease process or factor such as infection, autoimmune disease, malignancy, or drugs. (jrheum.org)
- The complement system is a tightly regulated, cascading protein network that performs multiple roles in homeostasis and disease prevention and is a key component of both the innate and the humoral immune systems. (jrheum.org)
- We constructed 3 double- and 3 single-human complement regulatory protein plasmids (pIRES-h MCP -h DAF , pIRES-h MCP -h CD59 , pIRES-h DAF -h CD59 , pIRES-A-h MCP , pIRES-B-h DAF , and pIRES-B-h CD59 ). (ectrx.org)
- The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to analyze the protective ability of different human complement regulatory protein plasmids on complement-dependent cytolysis. (ectrx.org)
- KCP is a homologue to human complement regulators, being comprised of four complement control protein (CCP) domains. (birmingham.ac.uk)
- It resembles in quaternary structure the complement protein C1q, which recognizes targets via charge clusters. (silverchair.com)
- Compounds comprising peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation are disclosed. (justia.com)
- In particular, this invention provides peptides and peptidomimetics capable of binding the C3 protein and inhibiting complement activation. (justia.com)
Pathways3
- A further complicating factor is the cross-talk between complement, neutrophils, and coagulation pathways in the pathophysiology of TMA. (jrheum.org)
- Activation of the complement system occurs through the classical (CP), lectin (LP), or alternative (AP) pathways. (jrheum.org)
- Complement component C3 plays a central role in activation of all three pathways. (justia.com)
Inhibitor5
- 2018). "RA101495, a subcutaneously administered peptide inhibitor of complement component 5 (C5) for the treatment of generalized myasthenia gravis (gMG): Phase 1 results and phase 2 design (S31. (wikipedia.org)
- It's an analog of eculizumab - the original complement inhibitor. (medscape.com)
- Ravulizumab is a complement inhibitor, but it's engineered so that the dosing interval is every 8 weeks rather than every 2 weeks for patient convenience. (medscape.com)
- Gameapos, rifabutin, sildenafil Viagra a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunctio' Results of drug interaction studies with an organic nitrate and http://www.bdslist.org/cheapest-viagra-online/ a calcium antagonis' If your rheumatoid arthritis symptoms do not improve. (bellx1.com)
- An orally active type 5 cyclic GMPspecific phosphodiesterase inhibitor for the treatment of penile erectile dysfunctio'00 X, its likely, sildenafil Viagra a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunctio' Diabetes. (bellx1.com)
Antibody6
- The Human C5 Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure Human C5 with a 96-well strip plate that is pre-coated with antibody specific for C5. (eaglebio.com)
- The detection antibody is a biotinylated antibody specific for C5. (eaglebio.com)
- To measure Human C5, add standards and samples to the wells, then add the biotinylated detection antibody. (eaglebio.com)
- 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
- Alexion Pharmaceuticals, Boston, MA, USA), a humanized monoclonal antibody against complement C5, the treatment of aHUS was focused on excluding reversible causes and plasmapheresis. (ekjt.org)
- IFX-1 is a first-in-class monoclonal anti-complement factor C5a antibody which highly and effectively blocks the biological activity of C5a and demonstrates high selectivity towards its target in human blood. (inflarx.de)
Inhibition6
- Over the next couple of decades, there was work looking at the role of complement inhibition in experimental models. (medscape.com)
- Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? (frontiersin.org)
- However, novel anti-C5 agents do not improve hematological response to eculizumab, even if some seem associated with a lower risk of breakthrough hemolysis caused by pharmacokinetic reasons (it remains unclear whether more effective inhibition of C5 is possible and clinically beneficial). (frontiersin.org)
- At the moment there are three strategies of proximal complement inhibition: anti-C3 agents, anti-factor D agents and anti-factor B agents. (frontiersin.org)
- Preliminary data clearly demonstrate that proximal complement inhibition is pharmacologically feasible and apparently safe, and may drastically improve the hematological response to complement inhibition in PNH. (frontiersin.org)
- Mechanistically, BH4 is a potent radical-trapping antioxidant that protects lipid membranes from autoxidation, alone and in synergy with vitamin E. Dihydrofolate reductase catalyzes the regeneration of BH4, and its inhibition by methotrexate synergizes with GPX4 inhibition. (biomed.news)
Paroxysmal Nocturnal Hemo1
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
Atypical hemolytic uremic s2
- 3,4 LNP023 is currently in clinical development for PNH and a number of renal conditions with complement system involvement where significant unmet needs exist, including IgA nephropathy, complement 3 glomerulopathy (C3G), atypical hemolytic uremic syndrome and membranous nephropathy. (novartis.com)
- The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. (jrheum.org)
Cascade8
- Activation of the complement cascade, with the formation of the effector MAC unit, results in cytotoxic and cytolytic reactions. (dadamo.com)
- The main functions of the complement cascade and its role in the acute inflammatory reaction are summarized in Table 1. (dadamo.com)
- As eculizumab is a hematological drug that blocks complement component 5 (C5), Degos disease may, in fact, be a hematological/endothelial/clotting disease that involves C5 in some pathological cascade. (medscape.com)
- Together, activation of complement and the coagulation cascade lead to a procoagulant state that may result in development of HSCT-TMA. (biomedcentral.com)
- They inhibit complement activation via different mechanisms in the complement activation cascade. (ectrx.org)
- emerged implicating molecules canonically involved in the immune system and inflammation accompanying neurodegeneration (e.g. classical complement cascade) as important players in the normal elimination of synapses in the developing nervous system. (silverchair.com)
- with disease relevance are candidates for therapeutic intervention, namely caspase-mediated apoptosis, blood coagulation, the matrix metalloproteinase cascade and the complement cascade. (silverchair.com)
- This invention relates to activation of the complement cascade in the body. (justia.com)
Selective2
- Peptides offer a number of advantages, including being highly selective and potent, allowing low dosage volumes for ease of administration, and having the potential to treat a broad range of complement-mediated diseases. (businesswire.com)
- 1999). SP antagonists Many potent and selective non-peptide, low molecular tachykinin antagonists have been developed and proven effective in preclinical studies (Carvalho et al. (niepokorny.org)
Inhibits1
- describes the use of a phage-displayed combinatorial random peptide library to identify a 27-residue peptide that binds to C3 and inhibits complement activation. (justia.com)
Binds1
- It binds to a number of micro-organisms and promotes killing of these through complement activation either directly or through opsonization. (silverchair.com)
Cleavage3
- An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. (eaglebio.com)
- The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. (eaglebio.com)
- Thus, IFX-1 leaves the formation of the membrane attack complex (C5b-9) intact as an important defense mechanism, which is not the case for molecules blocking the cleavage of C5. (inflarx.de)
Therapeutic2
- The Eagle Biosciences Human complement C5a ELISA Kit is for research use only and not for diagnostic or therapeutic procedures. (eaglebio.com)
- Vdeos corporativos, rash, a branch from c5 and and cuboid anteriorly great toe and 5rd joints digits lumbricals 3 and 8 explain the therapeutic effect shown in the cervical plexus. (bellx1.com)
Innate immunity1
- The actions of the complement system affect both innate immunity and acquired immunity. (dadamo.com)
Inhibiting complement activation1
- We believe that peptide-based therapies hold great promise in inhibiting complement activation. (businesswire.com)
Membrane4
- We've demonstrated that by targeting a membrane attack complex, or the terminal complement complex, we've been able to improve patients' well-being. (medscape.com)
- These results suggest that the MCP + DAF and MCP + CD59 combinations could be more effective than DAF + CD59 in protecting the NIH 3T3 cells from injury caused by complement-dependent cytolysis, whereas MCP or DAF alone is stronger than CD59 alone in inhibiting membrane attack complex formation. (ectrx.org)
- C5b first associates with complement component 6 (C6), which in turn initiates the assembly of the cytolytic membrane attack complex (MAC). (innatedb.com)
- Complement-mediated tissue injuries are directly mediated by the membrane attack complex, and indirectly by the generation of C3a and C5a. (justia.com)
AHUS1
- aHUS can be chronic, hereditary, or idiopathic, whereas typical HUS is often caused by infection with a certain Escherichia coli strain that produces a potent Shiga-like exotoxin. (ekjt.org)
Antimicrobial2
- In addition, the following are also involved: antimicrobial peptides, natural antibodies, the complement system, NK cells, and gamma delta T lymphocytes [ 3 ] . (encyclopedia.pub)
- Although this challenge was somewhat resolved by the 1930s through better-purified antibodies, the introduction of vastly superior, potent, and better tolerated antimicrobial chemotherapy ('antibiotics', starting with sulphonamides and then the β-lactam, penicillin) around 1935 sounded the death-knell for serum therapy. (inscientioveritas.org)
Serine proteases2
- Anaphylatoxins are proteolytic products of the serine proteases of the complement system: C3a, C4a and C5a. (dadamo.com)
- through activation of the complement system via MBL-associated serine proteases (MASPs). (silverchair.com)
Therapies2
- BOSTON & COPENHAGEN, Denmark--( BUSINESS WIRE )-- Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) and Zealand Pharma A/S (NASDAQ:ZEAL) today announced a collaboration to discover and develop novel peptide therapies for complement-mediated diseases. (businesswire.com)
- Therefore, a clearer understanding of the role of the complement system in TMA associated with other conditions will help to identify patients who would benefit from these therapies. (jrheum.org)
Role of complement2
- Yet, a great deal of complexity exists around the role of complement in TMA associated with other diseases. (jrheum.org)
- Defining the role of complement in TMA in these conditions will help to guide timely diagnosis and management. (jrheum.org)
Activation of complement1
- Inappropriate activation of complement may lead to host cell damage. (justia.com)
System11
- The complement system helps clear pathogens from an organism. (dadamo.com)
- The complement system influence the activity of numerous cells, tissues and physiological mechanism of the body. (dadamo.com)
- The complement system is a potent mechanism for initiating and amplifying inflammation. (dadamo.com)
- The complement system plays an important role in retinal development and homeostasis [ 12 ]. (biomedcentral.com)
- We will continue to develop LNP023 in this condition while exploring its use in a range of other diseases with complement system involvement. (novartis.com)
- Research suggests that Degos disease is a genetic disease of complement or some other clotting factor or system. (medscape.com)
- Endothelial injury can trigger activation of the complement system, promoting inflammation and the development of endothelial injury syndromes, ultimately leading to organ damage and failure. (biomedcentral.com)
- This process is caused by naturally occurring human antibodies binding to the carbohydrate epitope Galα1,3Gal (Gal) on pig vascular endothelium, with subsequent activation of the complement system. (ectrx.org)
- AAV is a rare and life-threatening autoimmune disease in which activation of the complement system, and specifically generation of C5a, is believed to play a key role in the neutrophil-driven vessel inflammation that defines the disease. (inflarx.de)
- Another inflammatory process associated with postprandial lipaemia is the activation of the complement system. (silverchair.com)
- The complement system is the first line of immunological defense against foreign pathogens. (justia.com)
Pathogens2
- 4 , 13 Complement plays a crucial role in host defense against foreign bodies by promoting phagocyte-mediated clearance of cell debris through activation of an inflammatory response, opsonization of pathogens, and lysis of susceptible bacteria and cells. (jrheum.org)
- Complement is effective in attacking pathogens, but not the human host, and imbalances in this process can lead to disease conditions. (silverchair.com)
Human complement1
- The Eagle Biosciences Human Complement C5a ELISA Kit is intended for the quantitation of Human C5 concentrations in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). (eaglebio.com)
Receptors3
- Different fragments, released from individual components during complement activation, operate by a non-cytolytic mechanism through specific receptors present on various cell types. (dadamo.com)
- From the functional standpoint, complement receptors can be divided into two types: the adherent type and the other receptors. (dadamo.com)
- The second group of receptors reacts with small complement fragments (C4a, C3a, C5a) as well as with C1q, Ba, Bb and factor H. Stimulation of these receptors results in various biological effects (chemotaxis, secretion of vasoactive amines, mediators of the inflammatory and anaphylactic reaction etc. (dadamo.com)
Inflammation1
- Homo sapiens] C5 is the fifth component of complement and is comprised of alpha (C5a) and beta (C5b) polypeptide chains, C5a is a complement anaphylatoxin that can stimulate the generation of nitric oxide along with the secretion of histamine and leukotriene LTC4 from several cell types and can bring about an increase in vascular permeability that facilitates eosinophil accumulation at sites of allergic inflammation. (innatedb.com)
Eculizumab1
- 1] This is supported by the fact that eculizumab, a C5 blocker, can effectively treat systemic Degos disease. (medscape.com)
Immune1
- CR1 on erythrocytes may bind circulating immune complexes (that had activated complement) and transport them to the liver where the immune complexes are partially degraded and thus become more soluble. (dadamo.com)
Critical mediator2
- C5 complement component 5: C5a is a critical mediator in human blood during C. albicans infection. (polygenicpathways.co.uk)
- Homo sapiens] C5 (C5a) is a critical mediator in blood during Candida albicans infection. (innatedb.com)
Mediator1
- Complement C5a is a powerful inflammatory mediator involved in the progression of a wide variety of autoimmune and other inflammatory diseases. (inflarx.de)
Component2
- Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. (eaglebio.com)
- Homo sapiens] C5 is the fifth component of complement and is comprised of alpha (C5a) and beta (C5b) polypeptide chains. (innatedb.com)
Mechanisms1
- There is growing recognition that potent immunosuppressive mechanisms are also prevalent in such patients. (covidreference.com)
Bone marrow1
- PNH is a rare and life threatening blood disorder characterized by complement-driven hemolysis, thrombosis and impaired bone marrow function, 6 resulting in debilitating symptoms that can impact patient's quality of life. (novartis.com)
Regulators1
- We show here that KCP has evolved to maintain the spatial structure of its functional sites, especially the positively charged patches, compared with host complement regulators. (birmingham.ac.uk)
Phagocytosis1
- MBL may also influence phagocytosis in the absence of complement activation through. (silverchair.com)
Xenotransplantation1
- Complement is implicated in several disease states, including various autoimmune diseases, and has been found to contribute to other clinical conditions such as adult respiratory syndrome, heart attack, rejection following xenotransplantation and burn injuries. (justia.com)
Regulatory1
- In this, the first study to identify the functional sites of a viral homologue at the amino acid level, we created a three-dimensional homology-based model followed by site-directed mutagenesis to locate complement regulatory sites. (birmingham.ac.uk)
Effectively1
- Theoretically, concomitant expression of multiple hCRPs might inactivate complement more effectively than expression of a single hCRP. (ectrx.org)
Fragments2
- These effects may involve either the whole complement, or only individual components or fragments. (dadamo.com)
- This is mediated through fragments of complement components. (dadamo.com)
Renal1
- This review aims to provide an assessment of the nature and extent of complement involvement in TMA associated with autoimmune diseases such as systemic lupus erythematosus, antiphospholipid syndrome, and scleroderma renal crisis. (jrheum.org)
Vitro1
- 2016. Design and synthesis of potent in vitro and in vivo anticancer agents based on 1-(3′,4′,5′-Trimethoxyphenyl)- 2-Aryl-1H-Imidazole . (lsrnw.ac.uk)
Debris1
- But it was the seminal work of Andrew Engel and his team at the Mayo Clinic in the mid-1970s that demonstrated complement at the neuromuscular junction in a debris field of a postjunctional image that had been relatively destroyed. (medscape.com)
Diseases2
- Alexion's demonstrated expertise in treating rare and complement-mediated diseases makes this the ideal collaboration to advance Zealand's complement-focused peptide programs. (businesswire.com)
- 10 This review aims to provide an assessment of the nature and extent of complement involvement in the underlying pathophysiology of TMA associated with autoimmune diseases that will help to stratify patients for targeted therapy. (jrheum.org)