This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. (nih.gov)
The delayed rectifier potassium conductance in the sarcolemma and the transverse tubular system membranes of mammalian skeletal muscle fibers. (uni-bielefeld.de)
We first present a minimal, isopotential spiking model neuron with transient and persistent sodium, delayed-rectifier, and A-type potassium channels. (biomedcentral.com)
A delayed rectifier subtype of shaker potassium channels that is commonly mutated in human episodic ATAXIA and MYOKYMIA. (ucdenver.edu)
This toxin does not block Shab, Shaw, Shal and Eag channels. (wikipedia.org)
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (nih.gov)
This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. (nih.gov)
3. Neither are the Shaker (Kv1), Shab (Kv2) & Shaw (Kv3) subfamilies of currents, nor HERG, KvLQT1/IsK, inhibited by phrixotoxins which appear specific of the Shal (Kv4) subfamily of currents & also block I(to1) in isolated murine cardiomyocytes. (smartox-biotech.com)
Currents4
SHL-1 currents strongly resembled Shal currents in other species except that they were active in a more depolarized voltage range. (wikigenes.org)
This model allows us to investigate the contributions of the two major types of A-type currents Shal and Shaker that are different in spatial expression over the neuron and in terms of electrophysiological and activity-related characteristics. (biomedcentral.com)
In the present study, two new peptides, phrixotoxins PaTx1 & PaTx2 (29-31 amino acids), which potently block A-type potassium currents, have been purified from the venom of the tarantula Phrixotrichus auratus. (smartox-biotech.com)
6. It was concluded that phrixotoxins, are new & specific blockers of Kv4.3 & Kv4.2 potassium currents, & hence of I(to1) that will enable further studies of Kv4.2 & Kv4.3 channel &/or I(to1) expression. (smartox-biotech.com)
Kcnd31
These results imply that channels potentially involved in volume regulation of murine spermatozoa include the voltage-dependent Kv1.4 (also known as KCNA1), Kv1.5 (KCNA5), Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3), mink (KCNE1), & acid-sensitive TASK2 (KCNK5) & TASK3 (KCNK9). (smartox-biotech.com)
Alpha-subunits2
channel properties depend on the type of alpha subunits that are part of the channel (By similarity). (nih.gov)
Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). (nih.gov)
Inhibition1
Inhibition of the Shaker channels by CNF-Sr3 is reversible. (wikipedia.org)
Shaker potassium3
Belongs to the shaker potassium channel beta subunit family. (ucsc.edu)
Crystal structure of the tetramerization domain of the Shaker potassium channel. (embl.de)
We have determined the crystal structure of the T1 domain of a Shaker potassium channel at 1.55 A resolution. (embl.de)
Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. (embl.de)
Transmembrane1
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. (nih.gov)
Genes2
Significant changes shared by the fly species belong to the expression of genes involved in processes such as oxidation-reduction process, iron-ion binding, and voltage-gated potassium-channel activity. (nature.com)
Most of the important membrane ion channel genes, such as voltage-gated sodium and potassium channels, were first identified and isolated in the fruit fly. (biomedcentral.com)
Inactivation3
Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305). (nih.gov)
Overall, this neuron model will enable us to investigate the effect Na channel splice variants by varying half-activation and inactivation voltages and ratio of a persistent component. (biomedcentral.com)
Lin WH, Wright DE, Muraro NI, Baines RA: Alternative Splicing in the Voltage-Gated Sodium Channel DmNa(v) Regulates Activation, Inactivation, and Persistent Current. (biomedcentral.com)
Tetrameric2
Voltage-dependent, ion-selective channels such as Na+, Ca2+ and K+ channel proteins function as tetrameric assemblies of identical or similar subunits. (embl.de)
Forms tetrameric potassium-selective channels through which potassiumions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). (nih.gov)
Homo1
Homo sapiens potassium voltage-gated channel subfamily A regulatory beta subunit 2 (KCNAB2), transcript variant 2, mRNA. (ucsc.edu)
Neurons5
Previous work has shown that the Shal potassium channel subfamily underlies the predominant fast transient outward current in Drosophilaneurons (Tsunoda, S., and Salkoff, L. (1995) J. Neurosci. (wikigenes.org)
Technical advances have now made possible direct electrophysiological recording of channels in central neurons, allowing the genetic advantages of this system to be applied to analysis of cellular and circuit function and homeostasis. (biomedcentral.com)
An important open question is the functional effect of channel splice variants that has recently been found in Drosophilaneurons. (biomedcentral.com)
Using iterative database searches, a statistically significant sequence similarity was detected between the POZ (poxvirus and zinc finger) domains found in a variety of proteins involved in animal transcription regulation, cytoskeleton organization, and development, and the tetramerization domain of animal potassium channels. (embl.de)
KCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task? (uni-bielefeld.de)
As the specific mechanisms behind this phenomenon are unknown, spermatozoa from mice were screened for sensitivities to inhibitors known to affect specific channels involved in volume regulation of somatic cells. (smartox-biotech.com)
Volume regulation of spermatozoa may involve novel voltage-gated & pH-sensitive potassium channels, which could be valuable targets for the development of a posttesticular male contraceptive. (smartox-biotech.com)
Member2
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (ucsc.edu)
This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassiumion channels and are prominent in the repolarization phase of the action potential. (utsouthwestern.edu)
Subunits2
It is known to confer specificity for tetramer formation, so the heteromeric assembly of K+-channel subunits is an important mechanism for the observed channel diversity. (embl.de)
Probing molecular identity of native single potassium channels by overexpression of dominant negative subunits. (ucdenver.edu)
Functional1
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (nih.gov)
Toxin1
K v 1, K v 2 and K v 3 channel subfamilies are insensitive to this toxin. (smartox-biotech.com)
Structural1
Fold prediction and evolutionary analysis of the POZ domain: structural and evolutionary relationship with the potassium channel tetramerization domain. (embl.de)
Activity2
Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. (ucsc.edu)
We show how the Shal channel properties change between the larval stages of 1st and 3rd instar, and we show the effect of this change on neuronal activity characteristics. (biomedcentral.com)
Properties2
It does so by altering the gating properties of the channels. (smartox-biotech.com)
70 nM, by altering the gating properties of these channels. (smartox-biotech.com)
Role2
The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration. (nih.gov)
SHL-1 channels are apparently important in fine-tuning complex behaviors, such as mating, that play a crucial role in the survival and propagation of the species. (wikigenes.org)
Expression3
The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
Vullhorst D, Klocke R, Bartsch JW, Jockusch H. Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation pattern. (uni-bielefeld.de)
Homogeneous development of electrical excitability via heterogeneous ion channel expression. (ucdenver.edu)
Major1
This graph shows the total number of publications written about "Kv1.1 Potassium Channel" by people in this website by year, and whether "Kv1.1 Potassium Channel" was a major or minor topic of these publications. (ucdenver.edu)
Domain1
Using the crystal structure of the Aplysia Shaker channel tetramerization domain as a template, the common structure of the POZ domain class was predicted. (embl.de)