• Potassium voltage-gated channel subfamily D member 3 also known as Kv4.3 is a protein that in humans is encoded by the KCND3 gene. (wikipedia.org)
  • Kv4.3 is a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. (wikipedia.org)
  • Previous work has shown that the Shal potassium channel subfamily underlies the predominant fast transient outward current in Drosophila neurons (Tsunoda, S., and Salkoff, L. (1995) J. Neurosci. (wikigenes.org)
  • This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. (nih.gov)
  • 3. Neither are the Shaker (Kv1), Shab (Kv2) & Shaw (Kv3) subfamilies of currents, nor HERG, KvLQT1/IsK, inhibited by phrixotoxins which appear specific of the Shal (Kv4) subfamily of currents & also block I(to1) in isolated murine cardiomyocytes. (smartox-biotech.com)
  • Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
  • This model allows us to investigate the contributions of the two major types of A-type currents Shal and Shaker that are different in spatial expression over the neuron and in terms of electrophysiological and activity-related characteristics. (biomedcentral.com)
  • We first present a minimal, isopotential spiking model neuron with transient and persistent sodium, delayed-rectifier, and A-type potassium channels. (biomedcentral.com)
  • This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. (nih.gov)
  • Kv4.2 is a Shal-type potassium channel that passes an A-type current and is localized to dendrites and cell bodies in the hippocampus. (utmb.edu)
  • These observations indicate that Kv4.2 is a substrate for ERK in vitro and in vivo, and suggest that ERK may regulate potassium-channel function by direct phosphorylation of the pore-forming a subunit. (utmb.edu)
  • 6. It was concluded that phrixotoxins, are new & specific blockers of Kv4.3 & Kv4.2 potassium currents, & hence of I(to1) that will enable further studies of Kv4.2 & Kv4.3 channel &/or I(to1) expression. (smartox-biotech.com)
  • These results imply that channels potentially involved in volume regulation of murine spermatozoa include the voltage-dependent Kv1.4 (also known as KCNA1), Kv1.5 (KCNA5), Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3), mink (KCNE1), & acid-sensitive TASK2 (KCNK5) & TASK3 (KCNK9). (smartox-biotech.com)
  • It contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential. (wikipedia.org)
  • The condition stems from loss of fragile X mental retardation protein (FMRP), which regulates a wide range of ion channels via translational control, protein-protein interactions and second messenger pathways. (bvsalud.org)
  • Due to the prominent role of potassium channels in regulating the electrical properties of membranes, modulation of these channels by ERK could play an important role in mediating learning-related synaptic plasticity in the CNS. (utmb.edu)
  • Consistent with this, pharmacological or genetic interventions that target dysregulated ion channels effectively restore neuronal excitability, synaptic function and behavioural phenotypes in FXS animal models. (bvsalud.org)
  • The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
  • Long QT syndrome (LQTS), Brugada syndrome (BrS), and catecholaminergic polymorphic ventricular tachycardia (CPVT) are genetic diseases of the heart caused by mutations in specific cardiac ion channels and are characterized by paroxysmal arrhythmias, which can deteriorate into ventricular fibrillation. (bvsalud.org)
  • Technical advances have now made possible direct electrophysiological recording of channels in central neurons, allowing the genetic advantages of this system to be applied to analysis of cellular and circuit function and homeostasis. (biomedcentral.com)
  • In this review, we summarize different insights gained from these models with a focus on electrophysiological perturbations caused by different ion channel mutations and discuss how will this knowledge help develop better stratification and more efficient personalized therapies for these patients. (bvsalud.org)
  • For this full model neuron, parameters for individual ion channels are required. (biomedcentral.com)
  • Overall, this neuron model will enable us to investigate the effect Na channel splice variants by varying half-activation and inactivation voltages and ratio of a persistent component. (biomedcentral.com)
  • SHL-1 channels are apparently important in fine-tuning complex behaviors, such as mating, that play a crucial role in the survival and propagation of the species. (wikigenes.org)
  • The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration. (nih.gov)
  • We show how the Shal channel properties change between the larval stages of 1st and 3rd instar, and we show the effect of this change on neuronal activity characteristics. (biomedcentral.com)
  • In LQTS3 and BrS different mutations in the SCN5A gene lead to a gain-or a loss-of-function of the voltage-gated sodium channel Nav1.5, respectively. (bvsalud.org)
  • As the specific mechanisms behind this phenomenon are unknown, spermatozoa from mice were screened for sensitivities to inhibitors known to affect specific channels involved in volume regulation of somatic cells. (smartox-biotech.com)
  • Several studies have shown that Na+ current abnormalities in LQTS3 and BrS can also cause Ca2+-signaling aberrancies in cardiomyocytes (CMs). (bvsalud.org)
  • SHL-1 currents strongly resembled Shal currents in other species except that they were active in a more depolarized voltage range. (wikigenes.org)
  • Potassium channels where the flow of K+ ions into the cell is greater than the outward flow. (lookformedical.com)
  • The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
  • Kv4.3 is a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. (wikipedia.org)
  • Potassium voltage-gated channel subfamily D member 3 also known as Kv4.3 is a protein that in humans is encoded by the KCND3 gene. (wikipedia.org)
  • This update of the City's standards, entitled Landscape and Irrigation Design Manual, reflects current landscape industry standards and practices, and addresses new State mandates for greater efforts at water conservation and more efficient use of water in landscaping by working in conjunction with the Landscape Efficiency standards contained i n Chapter 17.41 of the Poway Municipal Code (PMC). (poway.org)
  • Coly Concrete Irrigation Supplies has been operating for 20 years and the current owners are ready to In addition to the divider, deflectors and extender grates, epvp offers baking stones, BBQ rib racks, chicken sitters and more. (ab-uebersetzer.com)