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  • protein
  • Co-expression of KCNQ4 and prestin, the OHC motor protein, altered the voltage activation by a further −15 mV. (springer.com)
  • expression
  • Using CHO cells as a mammalian expression system, we have examined the properties of KCNQ4 channels under different phosphorylation conditions. (springer.com)
  • current
  • The potassium channel KCNQ4, expressed in the mammalian cochlea, has been associated tentatively with an outer hair cell (OHC) potassium current, I K,n , a current distinguished by an activation curve shifted to exceptionally negative potentials. (springer.com)
  • The expressed current showed the typical KCNQ4 voltage-dependence, with a voltage for half-maximal activation ( V 1/2 ) of −25 mV, and was blocked almost completely by 200 µM linopirdine. (springer.com)
  • Moreover, the action potential firing rates evoked by the depolarizing current and BK Ca channel blockers were remarkably decreased by application of resveratrol. (biomedcentral.com)
  • inhibitor
  • Moreover, the effects of resveratrol on action potential firing rate and the BK Ca channel inhibitor TEA (or paxilline)-induced hyperexcitability were also evaluated. (biomedcentral.com)