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  • class
  • In contrast to the Kv class, Kir channels are open at the resting potential of most cells and thus are their major hyperpolarizing influence ( 21 ). (physiology.org)
  • flow
  • Inwardly rectifying potassium channels (Kir) are responsible for regulating diverse processes including: cellular excitability, vascular tone, heart rate, renal salt flow, and insulin release [ PMID: 10102275 ]. (ebi.ac.uk)
  • By analogy with other secretory epithelia, basolateral K + channels would provide the counterion, and potentially some of the driving force, for anion secretion and transepithelial water flow into the apical lumen (bile canaliculus) adjoining pairs of hepatocytes. (physiology.org)
  • Inward rectifier potassium channels are characterised by a greater tendency to allow potassium to flow into the cell rather than out of it. (ebi.ac.uk)
  • Role
  • In the work described here, we have demonstrated the use of flock house virus (FHV) as a model system for virus infection in bees and revealed an important role for the regulation of the bee antiviral immune response by ATP-sensitive inwardly rectifying potassium (K ATP ) channels. (unl.edu)
  • The role of K + channels in proliferation has been well documented in many types of normal and malignant cells, including lymphocytes ( 10 ), breast cancer cells ( 11 , 12 ), colon cells ( 13 ), and prostate cancer cells ( 14 ). (aacrjournals.org)
  • activity
  • AEA (10 μM) also inhibited Ca 2+ channels in a voltage-independent, CB1R-independent, and PTX-insensitive manner, whereas 2-AG and 2-AGE were devoid of this activity. (aspetjournals.org)
  • increases
  • We have shown that treatment with the K ATP channel agonist pinacidil increases survival of bees while decreasing viral replication following infection with FHV, whereas treatment with the K ATP channel antagonist tolbutamide decreases survival and increases viral replication. (unl.edu)