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  • cardiac
  • Besides membrane potential modulation, SK channels have been found to be involved in cardiac pacemaker cell development from ES cells and morphological shaping of neural stem cells. (hindawi.com)
  • Distinct SK channel subtype expression in ES cells might elucidate their precise impact during cardiac development. (hindawi.com)
  • The cassette is readily expressed under the control of doxycycline, and the overexpression of SK4 led to an increase in cardiac and pacemaker cell differentiation thereby serving as a unique tool to characterize the cell biological variances due to specific SK channel overexpression. (hindawi.com)
  • Present study directly defines the functional roles of SK2 channels in transgenic mice using a genetically engineered model, and provides a possible link between abnormalities in cardiac SK2 channels and cardiac arrhythmias. (nih.gov)
  • subtype
  • We chose SK channel subtype 4 as a potential candidate influencing embryonic stem cell differentiation. (hindawi.com)
  • The subtype SK2 channels were up-regulated under hypoxia, shown with pharmacological tools and with mRNA analysis. (nih.gov)
  • human
  • To this end, we tested a large number of AADs on the human K Ca 2.2 and K Ca 2.3 channels to assess their effect on this new target using automated whole-cell patch clamp. (sophion.com)
  • Modulation
  • In the present study, we examine β modulation of several slo splice variants over a wide range of voltage and calcium concentrations. (jneurosci.org)
  • SK2 channels, therefore, may represent a target for pharmacologic modulation of bile flow. (nih.gov)
  • increase
  • Bradykinin (1 μM), adenosine 5'-triphosphate (3 μM) and acetylcholine (3 μM) applied extracellularly evoked a biphasic increase in NP(o) (where N is number of channels activated) of the Ca2+-activated K+ channel studied in the whole-cell recording configuration. (edu.au)
  • After the first 24h, potassium current increased without increase in intracellular Ca2+, and mitochondrial potential remained high. (ox.ac.uk)
  • In each individual cell we observed either an increase of the amplitude of KCa current, or a complete shutdown of the channels. (ox.ac.uk)
  • affinity
  • The replacement of histidine 236 from hIKCa1 channel with a smaller amino acid, cystein, did not change MTX binding affinity, however, partially affected the pH0 dependency of its block at low pH0. (ovid.com)
  • In contrast, CTX binding affinity to the hIKCa1_H236C channel mutant was increased suggesting that His236 might play a role in the binding of CTX, but has only a weak influence in the binding of MTX to hIKCa1 channels. (ovid.com)