• The molecular nature of this important current has yet to be established, but in this study, we provide strong evidence to suggest that IK SO is the functional correlate of the recently identified two-pore domain potassium channel TASK-1. (wright.edu)
  • We hypothesize that HFD causes an upregulation of 2-pore domain potassium channels, resulting in hyperpolarization of nodose ganglia (NG) and decreased vagal response to satiety signals, which contribute to hyperphagia. (jci.org)
  • We show that a 2-week HFD caused an upregulation of 2-pore domain TWIK-related spinal cord K+ (TRESK) and TWIK-related acid-sensitive K+ 1 (TASK1) channels by 330% ± 50% and 60% ± 20%, respectively, in NG. (jci.org)
  • A Functional Role for the Two-Pore Domain Potassium Channel TASK-1 in " by Julie A. Millar, Lynne Barratt et al. (wright.edu)
  • Abstract The ATP-sensitive potassium channels (K ATP ) are activated either by a decrease in intracellular ATP content or by a lowering of the ATP-ADP ratio such as during stroke. (ahajournals.org)
  • Abstract -Potassium ion (K + ) channel activity is a major regulator of vascular muscle cell membrane potential ( E m ) and is therefore an important determinant of vascular tone. (ahajournals.org)
  • Browne DL, Gancher ST, Nutt JG, Brunt ERP, Smith EA, Kramer P, Litt M (1994) Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene KCNA1. (springer.com)
  • In Potassium Channels: Methods and Protocols , experts in the field present a range of experimental approaches that have been developed to investigate potassium channel structure, function, pharmacology, cell biology, gene expression, and their role in disease. (springer.com)
  • There is genetic evidence that the plethora of K + channels results from several major genetic events, such as gene fusions and gene duplications ( Anderson and Greenberg, 2001 ). (plantphysiol.org)
  • The tandem architecture of the TWIK channels, with the tandem 2TM structure (2*2TM) structure, probably occurred after a gene duplication of the pore module. (plantphysiol.org)
  • Gene fusion of the precursor to the latter could explain the structure of the TOK channel in which the 2TM motive and the 6TM motive are combined (6+2TM). (plantphysiol.org)
  • As further progress is made in the development of more selective drugs and through molecular approaches such as gene targeting technology in mice, specific K + channel abnormalities and their causes in particular diseases should be more readily identified, providing novel directions for vascular therapy. (ahajournals.org)
  • A more recent study found that at moderate concentrations (0.1-1 mM), salicylate also causes a concentration-dependent reversible reduction of a voltage-gated potassium channel, which is encoded by KCNQ4 gene of OHCs ( 10 ). (frontiersin.org)
  • The human ether-a-go-go-related gene (hERG) encodes channels mediating the rapid delayed rectifier K+ current (IKr). (bl.uk)
  • Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. (wikigenes.org)
  • When coexpressed with the minK gene product, a slowly activating and much larger potassium current results. (rupress.org)
  • The other partner in the I Ks channel is the product of the LQT1 gene. (rupress.org)
  • This suggests that ChTX-sensitive K(+)-channel activation may be a common mechanism for the prejunctional modulation of sensory nerves in airways. (pnas.org)
  • Since potassium channels are intrinsically involved in repolarization, this study was designed to evaluate the effect of the nonsedating antihistamines on potassium channel modulation. (ahajournals.org)
  • The effects of extracellular acidosis on IhERG kinetics were preserved when the shortened hERG I b isoform was studied, indicating that a full-length N-terminus is not necessary for acidic modulation of hERG channel function. (bl.uk)
  • Evidence is presented that the decrease in 5-HT2CR editing is caused by down-regulation of adenosine deaminase ADAR2 and that editing of at least one other ADAR2 target, potassium channel Kv1.1, is decreased after SCI. (curehunter.com)
  • Studies at Yale University and elsewhere are showing that FMRP plays a significant role in the regulation of potassium channels. (fraxa.org)
  • Cooper EC, Milroy A, Jan YN, Jan LY, Lowenstein DH (1998) Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus. (springer.com)
  • Diochot S, Schweitz H, Béress L, Lazdunski M (1998) Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. (springer.com)
  • see the cover and the news story by Service) now present in two papers a 2.9-angstrom-resolution crystal structure and a mechanistic analysis for eukaryotic Kv1.2 channels from the Shaker family. (sciencemag.org)
  • Prof. Henning Stahlberg's team at the Biozentrum of the University of Basel has now elucidated the full structure of a bacterial counterpart of this type of potassium channel, which has provided new insights into its functioning. (innovations-report.com)
  • This observation raises the possibility that ion channels other than Kv1.3, such as KCa3.1, may have functional activity. (nature.com)
  • Complementary DNAs representing three voltage-gated K(+) channels from humans (HuKI, HuKII, and HuKIV) were isolated, their nucleotide sequences determined, and their functional products examined electrophysiologically. (nih.gov)
  • Here, we examined the localization, native interactions, and functional properties of K V 8.2-containing channels in mouse, macaque, and human photoreceptors of either sex. (jneurosci.org)
  • The pore module, which consists of two transmembrane domains connected by a pore helix containing the canonical filter sequence of K + channels, assembles into a functional tetramer. (plantphysiol.org)
  • 1 2 3 4 5 6 This Brief Review will first provide a short description of the functional characteristics of the 4 main types of vascular K + channels and the likely physiological importance of these channels, as well as the phenomenon of K + channel-mediated, endothelium-dependent vascular hyperpolarization. (ahajournals.org)
  • Coupling of conformational changes in one domain to another provides the basis for transducing voltage and ligand binding into channel opening and, therefore, defines, together with the functional properties of the gate and sensors, the signal transduction properties of the channel. (rupress.org)
  • B) Schematic organization of functional domains in the tetrameric channel. (rupress.org)
  • In humans, the good news is that an FDA-approved drug, retigabine works by "opening" the Kv7 channel. (mdanderson.org)
  • Looking forward, potassium channel opener drugs could rescue some symptoms of Fragile X in humans. (fraxa.org)
  • The role of NO in the regulation of the mechanical properties of conduit arteries is controversial in humans, and the involvement of an endothelium-derived hyperpolarizing factor (EDHF), acting through calcium-activated potassium (K Ca ) channels, has never been investigated at this level in vivo. (ahajournals.org)
  • 2,4 Whether an increase in vascular calcium-activated potassium (K Ca ) channel activity after NO synthesis inhibition could contribute to the maintenance of basal conduit artery diameter and mechanics has never been investigated in vivo in humans. (ahajournals.org)
  • 12,13 In humans, the recent demonstration of the contribution of K Ca channels in the regulation of forearm arteriolar resistance strongly suggests a role for EDHF in vivo. (ahajournals.org)
  • Potassium channel activator Atten. (mendeley.com)
  • The present invention describes novel nitrosated and/or nitrosylated potassium channel activators, and novel compositions comprising at least one nitrosated and/or nitrosylated potassium channel activator, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates. (google.com)
  • The present invention describes novel nitrosated and/or nitrosylated potassium channel activators, and novel compositions comprising at least one nitrosated and/or nitrosylated potassium channel activator, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one vasoactive agent. (google.com)
  • Voltage-gated Kv1.3 and Ca 2+ -dependent KCa3.1 are the most prevalent K + channels expressed by human and rat T cells. (nature.com)
  • However, experiments with Kv1.3 KO rats and Kv1.3 siRNA knockdown or channel-specific inhibition of human T cells show that maximal T-cell responses against autoantigen or repeated tetanus toxoid stimulations require both Kv1.3 and KCa3.1. (nature.com)
  • Cui J, Aldrich RW (2000) Allosteric linkage between voltage and Ca 2+ -dependent activation of BK-type mslo1 K + channels. (springer.com)
  • Patch-clamp studies of microglial cells showed that these cells express a wide variety of potassium channels. (frontiersin.org)
  • The present analysis of kcne3-/- mice strongly supports a crucial role of KCNQ1/KCNE3 channels in salt- and fluid secretion across intestinal and airway epithelia. (hu-berlin.de)
  • KCNQ1 through KCNQ5, and KCNQ channel has six transmembrane domains and a single pore loop ( 11 ). (frontiersin.org)