Potassium channel h family. Medical search. Frequent questions

These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and toxin binding properties. (wikipedia.org)
It has recently been reported that dipeptidyl aminopeptidase X (DPPX) interacts with the voltage-gated potassium channel Kv4 and that co-expression of DPPX together with Kv4 pore forming alpha-subunits, and potassium channel interacting proteins (KChIPs), reconstitutes properties of native A-type potassium channels in vitro. (proteopedia.org)
Collagens are a family of proteins that strengthen and support many tissues in the body. (nih.gov)
Channels made with KCNH2 proteins (also known as hERG1) are active in heart (cardiac) muscle. (nih.gov)
The proteins produced from the KCNH2 gene and another gene, KCNE2 , interact to form a functional potassium channel. (nih.gov)
Ion channels are specialized proteins found in cell membranes, which facilitate the movement of specific ions across the plasma membrane. (spandidos-publications.com)
Some of these loci have been identified further as specific mutations in the KCNQ2 and KCNQ3 M-type potassium channel proteins. (medscape.com)
From NCBI Gene: This gene encodes a protein that belongs to a conserved family of potassium channel tetramerization domain (KCTD)-containing proteins. (nih.gov)
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. (thermofisher.com)
KCNIP4 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. (prosci-inc.com)
Members of the KCNIP family are small calcium binding proteins. (prosci-inc.com)
The family was identified by neuroscientist Ardem Patapoutian at The Scripps Research Institute in California, US, and he named the two related ion channel proteins Piezo1 and Piezo2 - from the Greek word for pressure. (chemistryworld.com)
Ion channels are pore-containing proteins, found in cell's lipid membranes. (chemistryworld.com)
Piezo proteins are not the first ion channels discovered that respond to mechanical force. (chemistryworld.com)
Before discovering Piezo proteins Patapoutian's lab had already discovered the first cold-activated ion channel (which also acts as a menthol receptor, explaining the cold sensation the compound creates). (chemistryworld.com)
This domain is found in sodium, potassium, and calcium ion channels proteins. (embl.de)
In some Na channel proteins the domain is repeated four times, whereas in others (e.g. (embl.de)
The Kv family of ion channels are tubular-shaped proteins allocated in the membrane of neurons. (ehu.eus)
These proteins control the traffic flow of potassium ions between the inside and outside of the cell, and hence, electrical communication between neurons and muscles. (ehu.eus)
These seizure events can have a variety of causes, including genetic variants in a family of proteins that regulate potassium ions in the brain. (wustl.edu)

One beta subunit, produced from the KCNE1 gene, binds to the channel and regulates its activity. (medlineplus.gov)
Ehmke H. Physiological functions of the regulatory potassium channel subunit KCNE1. (medlineplus.gov)
19. Modification of delayed rectifier potassium currents by the Kv9.1 potassium channel subunit. (nih.gov)
One such gene- KCNAB2 -encodes the potassium channel auxiliary subunit Kvβ2, which has been previously shown to modulate voltage-gated potassium currents in heterologous expression systems. (jneurosci.org)
[ 17 ] Another family has been noted to have abnormalities in the acetylcholine alpha-4 receptor subunit, which also has been associated with autosomal dominant, nocturnal frontal lobe epilepsy. (medscape.com)
They are integral subunit components of native Kv4 channel complexes. (prosci-inc.com)

It defines molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. (wikipedia.org)
All K+ channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). (wikipedia.org)
In families that contain one P-domain, four subunits assemble to form a selective pathway for K+ across the membrane. (wikipedia.org)
The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. (wikipedia.org)
K+ channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. (wikipedia.org)
In addition, there are K+ channel alpha-subunits that possess two P-domains. (wikipedia.org)
These subunits do not themselves possess any functional activity, but appear to form heteromeric channels with Kv2 subunits, and thus modulate Shab channel activity. (wikipedia.org)
The N-terminal, cytoplasmic tetramerization domain (T1) of voltage-gated potassium channels encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. (wikipedia.org)
The KCNE1 protein regulates a channel made up of four parts, called alpha subunits, which are produced from the KCNQ1 gene. (medlineplus.gov)
KCNT1 and KCNT2 respectively encode the K Na 1.1 (Slack) and K Na 1.2 (Slick) subunits of the sodium-dependent voltage-gated potassium channel K Na . (frontiersin.org)
These subunits co-assemble to form homo or tetra-heteromeric K Na channels. (frontiersin.org)
I SA channel complexes include four subunits each of DPP6 and Kv4.2. (proteopedia.org)
14. Endogenous KCNE subunits govern Kv2.1 K+ channel activation kinetics in Xenopus oocyte studies. (nih.gov)
16. Accessory Kvbeta1 subunits differentially modulate the functional expression of voltage-gated K+ channels in mouse ventricular myocytes. (nih.gov)
Four alpha subunits, each produced from the KCNH2 gene, form the structure of each channel. (nih.gov)
while the β-subunits of potassium gated ion channels (AKR6 family) control Kv channel opening. (nih.gov)
In 1998, the channel subunits that underlie the M-current were identified as members of the voltage-gated Kv7 (KCNQ) potassium channel family ( Jentsch, 2000 ). (jneurosci.org)

Potassium two pore domain channel subfamily K member 4 is encoded by the gene KCNK4. (antibodiesinc.com)

K Na channels are voltage-gated potassium channels that are activated by an increase of cytoplasmic Na + concentration. (frontiersin.org)
We propose models of DPPX interaction with the voltage-gated potassium channel complex. (proteopedia.org)
4. Inhibitory effects of pimozide on cloned and native voltage-gated potassium channels. (nih.gov)
Voltage-gated potassium channels are essential regulators of neuronal excitability ( Bean, 2007 ). (jneurosci.org)
In 1980, Brown and Adams discovered a slowly activating voltage-gated potassium current that was blocked by muscarinic G-protein-coupled receptors in sympathetic neurons, which they named the M-current. (jneurosci.org)

An altered KCNE1 protein cannot regulate the flow of potassium ions through channels in the inner ear and cardiac muscle. (medlineplus.gov)
Scientists have connected a gene that regulates the flow of potassium into and out of cells with schizophrenia. (nih.gov)
The KCNH2 gene encodes a potassium channel, a type of protein that regulates the flow of potassium ions into or out of cells. (nih.gov)
As a result, the channels cannot properly regulate the flow of potassium ions in cardiac muscle cells. (nih.gov)
A study on schizophrenia has implicated machinery that maintains the flow of potassium in cells and revealed a potential molecular target for new treatments. (nih.gov)
By regulating the flow of potassium ions into the cell, potassium channels control when neurons fire - electrically discharge and release a chemical messenger that signals neighboring neurons in a circuit. (nih.gov)

This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. (nih.gov)
The KCNH2 gene belongs to a large family of genes that provide instructions for making potassium channels. (nih.gov)
Several additional genes have been associated with benign familial neonatal convulsions in single families, including KCNQ5 M-type potassium channel in one family. (medscape.com)
Expression of the mutated genes in xenopus oocytes has provided some insight into how the potassium channel mutation leads to lowering of the seizure threshold. (medscape.com)
Two distinct forms, EA1 and EA2 are caused by mutations in the neuronal potassium (KCNA1) and calcium (CACNA1A) channel genes respectively. (bmj.com)
Furthermore, our findings indicate that loss of channel function is a key disease mechanism and highlight genetic heterogeneity, suggesting there are additional new channel genes responsible for episodic ataxia. (bmj.com)
Methylation and expression data for all fifteen 2-pore domain potassium family genes were examined for 1040 women, and associations with triple-negative subtype (vs. luminal A) were evaluated using age/race adjusted generalized-linear models, with Bonferroni-corrected significance thresholds. (cdc.gov)
Mutations in different genes including Na + , Ca 2+ and K + channel genes have been associated with BrS, but nevertheless, 20-30% of BrS cases are related to mutations or variants in the SCN5A (encoding the ion channel Na v 1.5) gene. (umm.de)
Therefore, we used hiPS-CMs from BrS-patients carrying mutations or variants in Na + and Ca 2+ channel genes to perform mechanistic and drug-screening studies, in order to unveil pathogenic roles and underlying mechanisms of specific gene mutations or variants detected in BrS-patients and look for better effective drugs. (umm.de)
The numerous genes in the potassium ion channel family constitute the largest family of ion channels: this family is divided into different subtypes. (qxmd.com)

Areas in the prefrontal cortex (right) and hippocampus (left) where activity differed in healthy control subjects during thinking tasks, depending on whether they had the risk version of the KCNH2 potassium channel gene. (nih.gov)
KCNH2 is best known for its role in heart muscle, where it transports potassium ions out of cells, recharging the muscle after each heartbeat to maintain a regular rhythm. (nih.gov)
At least eight mutations in the KCNH2 gene have been found to cause short QT syndrome in a small number of affected families. (nih.gov)
The genetic changes alter the function of ion channels made with the KCNH2 protein, increasing the channels' activity. (nih.gov)
One type of potassium channel, called KCNH2, attracted the researchers' interest for its potential role in sustaining the type of neuronal firing that supports the higher mental functions disturbed in schizophrenia. (nih.gov)
Spurred by hints from postmortem studies of genetic variation linked to schizophrenia in the genomic neighborhood of KCNH2, the researchers analyzed the gene's association with the illness in 5 independent samples comprising hundreds of families. (nih.gov)
SQTS types 1-3 are linked to a gain of function of potassium channels caused by mutations in the KCNH2 (SQTS1), KCNQ1 (SQTS2) and KCNJ2 (SQTS3) gene. (umm.de)

Liddle syndrome: gain-of-function mutation in the gene encoding the apical epithelial sodium channel (ENaC) causes increased sodium absorption and subsequent HTN. (frontiersin.org)
BrS type 1 ECG could be unmasked by fever, sodium channel blockers and increased parasympathetic state. (umm.de)
Many are voltage-gated - activated by changes in the electrical membrane potential near the channel - but Piezo ion channels open in response to mechanical stimuli, allowing sodium, potassium and calcium ions into the cell. (chemistryworld.com)
In the study of neuronal receptors isolated and characterized for the first time all of the individual components of the mammalian sodium channel electro-excitability membranes. (ibch.ru)
Epithelial sodium channel (ENaC) is a primary determinant in regulating the transport of Na+ and the clearance of alveolar edema fluid. (bvsalud.org)
The aim of this study was to investigate the role of amiloride-sensitive sodium channel protein 1B (SCNN1B) on the proliferation and migration of human lung fibroblasts and the possible mechanism that promote the development of acute respiratory distress syndrome (ARDS). (bvsalud.org)

These channels are active in the inner ear and in heart (cardiac) muscle, where they transport potassium ions out of cells. (medlineplus.gov)

Encodes a defensin-like (DEFL) family protein. (or.jp)

KCNK4 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. (antibodiesinc.com)
Associations of two-pore domain potassium channels and triple negative breast cancer subtype in The Cancer Genome Atlas: systematic evaluation of gene expression and methylation. (cdc.gov)
Objectives: It is unclear whether 2-pore domain potassium channels are novel molecular markers with differential expression related to biologically aggressive triple-negative type breast tumors. (cdc.gov)
Our objective was to systematically evaluate associations of 2-pore domain potassium channel gene expression and DNA methylation with triplenegative subtype in The Cancer Genome Atlas invasive breast cancer dataset. (cdc.gov)
Triple-negative subtype was associated with distinct 2-pore domain potassium channel expression patterns. (cdc.gov)
Recently, a new family of ion channels, the background leak potassium channels or two-pore domain potassium (K2P) channels has been identified through the use of bioinformatics. (grantome.com)

We further revealed that SLO and CNG-3 channels act in thermosensory neurons and decelerate alteration in the responsiveness of these neurons, which occurs prior to the preference transition after a temperature shift. (nature.com)
In neurons, potassium channels help control when the cells fire to signal neighboring neurons. (nih.gov)
Conditional deletion of Kcnq2 from cerebral cortical pyramidal neurons showed that SF0034 requires the expression of KCNQ2/3 channels for reducing the excitability of CA1 hippocampal neurons. (jneurosci.org)
Moreover, it is unclear why or how motor neurons die in amyotrophic lateral sclerosis (ALS), yet we do know that the activity of these channels is altered and that these dying cells undergo spontaneous (uncontrolled) electrical discharges. (ehu.eus)
Hence, defects in ion channels may cause these motor neurons to degenerate. (ehu.eus)
The KCNQ potassium channel family has multiple functions, from regulating heartbeat (by KCNQ1) to controlling excitability of neurons (by KCNQ2-5). (wustl.edu)
Potassium ion channels play a crucial role in the electrical activity of neurons and are directly involved in the mechanism of epileptic seizures. (qxmd.com)

Voltage-gated Kv7 (KCNQ) channels are voltage-dependent potassium channels that are activated at resting membrane potentials and therefore provide a powerful brake on neuronal excitability. (jneurosci.org)
Especially, potassium channels that are open at potentials close to the resting membrane potential, such as the M-channel, provide a powerful brake to neuronal excitability. (jneurosci.org)
KCNQ2 and KCNQ3 are highly expressed in the central nervous system and are the principal contributors to the M-current, a critical potassium current that modulates neuronal excitability. (wustl.edu)

Genetic or experience-dependent reduction of KCNQ2/3 channel activity is linked with disorders that are characterized by neuronal hyperexcitability, such as epilepsy and tinnitus. (jneurosci.org)
Retigabine, a small molecule that activates KCNQ2-5 channels by shifting their voltage-dependent opening to more negative voltages, is an US Food and Drug Administration (FDA) approved anti-epileptic drug. (jneurosci.org)
As a result, the development of improved KCNQ2/3 channel activators is crucial for the treatment of hyperexcitability-related disorders. (jneurosci.org)
Heterologous expression of KCNQ2/3 channels in HEK293T cells showed that SF0034 was five times more potent than retigabine at shifting the voltage dependence of KCNQ2/3 channels to more negative voltages. (jneurosci.org)
and therefore increases KCNQ2-5 channel activity both at resting membrane potentials and after a train of action potentials. (jneurosci.org)
Jianmin Cui, PhD , professor of biomedical engineering in the McKelvey School of Engineering, and Nien-Du Yang, a doctoral student in biomedical engineering who conducts research in Cui's lab, teamed up with Harley Kurata, associate professor of pharmacology at the University of Alberta, and investigated the working mechanism of two potassium ion channels, KCNQ2 and KCNQ3. (wustl.edu)

Two P domain potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite . (neurotree.org)

1987. A mutant Paramecium with a defective calcium-dependent potassium conductance has an altered calmodulin: A nonlethal selective alteration in calmodulin regulation. (iup.edu)
The channel MscL (the large conductance mechanosensitive channel) acts as an emergency valve and stops bacteria swelling up and bursting on sudden exposure to water. (chemistryworld.com)

Mutations occurring on the Kv channels have been linked to different subtypes of epilepsies. (ehu.eus)

Hc KCR1 enables optogenetic control of K + gradients, which is promising for the study and potential treatment of potassium channelopathies such as epilepsy, Parkinson's disease and long-QT syndrome and other cardiac arrhythmias. (nature.com)
Dysfunction of potassium channels has notably been involved in various types of epileptic encephalopathies, including epilepsy of infancy with migrating focal seizures (EIMFS), previously known as malignant migrating partial seizures of infancy. (frontiersin.org)
[ 15 ] The specific location of the mutation appears to vary from family to family and at least 1 family has been noted to include an increased incidence of rolandic epilepsy. (medscape.com)
We propose that SF0034 provides, not only a powerful tool for investigating ion channel properties, but, most importantly, it provides a clinical candidate for treating epilepsy and preventing tinnitus. (jneurosci.org)
TREK, one of these mechanosensitive ion channels, is found in brain and heart nerve cells and seems to have an important role in protection against epilepsy. (chemistryworld.com)
Their findings uncover a conserved mechanism for KCNQ channel activation that is a target of both epilepsy-linked mutations and a small molecule compound. (wustl.edu)
Potassium channels and epilepsy. (qxmd.com)

This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. (thermofisher.com)

Cui's team has previously shown that KCNQ1, the cardiac KCNQ isoform, features a two-stage process in electro-mechanical coupling that leads to two distinct channel open states, the intermediate-open and activated-open. (wustl.edu)

Ranolazine extended-release tablets may be used with beta-blockers, nitrates, calcium channel blockers, anti-platelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers. (nih.gov)

The fourth TM domain has positively charged residues at every third residue and acts as a voltage sensor, which triggers the conformational change that opens the channel pore in response to a displacement in membrane potential. (wikipedia.org)
The maintenance of membrane potential mainly depends on the activities of cation channels and transporters. (mdpi.com)
15. Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. (nih.gov)
TASK-3 is a potassium channel member of the recently discovered two-pore potassium channels family (K2P) responsible for the background current maintaining the membrane resting potential. (europa.eu)
K channels) the protein forms a tetramer in the membrane. (embl.de)
These channels are voltage-activated so that they sense voltage changes across the cell membrane and open and close in response. (wustl.edu)
In cell and tissue culture systems these channels have been shown to contribute the establishment of the resting membrane potential of cells. (grantome.com)

By performing forward genetics to reveal mechanisms that underlie the plasticity of thermotaxis behavior in C. elegans , we demonstrated that SLO potassium channels and a cyclic nucleotide-gated channel, CNG-3, determine the timing of transition of temperature preference after a shift in cultivation temperature. (nature.com)

K+ channel tetramerisation domain is the N-terminal, cytoplasmic tetramerisation domain (T1) of voltage-gated K+ channels. (wikipedia.org)

Until recently it wasn't clear, but in 2010 the protein family responsible for this was discovered. (chemistryworld.com)

Loci on chromosome arm 20q have been identified for most families, and at least one family was identified to have a locus on chromosome arm 8q. (medscape.com)

Using whole-cell patch-clamp recordings, we have analyzed the functional consequences of those two novel KCNT2 mutations on reconstituted K Na 1.2 homomeric and K Na 1.1/K Na 1.2 heteromeric channels in transfected chinese hamster ovary (CHO) cells. (frontiersin.org)
notably, they decreased the global current density of heteromeric channels by ~25% (p.K564*) and ~55% (p.L48Qfs43). (frontiersin.org)

The Polymorphic Analysis of the Human Potassium Channel KCNE Gene Family in Meniere's Disease-A Preliminary Study. (cdc.gov)
Member of the R2R3 factor gene family. (or.jp)

Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel. (hu-berlin.de)
Activation of K2P channels causes hyperpolarization of cells resulting in inhibition of firing. (grantome.com)

5. Tyrosine kinases modulate K+ channel gating in mouse Schwann cells. (nih.gov)

These channels, which transport positively charged potassium atoms (ions) into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals. (medlineplus.gov)

3. Voltage sensitivity and gating charge in Shaker and Shab family potassium channels. (nih.gov)

20. Anomalous effects of external TEA on permeation and gating of the A-type potassium current in H. aspersa neuronal somata. (nih.gov)
Permeation Properties of Purified Pannexin 1 Channels in Proteoliposomes Biophysical Journal . (neurotree.org)

The 2TM domain family comprises inward-rectifying K+ channels. (wikipedia.org)

A member of the Aldehyde Dehydrogenase family of enzymes involved in the synthesis of acetate from ethanol. (nih.gov)

12. Effect of lanthanum on voltage-dependent gating of a cloned mammalian neuronal potassium channel. (nih.gov)

Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). (proteopedia.org)

18. Molecular site of action of the antiarrhythmic drug propafenone at the voltage-operated potassium channel Kv2.1. (nih.gov)
It offers a molecular understanding of the structural and biophysical properties of TASK-3 -currently unavailable- and opens the venue to the therapeutic targeting of this ion channel. (europa.eu)
In this study, we present the clinical, genetic and molecular expression results of mutations identified in a series of over 100 families from the UK who presented with clinical episodic ataxia over the last 15 years. (bmj.com)
Fourth, molecular studies of all expressed mutations demonstrate a loss of channel function as critical in disease pathogenesis. (bmj.com)
1990. Analysis of the molecular basis of calmodulin defects that effect ion channel-mediated cellular responses: site specific mutagenesis and microinjection. (iup.edu)
We knew that there were ion channels that are mechanically activated, we knew where they would be, but their molecular identity was not known. (chemistryworld.com)
Perform Molecular dynamics simulations to support the hypothesis that certain mutations cause erroneous cotranslational folding of the channel inside the Ribosome. (ehu.eus)

Little data available on high doses, long exposure, use with QT interval-prolonging drugs, potassium channel variants causing prolonged QT interval, in patients with a family history of(or congenital) long QT syndrome, or in patients with known acquired QT interval prolongation. (nih.gov)

Although some of the channels have been associated with temperature sensitivity, sensitivity to pain, response to inhalant anesthetics, and neuroprotection, the physiological functions of most of these channels in living organisms have yet to be established. (grantome.com)
Although this application will investigate the role of K2P channels in generating hot flashes, increasing our understanding of the physiological functions of these channels may provide insight into mechanisms of other age-associated diseases associated with hyperexcitability of the central nervous system. (grantome.com)

Functional analyses of the corresponding mutant homomeric channels in vitro suggested gain-of-function effects. (frontiersin.org)
10. Functional differences of a Kv2.1 channel and a Kv2.1/Kv1.2S4-chimera are confined to a concerted voltage shift of various gating parameters. (nih.gov)
The work proposed in this application will use a functional bioassay, radiotelemetric monitoring of tail skin temperature from estrogen deficient and replete mice, to monitor the effects of drugs that activate and inhibit K2P channels in a whole animal model. (grantome.com)

9. Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. (nih.gov)

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. (nih.gov)
The lab facility provides useful platforms for studying ion channel functions including ion channel gating kinetics, intracellular calcium homeostasis and single cell contraction. (umm.de)

In the heart, the channels are involved in recharging the cardiac muscle after each heartbeat to maintain a regular rhythm. (medlineplus.gov)
As a result, more potassium ions flow out of cardiac muscle cells at a critical time during the heartbeat, which can lead to an irregular heart rhythm. (nih.gov)

The KCNE1 gene provides instructions for making a protein that regulates the activity of potassium channels. (medlineplus.gov)
The KCNE1 protein is also produced in the kidneys, testes, and uterus, where it probably regulates the activity of other channels. (medlineplus.gov)
It is hypothesized herein that estrogen regulates the expression of K2P channels in the central nervous system and that the withdrawal of estrogen results in a decrease in the number or activity of these channels. (grantome.com)

Moreover, unlike retigabine, SF0034 did not shift the voltage dependence of either KCNQ4 or KCNQ5 homomeric channels. (jneurosci.org)

That distinction belongs to a family called TREK - a potassium-selective mechanically sensitive channel,' explains Philip Gottlieb from the State University of New York in the US. (chemistryworld.com)

These are usually highly regulated K+ selective leak channels. (wikipedia.org)

Anatomy10

Organisms11

Diseases3

Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes21

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science2

Proteins20

Subunit6

Subunits17

Subfamily K member1

Voltage-gated potassium5

Flow of potassium6

Genes10

KCNH27

Sodium6

Ions out of cells1

Encodes1

Pore domain6

Neurons7

Neuronal excitability3

KCNQ26

Pharmacology1

Conductance2

Different subtypes1

Epilepsy7

Rectifier1

KCNQ1

Calcium-Channel1

Membrane7

Cyclic1

Tetramerisation domain1

Protein family1

Loci1

Heteromeric channels2

Gene family2

Inhibition2

Modulate1

Atoms1

Shab1

Permeation2

Domain1

MEMBER1

Mammalian1

Modulates1

Molecular7

Variants1

Physiological Functions2

Functional3

Mechanism1

Intracellular calcium2

Cardiac muscle2

Regulates3

Homomeric channels1

Belongs1

Leak1