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  • Focuses on the key global Potassium Channel Blocker manufacturers, to define, describe and analyze the sales volume, value, market share, market competition landscape, SWOT analysis and development plans in next few years. (researchmoz.us)
  • block
  • Patch clamp electrophysiology, molecular modeling, and site-directed mutagenesis identified pore-lining glutamate 158 and isoleucine 159 as critical residues for block of the channel. (aspetjournals.org)
  • work
  • I spoke to Dr Shi at the W2W in Boston about his work and it sounded like he had found an even better way to work the potassium route. (rutgers.edu)
  • Journal
  • Marie-France Martin-Eauclaire and Pierre E. Bougis, "Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus ," Journal of Toxicology , vol. 2012, Article ID 103608, 9 pages, 2012. (hindawi.com)
  • cell
  • In whole-cell patch clamp electrophysiology experiments, VU0134992 inhibits Kir4.1 with an IC50 of 0.97 μM and is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 μM) at -120 mV. (aspetjournals.org)