Posttranscriptional regulated genes micro rna that regulates. Medical search. Frequent questions

MicroRNAs (miRNAs) regulate many physiological processes including body growth. (nature.com)
MicroRNAs (miRNAs) are endogenous noncoding RNAs that act as post-transcriptional regulators of gene expression by binding to the 3′-untranslated region (UTR) of target mRNAs. (nature.com)
miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of immune responses. (frontiersin.org)
MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)
miRNAs induce gene degradation and suppression of translation, or both, mainly by imperfect binding to miRNA recognition elements (MREs) within the 3′-untranslated region (UTR) of target mRNAs ( 1 ). (frontiersin.org)
The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. (mdpi.com)
Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). (mdpi.com)
MicroRNAs (miRNAs) are small noncoding endogenous RNAs containing 19 to 25 nucleotides that promote posttranscriptional control in regulating the expression of target gene by binding to the 3′-UTR sequences of its mRNA [ 5 ]. (hindawi.com)
Individual miRNAs are capable of regulating gene networks by interacting with multiple targets or by suppressing transcriptional controllers [ 6 , 8 ]. (researchsquare.com)
miRNAs are essential for brain development and function, with multiple miRNAs enriched in specific cell types where they regulate differentiation, structure and neurophysiological properties [ 9 , 10 ]. (researchsquare.com)
MicroRNAs (miRNAs) negatively regulate the expression of the target genes by binding to ʻseed sequences' in the 3'‑untranslated region (3'‑UTR) mRNA transcripts, and the variants within or nearby ʻseed sequences' may compromise or enhance miRNA/mRNA interaction leading to either ʻloss‑of‑function' or ʻgain‑of‑function' effects. (spandidos-publications.com)
MicroRNAs (miRNAs), a class of endogenous small non-coding RNAs of 20-25 nucleotides, modulate the expression of genes at the post-transcriptional level ( 7 ). (spandidos-publications.com)
miRNAs bind to complementary sequences present in the 3′-untranslated regions (3′-UTR) of target gene mRNAs and, thus, regulate translational interference or degradation of mRNAs ( 8 ). (spandidos-publications.com)
MicroRNAs (miRNAs or miRs) are small non-coding RNAs that participate in diverse cellular processes and negatively regulate gene expression at the post-transcriptional level by binding with 3′-untranslated regions (3′-UTRs) ( 2 - 4 ). (spandidos-publications.com)
A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
Recent studies have shown that interleukin (IL)-1β is a key inflammatory mediator in acute gouty arthritis (GA), and its level is regulated by microRNAs (miRNAs). (biomedcentral.com)
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate several gene expressions, pathways, and complex biological networks at the cellular level acting either exclusively or together with other miRNAs. (justia.com)
MiRNAs regulate both transcriptional and post-transcriptional gene expression as well as regulate several circuits involved in tissue repair, inflammation, hypoxia-response, and angiogenesis. (justia.com)
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression. (cornell.edu)
MicroRNAs (miRNAs) are found extensively involved in modulation of carcinogenesis and chemoresistance. (oncotarget.com)
This study aimed to investigate cisplatin (DDP)-susceptibility regulated by expression of the miRNAs and underlying pathways in GBC. (oncotarget.com)
MicroRNAs (miRNAs), single-stranded RNA molecules with 19~25 nucleotides in length, are recognized as key modulators governing multiple gene expression via binding to the 3' untranslated region (3'-UTR) of target mRNA at the posttranscriptional level [ 7 ]. (oncotarget.com)
In addition, circRNAs can regulate gene expression at transcriptional or post-transcriptional levels by titrating microRNAs (miRNAs), regulating transcription and interfering with splicing [ 13 , 14 ]. (ijbs.com)
MicroRNAs (miRNAs) are key components in post-transcriptional gene regulation in multicellular organisms. (biomedcentral.com)
One of the challenges to understand miRNA-mediated regulation is to identify co-regulating miRNAs that simultaneously regulate their target genes in a network perspective. (biomedcentral.com)
We created miRNA association network by using miRNAs sharing target genes based on sequence complementarity and co-expression patterns of miRNA-target pairs. (biomedcentral.com)
Cooperatively regulating miRNAs have been identified by network topology-based approach. (biomedcentral.com)
Cooperativity of miRNAs is evaluated by their shared transcription factors and functional coherence of target genes. (biomedcentral.com)
Pathway enrichment analysis of target genes in the cooperatively regulating miRNAs revealed the mutually exclusive functional landscape of miRNA cooperativity. (biomedcentral.com)
In addition, we found that one miRNA in the miRNA association network could be involved in many cooperatively regulating miRNAs in a condition-specific and combinatorial manner. (biomedcentral.com)
On the system level, we identified cooperatively regulating miRNAs in the miRNA association network. (biomedcentral.com)
We showed that the secondary structures of pre-miRNAs in cooperatively regulating miRNAs are highly similar. (biomedcentral.com)
This study demonstrates the potential importance of the secondary structures of pre-miRNAs in both cooperativity and specificity of target genes. (biomedcentral.com)
MicroRNAs (miRNAs) play crucial regulatory roles in repressing mRNA translation or mediating mRNA degradation by targeting mRNAs in a sequence-specific manner [ 1 ]. (biomedcentral.com)
Studying the cooperativity of miRNAs is a substantial step for understanding the contribution of co-regulating miRNAs towards a complex interplay between miRNAs. (biomedcentral.com)
We evaluate the miRNAs modules determined to be significantly cooperative by assessing the functional coherence of target genes co-regulated by the miRNA modules. (biomedcentral.com)
MicroRNAs (miRNAs) are small non-coding RNAs responsible for posttranscriptional regulation of gene expression. (lu.se)
MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene expression in many developmental and cellular processes. (biomedcentral.com)
MicroRNAs (miRNAs) are an abundant class of small (approximately 22 nt) endogenous non-coding RNAs that direct post-transcriptional regulation of gene expression. (biomedcentral.com)
miRNAs are either expressed from independent transcriptional units or derive from introns of protein-coding genes or exons or introns of long ncRNAs. (biomedcentral.com)
miRNA genes are transcribed by RNA polymerase II into long primary miRNA transcripts, termed pri-miRNAs that are usually several kilobases long and possess a 5' CAP and a poly(A) tail. (biomedcentral.com)
DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
From the list of genes that were targeted by the 73 diagnostic miRNAs, DGKE and WDR47 had significant associations with responses to both systemic therapies and radiotherapy in lung cancer. (cdc.gov)
This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)

Small noncoding RNAs called microRNAs (miRNA) negatively regulate gene expression by sequence-specific targeting of protein-coding transcripts [ 6 ]. (researchsquare.com)
Luciferase assays and online miRNA databases were used to validate that tumor protein p53 (TP53) is the target gene of miR‑125b. (spandidos-publications.com)
Among these, members of the let-7 miRNA family control many cell-fate determination genes to influence pluripotency, differentiation, and transformation. (cornell.edu)
The effect of regulated expression of the miRNA on cell migration, invasion, proliferation and apoptosis was examined by wound healing, transwell assays, CCK-8 assays, colony formation and flow cytometry assays, respectively. (oncotarget.com)
For example, genetic evidences in previous research suggest that the lin-28 gene is cooperatively regulated by the lin-4 miRNA and another unidentified miRNA [ 8 ]. (biomedcentral.com)
Through the centre, we have access to human islets from which we have investigated the miRNA-profile and together we perform large-scale RNA-sequencing studies in human islets that has given us the opportunity to investigate other non-coding RNAs such as the lncRNAs and their role in beta cell function. (lu.se)
Based on our identified miRNA-regulated network, we discovered three drugsBX-912, daunorubicin, and midostaurinthat can be repositioned to treat lung cancer, which was not known before. (cdc.gov)
Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)

Circular RNAs (circRNAs) are a large group of endogenous non-coding RNAs which are key members of gene regulatory processes. (ijbs.com)
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs with a covalently closed continuous loop that lacks 5'-3' polarity structure. (ijbs.com)

MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
We also identified a novel mRNA processing mechanism that expands human proteome at the posttranscriptional level and regulates gene expression (Yao, P, et al. (rochester.edu)
CircRNAs play a critical role in biological processes including transcription, mRNA splicing, RNA decay and translation [ 15 ]. (ijbs.com)
Cellular transitions require dramatic changes in gene expression that are supported by regulated mRNA decay and new transcription. (scentoferos.com)
Although some maternal mRNAs are targeted for degradation by microRNAs, this pathway does not fully explain mRNA clearance. (scentoferos.com)
Codon composition shapes maternal mRNA clearance during the maternal-to-zygotic transition in zebrafish, Xenopus, mouse, and Drosophila, and gene expression during homeostasis across human tissues. (scentoferos.com)
Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)

GRFs are a large gene family with highly conserved proteins. (biomedcentral.com)

In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)

Therefore, it is important to describe their mechanisms of actions, expression patterns and possible target genes and cellular pathways with which they interact. (mdpi.com)
Furthermore, we demonstrated that miR-21 regulates inflammatory responses through NF-κB signaling pathways. (frontiersin.org)
These alterations can take the form of epigenetic modifications, point mutations, translocations, amplifications or deletions and modify gene functions in ways that deregulate cellular signalling pathways leading to the cancer phenotype. (bmj.com)

This study demonstrates the roles of miR-488 and miR-920 in regulating the production of proinflammatory cytokines in the pathogenesis of GA. These findings suggest that miR-488 and miR-920 could serve as potential therapeutic targets in the treatment of GA. (biomedcentral.com)
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

MicroRNAs function to regulate the expression levels of other genes by several mechanisms. (wikipedia.org)
During his post-doctoral training under Dr. Paul Fox at Lerner Research Institute of Cleveland Clinic, he made contributions in understanding the translational control mechanisms regulating VEGFA (vascular endothelial growth factor-A) expression in human monocytes. (rochester.edu)
The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases. (rochester.edu)
A number of post-transcriptional mechanisms fine-tune the gene expression landscape. (researchsquare.com)
However, it is unclear how cerebral ischemic stroke regulates cardiac function, what are the direct effects of stroke on cardiac function, and what are the underlying molecular mechanisms. (justia.com)
Today we know that miR-375 also regulate several other mechanisms. (lu.se)

This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
Regulatory non-coding RNAs and RNA-binding proteins (RBPs) are important research areas in gene regulation and RNA biology. (rochester.edu)
Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in c. (rochester.edu)
MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. (researchsquare.com)
As they control cooperatively a large number of their target genes, they affect the complexity of gene regulation. (biomedcentral.com)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)

Sequencing as well as functional studies using antisense oligonucleotides, indicate important roles for microRNAs during the development of epilepsy through targeting transcripts involved in neuronal structure, gliosis and inflammation. (researchsquare.com)
Previous studies have demonstrated that microRNAs (miRs) serve important roles in the progression of human cancer types, including pancreatic cancer (PC), a highly lethal malignancy. (spandidos-publications.com)
A number of studies have demonstrated that altered expression of miRs serves critical roles in human cancers by directly regulating cell behaviors ( 5 - 7 ). (spandidos-publications.com)
The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

Our data provide a molecular explanation for Lin28 specificity and a model for how it regulates let-7. (cornell.edu)

However, the role of microRNA in mammalian tissue development and differentiation is still quite uncharacterized. (mdpi.com)
Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)

In molecular biology mir-542 microRNA is a short RNA molecule. (wikipedia.org)
He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
Molecular basis for interaction of let-7 microRNAs with Lin28. (cornell.edu)

Most PgGRF and PgGIF gene promoters contain some hormone- and stress- related cis-regulatory elements. (biomedcentral.com)
A central process in evolution is the recruitment of genes to regulatory networks. (scentoferos.com)
We engineered immotile strains of the bacterium Pseudomonas fluorescens that lack flagella due to deletion of the regulatory gene fleQ. (scentoferos.com)

Thus, to maintain a balance between host preservation and inflammatory pathology, the immune response and inflammation need to be tightly regulated. (frontiersin.org)

By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)

In addition, Kayed et al ( 15 ) demonstrated that RUNX2 was overexpressed in PC and could be regulated by certain cytokines, including transforming growth factor β1 and bone morphogenetic protein 2. (spandidos-publications.com)

However, to the best of our knowledge, the miRs that regulate RUNX2 expression in tumors are unknown. (spandidos-publications.com)

circPVT1 is significantly up-regulated in the osteosarcoma tissues, and circPVT1 may be a biomarker for the diagnosis of osteosarcoma [ 17 ]. (ijbs.com)

Since the first microRNA was identified in 1993 by Victor Ambros and colleagues (the lin-4 heterochronic gene in C. Elegans ), more than 24,000 microRNAs have now been identified. (mdpi.com)

The WRC domain can be combined with the cis-acting regions of downstream genes to regulate their expression. (biomedcentral.com)
Protein-RNA complex formation imposes specific conformations on both components that could affect downstream recognition by other processing factors. (cornell.edu)

microRNAs such as miR156 and miR172 and their corresponding targets are the key regulators of the phase changes in the floral transition [ 4 ]. (jabonline.in)

Since the insulin and growth phenotypes are rescued by expression of sNPFR1, we propose that the conserved miR-9a/miR-9 regulates body growth by modulating insulin signalling through its conserved sNPFR1/NPY2R target in both Drosophila and mammals. (nature.com)
In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)

Intriguingly, some of these RNA switches involve the interplay between microRNA and RNA-binding protein (Jafarifar, F, et al. (rochester.edu)

The expression level of the PgGIF gene changed only slightly after one week of heat treatment. (biomedcentral.com)

Based on the available public RNA-Seq data, the expression patterns of PgGRF and PgGIF genes were analysed from 14 different tissues. (biomedcentral.com)

The results of this study may be helpful for further study of the function of PgGRF and PgGIF genes and lay a foundation for further study of their role in the growth and development of Panax ginseng . (biomedcentral.com)
MicroRNA-126 (miR-126) is endothelial cell (EC) specific and plays a key role in regulating EC function, controlling angiogenesis, and maintaining vascular integrity. (justia.com)

We recently discovered a new type of stress-responsive, protein-directed human RNA switch that regulates expression of vascular endothelial growth factor-A in human monocytic cells (Ray, PS, et al. (rochester.edu)

Overexpression of miR-488 and miR-920 could significantly inhibit the gene and protein expression of IL-8 and TNF-α in MSU-induced THP-1 cells. (biomedcentral.com)
The expression of the PgGRF gene was significantly upregulated under GA3 induction and three weeks of heat treatment. (biomedcentral.com)

Upregulation of miR-488 and miR-920 could suppress MSU-induced IL-1β protein expression in THP-1 cells, but no significant difference in IL-1β messenger RNA levels was observed. (biomedcentral.com)

The two folded domains of Lin28 recognize two distinct regions of the RNA and are sufficient for inhibition of let-7 in vivo. (cornell.edu)

RAB18 was upregulated in HCC tissues and cell lines, and the expression of RAB18 was regulated by miR-455. (hindawi.com)
All the fresh tissues were snap-frozen in liquid nitrogen and stored at −80°C until RNA extraction. (hindawi.com)
GRF genes are usually expressed at higher levels in young tissues but at lower levels in mature tissues [ 6 ]. (biomedcentral.com)

This is predicted to exert an important influence on the gene expression landscape. (researchsquare.com)
During this period we could reveal how the influx of Ca 2+ regulates exocytosis and how second messengers like ATP and cAMP are important for priming of the insulin granules to become release ready. (lu.se)

These genetic alterations result in either activation or inactivation of specific gene functions that contribute to the process of carcinogenesis. (bmj.com)
10 Genes that, when activated, contribute to the carcinogenesis are generally termed proto-oncogenes. (bmj.com)

The main hormone regulating the blood glucose levels is insulin, secreted from beta cells, and glucagon, secreted from alpha cells. (lu.se)

Past studies have shown that growth-regulating factors ( GRFs ) and GRF -interacting factors ( GIFs ) are involved in regulating plant growth and development, responding to environmental stress, and responding to the induction of exogenous hormones. (biomedcentral.com)
A review of the English medical literatures was conducted by searching PubMed for studies concerning asthma and microRNAs. (cdc.gov)

Anatomy5

Organisms3

Chemicals and Drugs41

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes34

Information Science3

MiRNAs50

MiRNA8

Endogenous2

MRNA7

Highly conserved1

Pathway1

Pathways3

Pathogenesis3

Mechanisms6

Regulation7

Roles4

Specificity1

Differentiation2

Molecular3

Regulatory3

Inflammation1

Proteins1

Cytokines1

MiRs1

Osteosarcoma1

Heterochronic1

Downstream2

Regulators1

Target2

Interplay1

Level1

Expression patterns1

Function2

Vascular1

Significantly2

Protein expression1

Inhibition1

Tissues3

Important2

Carcinogenesis2

Levels1

Studies2