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  • apical dendritic
  • These results confirm the hypothesis that the broad spikes of MG cells originate in the soma and propagate through the molecular layer in the apical dendritic tree, and suggest the possibility that this backpropagation may contribute to `boosting' of the synaptic response in distal apical dendrites in certain circumstances. (biologists.org)
  • AMPA
  • Predictions were made for passive-cell current clamp recordings, combined AMPA and NMDA receptor responses, and local dendritic depolarization in response to unitary stimulations. (springer.com)
  • inhibition
  • Experimental work using pharmacological manipulations of the in vitro hippocampal slice preparation found that the 40 Hz-range field potential oscillations evoked under different circumstances exhibited different reliance on synaptic excitation and inhibition. (jneurosci.org)
  • The linear pulse to wave transfer function transforms the action potential density of the presynaptic population to the average inhibition or excitation at the postsynaptic population. (scholarpedia.org)
  • First, blocking GABA A receptor-mediated synaptic inhibition caused excitation to spread laterally throughout wide regions of layer 2/3 and layer 5 but not into neighboring barrels, suggesting that the local excitatory connections within layer 4 are restricted to single barrels and that inhibitory neurons control spread in supragranular and infragranular layers. (jneurosci.org)
  • Half of all amacrine cells are GABAergic inhibitory neurons that mediate lateral inhibition, and their light-evoked response consists of graded voltage changes and regenerative action potentials. (jove.com)
  • Thus understanding of how action potentials propagate in dendrites is important to elucidating the extent and strength of lateral inhibition. (jove.com)
  • Vivo
  • an endogenous pattern of action potential firing seen in these cells in vivo ( Ranck, 1973 ). (jneurosci.org)
  • Broad action potentials can be evoked in vivo by either corollary discharge input or electrosensory input, and in vitro by parallel fiber stimulation. (biologists.org)
  • We found that the α 2A -AR agonist guanfacine selectively inhibited this PBN input to the BNST, preferentially reducing the excitatory response in ex vivo mouse brain slices. (jneurosci.org)
  • amacrine cells
  • Receptive field properties of starburst cholinergic amacrine cells in the rabbit retina. (nih.gov)
  • Starburst amacrine cells did not display action potentials and the presence of a large, voltage-dependent outward current limited depolarizing responses to a maximum potential of about -40 mV. (nih.gov)
  • Propagation of Action Potentials from the Soma to Individual Dendrite of Cultured Rat Amacrine Cells is Regulated by Local GABA Input Journal of Neurophysiology. (jove.com)
  • In the present study, we used the dual whole cell patch-clamp technique on the soma and the dendrite of cultured rat amacrine cells and directly demonstrated that the action potentials propagate into the dendrites. (jove.com)
  • synaptically
  • Such regulation has been suggested to be driven by local, synaptically mediated, dendritic signals such as Ca 2+ . (physiology.org)
  • Single action potentials triggered synaptically or by somatic current injection immediately elevated Ca 2+ throughout the entire cell. (physiology.org)
  • TTX application in the deep fiber layer blocked the synaptically evoked ganglionic layer field potential and the `N 3 ' wave of the outer molecular layer field potential simultaneously, while the molecular layer `N 1 ' and `N 2 ' waves corresponding to synaptic activation of the apical dendrites remained intact. (biologists.org)
  • transients
  • Sorensen and Rubel 2006 ), leading to the suggestion that activity-dependent Ca 2+ transients could mediate such fine-tuning of dendritic properties. (physiology.org)
  • vitro
  • Using this technique in an ` in vitro ' interface slice preparation, we found that following either parallel fiber stimulation or an orthogonal field stimulus, a sink appeared in the ganglionic layer and propagated into the molecular layer. (biologists.org)
  • responses
  • However, the integration of responses within multiple dendritic and somatic compartments, with different specific membrane properties, suggests complex computational mechanisms that are still poorly understood. (biologists.org)
  • slices
  • In slices from these mice, we found that guanfacine enhanced, rather than suppressed, optogenetically initiated excitatory drive in BNST. (jneurosci.org)
  • structures
  • Electrical potential changes related to brain activity measured at the scalp by EEG are fundamentally limited by the distortive effects of the intervening structures, which severely hamper efforts to localise the signal source precisely. (bmj.com)
  • reversal
  • The centre light response had a linear current-voltage relation with a reversal potential close to 0 mV. (nih.gov)
  • precise
  • Owing to the importance of Wnt signaling in a wide range of biological fields, a better understanding of the precise mechanism of Wnt signaling might provide fundamental insights regarding its role in disease development and may provide novel targets for therapeutic applications. (hindawi.com)
  • temporal
  • This study evaluated a mouse model of temporal lobe epilepsy to test which pathological changes in the dentate gyrus correlate with seizure frequency and help prioritize potential mechanisms for further study. (stanford.edu)