Postsynaptic density plasticity dendritic field excitatory postsynaptic potentials. Medical search. Frequent questions

However, in all areas, dendritic synthesis of proteins is necessary for late long-term potentials in the hippocampal neurons. (wikipedia.org)
Usually curtailed by the hyperpolarizing local inhibition (due to the excitatory collateral system), this can lead to gradual recruitment of CA3 neurons and result in synchronized burst discharges. (wikipedia.org)
His work in the fields of Dendritic spine, such as Dendritic filopodia, overlaps with other areas such as Actin remodeling of neurons. (research.com)
In general Dendritic spine, his work in Dendritic filopodia is often linked to Actin remodeling of neurons, Actin remodeling and Plasma membrane Ca2+ ATPase linking many areas of study. (research.com)
His study in the fields of Axon, Cortical neurons and Phosphorylation under the domain of Cell biology overlaps with other disciplines such as Ubiquitin and Structured illumination microscopy. (research.com)
Information transmission in neural networks is often described in terms of the rate at which neurons emit action potentials. (frontiersin.org)
The adult hippocampus continuously generates new cohorts of immature neurons with increased excitability and plasticity. (jneurosci.org)
Our findings reveal a novel type of activity-dependent plasticity acting on the timing of neuronal maturation and functional integration of newly generated neurons along the longitudinal axis of the adult hippocampus. (jneurosci.org)
Our results reveal that CC connections are selectively wired to form monosynaptic excitatory loops and support a differential role of supragranular and infragranular neurons in hierarchical recurrent computations. (elifesciences.org)
One possibility is that CC inputs specifically modulate neurons projecting back to the source of those inputs (looped neurons) indirectly via intermediary inhibitory or excitatory cells in the local circuit. (elifesciences.org)
Another possibility, not mutually exclusive to the previous one, is that CC projections selectively synapse onto looped neurons directly to form interareal monosynaptic loops, which would be excitatory since most long-range cortical afferents are glutamatergic. (elifesciences.org)
Thus, long-range CC projections could selectively participate in excitatory monosynaptic loops by preferentially contacting looped IT neurons, while avoiding neighboring non-looped IT, PT, and CT neurons. (elifesciences.org)
Conversely, far from the soma the targets were mostly other excitatory neurons, about half of these being other HVC (RA) cells. (elifesciences.org)
Börgers C, Kopell N (2005) Effects of noisy drive on rhythms in networks of excitatory and inhibitory neurons. (yale.edu)
We found that the phosphorylation of isoform-specific sites in eEF1A2-an essential translation elongation factor in neurons-is a key modulator of structural plasticity in dendritic spines. (ibecbarcelona.eu)
FHM1 has a differential effect on short-term depression (STD) at TC synapses: compared to wild type (WT) mice, STD is greater at synapses contacting layer IV (L4) excitatory neurons while it is unaltered at synapses contacting L4 inhibitory neurons. (biomedcentral.com)
As a result, during repetitive thalamic firing, the gain-of-function of TC excitatory inputs on inhibitory neurons becomes larger than that on excitatory neurons and the I/E balance is relatively skewed towards inhibition in FHM1 L4 excitatory neurons [ 16 ]. (biomedcentral.com)
Donor embryonic cells have a greater potential for axonal outgrowth and regeneration than mature host neurons (Chen et al. (org.es)
Its biological implementation, however, is unclear and no reference to action selection or the postsynaptic neurons or even by local glia (Fig 5A and 5B). (stpancraschurch.org)

Using two-photon guided minimal stimulation in acute rat brain slices, we found that distal and proximal excitatory synapses onto granule cells are functionally distinct. (jneurosci.org)
Most excitatory synapses we examined onto granule cells activated both NMDARs and AMPA receptors, whereas a subpopulation appeared to be NMDAR silent. (jneurosci.org)
A , Schematic diagram of excitatory synapses onto granule cells. (jneurosci.org)
Dentate gyrus (DG) granule cells carrying homozygous mutation of L100P exhibit decreased synaptic excitation and intact synaptic inhibition, meanwhile Schaffer collateral-CA1 synapses of L100P mice display impaired synaptic plasticity. (biomedcentral.com)
Excitatory synapses in the brain, which use glutamate as the primary neurotransmitter, represent a crucial target for the action of stress and its mediators. (nature.com)
TSP binds to α2δ‐1 to drive the formation of excitatory synapses during development, suggesting that overactivation of this pathway may lead to exuberant excitatory synaptogenesis and network hyperexcitability seen in DCMs. (eneuro.org)
The FHM1 mouse model is consequently characterized by increased neurotransmission at both intra-cortical [ 15 ] and thalamocortical (TC) excitatory synapses [ 16 ]. (biomedcentral.com)
signalling at excitatory forebrain synapses Glutamatergic synapses are situated on dendritic propionate (AMPA) receptor subunit levels (NR1, NR2A, spines containing postsynaptic densities (PSDs), which NR2B, GluR1 and GluR2) were analysed in the forebrain by allow glutamate receptors to anchor through interactions both western blot of homogenates and immunohistochemis- with scaffolding proteins. (health-articles.net)
However, the climbing fibre input continuously exerts an activity-dependent repression on parallel fibre synapses, thus confining them to the distal Purkinje cell dendritic domain. (123dok.org)
Table 10 represents the distribution of synapses over the dendritic arborization of retinal TrkB-MO and p75-MO on contralaterally projecting axons, knockdown of TrkB did not experience excess apoptotic pressure. (stpancraschurch.org)
Because different subtypes of bipolar cells (Fig 1) (Euler and Wässle, 1995) and amacrine cells (Fig. 2) (MacNeil and Masland, 1998) have their axonal/dendritic terminals in the specific sublaminae of the IPL, it is crucial that dendrites of individual RGCs are also confined to specific strata in order to synapses with them. (org.es)
In mouse, the density of both ribbons and conventional synapses in the IPL continuously increases after eye opening and reaches the peak level by the age of P21 (Fig. 5B). (org.es)

Alexa 594-filled stimulating electrode positioned ∼20 μm from imaged dendritic region) reliably triggered Ca accumulations in two of the three imaged spines (sp1 and sp2) but not in the dendritic shaft segment. (jneurosci.org)
Synaptic plasticity involves structural modifications in dendritic spines that are modulated by local protein synthesis and actin remodeling. (ibecbarcelona.eu)
Activation of metabotropic glutamate receptor signaling triggered transient dissociation of eEF1A2 from its regulatory guanine exchange factor (GEF) protein in dendritic spines in a phosphorylation-dependent manner. (ibecbarcelona.eu)
opment of dendritic spines begins with the formation of branes, we found increases of NR2A and GluR2 but not filopodia. (health-articles.net)
The latter represent were co-immunoprecipitated from postsynaptic densities the most mature and stable spines. (health-articles.net)
spine density and of large, mushroom-type spines. (health-articles.net)
Interestingly, Purkinje cells have the intrinsic ability to generate a high number of spines over their entire dendritic arborisations, which can be innervated by the parallel fibres. (123dok.org)
For example, in EphB1/ EphB2/EphB3-deficient mice dendritic spines (the small protru-sions bearing postsynaptic structures) have reduced density and size [3,7,8] while activation of EphB receptors by ephrins induces rapid dendritic spine formation [7,9]. (123dok.org)

Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. (ibecbarcelona.eu)
FHM1 mutations result in gain-of-function of recombinant human Ca V 2.1 channels and native neuronal Ca V 2.1 channels in FHM1 knock-in mice, causing the enhancement of action potential evoked Ca 2+ influx [ 12 , 13 , 14 , 15 ]. (biomedcentral.com)
Changes in the placement of cells within the network due to delays in neuronal migration, the absence of a full formation of dendritic arbors and spine upon which synaptic contacts are made, and the lagging of transmission of electrical impulses due to insufficient myelination will individually and cumulatively impair synaptic function. (aopwiki.org)
Since synaptogenesis follows the early neurodevelopmental processes such as neuronal and glial cells proliferation, migration, alterations in dendritic arborisation etc., therefore, it encompasses, possible changes in these early stages of brain development that could also be triggered under hypothyroidism, leading to defective synaptogenesis and resulting in abnormal function of neuronal network function. (aopwiki.org)
Intracerebral grafting presently remains an experimental model used to address fundamental questions concerning brain development, neuronal plasticity, regeneration and formation of topographic connections. (org.es)

α2δ-1 signaling drives apoptotic cell death, anatomic reorganization, excitatory synaptogenesis, astrocytosis, and network hyperexcitability in a model of insult-induced cortical malformation known as freeze lesion (FL). (eneuro.org)
Computational studies suggest that this shift is specifically due to enhanced cortical excitatory transmission. (biomedcentral.com)
A paper recently published by eLife on forebrain cortical synaptic plasticity reports that retinoic acid (RA) alters synaptopodin-dependent metaplasticity in mouse dentate granule cells (Lenz et al. (preprints.org)
Here we demonstrate that this can be achieved by a well-established model of cortical self-organization based on a well-orchestrated interplay between several plasticity processes. (preprints.org)

Richard J. Weinberg focuses on Neuroscience, Cell biology, Postsynaptic density, Dendritic spine and Synapse. (research.com)
Neuroscience, Synapse, Dendritic spine, Cell biology and Synaptic plasticity are his primary areas of study. (research.com)
Here, we used mice with a genetic deletion of α2δ‐1 to determine how α2δ‐1 contributes to cell death, elevated excitatory synapse number, and in vitro network function after FL and to examine the molecular specificity of GBP's effects. (eneuro.org)
We also find that GBP can reduce FL-induced increases in excitatory synapse number in α2δ-1 knock-out (KO) mice, indicating GBP has α2δ-1-independent anti-synaptogenic effects. (eneuro.org)
The molecular mechanisms that underpin synapse formation and plasticity. (edu.au)
the parallel fibres contact the distal dendritic domain, where synapse and spine density is high. (123dok.org)
In the retina, RGCs synapse with bipolar and amacrine cells in the inner plexiform layer (IPL) to receive excitatory and inhibitory synaptic inputs respectively. (org.es)

Markram's research has focused on synaptic plasticity and the microcircuitry of the neocortex, in which he has discovered fundamental principles governing synaptic plasticity and the structural and functional organization of neural microcircuitry. (epfl.ch)
Furthermore, they maintain a remarkable presence in the adult brain, especially in regions characterized by a high degree of structural plasticity in adulthood, such as the hippocampus, olfactory bulb and cerebellum [2,4-6]. (123dok.org)

These cells undergo synchronous and paroxysmal depolarizations, firing short sequences of action potentials called bursts. (wikipedia.org)
Calcium entry into the cell causes more prolonged depolarization and increased action potentials. (wikipedia.org)

Recent studies in the hippocampus and cerebral cortex show that Eph receptors and ephrins are important in the regulation of synaptic morphology and plasticity. (123dok.org)

Our findings suggest that the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice. (biomedcentral.com)

Future directions include the clarification of the pathways of synaptic plasticity in the whole brain network following neuromodulation after stroke, and investigation of the different roles of distinctive cell populations in neural plasticity enhancement. (bnmjournal.com)

Primary apical dendrites remain poorly branched until they reach the ML, where they become extensively branched and receive excitatory synaptic inputs from the medial and lateral EC. (biomedcentral.com)

In contrast, the latter remain in the inner third of the GCL (near the hilus) and, depending on their degree of maturation, they show dendritic trees of variable complexity [ 15 ]. (biomedcentral.com)
The timing of Met expression is linked to axon terminal outgrowth and synaptogenesis in the developing rodent and primate forebrain, and both in vitro and in vivo studies implicate this RTK in dendritic branching, spine maturation, and excitatory connectivity in the neocortex. (biomedcentral.com)

Although the dendritic arborization of granule cells is relatively small (50-200 μm) ( Shepherd and Greer, 1998 ), a single granule cell may receive synaptic inputs from mitral cells several millimeters away ( Shepherd and Greer, 1998 ), providing a theoretical basis for massive synaptic divergence. (jneurosci.org)

Spectral analysis of the local field potentials revealed an increase in the β/low γ range of WT mice following the abrupt reversal of contrast gratings. (biomedcentral.com)

The convergence of two types of excitatory inputs onto GABAergic granule cells provides a novel mechanism for regulating the degree of interglomerular processing of sensory input in the olfactory bulb through piriform cortex/olfactory bulb synaptic interactions. (jneurosci.org)
These results suggest that the proximal excitatory inputs to granule cells may play an important role in gating recurrent and lateral dendrodendritic inhibition (DDI) in the olfactory bulb. (jneurosci.org)
Cerebellar Purkinje cells are innervated by two different excitatory inputs. (123dok.org)

A single surface shock of the cerebral cortex induces a 10-20 ms negative potential, a manifestation of the summed excitatory post-synaptic potentials (EPSPs) evoked in the distal portions of the apical dendrite. (wikipedia.org)

His work carried out in the field of Neuroscience brings together such families of science as Glutamate receptor, AMPA receptor and Synaptic plasticity. (research.com)
Positive allosteric modulators of α-amino-3-hydroxyl-5-methyl-4-isoxazole- propionate (AMPA)-type glutamate receptors ("ampakines" and functionally related compounds) constitute a relatively new class of psychoactive drugs that enhance fast, excitatory transmission in the brain. (escholarship.org)
After eye opening, a surge of glutamate receptor-mediated spontaneous excitatory postsynaptic currents (sEPSCs) and GABA/glycine receptor-mediated spontaneous inhibitory postsynaptic currents emerges around P25 (Fig. 5B). (org.es)

Injury to the brain areas concerned with vision can cause a variety of disorders ranging from visual field defects to much more complex deficits like visual agnosia. (org.es)

Expression of a nonphosphorylatable eEF1A2 mutant stimulated mRNA translation but reduced actin dynamics and spine density. (ibecbarcelona.eu)
When electrical activity is blocked in vivo by tetrodotoxin leading to a high spine density in Purkinje cell proximal dendrites, stimulation of Eph receptor activation recapitulates the spine repressive effects of climbing fibres. (123dok.org)

As a part of the same scientific family, Richard J. Weinberg mostly works in the field of Excitatory postsynaptic potential, focusing on Neurotransmission and, on occasion, Glutamatergic. (research.com)

L100P mutant slices exhibit decreased excitatory synaptic transmission (sEPSCs and mEPSCs) in dentate gyrus (DG) and impaired long-term potentiation in the CA1 region of the hippocampus. (biomedcentral.com)

His Synaptic plasticity research is multidisciplinary, incorporating elements of Long-term potentiation, Perineuronal net, Hippocampus and Forebrain. (research.com)

Based on the fact that seizure activity is frequently associated with autism and that abnormal evoked potentials have been observed in autistic individuals in response to tasks that require attention, several investigators have recently proposed that autism might be caused by an imbalance between excitation and inhibition in key neural systems including the cortex. (neurotransmitter.net)

6.4 Development of retinal ganglion cell dendritic structure and synaptic connections. (org.es)

Memory tests showed mild to a strong improvement in memory function, increased expression levels of postsynaptic density protein 95 (PSD95), and low-density lipoprotein receptor-related protein 1 (LRP1), which are involved in synaptic plasticity and amyloid-beta (Aβ) elimination, respectively. (biomedcentral.com)

It appears that the acupuncture stimulus affects the density over time of NMDA receptors and that this affects the patient's perception of pain. (aahclinic.com)
Several reports have shown modulation of Cys-loop receptors by phytocannabinoids and endocannabinoids independent of cannabinoid receptors with potential physiological or therapeutic consequences. (researchgate.net)

His Dendritic spine study integrates concerns from other disciplines, such as Cerebral cortex, Striatum and Biological neural network. (research.com)

This developmental remodeling of RGC dendrites is thought to play an important role in synaptogenesis and the formation of lamina-restricted dendritic distributions of RGCs. (org.es)

His work on SHANK2 and Disks Large Homolog 4 Protein as part of his general Postsynaptic density study is frequently connected to Actin cytoskeleton, thereby bridging the divide between different branches of science. (research.com)
Elevated intracellular Ca 2+ can activate the transcription factor cyclic AMP response element binding protein (CREB), thereby potentially initiating the expression of genes that are important for synaptic plasticity, neurite growth and dendritic spine development [ 20 - 22 ]. (biomedcentral.com)

These results further support a unifying hypothesis for ultrasonic neuromodulation, highlighting the potential of advanced waveform design for obtaining cell-type-selective network control. (eneuro.org)
The review focuses on discussing the neuroplastic mechanisms of those brain stimulation techniques in stroke rehabilitation, also including some new options for neuromodulation which have great potential in stroke rehabilitation, such as optogenetic stimulation and environmental stimulation. (bnmjournal.com)

In the adult vertebrate brain, enzymatic removal of the extracellular matrix (ECM) is increasingly recognized to promote learning, memory recall, and restorative plasticity. (nature.com)
During learning processes in the developing and adult brain, variability of ECM densities and dynamic remodeling has been shown to support learning-dependent plasticity 14 , 15 . (nature.com)
In this regard, developmentally generated DGCs are preferentially located in the outer GCL (in close contact with the ML) and show wider dendritic angles and more primary dendrites than adult-born DGCs. (biomedcentral.com)
In the developing brain, they act as migratory and cell adhesive cues while in the adult brain they regulate dendritic spine plasticity. (123dok.org)
2021). However, the results reported here and those reported by others have not shown that endogenous RA is normally required for synaptic plasticity (or any other nongenomic effect) as there are no reports of genetic loss-of-function studies that remove endogenous RA in adult brain. (preprints.org)
Most of these RGCs have specific dendritic distribution in the IPL in adult retina as exemplified by the schematic (Figure 4) showing the branching patterns of mouse RGCs. (org.es)

We recorded extracellular field potentials from the primary visual cortex (V1) of head-fixed awake FHM1 knock-in ( n = 12) and wild type ( n = 12) mice in response to square-wave gratings with different visual contrasts. (biomedcentral.com)
FHM1 mice displayed similar amplitude but slower temporal evolution of visual evoked potentials. (biomedcentral.com)
In each of these mice we have inactivated the genes that encode for synaptic signalling molecules, such as agrin and laminins, or molecules that are needed to cluster ion channels in the postsynaptic membranes of muscles and/or neurones, such as rapsyn and gephyrin. (edu.au)
To address this gap in knowledge, we investigated the potential effects of chronic unpredictable mild stress (CUMS) on ApoE3 and ApoE4 target replacement (ApoE3-TR and ApoE4-TR) mice. (biomedcentral.com)

After a lesion, the density of cells containing tenascin-R transcripts increased significantly in the inferior olivary nucleus and in the white matter of the cerebellar cortex. (researchgate.net)
Injury to the occipital striate cortex results in corresponding homonymous visual field defects where typically all visual capacities are lost in the fields. (org.es)

More than 30% of dendritic filapodial branches in the mouse are replaced every hour by continuous dendritic growth and elimination (pruning) between P10-13 (see Fig 6 and movie 1). (org.es)

Taken together, these findings revealed the E/I synaptic abnormalities in the amygdala from two generations of the VPA-induced offspring with GABAergic deteriorations in the F2 generation, suggesting a potential therapeutic role of the GABAergic system to generational pathophysiology of ASD. (biomedcentral.com)

Individual pyramidal cells in the CA3 region have burst properties due to high densities of calcium channels in their proximal dendrites. (wikipedia.org)

As local cell density increases, tensile forces on E-cadherin adhesions are reduced, which prompts the accumulation of the G2 checkpoint kinase Wee1 and downstream inhibitory phosphorylation of Cdk1. (ibecbarcelona.eu)

This alteration persists throughout AD progression and leads to generalized dendritic atrophy at late stages of the disease. (biomedcentral.com)

In most mammals, RGCs can be divided into about 20 morphological subtypes based on their distinctive dendritic structure and synaptic connections (Kolb et al. (org.es)

The apical dendrites in these regions contribute significantly to memory, learning, and sensory associations by modulating the excitatory and inhibitory signals received by the pyramidal cells. (wikipedia.org)
Proximal apical dendrites and basal dendrites have approximately the same density. (wikipedia.org)

Neuromorphic sensory-processing systems provide an ideal context for exploring the potential advantages of temporal coding, as they are able to efficiently extract the information required to cluster or classify spatio-temporal activity patterns from relative spike timing. (frontiersin.org)
Using laminar current-source density (CSD) analysis, we found layer-specific changes of the spatiotemporal synaptic patterns with increased cross-columnar integration and simultaneous weakening of early local sensory input processing within infragranular layers Vb. (nature.com)

This and the lower maximum branch order suggest lower complexity than apical dendritic trees. (wikipedia.org)

Here, we show that epithelial cells sense local cell density through mechanosensitive E-cadherin adhesions to control G2/M cell-cycle progression. (ibecbarcelona.eu)

Richard J. Weinberg mainly investigates Cell biology, Postsynaptic density, Neuroscience, Postsynaptic potential and Excitatory postsynaptic potential. (research.com)
His studies deal with areas such as Immunocytochemistry, Postsynaptic potential and Biochemistry as well as Cell biology. (research.com)
Richard J. Weinberg mostly deals with Neuroscience, Cell biology, Inhibitory postsynaptic potential, Nerve net and Synaptic plasticity. (research.com)

Anatomy77

Organisms19

Diseases2

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Psychiatry and Psychology7

Phenomena and Processes39

Disciplines and Occupations3

Information Science4

Health Care2

Neurons19

Synapses12

Spines8

Neuronal5

Cortical4

Synapse7

Structural2

Action potentials2

Morphology1

Hippocampal1

Neural Plasticity1

Receive excitatory1

Maturation2

Synaptic inputs1

Local field pote1

Inputs3

Distal1

Glutamate3

Deficits1

Spine density2

Glutamatergic1

SEPSCs1

Forebrain1

Abnormal1

Retinal1

PSD951

Receptors2

Cerebral cortex1

Synaptogenesis1

Protein2

Neuromodulation2

Adult6

Mice4

Cortex2

Branches1

GABAergic1

Proximal dendrites1

Increases1

Persists1

Distinctive1

Dendrites2

Sensory2

Complexity1

Progression1

Cell3