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  • synapse
  • The precise contribution of the cadherin-β-catenin synapse adhesion complex in the functional and structural changes associated with the pre- and postsynaptic terminals remains unclear. (pnas.org)
  • cytoskeleton
  • The normal glutamatergic synaptic response is maintained by postsynaptic β-catenin in a cadherin-dependent manner and requires the C-terminal PDZ-binding motif of β-catenin but not the link to the actin cytoskeleton. (pnas.org)
  • sides
  • Hence, the intracellular actions of the cadherin-catenin complex could be regulated independently at the pre- and postsynaptic sides of the synaptic junction. (pnas.org)
  • Molecular
  • Little is known about the molecular pathway(s) involved, nor is it clear which aspect of "activity"-local synaptic signaling, postsynaptic firing, or large-scale changes in network activity-is required to induce synaptic scaling. (nih.gov)
  • sites
  • It was clustered at postsynaptic sites in the outer plexiform layer (OPL) and inner plexiform layer (IPL), and weak extrasynaptic expression was found in bipolar cells and ganglion cell axons. (jneurosci.org)
  • cell
  • However, the mechanism by which a single presynaptic volley elicits a long lasting burst of impulses in the postsynaptic cell has not yet been satisfactorily explained, and was the object of our investigation. (jneurosci.org)
  • Electron microscopy showed that PSD-95 was concentrated in processes that were postsynaptic at bipolar cell ribbon synapses (dyads). (jneurosci.org)
  • results
  • Our results show that the different loci of normalization can result in drastic differences in the model's behavior, suggesting that future experiments should investigate presynaptic factors of redistribution as well as the more widely studied postsynaptic factors. (utexas.edu)