Postprandial glucose alpha glucosidases. Medical search. Frequent questions

Vogilbose was discovered in 1981, and was first launched in Japan in 1994, under the trade name BASEN, to improve postprandial hyperglycemia in diabetes mellitus. (wikipedia.org)
Postprandial hyperglycemia (PPHG) is primarily due to first phase insulin secretion. (wikipedia.org)
This enzyme inhibition results in delayed glucose absorption and a lowering of postprandial hyperglycemia and thus may prevent reactive hypoglycemia. (medscape.com)
Postprandial hyperglycemia is also one of the earliest abnormalities of glucose homeostasis associated with type 2 diabetes and is markedly exaggerated in diabetic patients with fasting hyperglycemia. (diabetesjournals.org)
However, many questions remain unanswered regarding the definition of PPG and, perhaps most importantly, whether postprandial hyperglycemia has a unique role in the pathogenesis of diabetic complications and should be a specific target of therapy. (diabetesjournals.org)
Synthetic alpha-amylase and alpha-glucosidase inhibitors can improve blood glucose control in diabetic patients by effectively reducing the risk of postprandial hyperglycemia. (bvsalud.org)
In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia. (drugs-library.com)
Once the activity of alpha-glucosidase is reduced, the complex carbohydrates breakdown and glucose absorption are slowed down as well - it leads to the reduction of postprandial blood glucose level, also known as postprandial hyperglycemia. (unitedpharmacies-uk.md)
This helps to prevent a sudden surge in blood glucose occurring after the consumption of a meal (postprandial hyperglycemia). (si1denafilfored.com)
Pancreatic alpha (α)-amylase and intestinal α-glucosidase involved in the enzymatic breakdown of dietary carbohydrates are implicated in postprandial hyperglycemia. (academicjournals.org)
Dietary carbohydrates are broken down to simple sugars by the action of α-glucosidase and α-amylase and these enzymes are the primary and most promising targets of medical intervention to reduce hyperglycemia [ 5 , 6 ]. (jabonline.in)
Diabetes mellitus is an endocrine condition in which patients have elevated blood glucose levels (hyperglycemia). (myendoconsult.com)
Glucose accumulates in the serum causing hyperglycemia. (nurseslabs.com)
Diabetes can be managed by controlling postprandial hyperglycemia which can be achieved by inhibiting carbohydrate hydrolyzing enzymes like α-amylase and α-glucosidase. (arjournals.org)
The glycemic elemental profile further validates their role in controlling diabetes and hence C. maxima seeds could be explored as a potential herbal candidate for managing postprandial hyperglycemia causing type 2 diabetes mellitus. (arjournals.org)
Inhibitory effect of pine extract on α-glucosidase activity and postprandial hyperglycemia. (arjournals.org)
Current treatment strategies involve either preventing or delaying the intestinal absorption of glucose to lower the levels of postprandial hyperglycemia (PPHG). (ac.ir)
It may be started at a high dose in patients with severe hyperglycemia and in those with symptoms, if home glucose monitoring and close follow-up can be arranged. (medscape.com)

Alpha glucosidase inhibitors delay glucose absorption at the intestine level and thereby prevent sudden surge of glucose after a meal. (wikipedia.org)
A Cochrane systematic review assessed the effect of alpha-glucosidase inhibitors in people with impaired glucose tolerance, impaired fasting blood glucose, elevated glycated hemoglobin A1c (HbA1c). (wikipedia.org)
In many patients, use of alpha-glucosidase inhibitors (acarbose and miglitol) may help. (medscape.com)
Acarbose, miglitol are alpha-glucosidase inhibitors. (diabetescrunch.com)
Alpha-glucosidase inhibitors stop the enzymes in the small intestine from digesting starches. (diabetescrunch.com)
Peptides of natural origin are promising compounds that can serve as alpha-glucosidase inhibitors in the treatment of type 2 diabetes. (bvsalud.org)
It belongs to the group of medications known as alpha-glucosidase inhibitors. (lifevisionhealthcare.com)
Studies suggest that Salacia Reticulata may have a similar effect to medications used to treat diabetes, such as alpha-glucosidase inhibitors. (igelsparks.com)
The optimal conditions for microcapsules formation were selected based on the activity of microcapsules as inhibitors for the alpha-amylase enzyme, pointing out by the lowest number of IC 50 . (ugm.ac.id)
α-glucosidase inhibitors do not stimulate insulin release and therefore do of absorption and slightly delays absorption. (aboutdrugspdf.com)
Acarbose belongs to a class of drugs called alpha-glucosidase inhibitors. (verifiedmarketresearch.com)
Van de Laar FA, Lucassen PL, Akkermans RP, van de Lisdonk EH, Rutten GE and van Weel C. α-Glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis. (arjournals.org)

In the management of diabetes, health care providers usually assess glycemic control with fasting plasma glucose (FPG) and premeal glucose measurements, as well as by measuring HbA 1c . (diabetesjournals.org)
therefore, PPG concentrations refer to plasma glucose concentrations after eating. (diabetesjournals.org)
In nondiabetic individuals, fasting plasma glucose concentrations (i.e., following an overnight 8- to 10-h fast) generally range from 70 to 110 mg/dl. (diabetesjournals.org)
The magnitude and time of the peak plasma glucose concentration depend on a variety of factors, including the timing, quantity, and composition of the meal. (diabetesjournals.org)
In nondiabetic individuals, plasma glucose concentrations peak ∼60 min after the start of a meal, rarely exceed 140 mg/dl, and return to preprandial levels within 2-3 h. (diabetesjournals.org)
Fasting plasma glucose should be reduced to 60-70 mg/dl (3.3-3.9 mmol/L). (diabetescrunch.com)
Metformin improves glucose tolerance in patients with type-2 diabetes lowering both basal and postprandial plasma glucose. (genericbucket.com)
During treatment initiation and dose titration (see below), one-hour postprandial plasma glucose may be used to determine the therapeutic response to PRECOSE and identify the minimum effective dose for the patient. (drugs.com)
The therapeutic goal should be to decrease both postprandial plasma glucose and glycosylated hemoglobin levels to normal or near normal by using the lowest effective dose of PRECOSE, either as monotherapy or in combination with sulfonylureas, insulin or metformin. (drugs.com)
As a consequence of plasma glucose reduction, acarbose tablets reduce levels of glycosylated hemoglobin in patients with type 2 diabetes mellitus. (drugs-library.com)
The combined effects of diabetes mellitus (DM), admission plasma glucose (APG), and glycated hemoglobin (HbA1c) levels on predicting long-term clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) are unknown. (biomedcentral.com)
DM, admission plasma glucose (APG), and HbA1c levels are associated with clinical outcomes in patients with CVD. (biomedcentral.com)
the post- schedules, steady state plasma concentrations are reached within 24 to 48 hours and are prandial rise in plasma glucose is blunted in both normal and diabetic subjects resulting in generally less than 1 µg/ml. (aboutdrugspdf.com)
Acarbose acts non-systemically to slow down carbohydrate digestion and attenuates high levels of postprandial plasma glucose (PPG) is an essential manifestation in the early course of type 2 diabetes mellitus (T2DM) and a critical target for achieving glycemic control. (verifiedmarketresearch.com)
There are two other tests that have long been used for diagnosing diabetes: a fasting plasma glucose (FPG) of 126 mg/dL (7.0 mmol/L) or above and a 2-hour oral glucose tolerance test (OGTT) with a glucose of 200 mg/dL (11.1 mmol/L) or above. (myendoconsult.com)

Our findings suggest that CR has the greatest potential to possibly manage post-prandial blood glucose levels via the inhibition of alpha-glucosidase, and that the effect is through synergistic activity of the extract's phenolic compounds. (cranberryinstitute.org)
Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with type 2 diabetes mellitus. (genericbucket.com)
Mulberry leaf extracts are widely consumed in Asia for normalizing post-prandial blood glucose. (tastermonial.com)
As the base for Diabliss Sugar is cane Sugar, it tastes and processes like sugar but with lower post prandial blood glucose spiking. (powstik.com)
It is used in the management of type 2 diabetes mellitus along with diet and exercise to improve post-prandial blood glucose levels (when only diet and/or exercise or oral hypoglycemic drugs or insulin preparation in addition to diet and/or exercise does not result in adequate glycemic control). (netmeds.com)

Global transition over the last 50 years to a modern, sedentary lifestyle, combined with a shift toward processed-food diets higher in calories, carbohydrates, and saturated fat, are contributing to a concerning worldwide epidemic of impaired glucose tolerance. (bioactivesamerica.com)
Clinicians now understand that impaired glucose tolerance (IGT) is a predictor of diabetes in people with above-normal blood glucose and that addressing IGT can prevent or reverse the onset of the disease. (bioactivesamerica.com)
Acarbose has been shown to delay progression to type 2 diabetes in subjects with impaired glucose tolerance (IGT) and can reduce the risk of developing cardiovascular events in IGT subjects and type 2 diabetics. (verifiedmarketresearch.com)

Voglibose (INN and USAN, trade name Voglib, marketed by Mascot Health Series) is an alpha-glucosidase inhibitor used for lowering postprandial blood glucose levels in people with diabetes mellitus. (wikipedia.org)

The PPG profile is determined by carbohydrate absorption, insulin and glucagon secretion, and their coordinated effects on glucose metabolism in the liver and peripheral tissues. (diabetesjournals.org)
Since people with type 1 diabetes have no endogenous insulin secretion, the time and height of peak insulin concentrations, and resultant glucose levels, are dependent on the amount, type, and route of insulin administration. (diabetesjournals.org)
The term "glucose toxicity" is used to describe the situation where beta cells are damaged by chronically high blood glucose concentrations, suppressing insulin secretion. (vin.com)
A common view states that GLP-1 secretion in patients with type 2 diabetes is deficient and that this Dipeptidyl peptidase applies to a lesser degree in individuals with impaired Gastric inhibitory polypeptide glucose tolerance. (medicinelakex1.com)
This review summarises theliterature on this topic, including a meta-analysis of published studies on GLP-1 secretion in individuals with and withoutdiabetes after oral glucose and mixed meals. (medicinelakex1.com)
Our analysis Incretins are gut-derived hormones that can stimulate insulin does not support the contention of a generalised defect in secretion and make a significant contribution to overall nutrient-related GLP-1 secretory responses in type 2 diabetes postprandial insulin release One of them, glucagon- patients. (medicinelakex1.com)
Insulin secretion decreases and hormones that promote higher blood glucose levels, such as glucagon, cortisol, growth hormone and epinephrine, all increase. (findmeacure.com)
Nateglinide is an amino acid derivative that stimulates insulin secretion from the pancreas (within 20 minutes of oral administration), which, in turn, reduces blood glucose levels. (medscape.com)

VOGLIBOSE is a member of the alpha-glucosidase inhibitor class of anti-diabetic drugs used to treat type-2 diabetes mellitus. (lifevisionhealthcare.com)
Acarbose tablets are an oral alpha-glucosidase inhibitor for use in the management of type 2 diabetes mellitus. (drugs-library.com)

Green tea (GT), cranberry (CR), and tart cherry extracts were evaluated for their ability to inhibit yeast alpha-glucosidase, relevant to glucose uptake. (cranberryinstitute.org)
Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. (genericbucket.com)
Pinapababa ng corosolic acid ang mga antas ng asukal sa dugo sa pamamagitan ng pagtaas ng sensitivity ng insulin, pagpapahusay ng glucose uptake, at pagpigil sa alpha-glucosidase - isang enzyme na tumutulong sa pagtunaw ng mga carbs. (hotgoods.asia)
Another study suggests C3R could inhibit the glucose uptake in Caco-2 cells [ 19 ]. (biomedcentral.com)
However, in type 2 diabetes, these intracellular reactions are diminished, making insulin less effective at stimulating glucose uptake by the tissues and at regulating glucose release by the liver. (nurseslabs.com)
It reduces hepatic glucose output, may decrease intestinal absorption of glucose, and may increase glucose uptake in peripheral tissues. (medscape.com)

Blood Glucose Control - Voglibose is an alpha-glucosidase inhibitor, which help in slows down the absorption and digestion of carbohydrates in the intestine. (lifevisionhealthcare.com)
The aqueous leaf extract of V. doniana was the strongest inhibitor of α-amylase with half-maximal inhibitory concentration (IC50) of 3.09 ± 0.22 mg/ml while the ethanol leaf extract was the strongest inhibitor of α-glucosidase with IC50 of 17.12 ±1.42 mg/ml. (academicjournals.org)
Acarbose is an alpha-glucosidase inhibitor that decreases intestinal absorption of carbohydrates and is used as adjunctive therapy in the management of type 2 diabetes. (verifiedmarketresearch.com)

1-DNJ naturally inhibits alpha-glucosidase enzyme delaying the absorption of carbohydrates in the small intestine and thus have a lowering effect on postprandial blood glucose and insulin levels. (greensilk.com)
It is a starch blocker and inhibits alpha-glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates. (verifiedmarketresearch.com)
The in vitro studies against α-glucosidase enzyme was evaluated for C1 and C2 (IC 50 values of 7.31 ± 0.12 and 7.80 ± 0.93 µg/ml, respectively) which revealed a mixed type inhibition and entailed two inhibition constants viz. (jabonline.in)
A significant amount of excess glucose enters the polyol pathway and involves aldose reductase (AR) enzyme for its conversion to sorbitol, which accumulates resulting in impairment in the membrane permeability and leads to the microvascular and cardiovascular complications [ 7 ]. (jabonline.in)
1 unit is defined as the amount of enzyme required to release 1 µmol p -nitrophenyl (in the presence of excess quantities of α-glucosidase) in 1 min at 40°C. In the present study, 15 laboratories analyzed 16 samples as blind duplicates. (megazyme.com)

The anti-CD3 monoclonal antibody teplizumab can delay progression to symptomatic type 1 diabetes in patients who are presymptomatic and have mild glucose elevations and autoantibodies. (msdmanuals.com)
Modern treatments for diabetes mellitus, often known as type 2 or type 1 diabetes, are mostly centered on the use of prescription medicines to reduce blood glucose levels. (diabetescrunch.com)
Pramlintide, a synthetic derivative of amylin, is an injectable antihyperglycemic drug that regulates postprandial glucose levels in people with type 1 and types 2 diabetes . (diabetescrunch.com)
Diabetes mellitus is a serious metabolic disorder characterized by abnormal blood glucose levels in the body. (bvsalud.org)
A medical condition called diabetes is characterized by blood glucose levels that are elevated. (lifevisionhealthcare.com)
Voglibose can help patients with diabetes mellitus who have been taking additional diabetic medications to lower their high postmeal glucose levels. (lifevisionhealthcare.com)
There are several benefits of the Voglibose Tablet, its main role is to maintain blood glucose levels in people who suffer from type 2 diabetes. (lifevisionhealthcare.com)
Voglibose can assist in reducing HbA1c levels, a crucial marker of long-term glucose control, when used as a part of a comprehensive diabetes management plan. (lifevisionhealthcare.com)
The costs associated with managing blood glucose levels and controlling diabetes are daunting. (bioactivesamerica.com)
But when insulin production becomes inefficient and the body cannot produce enough to maintain normal blood glucose levels, the patient develops insulin resistance, or type 2 diabetes. (bioactivesamerica.com)
The S. oblonga species has been the subject of several clinical studies since 2005 demonstrating strong efficacy in reducing and controlling blood glucose levels in both healthy subjects and patients with type 2 diabetes. (bioactivesamerica.com)
In India, it is popularly known as insulin plant due to the consumption of leaves of Costus igneus helps to prevent diabetes mellitus by decreasing the blood glucose level. (ijpsr.com)
Tumutulong na maiwasan ang postprandial blood sugar spike sa mga may diabetes. (hotgoods.asia)
Taking measures to regulate blood glucose, blood pressure, and cholesterol levels can reduce potential complications associated with diabetes. (thepleasantgroveway.com)
The fundamental aspect of diabetes involves the interaction of blood sugar, insulin, and glucose regulation. (thepleasantgroveway.com)
Hence, maintaining glucose levels is fundamental for the overall health and well-being of individuals with diabetes. (thepleasantgroveway.com)
Gestational diabetes mellitus is characterized by glucose intolerance of any degree that occurs during pregnancy. (nurseslabs.com)

Glucose concentrations begin to rise ∼10 min after the start of a meal as a result of the absorption of dietary carbohydrates. (diabetesjournals.org)
Voglibose's main work is to regulate postprandial (after-meal) blood glucose levels by preventing certain intestine-based enzymes from dissolving complex carbohydrates into simple sugars (glucose). (lifevisionhealthcare.com)
Salacia Reticulata can lower blood sugar levels by altering carbohydrates' breakdown and glucose absorption in the intestine. (igelsparks.com)
Salacia Reticulata is said to inhibit the activity of enzymes responsible for breaking down carbohydrates into glucose in the digestive system. (igelsparks.com)
Acarbose is a complex oligosaccharide that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. (drugs-library.com)
Posmeal MD (Voglibose) helps reduce blood glucose level by blocking the intestinal alpha-glucosidase, which is one of the hydrolase enzymes and which are involved in breaking down such components of carbohydrates as saccharides, including disaccharides, oligosaccharides, and polysaccharides. (unitedpharmacies-uk.md)
It is defined as a disorder in which the body's ability to produce or respond to the hormone insulin is impaired, resulting in abnormal metabolism of carbohydrates and elevated levels of glucose in the blood. (ijpsr.com)
Insulin, a hormone produced by the pancreas, plays a pivotal role in the body's ability to use glucose from carbohydrates in food for energy or to store glucose for future use. (thepleasantgroveway.com)
These agents lower postprandial glucose by slowing glucose absorption and delaying the hydrolysis of ingested complex carbohydrates and disaccharide. (medscape.com)

These medications cause reversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. (medscape.com)
The ingredient "Voglibose" in VOGLIBOSE blocks the intestinal enzymes that convert complex sugars into simple sugars like glucose. (lifevisionhealthcare.com)
It is an anti-diabetic tablet and blocks the digestive enzymes that convert complex sugars into simple sugars like glucose. (lifevisionhealthcare.com)
These drugs inhibit absorption of intestinal enzymes such as maltase, isomaltase, and sucrase, which leads to reduced carbohydrate absorption and postprandial glycemia. (bioactivesamerica.com)
Salacia Reticulata functions by interacting with body enzymes and altering glucose metabolism. (igelsparks.com)
The antihyperglycemic action of acarbose results from a competitive, reversible inhibition of pancreatic alphaamylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. (drugs-library.com)
VOGIPAX 0.3MG TABLET works by inhibiting the intestinal enzymes that are responsible for breaking complex sugars into simple sugars such as glucose. (netmeds.com)
These interventions block the action of sucrase, amylase, and glucosidase, digestive enzymes responsible for the breakdown of various forms of carbohydrate. (foodtrients.com)
In vitro data supported the underlying mechanism and indicated that C3R might modulate postprandial glycemia by inhibiting carbohydrate digestive enzymes and decreasing glucose transport in the small intestine. (biomedcentral.com)
However, in a more established disease condition, mere control of the blood glucose levels does not suffice and requires a treatment comprising the inhibition of several other enzymes that are involved in the development of complications. (jabonline.in)
The blocking group in BPNPG7 prevents hydrolysis of this substrate by exo -acting enzymes such as amyloglucosidase, α-glucosidase, and β-amylase. (megazyme.com)
The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. (hindawi.com)
Mg, Ca, K and Na which are well known glycemic elements and hence could be responsible for inhibitory activity of carbohydrate hydrolyzing enzymes.Thus, α-amylase and α-glucosidase inhibitory action of C. maxima seeds would be responsible for their antidiabetic activity. (arjournals.org)

Therapeutic goals for HbA 1c and preprandial glucose levels have been established based on the results of controlled clinical trials. (diabetesjournals.org)
Even though glucose concentrations have returned to preprandial levels by 3 h, absorption of the ingested carbohydrate continues for at least 5-6 h after a meal. (diabetesjournals.org)
Oral antidiabetic medicines are medications that are used orally to lower blood glucose levels in diabetic individuals. (diabetescrunch.com)
The purpose of this oral medication is to get blood glucose levels back to normal. (diabetescrunch.com)
It lowers fasting blood glucose levels by 35-40 mg/dl (1.9-2.2 mmol/L). (diabetescrunch.com)
As a result, blood glucose levels don't spike sharply right after eating. (lifevisionhealthcare.com)
After meals, blood glucose levels rise slowly as a result, reducing the risk of unexpected blood sugar spikes. (lifevisionhealthcare.com)
thereafter, insulin and its receptors work to transfer the blood glucose to storage cells in the body, which brings blood sugar levels back to a normal range within a couple of hours. (bioactivesamerica.com)
While diet and exercise are important tools, researchers are also exploring additional alternatives for effectively controlling blood glucose levels, with a goal of helping to manage the disease and prevent its associated metabolic complications. (bioactivesamerica.com)
Mulberry leaf extract increases a beneficial hormone adiponectin , which regulates glucose levels, reduces fat accumulation, and lowers damaging inflammatory mediators. (greensilk.com)
It can offer various advantages such as reduction in glucose synthesis, improved insulin sensitivity, lower blood sugar levels, and decreased glycated hemoglobin levels. (igelsparks.com)
It can increase insulin sensitivity, facilitating glucose transportation and utilization, leading to healthy blood glucose levels. (igelsparks.com)
This results in a slower and more controlled release of glucose into the bloodstream, preventing spikes in blood sugar levels after meals. (igelsparks.com)
A study published in the Journal of Medicinal Food found that taking 240mg of Salacia Reticulata extract twice a day reduced fasting blood glucose levels by 8.7% over six weeks. (igelsparks.com)
Once a 25 mg t.i.d. dosage regimen is reached, dosage of PRECOSE should be adjusted at 4-8 week intervals based on one-hour postprandial glucose or glycosylated hemoglobin levels, and on tolerance. (drugs.com)
If no further reduction in postprandial glucose or glycosylated hemoglobin levels is observed with titration to 100 mg t.i.d., consideration should be given to lowering the dose. (drugs.com)
Systemic non-enzymatic protein glycosylation, as reflected by levels of glycosylated hemoglobin, is a function of average blood glucose concentration over time. (drugs-library.com)
1 An estimated 84 million adults-about 33.9%—have prediabetes, based on results of their fasting glucose and glycated hemoglobin levels (A1C). (ajmc.com)
According to 2007 data from the National Institutes of Health, 25% of Americans 20 years and older had abnormally high levels of glucose in the blood-a pre-diabetic state. (foodtrients.com)
Instead of absorbing and converting these sugars into higher than desired blood glucose levels, you may be able to safely eliminate many of these excess carbohydrate calories. (foodtrients.com)
These natural "carb-blockers" provide a practical approach to help lower glucose levels, improve age-related markers of health, and regain glycemic control. (foodtrients.com)
In animal models, L-arabinose virtually eliminates the rise in blood sugar following administration of sucrose, with blood glucose levels rising only 2% higher than in control animals that did not receive sucrose. (foodtrients.com)
L-arabinose did not exert any effect on serum glucose levels in control animals that did not receive sucrose. (foodtrients.com)
A study combining L-arabinose and white bean extract not only smoothed out postprandial glucose spikes and reduced insulin levels-it lowered systolic blood pressure. (foodtrients.com)
Blueberry fruit and leaf might affect blood glucose levels and could interfere with blood sugar control during and after surgery. (medlineplus.gov)
The brain then sends out messages that trigger a series of events, including changes in hormone and nervous system responses that are aimed at increasing blood glucose levels . (findmeacure.com)
They tested single doses of mulberry extract together with maltodextrin to test mulberry's ability to help control blood glucose levels. (plantmedicines.org)
On three test periods, the researchers found the mulberry helped control glucose levels by betwen 22 and 24 percent using double doses. (plantmedicines.org)
RESULTS: None of LAB, losartan, and amlodipine exhibited effects on blood glucose levels. (e-dmj.org)
Insulin aids the entry of glucose into cells for energy use, thereby maintaining appropriate glucose levels in the body. (thepleasantgroveway.com)
In a healthy individual, insulin signals the liver, muscle, and fat cells to take in glucose from the blood, lowering blood glucose levels and keeping them within a normal range. (thepleasantgroveway.com)
However, when there is a deficiency or absence of insulin in the body, glucose is unable to enter the cells to be utilized as energy, causing elevated blood sugar levels and potential health complications. (thepleasantgroveway.com)
Elevated glucose levels may result in symptoms such as extreme thirst, frequent urination, fatigue, and increased hunger. (thepleasantgroveway.com)

Voglibose delays the absorption of glucose thereby reducing the risk of macrovascular complications. (wikipedia.org)
Voglibose 0.3 mg works by decreasing hepatic sugar production and slowing down glucose absorption. (si1denafilfored.com)

Consuming it on a regular basis can improve glucose metabolism and insulin response, reducing the risk of diseases caused by high blood sugar. (igelsparks.com)
In normal conditions, insulin binds to special receptors on the cell surfaces and initiates reactions involved in glucose metabolism. (nurseslabs.com)

Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine, while the membrane-bound intestinal alpha-glucosidases hydrolyze oligosaccharides, trisaccharides, and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. (drugs-library.com)

0.05) reduction in the fasting blood glucose level of the extract treated groups of animals compared to the untreated diabetic group. (academicjournals.org)

In diabetic cats, factors such as insulin resistance, deposition of islet amyloid, pancreatitis, and glucose toxicity contribute to loss of pancreatic beta cells. (vin.com)

Evaluation of Phenolic Phytochemical Enriched Commercial Plant Extracts on the In Vitro Inhibition of alpha-Glucosidase. (cranberryinstitute.org)
The total phenolic content (TPC), antioxidant activity, and in vitro inhibitory activity of yeast alpha-glucosidase were examined for the extracts in the present study. (cranberryinstitute.org)
Potential alpha-glucosidase-inhibiting peptides obtained from aqueous and saline extracts from dry-cured pork loins inoculated with probiotic LAB were evaluated using in vitro and in silico methods. (bvsalud.org)
The in vitro alpha-amylase inhibitory activity of the microencapsulated product is also investigated. (ugm.ac.id)
Preliminary in vitro evaluation of the antidiabetic activity of crude extract and its furanocoumarins was carried out ( α -amylase, α -glucosidase, and β -galactosidase). (hindawi.com)
The aim of the present study was to investigate, α-amylase and α-glucosidase inhibitory activities of the aqueous extract of Cucurbita maxima seeds in vitro and to correlate their activity with their phytoelemental profile quantitatively assessed by Laser-Induced Breakdown Spectroscopy (LIBS). (arjournals.org)
In vitro assay of alpha-amylase inhibitory activity of some indigenous plants. (ac.ir)
11. Keerthana G, Kalaivani MK, Sumathy A. In vitro alpha amylase inhibitory and anti- oxidant activities of ethanolic leaf extract of Croton bonplandianus. (ac.ir)

The development of therapeutic strategies for restoring and maintaining blood glucose homeostasis is still in progress. (bvsalud.org)

Mulberry leaf extract may reduce blood glucose responses following sugar intake by reducing gastrointestinal carbohydrate absorption via alpha-glucosidase inhibition activity of iminosugar constituents such as 1-deoxynojirimycin (DNJ). (tastermonial.com)
This study was therefore designed to investigate the ability of the leaf extracts of Vitex doniana to inhibit α-amylase and α-glucosidase as well as the in-vivo antidiabetic potential of the ethanol leaf extract. (academicjournals.org)
Mulberry leaf extract significantly reduces total blood glucose rise after ingestion of maltodextrin over 120 minutes. (plantmedicines.org)

Many people find it necessary to use glucose-lowering prescription medications such as acarbose and miglitol. (bioactivesamerica.com)

Potent α-glucosidase and α-amylase inhibitory activities of standardized 50% ethanolic extracts and sinensetin from OrthosiphonstamineusBenth as anti-diabetic mechanism. (ac.ir)

The docking studies proved that oligopeptides VATPPPPPPPK, DIPPPPM, TPPPPPPG, and TPPPPPPPK obtained by hydrolysis of proteins from ripening dry-cured pork loins showed the potential to bind to the human alpha-glucosidase molecule and may act effectively as a potential antidiabetic agent. (bvsalud.org)

Hypoglycemic symptoms and manifestations can be divided into those produced by the counterregulatory hormones (epinephrine/adrenaline and glucagon) triggered by the falling glucose, and the neuroglycopenic effects produced by the reduced brain sugar. (findmeacure.com)

This prevents the level of blood glucose from increasing very high immediately after meals. (netmeds.com)
When the circulating level of blood glucose falls, the brain actually senses the drop. (findmeacure.com)

GT had higher TPC and antioxidant activity, but CR demonstrated a greater alpha-glucosidase inhibitory activity, on phenolic basis. (cranberryinstitute.org)
TPC, antioxidant activity, and yeast alpha-glucosidase inhibitory activity were determined for the fractions. (cranberryinstitute.org)
CAE had a greater TPC and antioxidant activity than CME, but the two fractions had a synergistic effect when inhibiting yeast alpha-glucosidase. (cranberryinstitute.org)
YaoY, Sang W, Zhou M and Ren G. Antioxidant and α-glucosidase inhibitory activity of colored grains in China. (arjournals.org)

1) use of multiple-dose insulin injections (3-4 injections per day) and 2) matching of mealtime (prandial) insulin to carbohydrate intake, before meal blood glucose reading, and anticipated exercise. (myendoconsult.com)

Participants with approximately 10 to 15 min after eating , peaks during impaired oral glucose tolerance ranked between healthy the second hour and then slowly declines to baseline over volunteers and type 2 diabetic patients and thus had an several hours. (medicinelakex1.com)

Glucose biosynthesis in the liver is reduced by biguanides. (diabetescrunch.com)
They also reduce the synthesis of glucose in the liver. (diabetescrunch.com)
It can reduce glucose synthesis in the liver and skeletal muscles, thus contributing to glucose management. (igelsparks.com)
As mentioned above, there is a store in the liver of glycogen that can be converted to glucose rapidly. (findmeacure.com)

To reverse this lethal epidemic of impaired glucose control, aging individuals often require more aggressive measures than merely limiting carbohydrate intake. (foodtrients.com)

The adzuki bean paste showed potential hypoglycemic activity in both normal mice and streptozotocin (STZ)-induced diabetic rats after an oral administration of sucrose, but did not show any effect on the blood glucose concentration after glucose administration, suggesting that the active fraction suppressed the postprandial blood glucose level by inhibiting alpha-glucosidase and alpha-amylase, irrespective of the endogenous blood insulin level. (healthjade.com)

Slowed starch digestion can theoretically increase satiety by modulating glucose "spiking" and depletion that occurs after carbohydrate-rich meals. (cranberryinstitute.org)
Slowing food digestion helps keep blood glucose from rising very high after meals. (elispot.biz)

Elevated postprandial glucose (PPG) concentrations may contribute to suboptimal glycemic control. (diabetesjournals.org)
The concentrations of cranberry phytochemicals required to inhibit 50% of albumin glycation (EC(50)) in albumin-glucose assay were lower than that of aminoguanidine except for water fraction I. Cranberry phytochemicals inhibited glycation of human serum albumin mediated by methylglyoxal, but the EC(50) were higher than that of aminoguanidine. (cranberryinstitute.org)
Oral to mean values of about 16 to 17 pmol/l in 33 healthy glucose is a good stimulus for the release of GLP-1, participants and 13 to 14 pmol/l in 54 type 2 diabetic whereas plasma GLP-1 concentrations do not change when patients, both after 60 min. (medicinelakex1.com)

The most promising sequences were molecularly docked to test their interaction with the human alpha-glycosidase molecule (PDB ID: 5NN8). (bvsalud.org)
One metabolite (formed by cleavage of a glucose molecule from acarbose) also has alpha-glucosidase inhibitory activity. (drugs-library.com)

Anatomy8

Organisms12

Diseases14

Chemicals and Drugs101

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Psychiatry and Psychology3

Phenomena and Processes38

Technology, Industry, Agriculture7

Information Science3

Health Care7

Hyperglycemia18

Inhibitors12

Plasma glucose15

Post-prandial5

Impaired glucose t3

Lowering postprandial blood glucose1

Secretion8

Type 2 diabet2

Uptake6

Inhibitor3

Enzyme5

Diabetes17

Carbohydrates9

Enzymes13

Levels33

Voglibose2

Metabolism2

Small intestine1

Reduction1

Pancreatic beta cells1

Vitro8

Restoring and maintaining b1

Extract3

Acarbose and miglitol1

Inhibitory activities1

Antidiabetic1

Glucagon1

Level of blood glucose2

Antioxidant4

Meal1

Diabetic patients1

Liver4

Epidemic of impaired1

Blood glucose concentration1

Meals2

Concentrations3

Molecule2