• Characteristics associated with swallowing changes after concurrent chemotherapy and radiotherapy in patients with head and neck cancer. (uchicago.edu)
  • Medical history of chemotherapy or endocrine therapy for breast cancer, or with treatment history of radiotherapy. (astrazenecaclinicaltrials.com)
  • Due to the aggressiveness, rapid growth of these tumors and the proximity of important structures, the treatment often requires use of pre-postoperative neo-adjuvant radiotherapy and / or chemotherapy. (parcdesalutmar.cat)
  • Chemotherapy and radiotherapy are associated with side effects which reduce tolerance to treatment and likelihood of tumour response. (cambridge.org)
  • In many cases, an aggressive surgical treatment, which includes major bone resection and is sometimes associated with radiotherapy and chemotherapy, is required for better control of local recurrence and metastasis in such lesions. (bvsalud.org)
  • With regards to treatment, the role of surgical resection, radiotherapy, chemotherapy, and tumor-treating fields will be presented. (cancernetwork.com)
  • Adjuvant chemotherapy prolongs relapse-free and overall survival for patients with stage III gastric cancer in a real-world situation. (springeropen.com)
  • People receiving operation for gastric cancer without adjuvant chemotherapy are at risk for disease recurrence. (springeropen.com)
  • Data from a recent randomized trial enrolling only patients with II-IIIB gastric cancer revealed a 36 % recurrence rate in 5 years for patients without adjuvant chemotherapy after D2 dissection (Noh et al. (springeropen.com)
  • Before 2000, there was no large-scaled randomized phase III trial to evaluate the benefit of adjuvant chemotherapy on the survival of patients with gastric cancer after operation. (springeropen.com)
  • Information on adjuvant chemotherapy in gastric cancer is largely derived from meta-analyses. (springeropen.com)
  • Although some meta-analyses suggested a positive effect of adjuvant chemotherapy on survival of patients with gastric cancer (Hejna et al. (springeropen.com)
  • Here, we report a case of complete remission for more than 12 years following hepatic arterial infusion chemotherapy (HAIC) in a patient with solitary metachronous liver metastasis from gastric cancer. (biomedcentral.com)
  • Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. (epnet.com)
  • Recently, the survival rate of gastric cancer patients has improved because of early diagnosis, curative surgery, and adjuvant chemotherapy ( 1 , 2 ). (iiarjournals.org)
  • Patients with advanced gastric cancer usually receive anticancer agents as adjuvant therapy after curative surgery ( 2 , 17 , 18 ), and some studies demonstrated that anticancer agents could reduce BMD ( 19 , 20 ). (iiarjournals.org)
  • A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer. (helsedirektoratet.no)
  • Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. (helsedirektoratet.no)
  • Considering the relationships among surgical treatments, inflammation and carcinogenesis, non-steroidal anti-inflammatory drugs (NSAIDs) are a candidate postoperative treatment for preventing recurrence and maintaining QOL. (bmj.com)
  • In this study, we investigate the effects of the perioperative administration of flurbiprofen axetil on postoperative recurrence in patients with non-small cell lung cancer. (bmj.com)
  • The primary analysis will evaluate the treatment effect of flurbiprofen axetil on postoperative recurrence. (bmj.com)
  • This is the first study to evaluate the effect of the perioperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) on postoperative recurrence in non-small cell lung cancer. (bmj.com)
  • There is data that shows that among patients with early-stage or locally advanced NSCLC, the risk of recurrence after postoperative chemotherapy or other definitive treatment may be higher among patients with epidermal growth factor receptor (EGFR)-mutated disease than among those with EGFR wild-type disease. (n1x10.com)
  • Therefore, the identification of reliable criteria and/or novel biomarkers for predicting a risk of recurrence is needed to identify the patients who should receive postoperative adjuvant chemotherapy. (spandidos-publications.com)
  • The risk of postoperative recurrence is higher in lung cancer patients who smoke than non-smokers. (biomedcentral.com)
  • However, objective evaluation of the postoperative recurrence risk is difficult using conventional pathological prognostic factors because of their lack of reproducibility. (biomedcentral.com)
  • Because cigarette smoking and oncogenesis alter lipid metabolism in lung tissue, we hypothesized that the lipid profiles in lung cancer tissues are influenced by cigarette smoking and can reflect the postoperative recurrence risk in smoking lung cancer patients. (biomedcentral.com)
  • This study aimed to identify lipid biomarkers that reflect the smoking status and the postoperative recurrence risk. (biomedcentral.com)
  • Lipids that were influenced by smoking status and reflected postoperative recurrence and pathological prognostic factors were screened. (biomedcentral.com)
  • From our data, we propose three PC isomers, PC (14:0_18:2), PC (16:1_16:1), and PC (16:0_16:2), and a lipid peak of m/z 736.5276 as novel candidate biomarkers for postoperative recurrence risk in lung ADC and SQCC patients who are smokers. (biomedcentral.com)
  • Hence, predicting the postoperative recurrence risk in individual NSCLC patients who are smokers will contribute to developing a qualified postoperative therapeutic strategy. (biomedcentral.com)
  • Therefore, identifying novel and objective biomarkers that reflect postoperative recurrence risk in smokers NSCLC patients is needed. (biomedcentral.com)
  • Specific lipids in cancer tissues have been reported as potential biomarkers reflecting patient prognosis and the risk of postoperative recurrence. (biomedcentral.com)
  • Adjuvant radiation following clear margin resection of high T-stage cutaneous squamous cell carcinoma halves the risk of local and locoregional recurrence: A dual-center retrospective study. (dana-farber.org)
  • These data led to approval by the US Food and Drug Administration (FDA) for adjuvant nivolumab in patients at high risk for recurrence after undergoing radical resection of UC [2]. (nursingcenter.com)
  • The trial involved 680 patients with stage IB to IIIA EGFR mutation-positive NSCLC, aged between 30 and 86 in 26 countries, which were randomly assigned to receive postoperative adjuvant osimertinib, a third-generation, oral, central nervous system (CNS) active EGFR-TKI, (epidermal growth factor-tyrosine kinase inhibitor) or placebo, with or without chemotherapy. (n1x10.com)
  • Most chemotherapy regimens include 5-FU, which remains the mainstay for treatment of this tumor. (cancernetwork.com)
  • Participants in the control arm will receive one of the protocol specified platinum based chemotherapy regimens for 4 cycles. (genentech-clinicaltrials.com)
  • The association between chemotherapy regimens and survival endpoints, including distant metastasis-free survival (DMFS), overall survival (OS) and disease-free survival (DFS), were evaluated and adjusted with PS. (biomedcentral.com)
  • The influence of adjuvant chemotherapy on the survival of gastric adenocarcinoma patients in a stage-specific manner is controversial. (springeropen.com)
  • Higher overall survival from adjuvant chemotherapy in stage II patients with node involvement did not reach the level of statistical significance ( P = 0.102). (springeropen.com)
  • 75 years were included in a subgroup analysis in which the benefit of adjuvant chemotherapy on relapse-free survival and overall survival were demonstrated for patients with stage III disease. (springeropen.com)
  • 2002 ). Fortunately, in the last decade, randomized, placebo-controlled, phase III clinical trials have proven the survival advantage conferred by adjuvant chemotherapy after D2 lymph node dissection (Noh et al. (springeropen.com)
  • Modifying the delivery of systemic chemotherapy to improve patients' survival is another progress in colorectal cancer management, known as total neoadjuvant therapy (TNT). (coloproctol.org)
  • Marginal or poor overall survival resulted from micrometastatic disease during the waiting period after the nCRT to surgery and poor compliance with postoperative adjuvant chemotherapy. (coloproctol.org)
  • Of the 10-20% of patients who present with resectable tumors, the 5-year surviva rate is still only about 20%, with a median survival of around 23-43 months with adjuvant therapy ( 2 - 4 ). (iiarjournals.org)
  • However, the improvement of overall survival achieved by postoperative adjuvant chemotherapy may be insufficient in consideration of the deterioration of quality of life (QOL). (bmj.com)
  • Oxaliplatin/5FU/LV in adjuvant colon cancer: updated efficacy results of the MOSAIC trial, including survival, with a median follow-up of six years [abstract]. (medscape.org)
  • Therefore, myelosuppression and gastrointestinal side effects caused by preoperative DCF therapy may worsen postoperative infections leading to life-threatening diseases in high-risk patients with esophageal cancer and may reduce long-term survival benefits by increasing the incidence of postoperative infections. (biomedcentral.com)
  • The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction - a phase III trial of the German AIO/CAO-V/CAOGI. (helsedirektoratet.no)
  • Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer: The AIO-FLOT3 Trial. (helsedirektoratet.no)
  • In a placebo-controlled phase III trial of over 700 patients with urothelial carcinoma (UC) and high-risk disease after radical cystectomy, one year of adjuvant nivolumab improved disease-free survival (median 21 versus 11 months) [1]. (nursingcenter.com)
  • In a randomized trial among 300 patients with cervical cancer undergoing postoperative radiation, disease-free survival was similar with image-guided IMRT versus 3D-CRT (77 versus 81 percent), but three-year cumulative incidence of late toxicity was reduced (28 versus 49 percent) [3]. (nursingcenter.com)
  • Immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer. (epnet.com)
  • Compared to patients without BOFJ, those with BOFJ had a higher preoperative body mass index (23.3 kg/m 2 versus 20.9 kg/m 2 , P = 0.022), and greater postoperative body weight loss rate: 3 month, decrease to 84.2% of initial body weight versus 89.3% ( P = 0.002). (biomedcentral.com)
  • Comparison Efficacy of Oral Fluid Versus Intravenous Fluid Replacement in Postoperative Primary Total Knee Arthroplasty : A Randomized Controlled Trial. (who.int)
  • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. (helsedirektoratet.no)
  • However, the trial also showed increased toxicity with IP chemotherapy versus IV chemotherapy. (medscape.com)
  • The standard nCRT group received long-course CRT (either 50.4 Gy with 28 fractions or 50.0 Gy with 20 fractions) with capecitabine (twice daily oral capecitabine 825 mg/m 2 during the radiation period) followed by TME within 6 to 10 weeks after CRT was completed. (coloproctol.org)
  • We aimed to evaluate the safety and efficacy of adding capecitabine (a known radiosensitizer by direct and abscopal effects) to concurrent radiation in the adjuvant setting after resection of pancreatic adenocarcinoma. (iiarjournals.org)
  • Patients and Methods: We conducted a retrospective study of 63 patients diagnosed from 2004-2013 with histopathologically-confirmed stage I/II pancreatic cancer treated with a surgical resection followed by adjuvant concurrent chemoradiation to at least 45 Gy using 3D planning and capecitabine at 1,600 mg/m 2 /day (Monday-Friday) for 6 weeks. (iiarjournals.org)
  • Conclusion: Concurrent chemoradiation using capecitabine as a radiosensitizer in the adjuvant setting for pancreatic cancer was completed by the vast majority of patients in this series. (iiarjournals.org)
  • Over 95% of people with oral squamous cell carcinoma smoke tobacco, drink alcohol, or both. (msdmanuals.com)
  • In the US, 3% of cancers in men and 2% in women are oral squamous cell carcinomas, most of which occur after age 50. (msdmanuals.com)
  • As with most head and neck sites, squamous cell carcinoma is the most common oral cancer. (msdmanuals.com)
  • This photo shows a close-up of the inside of the mouth (the buccal mucosa) in a patient with squamous cell carcinoma of the oral mucosa. (msdmanuals.com)
  • Novel Midkine Inhibitor iMDK Inhibits Tumor Growth and Angiogenesis in Oral Squamous Cell Carcinoma. (kawasaki-m.ac.jp)
  • Anti-tumor effect of a novel FAK inhibitor TAE226 against human oral squamous cell carcinoma. (kawasaki-m.ac.jp)
  • Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer. (epnet.com)
  • The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanagawa). (epnet.com)
  • Introduction In patients with non-small cell lung cancer, surgical treatment with postoperative adjuvant chemotherapy is performed. (bmj.com)
  • Effective surgical adjuvant therapy for high-risk rectal carcinoma. (medscape.org)
  • These dramatic changes reflected the results of 2 prospective randomized clinical trials, i.e., the RAPIDO (Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation) trial [ 8 ] and PRODIGE (Partenariat de Recherche en Oncologie Digestive) 23 trial [ 9 ] in 2021. (coloproctol.org)
  • Patients of BOFJ had greater preoperative body mass, shorter distance between jejunostomy and midline, and greater postoperative weight loss. (biomedcentral.com)
  • Immunosuppression induced by a preoperative chemotherapeutic treatment can increase postoperative infections. (biomedcentral.com)
  • Distant metastasis has been the main failure pattern for locoregionally advanced rectal cancer (LARC) patients, and intensified neoadjuvant chemotherapy has become a popular research topic. (biomedcentral.com)
  • This includes patients with muscle-invasive or node-positive disease after receiving neoadjuvant chemotherapy, or those with extravesicular extension or node-positive disease who did not receive neoadjuvant chemotherapy and were ineligible for or refused adjuvant cisplatin-based chemotherapy. (nursingcenter.com)
  • Objectives: Postoperative pancreatic fistula (POPF) is a major cause of morbidity after pancreatic surgery. (bvsalud.org)
  • His clinical interests include thyroid and parathyroid disease, trans-oral laser and robotic surgery for head and neck cancers. (ahns.info)
  • Treatment is with surgery, radiation, or both, although surgery plays a larger role in the treatment of most oral cavity cancer. (msdmanuals.com)
  • 3 Although there have been no randomised controlled trials to compare surgery with radiation therapy or chemotherapy, observational studies have suggested that surgery is the most curative treatment for lung cancer. (bmj.com)
  • In the present report, we describe successful recovery from recurrent pyoderma gangrenosum that developed after pacemaker implantation as the second surgery, in a patient who had recovered from postoperative pyoderma gangrenosum following lung cancer surgery. (biomedcentral.com)
  • During the past decade perioperative chemotherapy, pre- or postoperative radio-chemotherapy, and, in Asian populations, adjuvant chemotherapy have been shown to improve the outcome of patients with advanced GC and GEJ cancers suited for surgery. (docksci.com)
  • Chemotherapy is usually given after surgery. (medscape.com)
  • The CAO/ARO/AIO-12 trial [ 10 , 11 ] and OPRA (Organ Preservation of the Rectal Adenocarcinoma) trial [ 12 ] comparing the induction and consolidation chemotherapy as a TNT have been reported. (coloproctol.org)
  • The RAPIDO trial [ 8 ] compared the short-course radiation therapy followed by consolidation chemotherapy with standard long-course nCRT. (coloproctol.org)
  • However, an important role exists for the use of chemotherapy and/or radiation therapy in an adjuvant or neoadjuvant setting, and in the treatment of patients with unresectable disease. (medscape.com)
  • For adjuvant radiation for cervical cancer, newer techniques such as intensity- modulated radiation therapy (IMRT) are being evaluated as less toxic options compared with three-dimensional conformal radiation therapy (3D-CRT). (nursingcenter.com)
  • This randomized, active-controlled, multicenter, open-label, Phase III study is designed to investigate the efficacy and safety of alectinib compared with platinum-based in the adjuvant setting. (genentech-clinicaltrials.com)
  • Oral lesions are asymptomatic initially, highlighting the need for oral screening. (msdmanuals.com)
  • A new treatment strategy named total neoadjuvant therapy (TNT), consists of chemotherapy given before or after the CRT to control micrometastatic disease earlier and improve compliance with chemotherapy. (coloproctol.org)
  • A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia. (uchicago.edu)
  • this enhances the likelihood of removing all cancer cells (complete resection) and identifies patients who will require additional treatment (i.e. adjuvant chemotherapy). (wikipedia.org)
  • Adjuvant treatment, after complete tumor resection, has included chemotherapy when recommended. (n1x10.com)
  • Adjuvant Nutrition in Cancer Treatment Symposium. (lifeovercancer.com)
  • Patients were then planned for treatment with adjuvant nivolumab for 3 months. (bmj.com)
  • Variables potentially influencing chemotherapy treatment selection were used to generate propensity scores (PS). (biomedcentral.com)
  • Final Results of a Randomized Phase 2 Trial Investigating the Addition of Cetuximab to Induction Chemotherapy and Accelerated or Hyperfractionated Chemoradiation for Locoregionally Advanced Head and Neck Cancer. (uchicago.edu)
  • Osimertinib, a third-generation oral EGFR-TKI, potently and selectively inhibits both EGFR-TKI sensitizing and EGFR p.Thr790Met resistance mutations. (ersnet.org)
  • Definitive chemoradiation for locally-advanced oral cavity cancer: A 20-year experience. (uchicago.edu)
  • Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. (uchicago.edu)
  • Chemoradiation for patients with advanced oral cavity cancer. (uchicago.edu)
  • In addition, as seen in other disease sites (head and neck cancer, sarcoma), postoperative radiation for patients with incompletely resected malignancies continues to play an important role ( 6 ). (iiarjournals.org)
  • Oral cancer refers to cancer occurring between the vermilion border of the lips and the junction of the hard and soft palates or the posterior one third of the tongue. (msdmanuals.com)
  • Postoperative adjuvant randomised trial comparing chemo-endocrine therapy, chemotherapy and immunotherapy for patients with stage II breast cancer: 5-year results from the Nishinihon Cooperative Study Group of Adjuvant Chemo-endocrine Therapy for Breast Cancer (ACETBC) of Japan. (epnet.com)
  • Randomized adjuvant trial to evaluate the addition of tamoxifen and PSK to chemotherapy in patients with primary breast cancer. (epnet.com)
  • 5-year results from the Nishi-Nippon Group of the Adjuvant Chemoendocrine Therapy for Breast Cancer Organization. (epnet.com)
  • Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. (epnet.com)
  • This subspecialty includes complex reconstruction of oral and cervical region following cancer resection. (parcdesalutmar.cat)
  • Resting energy expenditure and body mass changes in women during adjuvant chemotherapy for breast cancer. (lifeovercancer.com)
  • Harvie MN, Campbell IT, Baildam A, Howell A. Energy balance in early breast cancer patients receiving adjuvant chemotherapy. (lifeovercancer.com)
  • Reduced rates of metabolism and decreased physical activity in breast cancer patients receiving adjuvant chemotherapy. (lifeovercancer.com)
  • Jejunal interposition reconstruction with a stomach preserving esophagectomy improves postoperative weight loss and reflux symptoms for esophageal cancer patients. (kawasaki-m.ac.jp)
  • Consequently, novel objective biomarkers that reflect postoperative risk in lung cancer patients who smoke must be identified. (biomedcentral.com)
  • Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)
  • Accuracy of hydro-multidetector row CT in the local T staging of oesophageal cancer compared to postoperative histopathological results. (helsedirektoratet.no)
  • Cancer chemotherapy and pharmacology, 65 (6), 1009-1021. (helsedirektoratet.no)
  • When adjuvant radiation is indicated for cervical cancer, we suggest image-guided IMRT, but 3D-CRT is an acceptable alternative. (nursingcenter.com)
  • All patients with stage II or higher cancer should be considered for front-line chemotherapy based on burden of disease and ability to achieve optimal primary resection. (medscape.com)
  • Advanced rectal cancers were traditionally treated with neoadjuvant chemoradiation therapy (nCRT) followed by total mesorectal excision (TME) and postoperative adjuvant chemotherapy [ 1 , 2 ]. (coloproctol.org)
  • Outcomes of induction chemotherapy followed by concurrent chemoradiation for nasopharyngeal carcinoma. (uchicago.edu)
  • Chemotherapy/immunotherapy is usually used with an adjuvant or palliative intention. (medscape.com)
  • Our aim was to clarify the incidence of bowel obstruction associated with a feeding jejunostomy (BOFJ) after thoracoscopic esophagectomy and its association to characteristics and postoperative change in body weight. (biomedcentral.com)
  • Therefore, the aim of our study was to clarify the incidence of bowel obstruction associated with a feeding jejunostomy (BOFJ) after thoracoscopic esophagectomy (TSE) and to evaluate the association between BOFJ and the patients' characteristics or postoperative course of change in body weight (BW). (biomedcentral.com)
  • There was no significant between-group difference in the postoperative morbidity rate (bDCF 45.5% vs. DCF 32.4%) or in the histological therapeutic effect. (biomedcentral.com)
  • Fifty-nine patients with esophageal carcinoma underwent an esophagectomy after DCF or bDCF therapy as primary chemotherapy. (biomedcentral.com)
  • Post operative chemotherapy is recommended in patients with NSCLC with stages II to IIIA. (ersnet.org)
  • High-risk features such as stage IC, higher grade, or clear-cell histology should prompt consideration of adjuvant chemotherapy. (medscape.com)
  • To further explore this topic, we retrospectively analyzed the impact of adjuvant chemotherapy on the clinical outcomes of 77 stage II and 117 stage III patients diagnosed between January 2008 and December 2012. (springeropen.com)
  • A cross-over study of the effect of a single oral feeding of medium chain triglyceride oil vs. canola oil on post-ingestion plasma triglyceride levels in healthy men. (lifeovercancer.com)
  • The feasibility of DCF therapy is a concern, particularly for elderly patients, patients with moderate organ disorders, and patients suffering from malnutrition caused by dysphagia or insufficient oral intake. (biomedcentral.com)
  • Postoperative disrupted abdominal wall management by a new tissue expansion technique. (who.int)
  • Mucosal melanomas in the head and neck region account for half of all mucosal melanomas, occurring mainly in the upper respiratory tract, oral cavity, and pharynx. (medscape.com)
  • The most prevalent clinical presentation of tumors within the oral cavity is a painless mass. (medscape.com)
  • Most dental professionals carefully examine the oral cavity and oropharynx during routine care and may do a brush biopsy of abnormal areas. (msdmanuals.com)