RegimensGastricCapecitabinePerioperativeGimeracilNeoadjuvantPathological stageTrastuzumabOxaliplatinImmunotherapyOverall survivalRecurrenceClinical trialsUracilChemotherapeuticRadiation therapyTumorsImmunochemotherapyCancerPlaceboVersusStageTherapyIncludePatientOralEffectCommonRecommended for patientsYear
Regimens5
- The random stratification factors include adjuvant chemotherapeutic regimens (XELOX versus SOX) and tumor anatomical sites (gastric adenocarcinoma versus gastroesophageal junction adenocarcinoma). (centerwatch.com)
- Combination chemotherapy regimens are standard recommendations in the adjuvant setting. (medscape.com)
- Phase II trials of the oral regimen, UFT (tegafur and uracil) plus leucovorin, have demonstrated that this combination has antitumor activity similar to intravenous regimens of fluorouracil (5-FU) plus leucovorin. (cancernetwork.com)
- For description of chemotherapy and chemoradiotherapy regimens, see Gastric Cancer Treatment Protocols . (medscape.com)
- For chemotherapy, two-drug cytotoxic regimens that include a platinum agent are generally preferred for first-line therapy. (medscape.com)
Gastric15
- Here, we report a case of complete remission for more than 12 years following hepatic arterial infusion chemotherapy (HAIC) in a patient with solitary metachronous liver metastasis from gastric cancer. (biomedcentral.com)
- This international, multicenter, randomized, double-blind phase III study intends to recruit 680 patients who have received radical gastrectomy (R0 resection, D2 or more extended lymphadenectomy) with postoperative pathological stage II or III (AJCC Cancer Staging Manual, 8th Edition) gastric or EGJ adenocarcinoma to evaluate the efficacy and safety of JS001 combined with postoperative adjuvant chemotherapy versus placebo combined with postoperative adjuvant chemotherapy. (centerwatch.com)
- The influence of adjuvant chemotherapy on the survival of gastric adenocarcinoma patients in a stage-specific manner is controversial. (springeropen.com)
- Adjuvant chemotherapy prolongs relapse-free and overall survival for patients with stage III gastric cancer in a real-world situation. (springeropen.com)
- People receiving operation for gastric cancer without adjuvant chemotherapy are at risk for disease recurrence. (springeropen.com)
- Data from a recent randomized trial enrolling only patients with II-IIIB gastric cancer revealed a 36 % recurrence rate in 5 years for patients without adjuvant chemotherapy after D2 dissection (Noh et al. (springeropen.com)
- Before 2000, there was no large-scaled randomized phase III trial to evaluate the benefit of adjuvant chemotherapy on the survival of patients with gastric cancer after operation. (springeropen.com)
- Information on adjuvant chemotherapy in gastric cancer is largely derived from meta-analyses. (springeropen.com)
- Although some meta-analyses suggested a positive effect of adjuvant chemotherapy on survival of patients with gastric cancer (Hejna et al. (springeropen.com)
- Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
- Namikawa T, Maeda H, Kitagawa H, Oba K, Tsuji A, Yoshikawa T, Kobayashi M, Hanazaki K. Treatment using oxaliplatin and S-1 adjuvant chemotherapy for pathological stage III gastric cancer: a multicenter phase II study (TOSA trial) protocol. (u-tokyo.ac.jp)
- Effects of the immunomodulator PSK on the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) to 5-fluorouracil (5-FU) were examined in 10 patients with advanced gastric cancer and who had undergone curative resection. (mushroomstudies.co)
- As the clinical dose of PSK had no apparent influence on the metabolism of tegafur to 5-FU, the combination of PSK and tegafur can be prescribed to treat patients with advanced gastric cancer. (mushroomstudies.co)
- Postoperative PSK and OK-432 immunochemotherapy for patients with gastric cancer. (mushroomstudies.co)
- We evaluated the effects of chemotherapy given postoperatively with and without immunomodulators on the survival of patients who had undergone resection for gastric cancer. (mushroomstudies.co)
Capecitabine2
- The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes 5-fluorouracil, capecitabine, and tegafur. (wikipedia.org)
- Adjuvant treatments include: 5-fluorouracil administered together with folinic acid, or more recently, oral fluoropyrimidines such as capecitabine, in combination with oxaliplatin or irinotecan. (biomedcentral.com)
Perioperative4
- In this study, we investigate the effects of the perioperative administration of flurbiprofen axetil on postoperative recurrence in patients with non-small cell lung cancer. (bmj.com)
- This is the first study to evaluate the effect of the perioperative administration of non-steroidal anti-inflammatory drugs (NSAIDs) on postoperative recurrence in non-small cell lung cancer. (bmj.com)
- During the past decade perioperative chemotherapy, pre- or postoperative radio-chemotherapy, and, in Asian populations, adjuvant chemotherapy have been shown to improve the outcome of patients with advanced GC and GEJ cancers suited for surgery. (docksci.com)
- Perioperative, neoadjuvant chemotherapy or chemoradiotherapy followed by surgery is appropriate. (medscape.com)
Gimeracil2
- Tegafur/uracil Tegafur/gimeracil/oteracil El Sayed YM, Sadée W (September 1983). (wikipedia.org)
- Therefore, GEM and tegafur-gimeracil-oteracil potassium (TS-1) were administered as third-line chemotherapy. (springeropen.com)
Neoadjuvant1
- The best candidates for neoadjuvant chemotherapy are patients with ER-negative and/or Her2Neu-positive expressing tumors, whose pathologically complete response (pCR) rates can approach 65% (in Her2Neu-positive cancers) and predict long-term survival. (medscape.com)
Pathological stage1
- A 59-year-old man underwent an extended cholecystectomy for GBC (pathological stage II, T2 N0 M0, [per UICC 7th edition]) that was incidentally found during cholelithiasis surgery, and was then treated with adjuvant gemcitabine (GEM). (springeropen.com)
Trastuzumab2
- Neratinib: A tyrosine kinase inhibitor approved for the extended adjuvant treatment of patients with early-stage Her2Neu-positive breast cancer, following adjuvant trastuzumab-based therapy. (medscape.com)
- The introduction of trastuzumab in combination with platinum/fluoropyrimidine-based chemotherapy for patients with HER2-positive disease has marked a turning point. (docksci.com)
Oxaliplatin1
- Considering advanced disease, first-line chemotherapy including the combination of folinic acid with continuous infusion of 5-FU, along with oxaliplatin (FOLFOX) or irinotecan (FOLFIRI) are reasonable choices, with comparable effectiveness in terms of objective responses and survival [ 9 ]. (biomedcentral.com)
Immunotherapy4
- We report here a rare case of a patient who has currently survived almost 10 years with recurrent GBC with peritoneal dissemination and liver metastases, which has been well controlled by a multidisciplinary approach including chemotherapy, immunotherapy, and surgery. (springeropen.com)
- Overall, 44.1% of patients treated with lenvatinib plus pembrolizumab received subsequent systemic anti-cancer treatment (34.9% tyrosine kinase inhibitor, 14.4% immunotherapy, 3.5% chemotherapy). (medicom-publishers.com)
- Of all patients treated with lenvatinib plus placebo, 52.1% received subsequent systemic therapy (40.1% tyrosine kinase inhibitor, 22.8% immunotherapy, 3.3% chemotherapy). (medicom-publishers.com)
- Radiotherapy, chemotherapy, targeted therapy, and immunotherapy are basically intended to provide another choice for patients with post- or non-operative conditions. (frontiersin.org)
Overall survival4
- However, the improvement of overall survival achieved by postoperative adjuvant chemotherapy may be insufficient in consideration of the deterioration of quality of life (QOL). (bmj.com)
- Major Cancer and Leukemia Group B (CALGB) chemotherapy clinical trials have consistently shown that chemotherapy produces significantly better disease-free and overall survival, particularly in patients with ER-negative disease. (medscape.com)
- Higher overall survival from adjuvant chemotherapy in stage II patients with node involvement did not reach the level of statistical significance ( P = 0.102). (springeropen.com)
- 75 years were included in a subgroup analysis in which the benefit of adjuvant chemotherapy on relapse-free survival and overall survival were demonstrated for patients with stage III disease. (springeropen.com)
Recurrence5
- Considering the relationships among surgical treatments, inflammation and carcinogenesis, non-steroidal anti-inflammatory drugs (NSAIDs) are a candidate postoperative treatment for preventing recurrence and maintaining QOL. (bmj.com)
- The primary analysis will evaluate the treatment effect of flurbiprofen axetil on postoperative recurrence. (bmj.com)
- Therefore, the identification of reliable criteria and/or novel biomarkers for predicting a risk of recurrence is needed to identify the patients who should receive postoperative adjuvant chemotherapy. (spandidos-publications.com)
- Three months later, when a recurrence-suspected lesion was detected in segment 5 (S5) of his liver, we started adoptive immunotherapies with cytokine-activated killer (CAK) cell infusions, combined with chemotherapy. (springeropen.com)
- After a year of adjuvant immunochemotherapy, the S5 lesion disappeared on imaging, but lesions suspected metastatic recurrence again appeared in S7 and S8 at 4 years and 6 months post-surgery, for which GEM and cisplatin (CDDP) were administered as second-line chemotherapy. (springeropen.com)
Clinical trials1
- 2002 ). Fortunately, in the last decade, randomized, placebo-controlled, phase III clinical trials have proven the survival advantage conferred by adjuvant chemotherapy after D2 lymph node dissection (Noh et al. (springeropen.com)
Uracil3
- It is a component of the combination drug tegafur/uracil. (wikipedia.org)
- This study aimed to assess the postoperative esophageal displacement after lobectomy and to clarify its impact on the continuity of tegafur-uracil treatment. (nii.ac.jp)
- Methods: Patients who received adjuvant tegafur-uracil therapy after lobectomy between April 2009 and March 2019 were retrospectively analyzed. (nii.ac.jp)
Chemotherapeutic1
- Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. (wikipedia.org)
Radiation therapy3
- 3 Although there have been no randomised controlled trials to compare surgery with radiation therapy or chemotherapy, observational studies have suggested that surgery is the most curative treatment for lung cancer. (bmj.com)
- In inoperable cases, many patients must rely on chemotherapy and radiation therapy, which are not sufficiently effective. (springeropen.com)
- Radiation therapy is often given with chemotherapy. (medscape.com)
Tumors1
- For patients with unresectable tumors, treatment with fluoropyrimidine- or taxane-based chemoradiotherapy (category 1 recommendation) or chemotherapy is acceptable. (medscape.com)
Immunochemotherapy1
- Data related to the duration of postoperative survival were calculated for those who received chemotherapy, i.e. an individualized combination of various agents given with or without the immunomodulators PSK, a protein extract of the fungus Coriolus versicolor, and/or OK-432, a preparation of an attenuated strain of Streptococcus (immunochemotherapy). (mushroomstudies.co)
Cancer6
- Introduction In patients with non-small cell lung cancer, surgical treatment with postoperative adjuvant chemotherapy is performed. (bmj.com)
- Adjuvant therapy for breast cancer is designed to treat any potential micrometastatic disease, or breast cancer cells that have escaped the breast and regional lymph nodes but have not yet established an identifiable metastasis. (medscape.com)
- Patients with ER-positive, Her2Neu-negative locally advanced breast cancer (LABC) are unlikely to achieve a pCR from currently available chemotherapy. (medscape.com)
- Adjuvant chemotherapy in stage III colon cancer is fully justified. (biomedcentral.com)
- Many patients with advanced cancer cannot receive long-term chemotherapy because the adverse effects of the treatment are not tolerable to such patients. (springeropen.com)
- Conclusions: Our study suggested that anatomical displacement of the esophagus after lobectomy may affect the discontinuation of oral adjuvant chemotherapy in patients with lung cancer. (nii.ac.jp)
Placebo1
- Patients meeting the inclusion criteria will be 1:1 randomized into JS001-chemotherapy group and placebo-chemotherapy group. (centerwatch.com)
Versus1
- In the largest of these trials, postoperative morbidity (43% versus 25%) and mortality (10% versus 4%) were higher in the D2 group. (medscape.com)
Stage1
- To further explore this topic, we retrospectively analyzed the impact of adjuvant chemotherapy on the clinical outcomes of 77 stage II and 117 stage III patients diagnosed between January 2008 and December 2012. (springeropen.com)
Therapy1
- Chemotherapy, as the most common and indispensable adjuvant therapy, is updated constantly with advances in research. (frontiersin.org)
Include1
- The major side effects of tegafur are similar to fluorouracil and include myelosuppression, central neurotoxicity and gastrointestinal toxicity (especially diarrhoea). (wikipedia.org)
Patient3
- The patient underwent HAIC with systemic chemotherapy. (biomedcentral.com)
- The patient is still disease-free without further chemotherapy more than 12 years after HAIC. (biomedcentral.com)
- His postoperative course was uneventful, and the patient was discharged on the 20th postoperative day. (biomedcentral.com)
Oral1
- Journal Article}, title = {Impact of thoracic esophageal displacement after lobectomy on the continuity of oral adjuvant chemotherapy. (nii.ac.jp)
Effect1
- Gastrointestinal toxicity is the dose-limiting side effect of tegafur. (wikipedia.org)
Common1
- Central neurotoxicity is more common with tegafur than with fluorouracil. (wikipedia.org)
Recommended for patients1
- Some studies suggested that adjuvant chemotherapy only be recommended for patients with positive lymph node (Earle and Maroun 1999 ), or not recommended because the benefit was small (Janunger et al. (springeropen.com)
Year1
- A total of 41 patients completed the 2-year adjuvant treatment and 27 patients discontinued it. (nii.ac.jp)