• Patients who were previously stable on doses of brand alendronate experienced an increase in AEs causing discontinuation after introduction of automatic substitution to generic alendronate. (biomedcentral.com)
  • But while pyrophosphate inhibits both osteoclastic bone resorption and the mineralization of the bone newly formed by osteoblasts, alendronate specifically inhibits bone resorption without any effect on mineralization at pharmacologically achievable doses. (wikipedia.org)
  • 11 12 One Danish cohort study looked at gastrointestinal cancers and reported an increased risk of oesophageal cancer associated with use of alendronate and a possible protective effect of higher doses for colorectal cancer. (bmj.com)
  • It is likely that similar risks are associated with generic versions, however clinical trials examining the GI tolerability of generic versions of alendronate compared to the original formulations are not available. (biomedcentral.com)