• MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. (mit.edu)
  • Filipowicz, W., Bhattacharyya, S. N. & Sonenberg, N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (nature.com)
  • MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
  • In this project, I will employ biochemical, cell, systems biology and computational approaches to study the relevance of post-transcriptional regulators such as RNA-binding proteins and microRNAs in DDR. (europa.eu)
  • As a momentous post-transcriptional regulator, microRNAs (miRNAs) are attracting more and more attention. (stjosephs-hospital.com)
  • microRNAs are small single-stranded RNA molecules of approximately 22 nucleotides that function as post-transcriptional gene regulators. (unina.it)
  • MicroRNAs (miRNAs) are well-recognized for their abilities to regulate gene expression post-transcriptionally in plants and animals. (frontiersin.org)
  • Furthermore, post-transcriptional gene expression regulation by cellular and/or EBV-derived microRNAs has attracted considerable attention. (spandidos-publications.com)
  • Furthermore, we discuss recent findings on EBV associated gastric carcinogenesis by focusing on the roles of latent genes, epigenetic abnormalities, genomic alterations, and post-transcriptional regulation by cellular and viral microRNAs (miRNAs). (spandidos-publications.com)
  • The non-coding post-transcriptional gene regulators muscle-specific microRNAs (miRNA) control muscle development and differentiation but when dysregulated lead to skeletal muscle (SM) disorder. (endocrine-abstracts.org)
  • In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
  • MicroRNAs (miRNAs) are small non-coding RNAs responsible for posttranscriptional regulation of gene expression. (lu.se)
  • However, experimental approaches have limitations when dealing with complex biological systems composed of multiple layers of regulation such as the transcriptional and post-transcriptional regulation by transcription factors (TFs) and miRNAs [ 2 ]. (hindawi.com)
  • Besides classical gene regulation, miRNAs have emerged as post-transcriptional regulators of angiogenesis. (plos.org)
  • MiRNAs are acknowledged as key regulator in posttranscriptional modification and our previous study found that miR-146a is a novel biomarker of PM 2.5 exposure. (medsci.org)
  • RNA-binding proteins (RBPs) mediate pivotal cellular functions such as RNA transport, degradation or translation and represent key effectors of post-transcriptional gene regulation. (nature.com)
  • Post-transcriptional regulation is the control of gene expression at the RNA level. (wikipedia.org)
  • After being produced, the stability and distribution of the different transcripts is regulated (post-transcriptional regulation) by means of RNA binding protein (RBP) that control the various steps and rates controlling events such as alternative splicing, nuclear degradation (exosome), processing, nuclear export (three alternative pathways), sequestration in P-bodies for storage or degradation and ultimately translation. (wikipedia.org)
  • These activate the ""late"" transcriptional reprogramming influencing DNA repair, cell cycle regulation and apoptosis. (europa.eu)
  • Transcriptional and Post-Transcriptional Regulation and Transcriptional Memory of Chromatin Regulators in Response to Low Temperature. (mpg.de)
  • This data is the first description of diauxic lag regulation involving two PTS and a multidomain regulator and could serve as a promising approach for studying the S. pneumoniae growth process on complex carbon sources as possibly encountered in the human host. (unisi.it)
  • Keini Dressano et al, Dynamic regulation of Pep-induced immunity through post-translational control of defense transcript splicing, Nature Plants (2020). (phys.org)
  • Computational analysis of crosstalk between transcriptional regulators and RNA-binding proteins suggests mutual regulation of polycomb proteins and SRSF1 influencing adult hippocampal neurogenesis. (bvsalud.org)
  • Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
  • We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)
  • The clock-regulated RNA-binding protein AtGRP7 (Arabidopsis thaliana glycine-rich RNA-binding protein) influences circadian oscillations of its transcript by negative feedback at the post-transcriptional level. (uni-bielefeld.de)
  • In this regard, most studies have focused on transcriptional regulators (TRs), epigenetic modifiers, or non- coding RNAs. (bvsalud.org)
  • Further, the polycomb complex proteins and SRSF1 could have a mutual regulatory relationship, suggesting a cross-talk between epigenetic /transcriptional and post-transcriptional regulatory pathways. (bvsalud.org)
  • Although the plant and animal kingdoms were separated more than 1,6 billion years ago, multicellular development is for both guided by similar transcriptional, epigenetic and posttranscriptional machinery. (lu.se)
  • There is evidence that circRNAs are specifically expressed in hematological malignancies or certain developmental stages, indicating that circRNAs have considerable regulatory potential by serving as post-transcriptional regulators ( 11 , 12 ). (spandidos-publications.com)
  • To accomplish this, the transcriptional unit is preceded by regulatory elements, such as promoters and enhancers, that modulate production of its protein encoding transcript ( Figure 1.2 ). (ernolaszlo.com)
  • We discovered specific chemical modifications that control regulatory function, transcriptional targets of the regulator, differential splicing of the targets and precise effects of splicing on both target function and overall plant immune responses and disease resistance. (phys.org)
  • ArcA is the regulatory protein of the dual-component regulator ArcAB, in which the later discovered ArcB acts as sensory protein [9]. (hormonessignaling.com)
  • Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)
  • Differentially expressed genes, upstream transcriptional regulators, and responses corresponding to inflammation/immune function and pathological changes (e.g. fibrosis) were persistent in the high dose but transient in the middle dose. (cdc.gov)
  • Global regulators control a vast number of genes, which must be physically separated on the genome and belong to different metabolic pathways [6]. (hormonessignaling.com)
  • Only seven global regulators are required to control the www.selleckchem.com/products/MGCD0103(Mocetinostat).html expression of 51% of all genes: ArcA, Crp, Fis, Fnr, Ihf, Lrp, and NarL. (hormonessignaling.com)
  • In contrast to global regulators, local regulators control only a few genes, e.g. 20% of all TFs control the expression of only one or two genes [7]. (hormonessignaling.com)
  • Our project offers a unique opportunity for Master's student to gain hands-on experience focused on transcriptional regulators with importance in expression of genes of outer membrane proteins that are essential in host-pathogen interaction. (lu.se)
  • We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
  • Nevertheless, the key regulators and mechanisms regulating T cell activation in the blood of CD have not been fully described. (hindawi.com)
  • This work went beyond simply identifying a new regulator of plant immunity," said Huffaker, of the detailed mechanisms uncovered. (phys.org)
  • We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
  • Taken together, our results suggest that post-transcriptional mechanisms play an important role in the brain both during development and in the adult brain. (lu.se)
  • However, for an immediate and effective response, global post-transcriptional control of mRNA stability, splicing and translation may be crucial during "immediate-to-early" DDR. (europa.eu)
  • The novel switch was found in Arabidopsis plants to control splicing of mRNA transcripts that encode signaling protein regulators of the plant immune response. (phys.org)
  • Thus, we propose a hypothesis, PM 2.5 exposure induces M1 polarization and miR-146a-3p is a potential upstream regulator by targeting SIRT1. (medsci.org)
  • The proposed project explores a previously uncharacterized link between post-transcriptional RNA operons and DDR. (europa.eu)
  • The establishment of large-scale genomic collaborative efforts along with the development of new single-cell transcriptomic techniques and multi-omics approaches have enabled characterization of the mutational and transcriptional profiles of many cancer types and helped to identify clinically actionable alterations as well as predictive and prognostic biomarkers. (cdc.gov)
  • We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)
  • SRSF1 may influence post-transcriptional stability, localization , and alternative splicing patterns of polycomb complex transcripts, and the polycomb proteins may in turn epigenetically influence the SRSF1. (bvsalud.org)
  • Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)
  • The mechanistic basis of DDR has been classically thought to consist of an ""early"" post-translational response, which results in activation of several signalling pathways and transciption factors. (europa.eu)
  • Mice were sacrificed at 0, 28, and 84 d post-exposure with lung, liver, and aorta collected for microarray-based gene expression profiling analyzed in conjunction with alterations in lavage proteins, alveolar macrophage function, histopathology, extrathoracic translocation, and systemic effects. (cdc.gov)
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
  • RNA-binding proteins (RBPs) have emerged as dominant molecular regulators. (bvsalud.org)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • There is very little molecular homology between mammals and plants for these core regulators. (lu.se)
  • FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. (thermofisher.com)
  • Also our study indicated that WSC induced an increase in the transcriptional expression of matrix metalloproteinases, MMP-2 and MMP-9 and an immune response regulator, Toll Like Receptor-4. (who.int)
  • In addition, CD8 + T cell transcriptional signatures were identified as reliable prognostic biomarkers in the blood of CD patients [ 6 , 7 ]. (hindawi.com)
  • ELAVL1 possibly acts as a key regulator of T cell activation via the NLR signaling pathway. (hindawi.com)
  • The regulators investigated in this study are the global regulator ArcA and the local regulator IclR. (hormonessignaling.com)
  • The second regulator investigated in this study, isocitrate lyase regulator (IclR), represses the expression of the aceBAK operon, which codes for the glyoxylate pathway enzymes isocitrate lyase (AceA), malate synthase (AceB), and isocitrate dehydrogenase kinase/phosphatase (AceK) [16]. (hormonessignaling.com)
  • The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators. (embl.de)
  • Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in 'scurfy' (sf) mice. (thermofisher.com)
  • Together, these results suggest that Smaug and Vts1 define a larger class of post-transcriptional regulators that act in part through a common transcript-recognition mechanism. (embl.de)
  • Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. (plos.org)
  • In line with our previous results, we found that there are marked differences between HD patients and controls at the protein level but not at the transcriptional level. (lu.se)
  • Holocarboxylase Synthetase: A Moonlighting Transcriptional Coregulator of Gene Expression and a Cytosolic Regulator of Biotin Utilization. (medscape.com)
  • Afterwards, whether Sirtuin1 (SIRT1) an important intermediate regulator in various physiological processes takes part in the macrophage polarization induced by PM 2.5 is unknown. (medsci.org)
  • Transcriptome Analysis of Soybean Leaf Abscission Identifies Transcriptional Regulators of Organ Polarity and Cell Fate. (stembook.org)
  • We performed an integrated bioinformatics analysis to find key regulators by NetworkAnalyst [ 10 ], a web-based visual analytics platform. (hindawi.com)
  • The experimental results and the related insights provided by the mathematical model provide evidence that the conflicting activation of the CelR regulator is at the origin of the lag phase during sequential growth on glucose and cellobiose. (unisi.it)
  • These results identify Alr3614 as a transcriptional repressor of the CAST system in Anabaena sp. (researchsquare.com)
  • DETAILS Desired ProfileThe candidate must be Graduate / Post Graduate with subject specialization and adequate experience of teaching. (timesjobs.com)
  • DETAILS Organisation : The Pine Crest SchoolJob Title : Post Graduate Teacher ( PGT ) - Biology Location : DLF City-1 , Gurugram ( formerly Gurgaon ) , Haryana , In. (timesjobs.com)