T-PLL has the immunophenotype of a mature (post-thymic) T-lymphocyte, and the neoplastic cells are typically positive for pan-T antigens CD2, CD3, and CD7 and negative for TdT and CD1a. (wikipedia.org)
Lymphomas1
In addition, cytoplasmic vacuoles are not uncommon in large cell lymphomas involving body cavities. (cytojournal.com)
Bone marrow1
T-cell-prolymphocytic leukemia (T-PLL) is a mature T-cell leukemia with aggressive behavior and predilection for blood, bone marrow, lymph nodes, liver, spleen, and skin involvement. (wikipedia.org)
Involvement2
In the spleen, the leukemic cell infiltrate both the red pulp and white pulp, and lymph node involvement is typically diffuse through the paracortex. (wikipedia.org)
In large cell lymphoma and leukemia cells involvement of body fluid this concept becomes less challenging. (cytojournal.com)
Blood1
100 x 109/L) along with low amounts of red blood cells and platelets in the blood are common findings. (wikipedia.org)
Difficult2
T-cell prolymphocytic leukemia is difficult to treat, and it does not respond to most available chemotherapeutic drugs. (wikipedia.org)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
Mature3
It is postulated that the originating cell line for this disease is a mature (post-thymic) T-cell. (wikipedia.org)
Despite its overall rarity, it is also the most common type of mature T cell leukemia. (wikipedia.org)
Large cell lymphoma and leukemia cells tend to have large size nuclei, less mature chromatin, and visible nucleoli with and without cytoplasmic vacuoles. (cytojournal.com)
Rare1
T-PLL is a very rare leukemia, primarily affecting adults over the age of 30. (wikipedia.org)
Small3
It represents 2% of all small lymphocytic leukemias in adults. (wikipedia.org)
A small cell variant comprises 20% of all T-PLL cases, and the Sézary cell-like (cerebriform) variant is seen in 5% of cases. (wikipedia.org)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
Treatment3
Most patients with T-cell prolymphocytic leukemia require immediate treatment. (wikipedia.org)
Some patients who successfully respond to treatment also undergo stem cell transplantation to consolidate the response. (wikipedia.org)
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Chronic2
Other names include T-cell chronic lymphocytic leukemia, "knobby" type of T-cell leukemia, and T-prolymphocytic leukemia/T-cell lymphocytic leukemia. (wikipedia.org)
Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disease of cytotoxic T cells or NK cells with LGL morphology and frequently complicated cytopenia and/or different autoimmune diseases, which often require medical interventions, although LGL leukemia itself is seldom lethal. (bvsalud.org)
Autologous stem cell trans1
Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Lymphoma11
Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
In doing so, the overarching goal of the Collaborative Research Center is to create and strengthen synergies towards the discovery of patho-mechanisms and the identification of innovative therapeutic strategies beyond the lymphoma cell-autonomous level. (sfb1530.de)
The close interactions with oncology centers of excellence in Cologne, Essen, Frankfurt, Berlin and Heidelberg and with major German lymphoma and leukemia study groups will allow for a rapid translation of major findings into clinical application. (sfb1530.de)
Improved patient outcomes can only be achieved in an interdisciplinary approach and strengthening of synergies towards the discovery of pathomechanisms and the identification of innovative therapeutic strategies beyond the lymphoma cell-autonomous level. (sfb1530.de)
The SFB1530 brings together the synergistic combination of efficient disruption of lymphoma cell-intrinsic oncogenic programs and a specific modulation of the lymphoma (immune) microenvironment. (sfb1530.de)
Macrophages in the B-cell lymphoma microenvironment represent a functional node in progression and therapeutic response. (sfb1530.de)
Pentose phosphate pathway (PPP) inhibition by specific compounds and shRNA targeting induced increased phagocytic lymphoma cell clearance. (sfb1530.de)
Moreover, macrophages provided decreased support for survival of lymphoma cells. (sfb1530.de)
Addition of the PPP inhibitor S3 to antibody therapy achieved significantly prolonged overall survival in an aggressive B-cell lymphoma mouse model. (sfb1530.de)
Stem cell transplant1
Some patients who successfully respond to treatment also undergo stem cell transplantation to consolidate the response. (wikipedia.org)
Aggressive3
T-cell-prolymphocytic leukemia (T-PLL) is a mature T-cell leukemia with aggressive behavior and predilection for blood, bone marrow, lymph nodes, liver, spleen, and skin involvement. (wikipedia.org)
OBJECTIVE: To explore and summarize the clinical characteristics and treatment of aggressive NK-cell leukemia (ANKL), and provide new insights for clinical diagnosis and treatment of this disease. (bvsalud.org)
Aggressive natural killer cell leukemia (ANKL) is a rare lymphoid neoplasm frequently associated with Epstein-Barr virus, with a disastrously poor prognosis. (bvsalud.org)
Tumor1
In vitro, abrogation of cFLIP cleavage sensitizes cells to tumor necrosis factor(TNF)-induced necroptosis and apoptosis by favoring complex-II formation. (sfb1530.de)
Erythroid1
Immunologic dysregulations in LGL leukemia contribute to the development of complications, for example, neutropenia with the involvement of Fas ligand system and, in pure red cell aplasia, which is a common complication among the patients of East Asian origin, impairing erythroid developments by cytotoxic T cells. (bvsalud.org)
Abnormal1
Immunophenotyping revealed abnormal NK cells in 5 cases. (bvsalud.org)
Bone1
The morphology of bone marrow cells in 7 patients showed similar large granular lymphocytes. (bvsalud.org)
Findings2
100 x 109/L) along with low amounts of red blood cells and platelets in the blood are common findings. (wikipedia.org)
Characteristic mutational features in STAT3, STAT5B, CCL22, and other genes in specific subtypes of LGL leukemia have been detected, that would be associated with immunologically mediated molecular pathogenesis in LGL leukemia, and these new findings may help in creating optimal diagnostic approaches or novel therapies for LGL leukemia. (bvsalud.org)
Cases1
A small cell variant comprises 20% of all T-PLL cases, and the Sézary cell-like (cerebriform) variant is seen in 5% of cases. (wikipedia.org)
Molecular1
In summary, the SFB1530 will undertake a holistic and interdisciplinary effort, which will create a comprehensive inventory of the major patho-mechanisms that define high-risk B cell malignancies in their specific microenvironment as a molecular framework for mechanism-based therapies. (sfb1530.de)
Require1
Most patients with T-cell prolymphocytic leukemia require immediate treatment. (wikipedia.org)
Syndrome1
The nuclei are usually round to oval in shape, with occasional patients having cells with a more irregular nuclear outline that is similar to the cerebriform nuclear shape seen in Sézary syndrome. (wikipedia.org)
Found1
Here, we found an essential role for cFLIP cleavage in restraining cell death in different pathophysiological scenarios. (sfb1530.de)
Patients1
[ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)