Termed bronchiolitis obliterans syndromeObliterative bronchiolitisDiseasesSyndromeInterstitial lung diPneumoniaPIBOTransplantationPaediatricLungClinicalPatientsChronicTobaccoInfectionLungsInfectionsViralTransplantChildrenResultsEarlyWorkersProfileGraft versusObliterativeHematopoietic Cell TransplantationTransplantationAcuteComplicationsClinicalAffectsPulmonarySevereInhalationDiseaseCigaretteRiskLong termRareCase
Termed bronchiolitis obliterans syndrome2
- The disease is often termed bronchiolitis obliterans syndrome (BOS) in the setting of post lung transplantation and hematopoietic stem cell transplant (HSCT). (wikipedia.org)
- Since OB is difficult to diagnose, a committee sponsored by now accepted as appropriate treatment for end-stage the International Society for Heart and Lung Transplan- tation (ISHLT) proposed a clinical description of OB, One-year survival for lung transplant recipients has termed bronchiolitis obliterans syndrome This risen from 47% in 1988 to 75% in 2001. (pdfdrugs.com)
Obliterative bronchiolitis3
- Bronchiolitis obliterans (BO), also known as obliterative bronchiolitis, constrictive bronchiolitis and popcorn lung, is a disease that results in obstruction of the smallest airways of the lungs (bronchioles) due to inflammation. (wikipedia.org)
- A number of studies were identified that showed short-term beneficial outcomes or the potential for such outcomes in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, asthma and post-transplant obliterative bronchiolitis. (ersjournals.com)
- What is less clear is the evidence for a role of macrolides in the treatment of other chronic inflammatory airway diseases, e.g. cystic fibrosis, bronchiectasis, asthma, obliterative bronchiolitis, chronic obstructive pulmonary disease (COPD) and chronic rhinosinusitis. (ersjournals.com)
Diseases7
- These insults include inhalation damage, post transplant auto-immune injury, post-infectious disease, drug reactions, and several auto-immune diseases. (wikipedia.org)
- Dr. Ardura is a pediatric infectious diseases (ID) physician at Nationwide Children's Hospital and Associate Professor of Pediatrics at The Ohio State University. (societyforpediatricresearch.org)
- Open Forum Infectious Diseases. (lu.se)
- European Journal of Clinical Microbiology and Infectious Diseases. (lu.se)
- CLASSIFICATION OF DISEASES AND INJURIES I. INFECTIOUS AND PARASITIC DISEASES (001-139) Includes: diseases generally recognized as communicable or transmissible as well as a few diseases of unknown but possibly infectious origin Excludes: acute respiratory infections (460-466) influenza (487. (cdc.gov)
- certain localized infections Note: Categories for "late effects" of infectious and parasitic diseases are to be found at 137. (cdc.gov)
- COPD is increasing worldwide because of increases in smoking and reduction in mortality due to infectious diseases. (msdmanuals.com)
Syndrome5
- BO and its clinical correlate bronchiolitis obliterans syndrome (BOS) affect up to 50-60% of patients who survive 5 yrs after surgery, irrespective of the type of transplant procedure 1 , 4 - 6 . (ersjournals.com)
- Bronchiolitis obliterans (post-infectious, associated with Stevens-Johnson Syndrome, associated with bone marrow transplant and lung transplant). (healthycyte.com)
- Some forms of viral pneumonia, particularly adenoviral disease, tend to cause bronchiolitis obliterans and hyperlucent lung syndrome. (pediatriconcall.com)
- Epidemiology of lower respiratory tract infections and community-acquired respiratory viruses in patients with bronchiolitis obliterans syndrome after hematopoietic cell transplant: a retrospective cohort study. (stanford.edu)
- Among 55 patients with bronchiolitis obliterans syndrome, 34 (61.8%) developed lower respiratory tract infections, which were associated with impaired lung function and a trend toward increased mortality. (stanford.edu)
Interstitial lung di1
- Cystic fibrosis, pulmonary hypertension, bronchiolitis obliterans, and interstitial lung disease are the most prevalent conditions leading to lung transplantation. (healthycyte.com)
Pneumonia3
- It is not related to cryptogenic organizing pneumonia, previously known as bronchiolitis obliterans organizing pneumonia. (wikipedia.org)
- Essential manifestations that creates sudden adjustments in the sufferers' conditions and so are frustrating for the clinicians, specifically for the intense care device (ICU) health suppliers, are aspiration pneumonitis (chemical substance pneumonitis) and aspiration pneumonia (infectious procedure secondary for an aspiration event) due to macroaspiration. (technuc.com)
- Murugappan M, Ahmed J, Morrow LE, Soundarajan S. Atypical Presentation of Bronchiolitis Obliterans Organizing Pneumonia. (creighton.edu)
PIBO3
- Abstract Objective: We aimed to further assess the evolution of pulmonary function and bronchodilator response in the Chinese case series with post-infectious bronchiolitis obliterans (PIBO). (authorea.com)
- Post-infectious bronchiolitis obliterans (PIBO) is a chronic lung disease involving fibrosis and obstruction of the terminal bronchioles. (usim.edu.my)
- Post-infectious bronchiolitis obliterans (PIBO) is a rare but severe complication of respiratory infections caused by usually benign viruses such as adenoviruses. (idrc-crdi.ca)
Transplantation2
- Furthermore, a meticulous approach to post-transplant management in the immediate post-operative period, in the early and long-term has contributed to continually improving long-term survival after lung transplantation. (ersjournals.com)
- PURPOSE OF REVIEW: Fever is a common manifestation of both infectious and noninfectious processes in recipients of hematopoietic cell transplantation (HCT) and chimeric antigen receptor T-cell (CAR-T) therapy. (stanford.edu)
Paediatric1
- No data are available in the literature about the levels of these AMPs in paediatric patients with post-infectious bronchiolitis obliterans (BO). (bezmialem.edu.tr)
Lung3
- Bronchiolitis obliterans is a common complication in lung transplants because transplanted lungs are at greater risk of alloimmunization as compared to healthy lungs. (wikipedia.org)
- Patients who develop BOS post lung transplant vary in disease latency and severity. (wikipedia.org)
- Bronchiolitis obliterans (BO) after LTx was first described in 1984 at Stanford University, Stanford, CA, USA, in heart-lung transplant recipients who showed a progressive decline inforced expiratory volume in one second (FEV 1 ) 3 . (ersjournals.com)
Clinical4
- Clinical profile and course of children with postinfectious bronchiolitis obliterans from a tertiary care hospital. (usim.edu.my)
- Clinical course of postinfectious bronchiolitis obliterans. (usim.edu.my)
- This article discusses the alloimmune-dependent and -independent risk factors for bronchiolitis obliterans, the current understanding of the pathogenesis of bronchiolitis obliterans based on results of animal and human studies, the clinical staging of the complication, strategies that may contribute to the prevention and/or early detection of bronchiolitis obliterans, and suggestions for future research. (ersjournals.com)
- The clinical diagnoses made by PCPs during the baseline and post-intervention phase were audited by a panel of pulmonologists. (bvsalud.org)
Patients2
- This study aimed to determine human -defensin 2 (hBD2) and LL-37 levels and compare between post-infectious BO patients and the control group. (bezmialem.edu.tr)
- OKT3 (5 mg/kg) was given intravenously on post-transplant days 1 to 5 with Methylprednisolone 500 mg IV was given to all patients immediately before reperfusion. (pdfdrugs.com)
Chronic2
- However, chronic allograft dysfunction in the form of bronchiolitis obliterans remains a major hurdle that threatens both the quality of life and long-term survival of the recipients. (ersjournals.com)
- Gout is a chronic, painful, non-infectious, non-lethal disease associated with crystal deposition of uric acid, when uric acid concentration exceeds 6.8 mg/dl plasma. (giornaleitalianodinefrologia.it)
Tobacco1
- Other risk factors post transplant including tobacco use, age of donor, age of recipient, lower baseline FEV1/FVC ratio, non-caucasian race, peripheral and lower circulating IgG levels. (wikipedia.org)
Infection1
- However, like the other respiratory viruses that affect this population, the infection can cause serious complications such as infection of the lower respiratory tract (ITRI), bronchiolitis obliterans (BO) and even death. (fapesp.br)
Lungs1
- [2] Some include chemical induced inflammation of the lungs as a subtype, which occurs from acidic but non-infectious stomach contents entering the lungs. (mdwiki.org)
Infections1
- Other lower respiratory tract infections seen in children are croup (laryngotracheobronchitis), bronchitis, and bronchiolitis. (pediatriconcall.com)
Viral1
- Current scientific trials are looking into cyclin-dependent kinase (CDK) inhibitors, such as for example roscovitine, an inhibitor of CDK1, -2, -5, -7, and -9, that lowers viral DNA synthesis, creation of late protein and infectious pathogen particles [4]. (niepokorny.org)
Transplant3
- Capable of conforming to the post-transplant regimen. (healthycyte.com)
- We hypothesize that this alkalinization would persist in the iron-laden post-transplant microenvironment increasing the risk of IA. (stanfordchildrens.org)
- As of December 1993, RATG was routinely used with a dose of 1.5 mg/kg given intravenously on post-transplant days 1, 2, 3, 5, and 7 after pre-medication with diphen- hydramine and acetaminophen. (pdfdrugs.com)
Children3
- Post infectious bronchiolitis obliterans in children. (usim.edu.my)
- Risk factors for the development of bronchiolitis obliterans in children with bronchiolitis. (usim.edu.my)
- Post-infectious bronchiolitis obliterans in children: a review of 42 cases. (usim.edu.my)
Results1
- Bronchiolitis obliterans results in worsening shortness of breath, wheezing, and a dry cough. (wikipedia.org)
Early1
- Prior descriptions occurred as early as 1956, with the term "bronchiolitis obliterans" used first by Reynaud in 1835. (wikipedia.org)
Workers1
- bronchiolitis obliterans in flavor-manufacturing workers has been identified in Ohio, California, Maryland, and New Jersey. (thepumphandle.org)
Profile1
- in addition to the change in the metabolomic profile due to the interaction caused by the infectious-tumor process. (fapesp.br)
Graft versus2
- 14. Quantitative computed tomography assessment of graft-versus-host disease-related bronchiolitis obliterans in children: A pilot feasibility study. (nih.gov)
- Pulmonary afflictions after HCT, such as peri-engraftment respiratory distress syndrome (PERDS), idiopathic and infectious pneumonia syndromes, diffuse alveolar hemorrhage (DAH), thrombotic microangiopathy (TMA), graft versus host disease (GVHD)/bronchiolitis obliterans, and interstitial lung disease progressing to pulmonary fibrosis are varied and complex. (nih.gov)
Obliterative3
- Bronchiolitis obliterans (BO), also known as obliterative bronchiolitis, constrictive bronchiolitis and popcorn lung, is a disease that results in obstruction of the smallest airways of the lungs (bronchioles) due to inflammation. (wikipedia.org)
- 6. Obliterative bronchiolitis: individual CT signs of small airways disease and functional correlation. (nih.gov)
- The disease starts as an obliterative bronchiolitis with concomitant vasculitis commonly following infections with certain organisms. (pediatriconcall.com)
Hematopoietic Cell Transplantation2
- 18. Inert Gas Washout in Bronchiolitis Obliterans Following Hematopoietic Cell Transplantation. (nih.gov)
- PURPOSE OF REVIEW: Fever is a common manifestation of both infectious and noninfectious processes in recipients of hematopoietic cell transplantation (HCT) and chimeric antigen receptor T-cell (CAR-T) therapy. (stanford.edu)
Transplantation7
- There is also a need for discovery of novel biomarkers that facilitate the diagnosis and respiratory care of patients post transplantation. (nih.gov)
- Recipient NOD2/CARD15 variants: a novel independent risk factor for the development of bronchiolitis obliterans after allogeneic stem cell transplantation. (cdc.gov)
- Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation. (cdc.gov)
- Sirolimus Following CsA Withdrawal: 2-4 months post-transplantation, withdraw CsA over 4-8 weeks ( 2.2 ). (nih.gov)
- Sirolimus and CsA Combination Therapy (for the first 12 months post-transplantation): One loading dose of up to 15 mg on day 1, followed by daily maintenance doses of 5 mg ( 2.3 ). (nih.gov)
- Afshar K, Bremer M, Ravichandran B, Feist AA, Golts E, Schonhoft EH, Yung G. Experience with Alpha-1 Proteinase Replacement Post-Lung Transplantation in Alpha-1 Antitrypsin Deficiency: A Single Center Case Series. (lidsen.com)
- Our primary objective was to assess potential benefits of continually administering A1-PI from pre- to post-transplantation for AATD LTx recipients. (lidsen.com)
Acute4
- Post-infectious bronchiolitis obliterans (PIBO) is a severe disorder following acute lower pulmonary infection in young children, especially caused by adenovirus. (nih.gov)
- To continue to address this wide array of outstanding scientific questions involving post-HCT pulmonary complications across the lifespan, the NHLBI is interested in renewing its support for observational, mechanistic, and discovery-based research studies, mechanistic clinical trials, and novel medical device development that aim to elucidate mechanisms of acute airway, alveolar and vascular injury after HCT, and explore mechanism-based therapeutic strategies in this challenging field. (nih.gov)
- The main pathogenetic event seems to be acute bronchiolitis with obliteration of small airway in infancy or early childhood. (pediatriconcall.com)
- This case of life-threatening acute bronchiolitis posed a diagnostic and therapeutic challenge," write the authors. (scitechdaily.com)
Complications1
- However, this has simultaneously created newer unwanted opportunities for pathogens to cause infectious complications. (medscape.com)
Clinical1
- 2 More recently, additional evidence for this view has been put forward from evaluation of clinical criteria by microbiological 3 or post-mortem histological reference tests. (bmj.com)
Affects1
- Bronchiolitis obliterans affects up to 5.5% of people who have received HSCT. (wikipedia.org)
Pulmonary4
- 2. Correlation of high-resolution CT and pulmonary function in bronchiolitis obliterans: a study based on 24 patients associated with consumption of Sauropus androgynus. (nih.gov)
- 7. Xenon ventilation CT using dual-source and dual-energy technique in children with bronchiolitis obliterans: correlation of xenon and CT density values with pulmonary function test results. (nih.gov)
- 9. Quantitative CT and pulmonary function in children with post-infectious bronchiolitis obliterans. (nih.gov)
- 17. Pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans. (nih.gov)
Severe2
- Post-infectious bronchiolitis obliterans (PIBO) is a rare but severe complication of respiratory infections caused by usually benign viruses such as adenoviruses. (idrc-crdi.ca)
- Immunocompromised hosts, regardless of underlying illness or factors leading to immunosuppression, commonly present diagnostic challenges in the face of severe infectious disease processes. (medscape.com)
Inhalation1
- Given the patient's intense vaping exposure to flavored e-liquid and negative workup for other causes of bronchiolitis, we suspected that bronchiolitis obliterans might have been developing in this patient as in microwave popcorn factory workers exposed to occupational inhalation of diacetyl. (scitechdaily.com)
Disease1
- [ 15 ] The focus of this article is adult populations, although infectious disease issues germane to the pediatric SOT recipient are discussed in Special Host Considerations. (medscape.com)
Cigarette1
- Reference: "Life-threatening bronchiolitis related to electronic cigarette use in a Canadian youth" by Simon T. Landman, Inderdeep Dhaliwal, Constance A. Mackenzie, Tereza Martinu, Andrew Steele and Karen J. Bosma, 20 November 2019, CMAJ . (scitechdaily.com)
Risk3
- Other risk factors post transplant including tobacco use, age of donor, age of recipient, lower baseline FEV1/FVC ratio, non-caucasian race, peripheral and lower circulating IgG levels. (wikipedia.org)
- There has been an association shown between the increased use of peripheral stem cells and the risk of developing bronchiolitis obliterans. (wikipedia.org)
- We hypothesize that this alkalinization would persist in the iron-laden post-transplant microenvironment increasing the risk of IA. (stanfordchildrens.org)
Long term1
- The COVID-19 outbreak presents the unprecedented challenge for world public and medical practitioners and health care providers, the post COVID-19 condition (or long COVID) includes long term symptoms which may persist for months or years after SARS-CoV-2 infection. (journalmc.org)
Rare1
- Bronchiolitis obliterans is rare in the general population. (wikipedia.org)
Case1
- A team of authors from Lawson Health Research Institute in London, Ontario, and University Health Network (UHN) in Toronto, who were all involved in the care of the patient, report on the case of life-threatening bronchiolitis. (scitechdaily.com)