• During embryo development, naïve cell lineages undergo concurrent processes of fate specification and morphogenesis as critical steps towards the generation of differentiated tissues and organs. (elifesciences.org)
  • Several embryonic tissues and organs originate from small sets of progenitor cells. (elifesciences.org)
  • Cell Proliferation: Cleavage ensures the production of a sufficient number of cells for the subsequent development and construction of tissues and organs within the embryo. (microbiologynote.com)
  • Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
  • Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
  • A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. (wikipedia.org)
  • Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can cause developmental disorders. (wikipedia.org)
  • The development of the reproductive system is the part of embryonic growth that results in the sex organs and contributes to sexual differentiation. (wikipedia.org)
  • The three-dimensional culture allows the cells to self-organize into complex tissues using mechanical cues that are found during embryonic development," Koehler said. (iu.edu)
  • Taken together, these observations suggest a role of matrix metalloproteinases in the establishment of asymmetric organ development, likely through the regulation of morphogenetic signals. (bmj.com)
  • Here, we examine this question during the early stages of morphogenesis of the embryonic laterality organ, the first organ to form during vertebrate development, using the zebrafish as a model organism. (elifesciences.org)
  • Human embryo development and early organ formation remain largely unexplored due to ethical issues surrounding the use of embryos for research as well as limited availability of materials to study. (eurekalert.org)
  • Because monkeys are closely related to humans evolutionarily, we hope the study of these models will deepen our understanding of human embryonic development, including shedding light on some of the causes of early miscarriages. (eurekalert.org)
  • Further application of monkey blastoids can help to dissect the molecular mechanisms of primate embryonic development. (eurekalert.org)
  • FGFs are essential for early embryonic development, organ formation, and angiogenesis. (rcsb.org)
  • How, exactly, are genes turned on and off at different times and in different places during embryonic development so that we grow structures and organs rather than a becoming a big ball of cells that are all identical to that first cell? (byu.edu)
  • Haeckel aggressively argued that the development of an embryo repeats or recapitulates the progressive stages of lower life forms and that by studying embryonic development one could thus study the evolutionary history of life on earth. (asu.edu)
  • Embryonic differentiation is the process of development during which embryonic cells specialize and diverse tissue structures arise. (asu.edu)
  • The embryonic development and colour changes of eggs during incubation were documented. (researchgate.net)
  • The condition is thought to arise during embryonic development, when a structure that typically forms a single kidney splits in two. (livescience.com)
  • The face has a complex origin arising from a number of head structures and sensitive to a number of teratogens during critical periods of its development. (edu.au)
  • To know the 3 major parts (external, middle and inner) of hearing development and their embryonic origins. (edu.au)
  • Similarly, during Drosophila embryonic development, SERCA activity is required for the proper formation of both the central nervous system axon tracts and the network of tracheal tubules that deliver oxygen to tissues. (caltech.edu)
  • During embryonic development, amorphous cardiac precursor cells are organized into a rhythmically contracting, multi-chambered muscular structure, complete with valves, vessels, and a conduction system. (cshlpress.com)
  • This volume is therefore a valuable reference for all cell and developmental biologists, geneticists, and cardiologists who are interested in the early development and abnormalities of this complex, vital organ. (cshlpress.com)
  • Importantly, a precise temporal description of RPRM protein expression during the development of neuronal structures is still missing. (frontiersin.org)
  • Ex vivo whole embryonic kidney culture: a novel method for research in development, regeneration and transplantation. (ca.gov)
  • By the end of the embryonic stage, the beginnings of features such as fingers, eyes, mouth, and ears become visible, during this time, there is also development of structures important to support the embryo, including the placenta and umbilical cord. (indiachildnames.com)
  • During continued fetal development, the early body systems and structures that were established in the embryonic stage continue to develop. (indiachildnames.com)
  • 20 Epithelial tissue is essential for organ formation and development. (facts.net)
  • Combining organoids and CRISPR/Cas9 creates exciting new opportunities to study organ development and human disease in vitro. (prinsesmaximacentrum.nl)
  • Cleavage provides the necessary cells for subsequent embryonic development, without significant growth or alteration in embryo shape. (microbiologynote.com)
  • Wnt signaling is critical for normal embryonic development of the skin, bones, and other structures. (medscape.com)
  • Since Wnt signaling proteins cannot be released without the PORCN protein, and Wnt signaling is important for normal embryonic development, the defects found in this disorder are related to lack of Wnt signaling. (medscape.com)
  • Wnt proteins are key regulators of embryonic development. (medscape.com)
  • Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. (elifesciences.org)
  • Any sense organ (UBERON:6005155) that is part of some larval head (UBERON:6001730). (mcw.edu)
  • Courtship behaviour, captive breeding, embryonic and larval developments of Nemateleotris decora and its rearing with suitable live feed were described. (researchgate.net)
  • Dynamic imaging of Drosophila embryonic tracheal morphogenesis demonstrates that SERCA's principal function is to govern cell migration. (caltech.edu)
  • Some anatomical structures in the developing embryo disappear completely or regress substantially once they serve their developmental purpose, remaining only as scar-like vestiges (literally, "footprints") in the mature human. (answersingenesis.org)
  • Importantly, the embryo-like structures do not have full developmental potential. (eurekalert.org)
  • Researchers have generated 3D blastocyst-like structures from stem cells. (sciencedaily.com)
  • An international collaboration of researchers from the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan and Gladstone Institutes in the USA have generated 3D blastocyst-like structures from stem cells. (sciencedaily.com)
  • INDIANAPOLIS - Indiana University scientists have transformed mouse embryonic stem cells into key structures of the inner ear. (iu.edu)
  • In a paper published April 6 in the journal Cell Stem Cell , a team of investigators from China report for the first time the creation of embryo-like structures from monkey embryonic stem cells. (eurekalert.org)
  • The investigators started with macaque embryonic stem cells, which they exposed to a number of growth factors in cell culture. (eurekalert.org)
  • These factors induced the stem cells to form embryo-like structures for the first time using non-human primate cells. (eurekalert.org)
  • iPS cells showed many characteristics of human embryonic stem cells (hESCs) such as expression of pluripotency markers, reactivation of telomerase and the ability to form teratomas, demonstrating a potential to redifferentiate into descendants of all three embryonic lineages. (biologists.com)
  • Organoids are threedimensional (3D) structures derived from adult or embryonic stem cells that maintain many structural and functional features of their respective organ. (prinsesmaximacentrum.nl)
  • It is now increasingly possible to create specific cell types and organ-like structures from an embryonic stem cell state, with improved recapitulation of physiological conditions. (ox.ac.uk)
  • The reproductive organs develop from the intermediate mesoderm and are preceded by more primitive structures that are superseded before birth. (wikipedia.org)
  • Male reproductive organs, sagittal section. (medscape.com)
  • The testis is a paired, ovoid male reproductive organ that sits in the scrotum, separated from its mate by a scrotal septum. (medscape.com)
  • The related structures of upper lip and palate significantly contribute to the majority of face abnormalities. (edu.au)
  • In the skin, these abnormalities follow the embryonic lines of Blaschko. (medscape.com)
  • Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. (elifesciences.org)
  • Found in various organs and structures throughout the body, epithelial tissue plays a critical role in maintaining the function and integrity of these components. (facts.net)
  • From the skin that covers our bodies to the lining of our internal organs, epithelial tissue acts as a protective barrier and also facilitates the exchange of substances with the environment. (facts.net)
  • 04 The epithelial tissue can be found in various organs. (facts.net)
  • 09 The surface of epithelial tissue can have specialized structures. (facts.net)
  • Epithelial tissue covers the surfaces of organs, lines body cavities, and forms the inner lining of blood vessels and other structures. (facts.net)
  • The main function of epithelial tissue is to protect underlying structures from physical injury, pathogens, and dehydration. (facts.net)
  • The success of this journey is critical when the number of progenitors in a tissue or organ is limited. (elifesciences.org)
  • The differentiation of cells during embryogenesis is the key to cell, tissue, organ, and organism identity. (asu.edu)
  • The term sex cord refers to an embryonic structures that develop into ovarian follicles and stromal cells are the connective tissue of any organ. (osmosis.org)
  • To know the main structures derived from components of the pharyngeal arches (groove, pouch and arch connective tissue). (edu.au)
  • Readily identifiable discrete structures include clitoral tissue at the most anterior aspect of the introitus, a urethral opening, and a hymenal ring. (medscape.com)
  • Previous attempts to "grow" inner-ear hair cells in standard cell culture systems have worked poorly in part because necessary cues to develop hair bundles - a hallmark of sensory hair cells and a structure critically important for detecting auditory or vestibular signals - are lacking in the flat cell-culture dish. (iu.edu)
  • Because the head contains many different structures also review notes on sensory , respiratory , Integumentary ( tooth ), endocrine ( thyroid , parathyroid , pituitary , thymus ) and cleft lip / cleft palate . (edu.au)
  • In the zebrafish, rprma mRNA is expressed in the olfactory placodes (OP) and olfactory epithelium (OE), rprmb is observed in the tectum opticum (TeO) and trigeminal ganglion (Tg), whereas rprml is found primarily in the telencephalon (Tel). At protein level, RPRM is present in a subset of cells in the OP, and neurons in the OE, TeO, hindbrain and sensory peripheral structures. (frontiersin.org)
  • The cochlea, which houses the sensory organ for hearing, consists of a triangular-shaped, fluid-filled channel, the membranous labyrinth, that is housed within the bony labyrinth (otic capsule). (cdc.gov)
  • Hair cells have a bundle of elongated microvilli called stereocilia that project from the apical membrane into an extracellular gelatinous material that overlies the sensory area in each vestibular organ. (cdc.gov)
  • The blastoids also formed early gestation sacs, fluid-filled structures that develop early in pregnancy to enclose an embryo and amniotic fluid. (eurekalert.org)
  • MATERIALS AND METHODS: Metanephric kidneys were microdissected from the embryos of timed pregnant WT C57BL/C6 mice on days 12 to 16 of gestation (embryonic days 12 to 16). (ca.gov)
  • In first 10 weeks of gestation the cell divides rapidly and begin to differentiate into the various body systems, the basic outlines of the organ, body, and nervous systems are established. (indiachildnames.com)
  • Sex organs begin to appear during the third month of gestation. (indiachildnames.com)
  • Anatomical structures of great complexity seem to begin as much simpler forms. (answersingenesis.org)
  • Here, we describe in detail the spatiotemporal expression of three rprm genes ( rprma, rprmb , and rprm l) within distinct anatomical structures in the developing peripheral and central nervous system. (frontiersin.org)
  • PURPOSE: Whole metanephric organ culture represents a novel investigatory approach with potential application in many aspects of research in kidney regeneration and transplantation. (ca.gov)
  • 2 Although named differently across vertebrate taxa, this structure has been observed in many species such as mouse (node), rabbit (Hensen's node) and zebrafish (Kupffer's vesicle, KV). (bmj.com)
  • In vertebrates, the establishment of L-R asymmetry is a conserved process initiated by breaking symmetry at an organising structure, consisting of an embryonic cavity at the midline that is filled with extraembryonic fluid. (bmj.com)
  • Defects in these processes cause heterotaxy, the abnormal formation and arrangement of visceral organs that can range from complete inversion of symmetry to the selective misarrangement of organs. (bmj.com)
  • On the other hand, morphogens and cell-cell interactions are critical to form a complex, specialized organ such as the mammalian lung. (caltech.edu)
  • The study shows that the blastocyst-like structures very closely resemble actual blastocysts, and even induce proper changes in the uterus after being implanted in pseudo-pregnant mice. (sciencedaily.com)
  • After seven days of conversion treatment, the new process can produce 5-30 floating self-assembled blastocyst-like structures. (sciencedaily.com)
  • When they examined small clusters of cells a few days before they matured into the blastocyst-like structures, they found that the cells contained gene expression for totipotency that are found in two-cell embryos. (sciencedaily.com)
  • A further test comparing the blastocyst-like structures with their precursors showed that cells in the matured structures were bound close together--a hallmark of blastocyst formation and polarization that is the result of a process called compaction. (sciencedaily.com)
  • Next the group investigated how genetically and functionally similar their blastocyst-like structures were to actual blastocysts. (sciencedaily.com)
  • Nevertheless, when transplanted to the womb of pseudo-pregnant mice, the blastocyst-like structures often induced changes to the uterus that are necessary for successful blastocyst implantation, including the integration of the maternal blood supply. (sciencedaily.com)
  • Background Laterality in the vertebrate embryo is determined by left-right asymmetric gene expression driven by the flow of extraembryonic fluid across the embryonic node. (bmj.com)
  • This structure-the heart-is the first organ to form in vertebrate embryos, and all subsequent life processes depend on its proper function. (cshlpress.com)
  • In the new report, the team has refined their reprogramming technique to produce embryo-like structures that are more similar to real embryos. (sciencedaily.com)
  • The investigators also transferred these embryo-like structures into the uteruses of female monkeys and determined that the structures were able to implant and elicit a hormonal response similar to pregnancy. (eurekalert.org)
  • When studied under a microscope, the embryo-like structures, also called blastoids, were found to have similar morphology to natural blastocysts. (eurekalert.org)
  • In future work, the investigators plan to focus on further developing the system of culturing embryo-like structures from monkey cells. (eurekalert.org)
  • The researchers acknowledge the ethical concerns surrounding this type of research but emphasize that there are still many differences between these embryo-like structures and natural blastocysts. (eurekalert.org)
  • not unique for the embryonic system but are shared by other ogenesis regulation must consider different scales of multi-cellular modeling areas. (lu.se)
  • produces a video display of organ motion, such as heart valve or fetal motion. (theodora.com)
  • In doing so, they noticed structures that looked like early embryo blastocysts. (sciencedaily.com)
  • The implanted structures often grew and produced many types of cells that resembled those naturally found in early developing embryos. (sciencedaily.com)
  • In the early embryo, these cell layers form the basis for many of the body's organs and tissues. (medlineplus.gov)
  • These bulbs serve as storage organs, containing all the necessary nutrients and embryonic growth structures to produce flowers. (webbsdirect.co.uk)
  • One of the largest organs in the body, the liver is responsible for digesting nutrients and detoxifying dangerous substances. (weizmann-usa.org)
  • Researchers now say around 18% of healthy adults above the age of 50 face accelerated aging in at least one of their organs. (medicaldaily.com)
  • Scientists may now have the means to determine the precise cellular structure of human organs, which could improve researchers', doctors', and patients' understanding of human diseases.Researchers at the Weizmann institute in Israel, led by Ido Amit and Shalev Itzkovitz, reconstructed the cellular structure of the liver in a Nature article published in February 2017. (weizmann-usa.org)
  • These maps, which organize cells by their genomes, will help researchers and medical professionals to better understand how and why cellular structures lead to organ functions.While researchers have long been interested in cellular maps, the ability to determine the locations of cells and their genomic blueprints has been limited by available molecular biology techniques. (weizmann-usa.org)
  • Ectoderm-mesoderm interactions are essential for the formation of several structures that arise from the ectoderm, including the skin, hair, nails, teeth, and sweat glands. (medlineplus.gov)
  • UBM is a noninvasive real-time technique that allows accurate and reliable images of the heart and other organs in mice [ 1 - 3 ]. (hindawi.com)
  • Finally, we characterize embryonic-stage CHD in Foxj1 loss-of-function mice, demonstrating randomized heart looping. (bvsalud.org)
  • An example would be the median umbilical ligament, a fibrous remnant between the top of the bladder and the "belly-button," marking a structure important during the formation of the urinary bladder. (answersingenesis.org)
  • Starting before birth, this signaling pathway controls the formation of ectodermal structures such as hair follicles, sweat glands, and teeth. (medlineplus.gov)
  • The consistent ultrasound image obtained with the UBM can be used to visualize and guide injection into target organs [ 9 , 10 ], including mouse embryo, to aid in targeted delivery of drugs and viral particles [ 7 , 11 ]. (hindawi.com)
  • Denervation of embryonic mouse lung explants reveals that lung branching requires nerves. (caltech.edu)
  • 4) The mouse organ of Corti averages about 6 mm in length and contains about 700 inner hair cells and 2400 outer hair cells. (cdc.gov)
  • Single-cell RNA sequencing revealed that the different types of cells found within the structures had similar gene expression patterns to cells found in natural blastocysts or post-implantation embryos. (eurekalert.org)
  • Individual clones were able to differentiate into cells expressing markers of all three germ layers as well as form teratomas with organ-like structures typical of all three embryonic lineages. (biologists.com)
  • FOXJ1 is expressed in ciliated cells of the airways, testis, oviduct, central nervous system and the embryonic left-right organizer. (bvsalud.org)
  • The various cells in the organ of Corti can be examined by 'optically sectioning' or using the z-axis (fine focus) of a microscope to focus at successively deeper layers within the epithelium. (cdc.gov)
  • Disadvantages: 1) The hair cells and supporting cells in the organ of Corti are very small. (cdc.gov)
  • They found that many genes related to the outer/inner cell fates of blastocysts were present in the induced structures, but at lower than natural levels, indicating that the new technique does not perfectly reproduce blastocysts. (sciencedaily.com)
  • Specifically, it is critical for interactions between two embryonic cell layers called the ectoderm and the mesoderm. (medlineplus.gov)
  • The HTH motif shows some sequence similarity but a similar structure in a wide range of DNA-binding proteins (e.g., cro and repressor proteins, homeodomain proteins, etc. (wikipedia.org)
  • New types of lab-grown organ buds, also called organoids, popped up in 2013. (the-scientist.com)
  • 1 Derived from Greek words ( hetero , 'different', and taxy , 'arrangement'), this condition is hallmarked by misplacement of the visceral organs across the L-R axis of the body. (bmj.com)
  • In August, scientists raised small, three-dimensional models of embryonic human brains that could form some of the complex structures of the organ. (the-scientist.com)
  • To understand the molecular events in the FGF1 release pathway, we studied the FGF1-S100A13 tetrameric and FGF1-S100A13-C2A hexameric complex structures, which are both complexes possibly formed during the non-classical pathway of FGF1 release. (rcsb.org)
  • 10 20 30 40 50 60 Helix 2 and helix 3 form a so-called helix-turn-helix (HTH) structure, where the two alpha helices are connected by a short loop region. (wikipedia.org)
  • However, they did not form fetuses and the structures disappeared after about a week. (eurekalert.org)
  • The first structure observed is the otic placode, on the embryo head surface, that sinks into the mesenchyme to eventually form the inner ear. (edu.au)
  • Without these signals, hair follicles, teeth, sweat glands, and other ectodermal structures do not form properly, which leads to the characteristic features of hypohidrotic ectodermal dysplasia. (medlineplus.gov)
  • Additionally, mistaken beliefs about vestigial structures are a product of erroneous recapitulation claims. (answersingenesis.org)
  • HN - 2008 BX - Lateral Sinus MH - Atrial Septum UI - D054087 MN - A07.541.459.249 MS - The thin membrane-like muscular structure separating the right and the left upper chambers (HEART ATRIA) of a heart. (bvsalud.org)
  • The superficial appearance of some structures (like so-called "gill-slits," discussed below) leads to false faith in Haeckel's claims. (answersingenesis.org)
  • Histological and immunocytochemical analysis was performed to evaluate for signs of necrosis, and the structural integrity and functionality of organs during culture. (ca.gov)
  • The epididymis is a comma shaped, elongated structure composed of a single, fine tubular structure estimated up to 6 meters (approximately 20 feet) in length. (medscape.com)