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  • complexes
  • It is proposed that identification of PRC1-Br140 "bivalent complexes" in fly embryos supports and extends the bivalency model posited in mammalian cells, in which the coexistence of H3K4me3 and H3K27me3 at developmental promoters represents a poised transcriptional state. (sdbonline.org)
  • lysine
  • For example, although histone H3 lysine 4 mono‐methylation (H3K4me1) indicates the presence of transcriptional gene enhancers, it does not provide clearcut information about their actual position and stage‐specific activity. (embopress.org)
  • Mechanistically, addition of an acetyl group to a lysine residue alters the positive charge of the ε-amino group, thereby impacting electrostatic properties that prevent hydrogen bonding and generating a circumferential hydrophobic milieu. (biomedcentral.com)
  • tumor
  • Currently, we focus on two important tumor suppressor pathways that also play important roles in regulating tissue development and homeostasis, the transforming growth factor-β (TGFβ)/Smad pathway and Hippo pathway. (berkeley.edu)
  • 4) c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans. (univ-lille1.fr)
  • Roles
  • J. Scott Beeler , Timothy Shaver, Jennifer Pietenpol p63, a member of the p53 family of transcription factors, regulates signaling pathways that play essential roles during development and tumorigenesis. (vanderbilt.edu)