Tumors with high levels of infiltration by MDSCs have been associated with poor patient outcome and resistance to therapies. (wikipedia.org)
Although the cell lines did not differ in their intrinsic radiosensitivity, one of the HPV-positive tumor models, MOC1-HPV K1, showed a significantly longer growth delay after irradiation with a single dose of 15 Gy compared to parental MOC1 tumors. (biomedcentral.com)
Consistent with this, MOC1-HPV K1 tumors had a lower percentage of hypoxic tumor area and a higher percentage of proliferating cells. (biomedcentral.com)
tumors were analyzed by mass cytometry using markers to detect T cells and other lymphocytes. (stanford.edu)
Tumors from mice given anti-PD1 had larger numbers of memory CD8+ T cells (CD44+CD62L-KLRG1int) and T cells that expressed PD1, lymphocyte activating 3 (LAG3), and TIGIT compared with mice not given the antibody. (stanford.edu)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
Incubation of tumor cells with T cell-derived IFNγ and TNFα recapitulated the chemokine profile observed in vivo , confirming the capacity of antitumor CD8 T cells to mediate macrophage infiltration of tumors. (aacrjournals.org)
It is widely accepted that hypoxic stresses occur in most solid tumors. (nutriforce.cn)
Thus, solid tumors seem to build up a hostile hypoxic microenvironment that hampers cell-mediated immunity and dampen the efficacy of the immune response. (nutriforce.cn)
4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
When evaluating with microsatellite steady tumors, there is normally some proof for Kitty least partialC immunological development control in MSI malignancies, like (I) the thick regional lymphocytic infiltration (Crohn's-like lymphocytic response), (II) the elevated apoptotic growth cell amount, and (3) the low amount of isolated metastases that (4) network marketing leads to an improved general individual success [1]C[3]. (immune-source.com)
Microenvironment3
Furthermore, immunofluorescence staining of blood vessels, hypoxic areas, proliferating cells and immune cells was performed to characterize the tumor microenvironment of all three tumor models. (biomedcentral.com)
Accumulating data also suggest that hypoxic stress in the tumor microenvironment promotes tumor escape mechanisms through the emergence of immune-resistant tumor variants and immune suppression. (nutriforce.cn)
Unlike most other organs, the bone marrow microenvironment is physiologically hypoxic, a pre-requisite for normal bone marrow hematopoiesis. (haematologica.org)
Tissues3
Moreover, gene set enrichment analysis (GSEA) revealed that LAYN and its coexpressed genes primarily participated in immune response pathways, and LAYN expression was found significantly correlated with tumor immune cell infiltration in LIHC tissues. (hindawi.com)
Morphological features of OSMF especially fibrosis suggests a possibility of the hypoxic environment in diseased tissues. (ijpmonline.org)
Most of them generally follow the same pathway to make immune-activated cytotoxic T lymphocytes (CTLs) abundantly infiltrate into tumor tissues and destroy tumor cells [ 6 ]. (thno.org)
Macrophage infiltration2
Abundant macrophage infiltration of solid cancers commonly correlates with poor prognosis. (aacrjournals.org)
Consequently, a greater post-MI monocyte-derived myocardial macrophage infiltration was noted in Hmox1-deficient individuals. (springer.com)
Cytotoxic1
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)
Antitumor1
iii) The hypoxic tumor environment is immunosuppressive and prevents an antitumor response. (nutriforce.cn)
Infiltrate1
We discovered that, in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke. (jneurosci.org)
Prognosis3
Some patients with HPV-positive OSCC have a better prognosis and respond better to various treatment modalities, including radiotherapy or immunotherapy. (biomedcentral.com)
In general, our data provided evidence that HCG18/hsa-mir-148a-regulated high expression of LAYN is associated with immune cell infiltration and unfavorable prognosis of LIHC patients. (hindawi.com)
Impaired immune effector cell infiltration and inactivation of the immune response contribute to the poor prognosis of PDAC patients. (biomedcentral.com)
Angiogenesis2
Targeting the hypoxic niche, and more specifically hypoxia-inducible factor-2, may represent a viable strategy to inhibit angiogenesis in multiple myeloma and progression of this disease. (haematologica.org)
Weinberg characterized "aberrant metabolic phenotype" with "autologous proliferation signaling, apoptosis resistance, evasion of proliferation inhibition, continuous angiogenesis, infiltration and migration, unlimited replication capacity, immune escape" in tumor cells. (biomedcentral.com)
Cytokine1
Antigen presentation by the dendritic cell with the lymphocyte and cytokine response leading to airway inflammation and asthma symptoms. (medscape.com)
Immune cells2
These include efficient drug delivery, infiltration of immune cells by reducing the heterogeneity of intratumoral blood flow, and increased vascular permeability caused by tight associations between endothelial cells and perivascular cells [ 9 , 10 ]. (biomedcentral.com)
The infiltration of multiple types of tumor-promoting immune cells, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), regulatory T cells (Tregs) and other immune cells, mediates immune evasion and tumor progression [ 9 ]. (biomedcentral.com)
Hypoxia2
Promoter analyses revealed increased hypoxia-inducible factor-2 binding to the CXCL12 promoter under hypoxic conditions. (haematologica.org)
However, oxygen therapy might cause the accumulation of distal bronchial viscous secretions because of positive pressure ventilation mode, and thus increase airway resistance, aggravate systemic hypoxia [15]. (researchgate.net)
Mediate1
Additionally, TAMs in the hypoxic niches within the tumor are known to mediate resistance to several anticancer treatments and to promote cancer relapse. (nutriforce.cn)
Bone marrow1
Progressive infiltration of Gaucher cells in the bone marrow may lead to thinning of the cortex, pathologic fractures, bone pain, bony infarcts, and osteopenia. (medscape.com)
Mice2
After 7 mo, the LDLR-/- mice developed massive xanthomatous infiltration of the skin and subcutaneous tissue. (jci.org)
A series of experiments, including normobaric and hypobaric experiments, examined the effects of sea cucumber oligopeptides, soybean glycopeptides, and their mixtures on mice under hypoxic conditions. (seebio.cn)
Regulation3
STARD12 and STARD14 were expected to be potential biomarkers for LUAD, which were associated with epigenetic regulation, immune infiltration and ferroptosis. (medsci.org)
Hypoxic regulation of TAMs in cancer progression and therapy. (nutriforce.cn)
Perivascular gentle tissue infiltration encircling the descending thoracic aorta (arrows) is normally evident. (bioskinrevive.com)
Significantly1
Furthermore, the risk score was significantly related to tumor immune infiltration profiles and genome changes. (biomedcentral.com)
Hypothesis2
The negative RNA in situ hybridization coupled with the positive localization in the lung does favor the hypothesis of a systemic mechanism for the cardiac changes. (andrewbostom.org)
Therefore, we tested the hypothesis that a B-lymphocyte response to stroke could contribute to the onset of dementia. (jneurosci.org)
Cells4
STARD14 was negatively associated with the infiltration of CD8+T cells, while positively with CCL28 and immune checkpoints, including CTLA4 as well as PD-L2. (medsci.org)
Hypoxic cells activate a number of adaptive responses coordinated by various cellular pathways. (nutriforce.cn)
By deciphering these signals, we can develop targeted interventions to enhance immune cell infiltration, activation, and persistence, ultimately bolstering the body's ability to recognize and eliminate cancer cells. (screentx.com)
Only under hypoxic conditions, normal or differentiated cells produce large amounts of lactic acid by anaerobic glycolysis. (biomedcentral.com)
Lung1
A brain biopsy specimen was positive for influenza A(H1N1)pdm09 virus RNA, but a lungbiopsy specimen and cerebrospinal spinal fluid samples were negative. (cdc.gov)
Occur1
There are reports of oligoclonal bands in the CSF of stroke patients, suggesting that in some people a B-lymphocyte response to stroke may occur in the CNS. (jneurosci.org)
Characteristics1
Characteristics of the newly developed HPV-positive OSCC tumor models correlate with the transcriptomic profile of MOC1-HPV cell lines. (biomedcentral.com)
Pressure ventilation1
Increased respiratory support requirements such as increased inhaled oxygen concentration, positive pressure ventilation, or continuous positive airway pressure (CPAP) are commonly required before recovery begins. (medscape.com)
Airway1
Varying degrees of mononuclear cell and eosinophil infiltration, mucus hypersecretion, desquamation of the epithelium, smooth muscle hyperplasia, and airway remodeling are present. (medscape.com)
Cell4
Two monoclonal HPV-positive OSCC mouse cell lines were established by inducing the expression of HPV-16 oncogenes E6 and E7 in the MOC1 OSCC cell line using retroviral transduction. (biomedcentral.com)
However, the underlying functions of LAYN and its interplay with immune cell infiltration in LIHC are still unclear. (hindawi.com)
Then, the correlation between LAYN and immune cell infiltration in LIHC was explored. (hindawi.com)
Additionally, holothurian oligopeptides play a crucial role in the field of immunology, enhancing immune function, regulating T lymphocyte and NK cell activity. (seebio.cn)
Results1
Results showed 21 positive samples using the PCR, and only ten were positive according to the Giemsa dye, while 22 serum samples showed anti-C. abortusantibody. (bvsalud.org)
Found1
B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are found in the neuropil adjacent to the lesion. (jneurosci.org)
Brain1
Purpose : To test the hemodynamic and biochemical sequences of secondary cerebral energy failure after acute reversed hypoxic ischemic brain insult(HI) can be reproduced in newborn piglets. (e-cep.org)
Mouse2
Therefore, the aim of our study was to develop a transplantable immunocompetent mouse model of HPV-positive OSCC and characterize it in vitro and in vivo. (biomedcentral.com)
In conclusion, we developed and characterized a novel immunocompetent mouse model of HPV-positive OSCC that exhibits increased radiosensitivity and enables studies of immune-based treatment approaches in HPV-positive OSCC. (biomedcentral.com)