Porous scaffold. Medical search. Frequent questions

With further optimization in topologically ordered porosity design exploiting material property and fabrication technique, porous biodegradable metals could be the potential materials for making hard tissue scaffolds. (hindawi.com)
Zhang and Ma have developed [ 25 ] a highly porous biodegradable polymer/apatite composite scaffold (95% porosity) through a thermally induced phase separation technique, which resulted in significant improvement in mechanical properties compared to polymer-only scaffold. (hindawi.com)
After the paraffin spheres were dissolved and removed by cyclohexane, PLGA scaffold with controlled pore size, good interconnectivity and high porosity was obtained with apatite left on the pore surface uniformly throughout the whole scaffold. (manchester.ac.uk)
Although the phase composition and porosity of these two scaffolds are similar, their external shape and mechanical property were different. (yonsei.ac.kr)
Thus, this strategy of creating a three-dimensional (3D) micro/nano architecture that would increase the porosity of the fibrous scaffold and thereby improving the cell penetration, can be utilised for the generation of functional tissue engineered constructs in vitro. (mtechprojects.com)
Printed bone scaffolds with complex structures produced using additive manufacturing technology can mimic the mechanical properties of natural human bone, providing lightweight structures with modifiable porosity levels. (mdpi.com)
The porosity index of chitosan scaffold was around 90% and the diameter of pores was 50-350 μm. (nel.edu)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)

Biodegradable metal scaffolds have showed interesting mechanical property that was close to that of human bone with tailored degradation behaviour. (hindawi.com)
Ideally, a scaffold must be porous, bioactive, and biodegradable and possess adequate mechanical properties suited to the biological site. (hindawi.com)
A biodegradable scaffold allows the replacement of biological tissues via physiological extracellular components without leaving toxic degradation products. (hindawi.com)
Biodegradable polymers have been widely used and accepted as the most suitable materials for scaffolds due to their degradability, biocompatibility, and ease of processability [ 9 - 11 ]. (hindawi.com)
Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering. (elsevierpure.com)
We created double-layered porous scaffolds composed of synthetic biodegradable polymers by combining freeze-drying and porogen leaching techniques to create tissue- engineered articular cartilage. (elsevierpure.com)

Three-dimensional tissue growth in polymer scaffolds with different stiffness and in-vitro influence of BMP-2 on tissue formation in hydroxyapatite scaffolds. (mpg.de)

Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. (hindawi.com)
One of the most attractive subjects in tissue engineering is the development of a scaffold, a three-dimensional porous solid structure that plays a key role in assisting tissue regeneration [ 1 ]. (hindawi.com)
Its degradation rate should match the rate of new tissue regeneration in order to maintain the structural integrity and to provide a smooth transition of the load transfer from the scaffold to the tissue [ 3 ]. (hindawi.com)
Three-dimensional porous gas-foamed electrospun nanofiber scaffold for cartilage regeneration. (stembook.org)
Strategies to bone tissue engineering have focused on the use of synthetic or natural degradable materials as scaffolds for cell transplantation to guide bone regeneration. (manchester.ac.uk)
Schwann Cell-derived exosomes promote bone regeneration and repair by enhancing the biological activity of porous Ti6Al4V scaffolds. (amedeo.com)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)
The development of new biomaterials for tissue engineering provides a scientific basis for the creation of scaffolds that could provide appropriate regeneration and tissue repair 14 . (bvsalud.org)

The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)

First, natural polymers will be grafted onto the surface of pores of a collagen tissue scaffold to mimic the chondrocyte microstress environment of knee cartilage. (saralaurawilson.com)
Therefore, in this work the DNA encoding VEGF was applied to enhance the angiogenesis of a collagen scaffold. (researcher.life)
The complexes were then incorporated into the collagen scaffold, the loading being mediated by the feeding concentration and release in a sustained manner. (researcher.life)
John Dichiara, svp of clinical and regulatory affairs at ReGen Biologics, discussed the clinical performance of ReGen's collagen surgical mesh scaffold used for the reinforcement and repair of medial meniscus injuries. (genengnews.com)
Menaflex consists of chemically crosslinked, porous type 1 collagen sourced from bovine achilles tendons. (genengnews.com)

Polymers have been widely chosen as tissue scaffolding material having a good combination of biodegradability, biocompatibility, and porous structure. (hindawi.com)
Gel scaffold biodegradation rates and biocompatibility are quantified. (uw.edu)
Results show that Ta-PDA-Mg2 possessed the highest ion release, and all scaffolds showed excellent biocompatibility. (bvsalud.org)

The current promising fabrication technique for making scaffolds, such as computation-aided solid free-form method, can be easily applied to metals. (hindawi.com)
Jun, IK , Koh, YH & Kim, HE 2006, ' Fabrication of a highly porous bioactive glass-ceramic scaffold with a high surface area and strength ', Journal of the American Ceramic Society , vol. 89, no. 1, pp. 391-394. (korea.ac.kr)
Fabrication of highly porous scaffolds for tissue engineerin. (rwth-aachen.de)
A novel porous scaffold designed for application as a bone substitute, with a structure containing three-dimensional (3D) pore channels in a hydroxyapatite (HA) scaffold, was fabricated using a combination of a solid freeform fabrication (SFF) and cast in a mold using freezing casting method. (yonsei.ac.kr)
In this study, the printing capability of two different additive manufacturing (3D printing) techniques, namely PolyJet and micro-stereolithography (µSLA), are investigated regarding the fabrication of bone scaffolds. (mdpi.com)

Previous in vitro and small animal (murine) in vivo studies highlighted a porous hydroxyapatite/poly (DL-lactic acid) composite scaffold in combination with skeletal stem cells (SSCs) as a potential bone graft substitute candidate. (port.ac.uk)
In order to augment the interaction with the biological tissue, stem cells have recently been combined with metallic scaffolds for skeletal engineering applications. (diva-portal.org)
Porous chitosan scaffold and ngf promote neuronal differentiation of neural stem cells in vitro. (nel.edu)
Yi X, Jin G, Tian M, Mao W, Qin J. Porous chitosan scaffold and ngf promote neuronal differentiation of neural stem cells in vitro. (nel.edu)
For their bone reconstruction model, the scientists generated anatomically shaped scaffolds in the exact shape of the human temperomandibular joint (TMJ) bone from decellularized trabecular bone using digitized clinical images, seeded with human mesenchymal stem cells, and cultured with interstitial flow of culture medium. (genengnews.com)
For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)

A parallel in vitro analysis of ovine SSC seeded scaffolds was also performed. (port.ac.uk)
Third, the multiscale (nano- to macro- scale) mechanical properties of the composite tissue engineered scaffolds will be tested in vitro under tensile, compressive, and shear forces. (saralaurawilson.com)
Méthodologie expérimentale : plans statistiques d'expérience, en particulier dans le domaine des biomatériaux (planification d'expériences in vitro et in vivo). (epfl.ch)
In vitro cell culture demonstrated a significant improvement in the VEGF expression level from the TMC/DNA complexes containing scaffolds, in particular with a large amount of DNA. (researcher.life)
The physiochemical property of resultant Ta-PDA-Mg scaffold was characterized and their osteogenic and angiogenic effects were tested through a serial of experiments both in vitro and in vivo. (bvsalud.org)
To induce in vitro chondrogenesis, MSCs were seeded into MC solution retained within a porous polyurethane (PU) matrix. (nature.com)
MSCs have great therapeutic potential in tissue engineering, they can be expanded in vitro, and combined with scaffolds they can be inserted into wounds to promote healing and tissue replacement. (bvsalud.org)

The 3D-printed scaffold structures are used as supports in replacing and repairing fractured bone tissue. (mdpi.com)

This study demonstrates the effect of EBM-fabricated cp-Ti and Ti6Al4V porous scaffolds on hES-MPs behavior, in terms of cell attachment, growth and osteogenic differentiation. (diva-portal.org)
Displaying different chemical composition but similar surface properties, EBM-fabricated cp-Ti and Ti6Al4V scaffolds supported cell attachment and growth, and did not seem to alter the expression of genes involved in osteogenic differentiation and affect the alkaline phosphatase activity. (diva-portal.org)

Second, the pore size and shape of the composite tissue engineered scaffold will be structured by 3D printing. (saralaurawilson.com)

The use of electrospun extracellular matrix (ECM)-mimicking nanofibrous scaffolds for tissue engineering is limited by poor cellular infiltration. (mtechprojects.com)
To assess this, we fabricated electrospun porous poly(lactic acid) (PLA) scaffolds having nanoscale, microscale and combined micro/nano architecture and evaluated the structural characteristics and biological response in detail. (mtechprojects.com)

It is also desirable for a scaffold to have high interconnectivities between pores for uniform cell seeding and distribution, and for the nutrients and metabolites exchange at the cell/scaffold construct [ 4 - 6 ]. (hindawi.com)
The new approach was developed to ensure a relatively uniform apatite coating on the interior pore surfaces deep inside a scaffold, even for a relatively thick scaffold with small pores. (manchester.ac.uk)

abstract = "A bioactive glass-ceramic scaffold was fabricated, in which two interlaced three-dimensional (3-D) glass-ceramic walls could serve as active surfaces for the formation of a bond to bone. (korea.ac.kr)

86. Dynamics of ionic liquids in poly(vinyl alcohol) porous scaffold. (magritek.com)
In this study molecular dynamics of ionic liquids in poly(vinyl alcohol) scaffolds were investigated. (magritek.com)

In conclusion, interfacing hES-MPs to EBM-fabricated scaffolds may represent an interesting strategy for design of third-generation biomaterials, with the potential to promote implant integration in clinical conditions characterized by poor bone quality. (diva-portal.org)
Leader of the DIGITORR (Digital Oral Rehabilitation Research) team, focusing on validation of the digital workflow in prosthodontics and implant dentistry, 3D printed bone scaffold, bruxism monitoring etc. (researchgate.net)
Cobalt-chromium-molybdenum alloys with porous structures can be fabricated by additive manufacturing technique, which are attractive for use as scaffolds for bone implant applications. (utexas.edu)
The aim of this study was to compare this novel construct to a well-proven porous plasma sprayed tibial (PPS) implant after total knee arthroplasty. (lu.se)
Conclusion In conclusion the Regenerex implant could prove an effective scaffold material for coating of uncemented implants but did no better than the PPS component at 24 months of follow-up. (lu.se)

The dimensional accuracy, permeability, and mechanical properties of complex 3D-printed scaffold structures are analyzed to compare the advantages and drawbacks associated with the two techniques. (mdpi.com)

The aim of the current study was to scale up the bone cell-scaffold construct to large animals and examine the potential for repair of a critical-sized defect via an ovine model. (port.ac.uk)
Background Regenerex is a novel porous titanium construct with a three-dimensional porous structure and biomechanical characteristics close to that of normal trabecular bone. (lu.se)
Methods Sixty-one patients scheduled for an uncemented TKA were randomized to receive either a novel highly porous titanium construct Regenerex or the PPS tibial component. (lu.se)

In this study, 3D scaffold structures are designed with different combinations of architectural parameters. (mdpi.com)
Highly repeatable and consistent porous structures may be realised with strut sizes down to 100µm. (medicaldevice-network.com)

26 ] has shown that osteoblast survival and growth were significantly enhanced in the PLLA/HA composite scaffolds compared to the plain PLLA scaffolds. (hindawi.com)
Therefore, the present study evaluates the use of waste from the pod shell of cacao type CCN-51, which is abundant in Ecuador, for the production of porous scaffolds by alkaline treatments applying a response surface design (Central Composite Designs). (cetjournal.it)
Scaffolds were produced by means of an alkaline attack using NaOH, varying operating conditions such as reactant concentration, biomass concentration, operating time, temperature, and mesocarp dimensions to generate a prediction model through the implementation of a central composite design (CCD). (cetjournal.it)
Here, we present a new composite structure, consisting of porous three-dimensional graphene (3DG) decorated with nitrogen-doped carbon nanotube s (NCNT). (cdc.gov)

Scaffold-mediated mRNA in vivo transgene expression as well as ovalbumin antigen specific cellular and humoral immune responses are evaluated in vivo . (uw.edu)
secretion are seen with in vivo scaffold-mediated mRNA lipoplex delivery. (uw.edu)
The results demonstrated that the incorporation of TMC/DNA complexes could effectively enhance the in vivo VEGF expression and thereby the angiogenesis of implanted scaffolds. (researcher.life)

The device is anatomically shaped like a human meniscus and is intended, when sutured to the meniscus rim, to act as a tissue scaffold and fill the void left after meniscus loss. (genengnews.com)
The device provides a scaffold for meniscus-like fibrochondrocytic matrix production and the newly formed tissue integrates into the host meniscal rim. (genengnews.com)

The scaffolds containing the TMC/DNA complexes were subcutaneously implanted into Sprague-Dawley mice to study their angiogenesis via macroscopic observation, hematoxylin-eosin staining and immunohistochemical staining. (researcher.life)
Therefore, Mg doped 3D printed Ta scaffold could improve surface bioactivity and lead to better osteogenesis and angiogenesis, which may provide novel strategy to develop bioactive customized implants in orthopedic applications. (bvsalud.org)

Immobilizing magnesium ions on 3D printed porous tantalum scaffolds with polydopamine for improved vascularization and osteogenesis. (bvsalud.org)

This study was performed to evaluate the physical and biomechanical properties of the HA scaffolds fabricated by SFF and using polymer replication method (PRM), one of the conventional methods. (yonsei.ac.kr)

Hence, in this study, three concentrations of Mg were doped on the surface of 3D printed tantalum scaffolds utilizing the surface adhesion ability of polydopamine (Ta-PDA-Mg) to improve its surface bioactivity. (bvsalud.org)
Although the bioactivity was intermediate to that for nanofibre and microfibre scaffold, a unique result of this study was that the micro/nano combined fibrous scaffold showed improved cell infiltration and distribution than the nanofibrous scaffold. (mtechprojects.com)

In this study, we showed that this structure enabled the uniform seeding of goat chondrocytes in the scaffolds, and with low rates of leakage. (elsevierpure.com)
The created NCNT-3DG carbon scaffold is resilient towards significant volumetric change during cycling, while the NCNTs serve as lithiophilic sites for uniform lithium nucleation which enables uniform lithium deposition. (cdc.gov)

A physicochemical analysis by scanning electron microscopy (SEM), thermogravimetry, and Fourier transformed infrared spectroscopy (FTIR) showed important morphological and structural changes depending on the composition of the scaffold. (cetjournal.it)

Scientists have developed a new approach for making metal-metal composites and porous metals with a 'bicontinuous' structure in thin films. (materialstoday.com)

Finally, as a mechanical support, a scaffold must possess adequate mechanical stability to withstand both the implantation procedure and the mechanical forces that are typically experienced at the scaffold-tissue interface and does not collapse during patient's normal activities [ 3 ]. (hindawi.com)

Data suggest that during water evaporation, partial demixing of IL from the polymeric matrix leaves the remaining solvent confined in the porous structure formed by the PVA polymer. (magritek.com)
Although the porous structure of 3D printed Ta scaffolds could allow bone ingrowth, the surface property that reactive with surrounding tissue is still unfavorable and thus the early osteointegration is impeded. (bvsalud.org)
The authors hypothesised that cell penetration could be enhanced in scaffolds by using a hierarchical structure where nano fibres are combined with micron-scale fibres while preserving the overall scaffold architecture. (mtechprojects.com)
NSCs were cultured under four different conditions: on flat cover slips (2-D structure) in media with or without NGF, and on chitosan scaffold (3-D structure) in media with or without NGF. (nel.edu)

3D printed tantalum (Ta) scaffolds have enormous potential to repair bone defects and have applied in clinic in recent years. (bvsalud.org)

Porous chitosan scaffold was explored if it promoted neuronal differentiation of NSCs in the presence of nerve growth factor (NGF) in 3-dimensional (3-D) culture. (nel.edu)
The results suggest that the combination of chitosan scaffold and NGF exerts a synergistic effect on neuronal differentiation of NSCs, a requirement for successful integration into the damaged central nervous system. (nel.edu)

Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass. (mpg.de)

Anatomy3

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes10

Disciplines and Occupations2

Technology, Industry, Agriculture16

Porosity9

Biodegradable6

Polymer scaffolds1

Regeneration10

Materials for scaffolds1

Collagen5

Biocompatibility3

Fabrication5

Stem Cells6

Vitro7

Fractured bone tissue1

Ti6Al4V2

Pore size1

Electrospun2

Pores2

Abstract1

Poly2

Implant5

Permeability1

Construct3

Structures2

Composite4

Vivo3

Meniscus2

Angiogenesis2

Osteogenesis1

Biomechanical1

Bioactivity2

Uniform2

Composition1

Composites1

Implantation1

Structure4

Potential1

Differentiation2

Repair1