Pore domain potassium channels. Medical search. Frequent questions

Potassium two pore domain channel subfamily K member 12 is encoded by the gene KCNK12. (antibodiesinc.com)

After the application of both riluzole and ML67-33 activators, the three neuronal types responded with outward currents similar to those transported by TREK channels. (uvigo.es)
Furthermore, both increased temperature and intracellular acidification produced larger potassium currents comparable to those driven through TREK, as well as conductance increases in three NG neuronal types. (uvigo.es)
Currents through WT and mutated human TASK-1 channels transiently expressed in tsA201 cells were measured using whole-cell patch-clamp electrophysiology. (kent.ac.uk)
The recently identified 2-pore domain potassium (K2P) channels are believed to be responsible for leak K + currents. (medscape.com)
ML277 provides insights and a tool to investigate the gating mechanism of KCNQ1 channels, and our study reveals a new strategy for treating long QT syndrome by specifically enhancing the AO state of native I Ks currents. (elifesciences.org)
In neurons, TASK channels carrying hyperpolarizing \(K^+\) leak currents, and the pacemaker channel HCN2, carrying depolarizing Background Brain ischemia is known to include neuronal cell death and persisting neurological deficits. (uni-wuerzburg.de)
In neurons, TASK channels carrying hyperpolarizing \(K^+\) leak currents, and the pacemaker channel HCN2, carrying depolarizing \(I_h\), stabilize the membrane potential by a mutual functional interaction. (uni-wuerzburg.de)
Background potassium currents play an important role in the regulation of the resting membrane potential and excitability of mammalian neurons. (iisc.ac.in)
Although both ketamine and halothane inhibit potassium currents through the Kv2.1 channel, their mechanisms of action at this potential target may be different. (silverchair.com)

Thus, each subunit has two pore loops. (wikipedia.org)
the name of the channel comes from the fact that each subunit has two P (pore) domains in its primary sequence. (wikipedia.org)
Structurally, the pore-forming subunit of K ir channels is the α-subunit. (tocris.com)
Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. (tocris.com)
It adopts the canonical structural organization of the homo-tetrameric K V superfamily, in which each subunit contains six transmembrane segments (S1-S6), with the first four (S1-S4) forming the voltage-sensing domain (VSD) and the latter two (S5-S6) folding to the pore ( Sun and MacKinnon, 2017 ). (elifesciences.org)
Homo sapiens potassium voltage-gated channel subfamily A regulatory beta subunit 2 (KCNAB2), transcript variant 2, mRNA. (ucsc.edu)
Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. (ucsc.edu)
Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable). (ucsc.edu)
Belongs to the shaker potassium channel beta subunit family. (ucsc.edu)
Kir6.2 is the pore-forming subunit of the ATP-sensitive K(+) (K(ATP)) channel. (ox.ac.uk)
Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)

Inwardly rectifying potassium (Kir) channels open at the 'helix bundle crossing' (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore. (nature.com)
Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2. (ox.ac.uk)
The amino-terminal and carboxyl-terminal domains of inwardly rectifying potassium (Kir) channel subunits are both intracellular. (ox.ac.uk)

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. (nih.gov)
This gene provides instructions for making a protein called TASK3, which functions as a potassium channel. (medlineplus.gov)
The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (K ir 2.x), the G-protein-activated inward-rectifier channels (K ir 3.x) and the ATP-sensitive channels (K ir 6.x), which combine with sulphonylurea receptors. (tocris.com)
Site-directed mutagenesis was utilised to map the domains involved in protein-protein interaction. (imperial.ac.uk)
The encoded protein has six putative transmembrane segments, and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif. (thermofisher.com)
The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. (thermofisher.com)
Smooth muscle cells express Kv7.4 and Kv7.5 voltage-dependent potassium channels, which have each been implicated as regulators of smooth muscle contractility, though they display different sensitivities to signaling via cAMP/protein kinase A (PKA) and protein kinase C (PKC). (aspetjournals.org)
Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing BTB domain in the selected taxonomic class. (embl.de)
Examination of the structure resulted in the identification of several structural features and specific amino acid residues that may be involved in conserved protein-protein interactions mediated by the POZ domains as well as those that may contribute to the specificity of these interactions. (embl.de)
ROS may induce intracellular calcium increase and subsequent contraction of PASMCs via direct or indirect interactions with protein kinases, phospholipases, sarcoplasmic calcium channels, transient receptor potential channels, voltage-dependent potassium channels and L-type calcium channels, whose relevance may vary under different experimental conditions. (ersjournals.com)
This gene encodes one of the members of the two-pore-domain background potassium channel protein family. (nih.gov)
Regulation of Monocyte Chemotactic Protein - 1 secretion by the Two-Pore-Domain Potassium (K2P) channel TREK- 1 in human alveolar epithelial cells. (mcp-1.com)
The candidate genes exhibit expression patterns in lung and heart similar to that of known PAH risk genes, and most variants occur in conserved protein domains. (biomedcentral.com)
Although it is not clear whether anesthetics interact directly with the C-terminus, which is thought to reside intracellularly, this portion of the channel protein clearly influences the actions of both anesthetics. (silverchair.com)
Using an in vitro protein-protein interaction assay, we demonstrate that the two intracellular domains of Kir6.2 physically interact with each other, and we map a region within the N terminus that is responsible for this interaction. (ox.ac.uk)
This includes transitions between structural states, ligand binding or communication between protein domains via allostery. (kth.se)

ABSTRACT Potassium channels are critical for life, playing a variety of physiological roles including control of solute balance, cell volume, and cellular excitability. (unthsc.edu)

Two-pore domain potassium (K(+)) channels (K2P channels) control the negative resting potential of eukaryotic cells and regulate cell excitability by conducting K(+) ions across the plasma membrane. (rcsb.org)
An extracellular cap domain located above the selectivity filter forms an ion pathway in which K(+) ions flow through side portals. (rcsb.org)
Potassium channels transport positively charged atoms (ions) of potassium into and out of cells. (medlineplus.gov)
The flow of ions through potassium channels in neurons is involved in activating (exciting) the neurons and sending electrical signals in the brain. (medlineplus.gov)
This alteration reduces the flow of ions through the channels, which disrupts normal neuron development and excitability. (medlineplus.gov)
The concentration gradients are maintained by the sodium/potassium ATP pump (in an energy-dependent process) that transports sodium ions out of the cell and potassium ions into the cell. (medscape.com)
This active transport creates a concentration gradient that favors the extracellular diffusion of potassium ions. (medscape.com)
In addition, because the nerve membrane is permeable to potassium ions and impermeable to sodium ions, 95% of the ionic leak in excitable cells is caused by K + ions in the form of an outward flux, accounting for the negative resting potential. (medscape.com)
Once membrane depolarization is complete, the membrane becomes impermeable to sodium ions again, and the conductance of potassium ions into the cell increases. (medscape.com)
In order to illustrate the potential of the updated Geomfinder version, we show a case of use in which similar 3D patterns were detected in the cardiac ions channels NaV1.5 and TASK-1. (frontiersin.org)
Introduced negative charges at the HBC (G178D) in Kir2.2 channels forces opening, allowing pore wetting and free movement of permeant ions between the cytoplasm and the inner cavity. (nature.com)
Kv7 family channels mediate a voltage-dependent outward flux of potassium ions, which contributes to the establishment of negative membrane potentials in many cell types. (aspetjournals.org)
Ion channels are fundamental molecules in the nervous system that catalyze the flux of ions across the cell membrane. (iisc.ac.in)

The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess Goldman-Hodgkin-Katz (open) rectification. (wikipedia.org)

The Popeye domain containing (POPDC) genes encode sarcolemma-localized cAMP effector proteins. (imperial.ac.uk)
however, it may require other non-pore-forming proteins for activity. (antibodiesinc.com)
There are 113741 BTB domains in 107385 proteins in SMART's nrdb database. (embl.de)
Taxonomic distribution of proteins containing BTB domain. (embl.de)
The complete taxonomic breakdown of all proteins with BTB domain is also avaliable . (embl.de)
Using iterative database searches, a statistically significant sequence similarity was detected between the POZ (poxvirus and zinc finger) domains found in a variety of proteins involved in animal transcription regulation, cytoskeleton organization, and development, and the tetramerization domain of animal potassium channels. (embl.de)
Voltage-dependent, ion-selective channels such as Na+, Ca2+ and K+ channel proteins function as tetrameric assemblies of identical or similar subunits. (embl.de)
There is increasing evidence that direct interactions between volatile anesthetics and channel proteins may result in general anesthesia. (silverchair.com)
Recent evidence is in favor of direct interactions between volatile anesthetics and channel proteins as the underlying mechanism of general anesthesia. (silverchair.com)
There is increasing evidence that both of these domains are required for the regulation of Kir channels by agents such as G-proteins and nucleotides. (ox.ac.uk)

Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. (nih.gov)
Structurally, they associate with different VSD and pore conformations. (elifesciences.org)

This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. (thermofisher.com)
Using the crystal structure of the Aplysia Shaker channel tetramerization domain as a template, the common structure of the POZ domain class was predicted. (embl.de)
Crystal structure of the tetramerization domain of the Shaker potassium channel. (embl.de)
We have determined the crystal structure of the T1 domain of a Shaker potassium channel at 1.55 A resolution. (embl.de)
Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (ucsc.edu)
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (ucsc.edu)

KCNK3, the gene that encodes the two pore domain potassium channel TASK-1 (K2P3.1), has been identified as a possible disease-causing gene in heritable PAH. (kent.ac.uk)

Using voltage-clamp techniques, the authors examined the effect of two general anesthetics (ketamine and halothane) on a rat brain potassium channel of known amino acid sequence, and further assessed whether the inhibition of the channel is altered by a partial deletion of the C-terminal sequence of this channel. (silverchair.com)

This review summarises our current state of knowledge of the functional role of TASK-1 channels in the pulmonary circulation in health and disease, with special emphasis on current advancements in the field. (ersjournals.com)
The aim of this study is to characterise the functional properties and regulation of wildtype (WT) and mutated TASK-1 channels and understand how these might contribute to PAH and its treatment. (kent.ac.uk)
Functional current through these mutated channels could not be restored using activators of WT TASK-1 channels (pH 8.4, ONO-RS-082). (kent.ac.uk)
Thus, novel mutations in TASK-1 seen in PAH, substantially alter the functional properties of these channels. (kent.ac.uk)
Background:Beta-2 adrenergic receptors (β2ARs) but not beta-2 adrenergic receptors (β1ARs) form a functional complex with L-type Ca2+ channels (LTCCs) on the cardiomyocyte membrane. (imperial.ac.uk)
The functional channel is a homotetramer. (thermofisher.com)
The present studies identify distinct functional domains that confer differential sensitivities of Kv7.4 and Kv7.5 to stimulatory and inhibitory signaling and reveal structural features of the channel subunits that determine their biophysical properties. (aspetjournals.org)
functional channels form as homo- or hetero-tetramers of α -subunits ( Delmas and Brown, 2005 ). (aspetjournals.org)
Conclusions Here, we hypothesized that the absence of HCN2, an important functional counter player of TASK channels, affects neuronal survival during stroke-induced tissue damage. (uni-wuerzburg.de)
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (ucsc.edu)
In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2. (nih.gov)
Furthermore, a mutation within the conserved region of the N-terminal interaction domain, which disrupts its interaction with the C terminus, severely compromised the ability of both Kir6.2 and Kir2.1 to form functional channels, suggesting that this interaction may be a feature common to all members of the Kir family of potassium channels. (ox.ac.uk)
Functional states of the sodium channel (closed, open, and inactivated) and their structure help to understand the cardiac regulation processes. (bvsalud.org)
Heart relaxation also stands out as an active process, dependent on the energetic output and on specific ion and enzymatic actions, with the role of sodium channel being outstanding in the functional process. (bvsalud.org)

This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. (nih.gov)
Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner (PubMed:11319556). (nih.gov)

TWIK-related acid-sensitive potassium channel 1 (TASK-1 encoded by KCNK3) belongs to the family of two-pore domain potassium channels. (ersjournals.com)
The TASK-1 channel gene (KCNK3) has been identified as a possible disease-causing gene in heritable pulmonary arterial hypertension (PAH). (kent.ac.uk)
Keywords: TASK1 KCNK3 selective potassium route inhibitor bis-amide Maintenance of the detrimental relaxing membrane potential of excitable cells is dependent significantly over the broadly distributed category of two-pore domains potassium stations (K2P). (techuniq.com)

Los canales K2P más abundantes en el ganglio cervical superior son los TREK-2 y en el nodoso los TREK-1, mientras que los TRESK se expresan abundantemente en ambos ganglios. (uvigo.es)
Decreased abundance of TRESK two-pore domain potassium channels in sensory neurons underlies the pain associated with bone metastasis. (mpg.de)

In excitable cells potassium channels are involved in setting membrane potential and modulation of action potentials. (unthsc.edu)

R92 is at the end of the unstructured region.Compared to THIK-1, the 'silent' channel THIK-2 has an additional domain at its N-terminus (residues 6-24) which contains a putative retention signal (RRR). (uni-marburg.de)
Molecular dynamics simulations show how protonation of Kir2.2[G178D], or the D173 pore-lining residues, changes solvation, K + ion occupancy, and K + conductance. (nature.com)
It was previously reported that A1899 acts as an open-channel blocker and binds to residues of the P1 and P2 regions, the M2 and M4 segments, and the halothane response element . (bvsalud.org)
The recently described crystal structures of K2P channels together with the newly identified side fenestrations indicate that residues relevant for TASK-1 inhibition are not purely facing the central cavity as initially proposed. (bvsalud.org)
We have used TASK-1 homology models based on recently crystallized K2P channels and molecular dynamics simulation to demonstrate that the highly potent TASK-1 blocker A1899 requires binding to residues located in the side fenestrations. (bvsalud.org)
Unexpectedly, most of the previously described residues that interfere with TASK-1 blockade by A1899 project their side chains toward the fenestration lumina, underlining the relevance of these structures for drug binding in K2P channels. (bvsalud.org)
In contrast, binding of A1899 to residues of the side fenestrations might provide a physical "anchor", reflecting an energetically favorable binding mode that after pore occlusion stabilizes the closed state of the channels. (bvsalud.org)

Kv7 channels are encoded by KCNQ genes (1 through 5). (aspetjournals.org)

Heteromeric channels can also be formed within subfamilies, e.g. (tocris.com)
It is known to confer specificity for tetramer formation, so the heteromeric assembly of K+-channel subunits is an important mechanism for the observed channel diversity. (embl.de)

Mutations in K + channel sequences can lead to a variety of clinical disorders exemplifying their physiological importance [ 3 ]. (ersjournals.com)
We reported the crystal structure of a chicken Kir2.2[G178D] mutant channel 12 , in which the introduced G178D mutations at the HBC functionally stabilize the open conformation, a strategy used previously to obtain an open crystal structure of a bacterial homolog KirBac3.1 13 . (nature.com)
Recently, multiple studies have identified ~30 mutations in Slack channels that are associated with a variety of epilepsies, most frequently Malignant Migrating Partial Seizures of Infancy (MMPSI). (unthsc.edu)
Interestingly, these mutations are dominant, gain-of-function mutations resulting in a higher degree of Slack channel activity. (unthsc.edu)

TASK-1 channels are sensitive to a wide array of physiological and pharmacological mediators that affect their activity such as unsaturated fatty acids, extracellular pH, hypoxia, anaesthetics and intracellular signalling pathways. (ersjournals.com)
Conclusions: IMBX can block TREK-1 channels though the PKA pathway, it also can bind to the extracellular side of THIK-1 or THIK-2, leading to a direct block of the channels. (uni-marburg.de)
It is assumed that this ionic interplay between TASK and HCN2 channels enhances the resistance of neurons to insults accompanied by extracellular pH shifts. (uni-wuerzburg.de)
The process restores the excess of intracellular potassium and extracellular sodium and reinstates the negative resting membrane potential. (medscape.com)

Forskolin treatment reduced the sensitivity of Kv7.5 channels to Ciona intestinalis voltage-sensing phosphatase (Ci-VSP)-induced PIP 2 depletion, whereas activation of PKC with phorbol-12-myristate-13-acetate potentiated the Ci-VSP-induced decline in Kv7.5 current amplitude. (aspetjournals.org)

Ion channel gating and conductance are classically understood as separate processes. (nature.com)
The present data reveal how individual protonation events change the electrostatic microenvironment of the pore, resulting in step-wise alterations of ion pooling, and hence conductance, that appear as 'gated' substates. (nature.com)
In the G178D structure, the HBC gate is slightly wider than in previous structures, and molecular dynamics (MD) simulations demonstrate rapid wetting of the G178D pore at the HBC region, followed by further expansion and K + conductance through the channel. (nature.com)
Slack variants associated with these epilepsies are found in three clusters: the pore of the channel, and in two separate carboxy-terminal regulatory regions, Regulator of Conductance of K+ (RCK) and NAD+ binding domains. (unthsc.edu)

Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. (elifesciences.org)
In the heart, KCNQ1 associates with KCNE1 subunits to form I Ks channels that regulate heart rhythm. (elifesciences.org)
Here, we tested modulations of human KCNQ1 channels by an activator ML277 in Xenopus oocytes. (elifesciences.org)
This is used to reveal the coupling between the voltage sensor domains and the pore of the voltage-gated potassium channel KCNQ1. (kth.se)

citation needed] Their name is derived from the fact that the α subunits consist of four transmembrane segments, and each pair of transmembrane segments contains a pore loop between the two transmembrane segments. (wikipedia.org)

Furthermore, the effect of two well-known activators of these channels was determined. (uvigo.es)
The guanylate cyclase activator, riociguat, enhanced current through WT TASK-1 channels, however, like the other activators investigated, riociguat did not have any effect on current through mutated TASK-1 channels. (kent.ac.uk)
Current through these channels could not be restored by activators of TASK-1 channels. (kent.ac.uk)

Methods: Whole cell recording patch clamp measurements in mammalian cells was used to analyze K2P channels mentioned above. (uni-marburg.de)

R92 is localized to the linker region between cap helix 2 (C2) and the pore helix (P1). (uni-marburg.de)
Subsequent movement of the S4 helix from the intermediate state to the activated state then triggers conformational change of the pore from the IO state to the AO state. (elifesciences.org)
The highly conserved, amino-terminal cytoplasmic domain (approximately 130 amino acids) immediately preceding the first putative transmembrane helix S1 is designated T1. (embl.de)

These findings may improve our understanding of the roles of these channels in smooth muscle physiology and disease, particularly in conditions where Kv7.4 and Kv7.5 are differentially expressed. (aspetjournals.org)

In the present work, the effect of sensory stimuli such as temperature and pH was studied in the TREK channels of different NG neuronal types. (uvigo.es)
Job-1 is a two-pore domains potassium channel that's vital that you modulating cell excitability especially in the framework of neuronal pathways. (techuniq.com)
In former studies the expression of two different two-pore domain potassium \((K_{2P})\) channels (TASK1, TREK1) were shown to ameliorate neuronal damage due to cerebral ischemia. (uni-wuerzburg.de)

The capacity region of another special case of GBC namely Fading Broadcast Channel (FBC)was given in [Li and Goldsmith, 2001]and was shown that superposition of Gaussian codes is optimal for the FBC (treated as a vector degraded Broadcast Channel). (iisc.ac.in)

Fold prediction and evolutionary analysis of the POZ domain: structural and evolutionary relationship with the potassium channel tetramerization domain. (embl.de)

To evaluate the Swarm screening system, we optimized a series of heterologous optogenetic spiking HEK293 cell assays for several voltage-gated sodium channel subtypes including Nav1.2, Nav1.5, and Nav1.7. (frontiersin.org)
The Swarm was able to record pseudo-action potentials stably across all 24 objectives and provided pharmacological characterization of diverse sodium channel blockers. (frontiersin.org)
From a physiological and pathophysiological point of view, the conformational states of the sodium channel during heart function constitute a significant aspect for the diagnosis and treatment of heart diseases. (bvsalud.org)

Interestingly, the "interaction domain" is highly conserved throughout the superfamily of Kir channels. (ox.ac.uk)

In addition, TREK channels belonging to the family of two-pore domain (K2P) potassium channels, and especially TREK-1, are abundantly expressed in NG neurons. (uvigo.es)
Background: THIK-1, THIK-2 and TREK-1 and all belong to family of two-pore-domain potassium channel (K2P channels). (uni-marburg.de)
KCNKs, potassium two pore domain channel family K members, can maintain the resting potential, regulate the amplitude and duration of the plateau of the action potential, and change the membrane potential and membrane excitability. (jcancer.org)
KCNK12 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. (antibodiesinc.com)
Slack channels, encoded by KCNT1, are members of the Slo family of potassium channels, comprised of Slo1 (Maxi-K), Slo2.1 (Slick), Slo2.2 (Slack) and Slo3, a sperm-specific channel. (unthsc.edu)

Recent studies show that modulation of TASK-1 channels, either directly or indirectly by targeting their regulatory mechanisms, has the potential to control pulmonary arterial tone in humans. (ersjournals.com)
These observations support a distinctive mechanism responsible for the VSD-pore coupling at the AO state that is sensitive to ML277 modulation. (elifesciences.org)
After his Ph.D., he remained at UVA as a Research Assistant Professor, and initiated investigations into the CNS functions of two-pore-domain potassium channels, with an emphasis on their modulation by neurotransmitters and clinically important drugs. (virginia.edu)
His work on these channels included extensive mapping of their CNS expression patterns, identification of molecular bases for their modulation using mutational and biochemical analyses, and investigations into their functions in vivo by generating knockout mouse lines. (virginia.edu)
Gating modulation of the tumor-related Kv10.1 channel by Mibefradil. (mpg.de)

SIGNIFICANCE STATEMENT Kv7.4 and Kv7.5 channels are known signal transduction intermediates and drug targets for regulation of smooth muscle tone. (aspetjournals.org)
We recently proposed a role for the two-pore-domain K (+) (K2P) channels TREK-1 in the regulation of cytokine release from epithelial cells of the alveolar. (mcp-1.com)

The KCNK channel was originally called the K2P channel, and was later named the KCNK channel. (jcancer.org)

These channels are involved in sensory transduction of physical and chemical stimuli such as changes in pH, temperature or mechanical distension. (uvigo.es)

IUPHAR Database of Receptors and Ion Channels. (wikipedia.org)

In contrast, swapping carboxy-terminal phosphatidylinositol 4,5-bisphosphate (PIP 2 ) binding domains, or the entire C terminus, was without effect on the forskolin response, but the latter conferred responsiveness to arginine-vasopressin (an inhibitory PKC-dependent response). (aspetjournals.org)

Bulk Order Inquiry for Anti-THIK-2 K+ Channel Antibody FL650 Conjugate ------- (please add any order requirements, including desired quantity, timing, etc. (antibodiesinc.com)
Bulk Order Inquiry for Anti-TALK1 Potassium Channel Antibody FL490 Conjugate ------- (please add any order requirements, including desired quantity, timing, etc. (antibodiesinc.com)

Ion channel that contributes to passive transmembrane potassium transport (PubMed:23169818). (nih.gov)

Ischemia-induced cell depolarization: does the hyperpolarization-activated cation channel HCN2 affect the outcome after stroke in mice? (uni-wuerzburg.de)

Below is a list of the 15 known two-pore-domain human potassium channels: Ion channel Potassium channel Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). (wikipedia.org)
Here, we present the 3.4 angstrom resolution crystal structure of a human K2P channel, K2P1 (TWIK-1). (rcsb.org)
Potassium (K + ) channels constitute the largest group of ion channels in the human genome. (ersjournals.com)
Ion channel characterization in the human fetoplacental unit. (nottingham.ac.uk)
A synthetic peptide corresponding to a sequence at the C-terminus of human Kv1.1 potassium channel (465-481aa IAHYRQVNIRTANCTTA). (thermofisher.com)

To analyze the surface expression of the channel we used HA-tagged THIK-2 and thus quantified the copy number of the channels at the cell membrane using an antibody-based assay. (uni-marburg.de)

A role for two-pore potassium (K2P) channels in endometrial epithelial function Journal of Cellular and Molecular Medicine. (nottingham.ac.uk)
Teisseyre A, Gąsiorowska J and Michalak K: Voltage-gated potassium channels Kv1.3-potentially new molecular target in cancer diagnostics and therapy. (spandidos-publications.com)

The application of H89 (PKA inhibitor) and forskolin (PKA activator) did not modify the effects of IBMX on the channel. (uni-marburg.de)
A1899 is a potent and selective inhibitor of the two-pore domain potassium (K2P) channel TASK-1. (bvsalud.org)

TASK3 channels are especially abundant in nerve cells (neurons) in the brain, particularly the region of the brain that coordinates movement ( cerebellum ). (medlineplus.gov)

These channels are quite different in terms of structure, sequence and function and both have been regarded as important targets for drugs aimed at treating atrial fibrillation. (frontiersin.org)

These mutated TASK-1 channels are located at the plasma membrane to the same degree as wild type TASK-1 channels. (kent.ac.uk)
ONO-RS-082 and alkaline pH 8.4 both activate TASK-1 channels but do not recover current through mutant TASK-1 channels. (kent.ac.uk)
G106R or L214R mutated channels were located at the plasma membrane to the same degree as WT channels, however their current was markedly reduced compared to WT TASK-1 channels. (kent.ac.uk)
Riociguat enhancement of current through TASK-1 channels could contribute to its therapeutic benefit in the treatment of PAH. (kent.ac.uk)
Side Fenestrations Provide an 'Anchor' for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels. (bvsalud.org)

Chemicals and Drugs7

Phenomena and Processes2

Subfamily K member1

Currents9

Subunit11

Inwardly3

Protein17

Abstract1

Ions13

Tandem1

Proteins10

Structurally2

Shaker6

Encodes1

Brain potassium channel1

Functional14

Outward2

KCNK33

TRESK2

Excitable Cells1

Residues7

Genes1

Heteromeric2

Mutations4

Extracellular4

Phosphatase1

Conductance4

KCNQ14

Transmembrane segments1

Activators3

Mammalian1

Helix3

Physiology1

Neuronal3

20011

Structural1

Sodium3

Highly conserved1

Family5

Modulation5

Regulation2

KCNK1

Sensory1

Receptors1

Carboxy-terminal1

Conjugate2

Contributes1

Depolarization1

Human5

Assay1

Molecular2

Inhibitor2

Neurons1

Sequence1

TASK5