• Member viruses are a type of the porcine reproductive and respiratory syndrome viruses (PRRSV). (wikipedia.org)
  • PRRSV causes porcine reproductive and respiratory syndrome in swine. (wikipedia.org)
  • Criticism to this way of classifying the virus range from the multitude of possible combinations of different cut pattern of the three enzymes (leading to tens of thousands of different PRRSV RFLP patterns, with unknown epidemiological significance) to the quick change in RFLP types of a single virus in as few as 10 animal passages. (wikipedia.org)
  • Since the 1987 classification of type 2 (North American-like) PRRSV, the virus has greatly diversified. (wikipedia.org)
  • A strain of PRRSV (CHsx1401) was isolated from a Author affiliation: China Agricultural University, Beijing, China lung sample by using porcine pulmonary alveolar macro- phages. (cdc.gov)
  • PRRS virus (PRRSV), the ing regions and their deduced amino acid sequences of the causative agent of this disease, was identified in Europe virus were performed with representative PRRSV strains in 1991 and the United States in 1992 ( 2,3 ). (cdc.gov)
  • We report emergence of a novel PRRSV (NADC30-like) other strains showed that this virus had amino acid dele- in China that is genetically similar to the NADC30 strain tions that were identical to that in NADC30 ( 8 ) and MN184 isolated in the United States in 2008 ( 8 ). (cdc.gov)
  • Current vaccines do not provide sufficient levels of protection against divergent porcine reproductive and respiratory syndrome virus (PRRSV) strains circulating in the field, mainly due to the substantial variation of the viral genome. (unl.edu)
  • Two common viral pathogens of swine, namely, porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV), were investigated in regard to their effects on monolayer cultures of swine alveolar macrophages (AMs). (scienceopen.com)
  • Three-week-old cesarean-derived colostrum-deprived (CD/CD) pigs were inoculated with porcine circovirus type 2 (PCV2, n = 19), porcine reproductive and respiratory syndrome virus (PRRSV, n = 13), concurrent PCV2 and PRRSV (PCV2/PRRSV, n = 17), or a sham inoculum (n = 12) to compare the independent and combined effects of these agents. (scienceopen.com)
  • Microscopic lesions consistent with postweaning multisystemic wasting syndrome (PMWS) were present in both PCV2- and PCV2/PRRSV-inoculated pigs and included lymphoid depletion, necrotizing hepatitis, mild necrotizing bronchiolitis, and infiltrates of macrophages that occasionally contained basophilic intracytoplasmic inclusion bodies in lymphoid and other tissues. (scienceopen.com)
  • The PRRSV-I dtec-RT-qPCR comprises a series of species-specific targeted reagents designed for Porcine reproductive and respiratory syndrome virus type I detection by using qPCR. (geneticpcr.com)
  • PRRSV causes a disease of pigs, called porcine reproductive and respiratory syndrome, also known as blue-ear pig disease, characterized by reproductive failure in breeding stock and respiratory tract illness in young pigs. (geneticpcr.com)
  • The type 2 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) has spread throughout countries of southeast Asia, where it has caused severe economic losses. (biomedcentral.com)
  • Even countries presently free of PRRSV are at high risk for infection and spread of this virus. (biomedcentral.com)
  • Countries presently free from this highly virulent PRRSV, such as Japan, remain at high risk for the invasion and spread of this virus. (biomedcentral.com)
  • Porcine reproductive and respiratory syndrome virus (PRRSV) has caused huge economic losses in the global swine industry. (researchsquare.com)
  • Frequent genetic variations in this virus cause difficulties in controlling and accurately diagnosing PRRSV. (researchsquare.com)
  • Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped, single-stranded positive-sense RNA virus belonging to the family Arteriviridae of the order Nidovirales . (researchsquare.com)
  • PRRSV causes reproductive failure in sows and respiratory distress in pigs of all ages, resulting in significant economic losses for the swine industry worldwide (1, 2). (researchsquare.com)
  • Highly pathogenic-PRRS virus (HP-PRRSV) is a variant of PRRSV, which caused high morbidity and mortality. (ijbs.com)
  • In vitro infection experiments showed that the CD163 mutant strongly inhibited HP-PRRSV replication by inhibiting virus uncoating and genome release. (ijbs.com)
  • PRRSV infection results in severe reproductive failure in gilts and respiratory disease in pigs of all ages and further complicates polymicrobial disease syndromes such as porcine circovirus-associated disease ( 3 ). (ijbs.com)
  • PRRSV is a positive, single-stranded RNA virus belonging to family Arteriviridae, order Nidovirales ( 4 ). (ijbs.com)
  • PRRSV is highly prone to mutation, and thus, it is one of the most difficult viruses to control in pig production using traditional approaches ( 7 , 8 ). (ijbs.com)
  • Although Cluster of differentiation 163 (CD163) is identified as an essential receptor for mediating PRRS virus (PRRSV) infection, the important residues involved in infection on CD163 are still unclear. (chinaagrisci.com)
  • PRRSV challenge experiments in porcine alveolar macrophages (PAMs) isolated from the CD163-R561A pigs showed significantly lower susceptibility to PRRSV than that of CD163-R561 PAMs. (chinaagrisci.com)
  • Porcine reproductive and respiratory syndrome virus ( PRRSV ) causes significant economic losses to the pork industry worldwide. (bvsalud.org)
  • This study showed that artesunate (AS), one of the antimalarial drugs , potently suppressed PRRSV replication in Marc-145 cells and ex vivo primary porcine alveolar macrophages (PAMs) at micromolar concentrations. (bvsalud.org)
  • IMPORTANCE Porcine reproductive and respiratory syndrome virus ( PRRSV ) infections have continuously threatened the pork industry worldwide. (bvsalud.org)
  • We show that artesunate (AS), one of the antimalarial drugs , is a potent inhibitor against PRRSV replication in Marc-145 cells and ex vivo primary porcine alveolar macrophages (PAMs). (bvsalud.org)
  • PCR-based testing of FOF reveals presence of PRRS virus RNA only at the litter level, as opposed to conventional individual-animal-based sampling methods that demonstrate PRRSV RNA at the piglet level. (biomedcentral.com)
  • Background: The between-and within-herd variability of porcine reproductive and respiratory syndrome virus (PRRSV) antibodies were investigated in a cross-sectional study of 103 British pig herds conducted 2003-2004. (birmingham.ac.uk)
  • Porcine reproductive and respiratory syndrome virus (PRRSV) induces one of most important devastating disease of swine worldwide, and the current methods poorly control it. (biomedcentral.com)
  • PRRSV, a positive sense and single-stranded RNA virus, is a member of family Arteriviridae [ 1 ]. (biomedcentral.com)
  • A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally occurring PRRSV also are provided. (unl.edu)
  • The protective immunity of the modified live virus vaccine was evaluated in pigs born from seropositive sows, vaccinated at 1 day of age, upon inoculation with a PRRSV-1 isolate. (biomedcentral.com)
  • Field reports have suggested that transmission of porcine reproductive and respiratory syndrome virus (PRRSV) can occur by indirect means. (usda.gov)
  • Experiments were designed to determine if porcine reproductive and respiratory syndrome virus (PRRSV) or Bordetella bronchiseptica could be transmitted through indirect airborne contact. (usda.gov)
  • The first positive hit was an infection known as blue ear disease, or to give it its formal name - porcine reproductive and respiratory syndrome virus ( PRRSV ). (nationalgeographic.com)
  • virus (PRRSV) is important for developing methods to control and eliminate the virus. (k-state.edu)
  • Swine and poultry viruses, such as porcine reproductive and respiratory syndrome virus (PRRSV), porcine epidemic diarrhea virus (PEDV), and highly pathogenic avian influenza virus (HPAIV), are economically important pathogens that can spread via aerosols. (cdc.gov)
  • The highest virus concentrations were found with PEDV, followed by HPAIV and PRRSV. (cdc.gov)
  • Porcine reproductive and respiratory tion was conducted by using reverse transcription PCR and syndrome (PRRS), which is characterized by reproductive 14 pairs of primers ( 10 ), which had minor modifications failure in sows and respiratory disease in pigs of all ages, made on the basis of the genomic sequence of NADC30 is a viral disease with serious economic consequences for available in GenBank. (cdc.gov)
  • Porcine reproductive and respiratory syndrome (PRRS) is characterized by reproductive failure in sows and respiratory symptoms in piglets and growing pigs. (biomedcentral.com)
  • It can cause severe reproductive failure in sows and respiratory distress in young growing pigs [ 2 ]. (biomedcentral.com)
  • The disease is characterized by reproductive disorders in sows and respiratory disorders in pigs. (biomedcentral.com)
  • Two recent virus isolates from China (HENAN-XINX rum samples from diseased sows and piglets, and lungs and HENAN-HEB), whose sequences were submitted to and lymph nodes of dead piglets were tested for viral RNA GenBank in 2013, also had these deletions. (cdc.gov)
  • Phylogenetic analysis of porcine circovirus 3 circulating in Canadian pigs. (nih.gov)
  • Beside domestic pigs wild boars can also be affected by postweaning multisystemic wasting syndrome (PMWS). (vetline.de)
  • Neben Hausschweinen können auch Wildschweine an Postweaning Multisystemic Wasting Syndrome (PMWS) erkranken. (vetline.de)
  • The objective of these studies was to investigate if porcine postweaning multisystemic wasting syndrome (PMWS) could be induced in healthy pigs following contact with air from pigs with clinical signs of PMWS. (hindawi.com)
  • Postweaning multisystemic wasting syndrome (PMWS) is an important disease in weaned pigs worldwide. (hindawi.com)
  • Detection of porcine enteric coronaviruses including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis (TGE), and porcine deltacoronavirus (PDCoV), by real time PCR. (tamu.edu)
  • Conserved Patterns of Symmetric Inversion in the Genome Evolution of Bordetella Respiratory Pathogens. (cdc.gov)
  • A Synthetic Porcine Reproductive and Respiratory Syndrome Virus Strain" by Hiep Vu, Fangrui Ma et al. (unl.edu)
  • Suvaxyn PRRS MLV contains a modified strain of live PRRS virus, strain 96V198, that has been weakened so that it does not cause disease. (europa.eu)
  • Suvaxyn PRRS MLV contains a weakened strain of PRRS virus. (europa.eu)
  • Because there are two distinct genotypes of the PRRS virus, there has been uncertainty amongst many farmers about which strain they should vaccinate against," said Rika Jolie, DVM, PhD, Global Technical Director, MSD Animal Health. (merck-animal-health.com)
  • One study tested the efficacy of MSD Animal Health's Porcilis® PRRS in two Japanese farms endemically infected with the Type 2 strain of the virus. (merck-animal-health.com)
  • The study found that vaccinated pigs had fewer clinical signs and higher average daily weight gain after being exposed to this strain of the virus, compared to a non-vaccinated control group. (merck-animal-health.com)
  • Barrette found that the viruses form various Philippine sites are genetically further from each other than they are to the 1989 monkey strain that was the first to be discovered. (nationalgeographic.com)
  • This implies that the virus made its way into pigs on several occasions, rather than one strain accounting for all the modern infections. (nationalgeographic.com)
  • Development and characterization of new monoclonal antibodies against porcine Interleukin-17A and Interferon-gamma. (usda.gov)
  • Porcine Respiratory and Reproductive Syndrome (PRRS) - also called swine infertility and respiratory syndrome (SIRS), porcine epidemic abortion and respiratory syndrome (PEARS), mystery swine disease (MSD) or blue ear disease - is among the world's most important diseases in pig production. (laboklin.com)
  • Betaarterivirus suid 2 is a species of enveloped, positive-strand RNA viruses which infect domestic pigs. (wikipedia.org)
  • Members of the species are also known as porcine reproductive and respiratory syndrome virus 2. (wikipedia.org)
  • Bird Species Involved in West Nile Virus Epidemiological Cycle in Southern Québec. (nih.gov)
  • Detection of parvovirus in porcine species by PCR. (tamu.edu)
  • Ebola Reston virus (RESTV) is one of the six virus has been hypothesized that ongoing, undetected RESTV species of the Ebola virus in the family Filoviridae. (who.int)
  • Comparative genomics of hepatitis A virus, hepatitis C virus, and hepatitis E virus provides insights into the evolutionary history of Hepatovirus species. (cdc.gov)
  • Although three filoviruses have been identified in result in the emergence of more pathogenic viruses in animals in Asia, 3,4 RESTV is the only filovirus isolated humans and/or livestock. (who.int)
  • In addition, diseases of the respiratory tract may occur. (laboklin.com)
  • Coinfections and their molecular consequences in the porcine respiratory tract. (nih.gov)
  • Abstract Porcine reproductive and respiratory syndrome (PRRS) is recognized as one of the most infectious viral diseases of swine. (chinaagrisci.com)
  • Previous studies have shown that the nsp11 of equine arteritis virus(EAV), which is another member of family Arteriviridae, may play a key role in viral RNA synthesis and additional functions in the viral life cycle [ 8 ]. (biomedcentral.com)
  • Similar tools have already proved their worth in viral detective work - the closely related Virochip was used to identify the SARS virus in 2002. (nationalgeographic.com)
  • A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. (usda.gov)
  • The PRRS virus causes reproductive and respiratory disorders in the swine population worldwide and can result in severe economic losses. (merck-animal-health.com)
  • This virus is divided into European genotype 1 no. (cdc.gov)
  • Effect of the host genotype at a Porcine Reproductive and Respiratory Syndrome (PRRS) resistance marker on evolution of the modified-live PRRS vaccine virus in pigs. (usda.gov)
  • According to the study results, both Type 1 and Type 2 antibodies were present in each of the farms, a significant finding considering that farmers choose PRRS vaccines based on the virus genotype present in their farm. (merck-animal-health.com)
  • In addition, the reduction in CPE was abolished when the supernatants of PCV2-infected AMs were pre-treated with a mouse anti-recombinant porcine IFN-α antibody. (scienceopen.com)
  • PCV2 has proved to be necessary but not sufficient for development of PMWS, since the virus is present in both affected and PMWS-free pigs and herds [ 4 , 8 ]. (hindawi.com)
  • The PCV2 virus is transmitted between pigs by the oro-fecal and/or respiratory routes [ 9 , 10 ] and vertical transmission has also been documented [ 4 , 11 ]. (hindawi.com)
  • SUMMIT, NEW JERSEY, 26 September 2013 - MSD Animal Health (known as Merck Animal Health in the USA and Canada) presented new data showing that MSD Animal Health's PRRS vaccine is effective against different strains of the PRRS virus in Asia. (merck-animal-health.com)
  • Recombination between Vaccine and Field Strains of Porcine Reproductive and Respiratory Syndrome Virus. (cdc.gov)
  • Bovine respiratory disease (BRD) is one of the most common and costliest diseases affecting the dairy and beef industries. (absglobal.com)
  • However, in late state gestation transplacental infection to and from fetuses can occur and large scale reproductive failure may occur. (wikipedia.org)
  • The virus can spread very quickly by droplet infection and through the air. (laboklin.com)
  • RVG Peptide-Functionalized Favipiravir Nanoparticle Delivery System Facilitates Antiviral Therapy of Neurotropic Virus Infection in a Mouse Model. (nih.gov)
  • Prather's laboratory developed the pigs and Rowland's laboratory tested for the PRRS virus infection at Kansas State University's Large Animal Research Center. (k-state.edu)
  • natural infection of Ebola virus in NHPs. (who.int)
  • Another study of more than 200 pigs in Thailand compared the effect of Porcilis® PRRS and a Type 2 vaccine on levels of the cytokine Interleukin-10, which is reported to increase the severity of clinical disease associated with the PRRS virus. (merck-animal-health.com)
  • However, there is simply no way of knowing if the virus will cause or contribute to disease in pigs or humans at this time. (nationalgeographic.com)
  • Porcine reproductive and respiratory syndrome virus is a small, enveloped RNA virus, which contains a single-stranded, positive-sense, RNA genome with a size of 15 Kb. (geneticpcr.com)
  • As with previous outbreaks of the virus, there are no signs of any actual disease in the infected people. (nationalgeographic.com)
  • Assessment of air sampling methods and size distribution of virus-laden aerosols in outbreaks in swine and poultry farm s. (cdc.gov)
  • There have been five documented outbreaks of Ebola Reston virus (RESTV) in animals epidemiologically linked to the Philippines. (who.int)
  • In the decades that we have had the PRRS virus, we have looked at vaccines, diagnostics and other strategies and we have never been able to eliminate the disease," Rowland said. (k-state.edu)
  • Sequence and destroy: the quest to eliminate the last stocks of deadly rinderpest virus. (cdc.gov)
  • Weaner and grower pigs show mainly varying degrees of respiratory distress, and up to 20% of pigs may die. (biomedcentral.com)
  • The natural cytotoxicity receptor NKp44 (NCR2, CD336) is expressed on the majority of porcine NK cells ex vivo without stimulation. (usda.gov)
  • When a pig is given the vaccine, the pig's immune system recognises the virus as 'foreign' and makes antibodies against it. (europa.eu)
  • The study comprised two reproductive phases (cycles) in two commercial farrow to finish farms: Farm A (capacity: 550 sows) and Farm B (capacity: 220 sows). (researchgate.net)
  • Here, we substituted exon 7 of porcine CD163 with the corresponding exon of human CD163-like 1 ( hCD163L1 ) using a CRISPR/Cas9 system combined with a donor vector. (ijbs.com)
  • In this study, we first generated immortalized porcine alveolar macrophage (IPAM) cell lines harboring 40-residues (residues 523-562, including R561 (arginine (R) at position 561)) deletion of CD163. (chinaagrisci.com)
  • Similar to the genome of enveloped, positive-strand RNA virus of the family Arteri- NADC30, the genome of CHsx1401 (GenBank accession viridae . (cdc.gov)
  • The Antimalaria Drug Artesunate Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication by Activating AMPK and Nrf2/HO-1 Signaling Pathways. (bvsalud.org)
  • Removal of a piece of DNA responsible for interaction with a virus, and enabling virus movement or replication, can ultimately allow the cells to be virus-free. (absglobal.com)
  • Although these two genotypes differ greatly in their antigenic properties and genetic content, both cause almost similar syndromes. (geneticpcr.com)
  • Porcine reproductive and respiratory syndrome causes significant losses in the pig industry due to reproductive disorders and growth retardation," said Robert Barclay, Vice President, Asia Pacific, MSD Animal Health. (merck-animal-health.com)
  • Suvaxyn PRRS MLV is a veterinary vaccine used to protect pigs against porcine respiratory and reproductive syndrome (PRRS). (europa.eu)
  • In pregnant gilts and sows with no prior exposure to PRRS virus, Suvaxyn PRRS MLV must not be used in the second half of pregnancy because the virus in the vaccine may cross the placenta and affect the birth rate. (europa.eu)
  • The high fatality rates of most infections have prompted scientists to search for wild animals that could act as living headquarters from which the viruses could seed infections in the human populace. (nationalgeographic.com)
  • In the future, the immune system will be able to react against the virus more quickly. (europa.eu)
  • At the time the studies were conducted, the investigators concluded that "The high distribution to lung and slow elimination following a single dose of [Draxxin] are desirable pharmacokinetic attributes for an antimicrobial drug indicated for the treatment of respiratory disease in swine. (thepigsite.com)
  • To identify it, Barrette used a powerful tool called a "panviral microarray" - a small slide that contains the genetic signatures of tens of thousands of viruses, neatly arranged in a grid. (nationalgeographic.com)
  • The presence of RESTV in pigs poses a possibility of genetic evolution of the virus. (who.int)