• An analysis of patterns of non- synonymous and synonymous mutations revealed evidence of positive selection on immunologically important regions of the genome, further supporting the potential that immune-mediated selection shapes the evolutionary and epidemiological dynamics for this virus. (frontiersin.org)
  • PRCV excretion curves were similar in single and dual virus inoculated groups. (ugent.be)
  • The aim was to determine if dual infections, as compared to single virus infections, result in enhanced clinical manifestations. (ugent.be)
  • The analysis of amino acid sequences evidenced for GP5 and N-nucleocapsid proteins confirmed that the Romanian virus belonged to type 1. (mdpi.com)
  • NSP1β was found to inhibit both IFN regulatory factor 3 (IRF3)- and NF-κB-dependent gene induction by dsRNA and Sendai virus. (asm.org)
  • The virus was also found to inhibit the dsRNA-mediated upregulation of IFN-β gene transcription ( 36 ). (asm.org)
  • In cell culture, DRACO is reported to have broad-spectrum efficacy against many infectious viruses, including dengue flavivirus, Amapari and Tacaribe arenavirus, Guama bunyavirus, H1N1 influenza and rhinovirus, and has been additionally found effective against influenza in vivo in weanling mice. (wikipedia.org)
  • Although these enhanced immune responses clear virus from the serum and BALF more quickly than responses seen in other strains, if these responses go unchecked, as they seem to in this case, it can have disastrous consequences for the animal. (surrey.ac.uk)
  • Finally, the present invention describes the basic mechanism by which the virus RNA enters a target cell. (patents.com)
  • Despite control efforts involving improved biosecurity and different vaccination protocols, the virus continues to circulate and evolve. (frontiersin.org)
  • However, the low morbidity and mortality in the pig herd from which HB-XL was isolated indicate that the virulence of the virus was weak, so it has potential as a future vaccine strain. (mdpi.com)
  • The combination of this virus' extensive genetic diversity and its immunosuppressive characteristics has made it difficult to design vaccines that are effective in the event of heterologous challenge. (biomedcentral.com)