• The IDEXX RealPCR PEDV RNA Mix is used for the identification of porcine epidemic diarrhea virus RNA using the IDEXX RealPCR platform. (idexx.com)
  • In the U.S. alone, porcine epidemic diarrhea virus (PEDV) has caused losses of more than 8 million pigs. (idexx.com)
  • The clinical presentation of PEDV is indistinguishable from that of transmissible gastroenteritis virus (TGEV) and porcine deltacoronavirus (PDCoV), two other swine enteric coronaviruses of great concern. (idexx.com)
  • For my Ph.D. degree in Preventive Veterinary Medicine at Huazhong Agricultural University, I studied the molecular details of how animal coronaviruses, such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) evade host innate immune responses. (bu.edu)
  • Detection of porcine enteric coronaviruses including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis (TGE), and porcine deltacoronavirus (PDCoV), by real time PCR. (tamu.edu)
  • Porcine epidemic diarrhea virus (PEDV) is an emerging pathogenic coronavirus that causes a significant economic burden to the swine industry. (uu.nl)
  • As for several other alphacoronaviruses including the porcine transmissible gastroenteritis virus (TGEV) and the human coronavirus 229E (HCoV-229E), the aminopeptidase N (APN) protein was reported to be a functional receptor for PEDV. (uu.nl)
  • We show that overexpression of porcine APN renders MDCK cells susceptible to TGEV, but not to PEDV. (uu.nl)
  • Moreover, preincubation of these viruses with soluble APN or pretreatment of APN expressing ST cells with soluble TGEV-S1 blocked TGEV infection, but had no effect on infection by PEDV. (uu.nl)
  • To definitively prove this conclusion, we applied CRISPR/Cas9 genome engineering to knock out APN expression in PEDV-susceptible porcine (ST) and human cell lines (Huh7 and HeLa). (uu.nl)
  • Since 2010, outbreaks of genotype 2 (G2) porcine epidemic diarrhea virus (PEDV) have caused high mortality in neonatal piglets and have had devastating impacts on the swine industry in many countries. (biomedcentral.com)
  • The causative agent of PED is a single stranded, enveloped RNA virus named porcine epidemic diarrhea virus (PEDV), which belongs to the genera Alphacoronavirus , the family Coronaviridae , and the order Nidovirales [ 3 ]. (biomedcentral.com)
  • The coronaviruses, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) represent important sources of neonatal diarrhea on pig farms. (illinois.edu)
  • Since outbreaks of porcine epidemic diarrhea virus (PEDV) in the United States in 2013, explosive outbreaks of PED in South Korea have infected all age groups of pigs in 2014-2015 year. (scienceopen.com)
  • The porcine epidemic diarrhoea virus (PEDV), a member of the Coronaviridae family, causes acute diarrhoea and dehydration in pigs. (scienceopen.com)
  • Interestingly, we found that both of EPS and genome editing lacticaseibacillus casei could specifically target the IFN-λ expression in the IPEC-J2, which was beneficial against the PEDV infection in the virus replication and production with the qRT-PCR and indirect immunofluorescence methods. (biomedcentral.com)
  • Finally, the STAT3 cell single pathway was stimulated to transcribe IFN-λ with the EPS to elucidate the detailed mechanism of activating type III IFN signals receptor of IL-10R2, which play the function between anti-inflammation and anti-virus in the PEDV infection. (biomedcentral.com)
  • A new multiplex PCR test that combines Porcine Epidemic Diarrhea Virus (PEDv), Porcine Deltacoronavirus (PDCoV) and Transmissible Gastroenteritis Virus (TGEV) into one assay was implemented into the Molecular Diagnostic clinical testing schedule effective October 31st, 2016. (umnswinenews.com)
  • As a consequence these cells no longer bound TGEV-S1 and HCoV-229E-S1 at their surface and were resistant to infection by the corresponding viruses. (uu.nl)
  • In Alberta, reportable swine diseases include classical swine fever (CSF), porcine epidemic diarrhea (PED), foot-and-mouth (FMD) disease, swine delta coronavirus (SDCV), transmissible gastroenteritis and diseases caused by any toxic substance that is a threat to animal health or human health. (albertapork.com)
  • These recommendations evolved from observations during the SARS epidemic that failure to implement basic source control measures with patients, visitors, and healthcare personnel with signs and symptoms of respiratory tract infection may have contributed to SARS coronavirus (SARS-CoV) transmission. (cdc.gov)
  • Porcine alveolar macrophages (PAMs) from ANPEP knockout (KO) pigs showed resistance to PDCoV infection. (illinois.edu)
  • Severe outbreaks of enteric coronaviruses, characterized by acute and rapidly spreading diarrhea, are threatening swine operations worldwide. (idexx.com)
  • Detection of parvovirus in porcine species by PCR. (tamu.edu)
  • The type 2 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) has spread throughout countries of southeast Asia, where it has caused severe economic losses. (biomedcentral.com)
  • The pandemic G2a virus was partial neutralized by the antibodies invoked by the G1- based PED vaccine virus. (scienceopen.com)
  • A third disease caused by a capripoxvirus, lumpy skin disease of cattle, can also elicit protective immunity against sheep- and goatpox in sheep and goats, as illustrated by the Kenyan sheep- and goatpox vaccine which is derived from a lumpy skin disease virus that was isolated from sheep. (anipedia.org)
  • The primary signs are a watery diarrhea and mild systemic signs such as pyrexia, anorexia and lethargy. (wikipedia.org)
  • Clinically, ETEC induce a watery diarrhea in infected hosts by action of the two toxins, LT and ST. The LT enterotoxin is very similar to cholera toxin in both structure and mode of action. (zoologix.com)
  • This leads to secretion of fluid and electrolytes resulting in a watery diarrhea. (zoologix.com)
  • EPEC cause a watery diarrhea similar to ETEC, but do not produce ST or LT toxins. (zoologix.com)
  • Lacticaseibacillus is one of the predominant microorganisms in gut from human and animal, and the lacticaseibacillus have effective applications against the viral diarrhea of piglets in the farm. (biomedcentral.com)
  • There is a toxic effect on the kidneys, and diarrhea caused by this strain can be fatal, particularly in infants, due to acute kidney failure. (zoologix.com)
  • EAEC were originally recognized as one of the predominant etiologic agents of persistent diarrhea in developing countries and they remain an important cause of acute as well as protracted diarrhea in many parts of the world, including industrialized countries. (zoologix.com)
  • The virus infects the intestinal epithelium and causes villous atrophy, resulting in diarrhea and dehydration. (uu.nl)
  • Capripoxviruses are large brick-shaped, double stranded DNA viruses, morphologically indistinguishable from orthopoxviruses, measuring 295 by 265 nm. (anipedia.org)
  • The clinical syndrome is identical to Shigella dysentery and includes a dysentery-like diarrhea with fever. (zoologix.com)
  • In recent years, with the emergence and re-emergence of difficult-to-control diseases such as African swine fever or porcine epidemic diarrhoea, the perception of the critical importance of pig health and its relationship with biosecurity has increased in recent years. (biomedcentral.com)
  • Because sheep- and goatpox are serious epidemic diseases that may cause important losses in affected herds and represent also a major constraint to international trade for affected countries, they are classified in the list of animal diseases to be notified to the World Organization for Animal Health, the OIE: outbreaks should be reported immediately to the OIE. (anipedia.org)
  • More than 50% of the procedures in the VDL were related to the porcine species last year. (umnswinenews.com)
  • 35 Therefore, the classification used so far, based on the animal species from which the capripox virus is isolated, i.e. goatpox and sheeppox for viruses isolated from goat and sheep respectively, is inappropriate. (anipedia.org)
  • Here, we compared the biological function of extracellular polysaccharides (EPS) purified from lacticaseibacillus casei ( L. casei ) and gene editing lacticaseibacillus casei with the CRISPER-Cas9 technology, which were with the ability of antioxidation and anti-inflammation, and the EPS could also inhibit the ROS production within the Porcine Small Intestinal Epithelial Cells-J2 (IPEC-J2). (biomedcentral.com)
  • the host cell receptor is the first step in infection and the main determinant for virus tropism. (uu.nl)
  • Porcine reproductive respiratory syndrome (PRRS) virus. (thepigsite.com)
  • Alphaviruses are emerging and re-emerging viruses that cause severe disease and threaten public health worldwide. (bvsalud.org)
  • Interaction between virus infection and cell host response. (bu.edu)
  • Even countries presently free of PRRSV are at high risk for infection and spread of this virus. (biomedcentral.com)
  • Many viruses, including Kaposi Sarcoma Herpesvirus (KSHV), have evolved sophisticated countermeasures to extend the life of an infected host cell to support establishment of infection and virus proliferation. (mdpi.com)
  • However, it is not clear whether they are involved in foot-and-mouth disease virus (FMDV) infection and host response. (biomedcentral.com)
  • Although studies have demonstrated that circRNAs are involved in the regulation of host cells after viral infection, there is a lot to unravel to understand the role that circRNAs play in virus-host interactions and viral pathogenesis. (biomedcentral.com)
  • Of the recent emerged G2a viruses, J3142 strains showed potential recombination breakpoint (376-2,143nt) of S1 gene between KNU1303_Korea strain_G2a (KJ451046) and 45RWVCF0712_Thailand strain_G2b (KF724935). (scienceopen.com)
  • 4. The function of virus encoded proteins. (bu.edu)
  • The IHC lab participated in the 2016 AAVLD/NVSL Program for Inter-laboratory Comparison, and scored 100% in its detection of Porcine Circovirus type 2 in the test samples provided. (umnswinenews.com)
  • With SARS-CoV-2 as the model, the proposed method (RPA-TeaPNA-LFA) efficiently eliminated the false-positives, exhibiting a lowest detection concentration of 6.7 copies/µL of RNA and 90 copies/µL of virus. (bvsalud.org)
  • During analysis, sample status is determined as either positive (virus was detected at a certain level), inconclusive (very small amount may be present but questionable), and negative (no detection of the pathogen). (albertapork.com)
  • This chapter describes basic principles of ecology and evolution for waterborne viruses, bacteria, and protozoa (and yeasts and molds to a lesser extent) of public health concern as an aid to better understand how selective forces may alter one's ability to assess the microbial quality of water. (nationalacademies.org)
  • In other cases, for example, influenza A virus, animal pathogens have the potential for producing a pandemic event. (biomedcentral.com)
  • The timing was impeccable, as U-M had recently received funding from the National Pork Board to study the survival of porcine epidemic diarrhea virus in animal feed. (nationalhogfarmer.com)
  • Meng Z, Han R, Hu Y, Yuan Z, Jiang S, Zhang X, Xu J. Possible pandemic threat from new reassortment of influenza A(H7N9) virus in China. (123dok.net)
  • To be informative nomenclature needs to take other criteria such as molecular-based data that enable clear differentiation between these two viruses into consideration. (anipedia.org)
  • Some of these countries, including Japan, have broad epidemics of the local type 2 PRRSV, creating chronic pathogenicity in the domestic pig population. (biomedcentral.com)
  • certainly, it is difficult to recover live virus on tissue culture from scab material, but the presence of the virus within type A inclusion protein could protect the virus in the environment although this has not yet been proven. (anipedia.org)
  • Unfortunately, PCR testing does not allow differentiation between live, viable virus and virus/viral parts that are no longer infectious. (albertapork.com)
  • 3. The pathology research of RNA virus. (bu.edu)