Populations of endothelial cells. Medical search. Frequent questions

Systemic autoimmune diseases, such as rheumatoid arthritis (RA), exhibit accelerated atherosclerosis (AS) [ 1 - 4 ] as a consequence of endothelial dysfunction, leading to higher incidence of cardiovascular (CV) disease (at least 2-fold enhanced CV risk) and premature and higher mortality [ 5 , 6 ]. (hindawi.com)
SAA was shown to exhibit causal properties in AS, as a consequence of endothelial dysfunction (elevating tissue factor, as well as a variety of cytokines/chemokines) and early lesions (biglycan synthesis) [ 15 ] to plaque destabilization by inducing matrix metalloproteinases [ 16 ]. (hindawi.com)
Conclusions: This study has identified dysfunction of the systemic vascular endothelial cell in patients with normal pressure glaucoma. (bmj.com)
Dr. Solomon's research interests include endothelial cell dysfunction and inflammation in pulmonary arterial hypertension, methods of detection of cardiac allograft cellular rejection, and organizational structures and outcomes in the delivery of critical care cardiology. (nih.gov)
The peptide fraction was then found bioactive, producing endothelial cell inflammation and vascular dysfunction ex vivo akin to that induced with whole serum. (cdc.gov)
The serum peptide fraction, having cell-surface receptor ligand properties, conveys peripheral bioactivity in promoting endothelial cell inflammation, vasodilatory dysfunction and inhibiting angiogenesis. (cdc.gov)
Patients with PH exhibited higher circulating levels of microparticles compared to control subjects and in vitro or in vivo generated microparticles can induce endothelial dysfunction, interfere with coagulation pathways or modulate inflammatory phenomenon. (ersjournals.com)
However, many disease-predisposing factors and/or contributing factors have been identified, including inflammation, endothelial cell dysfunction, aberrant vascular wall cell proliferation and mutations in the bone morphogenetic protein-receptor type 2 ( Bmpr2 ) gene [ 1 - 3 ]. (ersjournals.com)
Future studies should test these hypotheses in high-risk patient populations, such as those affected by endothelial corneal dysfunction or glaucoma/hypertension. (bmj.com)
Endothelial dysfunction, as a comprehensive index of the overall CVD risk factor burden includes three main consequences, exposure of adhesion molecules, the activation and aggregation of platelets, cholesterol accumulation [ 20 ]. (biomedcentral.com)
Potential causes of endothelial dysfunction include sheer stress related to hypertension, oxidized low-density lipoprotein (LDL), homocysteine, and smoking. (medscape.com)

Treatment modalities for CSC include focal laser photocoagulation, photodynamic therapy (PDT), and intravitreal anti-vascular endothelial growth factor (VEGF) injections [ 14 ]. (plos.org)
In this study we focus on the immunoreactivity of the monoclonal antibody VEGF (C-1) in order to analyze its expression in two cell populations of regenerating mouse liver (hepatocytes and endothelial cells) after partial hepatectomy, and two transplanted hepatocarcinomas (ES2 and SS1K). (unlp.edu.ar)
The results showed strongly immunopositivity reaction for VEGF either in hepatocytes or endothelial cells of mouse regenerating liver. (unlp.edu.ar)
Gold standard anti-vascular endothelial growth factor (VEGF) treatment is an effective therapy, but the long-term prevention of visual decline has not been as successful. (ntu.edu.sg)

In older HIV-positive people with or at risk of cardiovascular disease, 24 weeks of low-dose methotrexate (LDMTX) reduced CD8-cell numbers and activation but did not quell other markers of inflammation or improve endothelial function [1]. (natap.org)
They hypothesized (1) that LDMTX would cause no more than a 15% increase in probability of "safety events" (including drops in CD4 count and virologic failure) compared with the background rate, and (2) that reducing inflammation would improve endothelial function assessed by flow-mediated vasodilation of the brachial artery. (natap.org)
Levels of CD8 cells, an inflammation indicator, fell significantly more with LDMTX than with placebo at weeks 8, 12, and 24 (-103 versus -2 cells, P = 0.001). (natap.org)
Endothelial cell count, intraocular pressure (IOP), central corneal thickness (CCT), intraocular inflammation and corrected distance visual acuity (CDVA) were compared 3 months postoperatively. (bmj.com)

Endothelial colony forming cells (or ECFCs) are adult endothelial progenitor cells capable of differentiating to regenerate endothelial cell populations. (wikipedia.org)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
The endothelium appears to be damaged both by AF and various other vascular diseases (e.g. hypertension) that frequently co-exist with the arrhythmia, with similar disruption to endothelial repair (normally effected by endothelial progenitor cells). (bham.ac.uk)
Interleukin-6, IL-6) in AF with particular reference to circulating progenitor cells (CPCs) as a novel marker of endothelial health/angiogenesis. (bham.ac.uk)
A lately developed and validated immunotagging technique makes use of three transcription issue antibodies to concurrently isolate enriched neuronal (NeuN+), astrocyte (paired field protein 6 (PAX6)+NeuN-), and oligodendrocyte progenitor ( OLIG2 +NeuN-) nuclei populations from non-diseased, recent (unfixed) snap-frozen postmortem human temporal neocortex tissue. (aetox.com)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

The studied parameters including mean endothelial cell density (MCD), mean cell area (MCA) and coefficient of variation (CV) in cell area were analyzed in all of the 525 eyes. (nih.gov)
The postoperative mean endothelial cell loss was 14.4% and 7.1% from baseline in the OVD1 and OVD2 groups, respectively (p=0.08). (bmj.com)

Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
BNP also stimulated the proliferation of WT1 + epicardium-derived cells but only in the hypoxic area of infarcted hearts. (elifesciences.org)
The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)
Recently I uncovered that ANKHD1 controls cell proliferation by directly binding to and modulating a subset of tumour-suppressor microRNAs (https://www.ncbi.nlm.nih.gov/pubmed/29695508). (sheffield.ac.uk)
We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
Inhibits proliferation and promotes osteogenic differentiation, while inhibiting adipogenic differentiation, of human amnion-derived mesenchymal stem cells (MSCs) and rabbit bone marrow-derived MSCs (Wu et al. (stemcell.com)
Decreased proliferation and Nanog expression in mouse embryonic stem (ES) cells, with increased erythroid differentiation (Chae et al. (stemcell.com)
MiR-133a-5p inhibits androgen receptor (AR)-induced proliferation in prostate cancer cells via targeting FUsed in Sarcoma (FUS) and AR. (nih.gov)
These cells are classified as totipotent and they can form any of the tissue types found in the adult body, in addition to having unlimited proliferation potential 6 . (bvsalud.org)

Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)
One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)
Bone marrow appears to contain three stem cell populations: hematopoietic stem cells, stromal stem cells and endothelial precursor cells. (bvsalud.org)

Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Low-serum cell culture medium for endothelial cells from large blood vessels. (promocell.com)
Most breast cancer deaths occur because the cancer has spread, or metastasized, which means that cells in the primary tumor have invaded blood vessels and traveled via the bloodstream to form tumors elsewhere in the body. (medindia.net)
In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread. (medindia.net)
Where these three cells come in contact is where tumor cells can enter blood vessels--a site called a tumor microenvironment of metastasis, or TMEM. (medindia.net)
For the subset of more recent patients, the researchers assessed tumor cell behavior--in particular, cancer cells' ability to cross the endothelium (inner layer) of blood vessels. (medindia.net)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)

These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
In the Vila Ellis Lab, we will investigate this newly discovered heterogeneity during development and regeneration with the ultimate objective of elucidating the transcriptional mechanisms underlying endothelial heterogeneity, endothelial cell fate, and the molecular and cellular components of lung angiogenesis. (northwestern.edu)

Methods: Identification of tumour-associated endothelial markers (TEM) by comparing antigen expression on normal vs t-CEC and assess the presence of t-CEC in peripheral blood of cancer patients by incorporating TEM in our novel flow cytometry-based CEC detection assay. (researchgate.net)
Methods: This study aims to demonstrate the use of HLA class I molecules in inducing human NK cell tolerance. (iupui.edu)

ECFC-like cells have also been generated from pluripotent stem cells, perhaps eliminating the need for direct harvesting of the cells for future use. (wikipedia.org)

Fuchs endothelial dystrophy (FED), a corneal endothelium disease, is one of the leading causes for corneal transplantation. (uwaterloo.ca)
During disease progression, Descemet membrane's (DM), the corneal endothelial basement membrane, biomechanical properties such as surface topography and stiffness are affected and form guttatas, pillar-like structures, with different geometries and varied stiffness. (uwaterloo.ca)
Corneal endothelial cells become apoptotic and their function is severely hampered. (uwaterloo.ca)
However, the impact of FED guttatas and stiffness on human corneal endothelial cells remains poorly understood. (uwaterloo.ca)
Hence, I hypothesized that guttatas and stiffness might affect corneal endothelial cell behavior such as increasing cell apoptosis. (uwaterloo.ca)
The impact of synthetic guttatas (s-guttata) dimensions on corneal endothelial cell behaviour in endothelial cell injection therapy conditions was studied. (uwaterloo.ca)
We describe corneal endothelial cell density and morphology in normal Iranian eyes and compare endothelial cell characteristics in the Iranian population with data available in the literature for American and Indian populations. (nih.gov)
Viscopack14 showed more corneal endothelial cell reduction, while DuoVisc had more occurrences of IOP values and spikes. (bmj.com)
1 Dispersive OVDs have lower molecular weight and shorter molecular chains that cause better adherence to the corneal endothelial cells resulting in greater protection against fluid turbulence and lens fragments during phacoemulsification. (bmj.com)

Certain cells within the heterogeneous group of colony forming cells are demonstrated to reach significantly higher population doublings, and retain high levels of telomerase activity. (wikipedia.org)
These have been termed high proliferative potential endothelial colony forming cells, or HPP-ECFCs. (wikipedia.org)
Vascular endothelial stem cells have been defined as rare endothelial colony forming cells with extremely high proliferative potential. (wikipedia.org)

Tissue clearing for whole organ cell profiling has revolutionized biology and imaging for exploration of organs in three-dimensional space without compromising tissue architecture. (elifesciences.org)
Human Liver Sinusoidal Endothelial cells were isolated from normal human liver tissue. (neuromics.com)
They obtained tumor cells using fine needle aspiration and placed them in a novel engineered tissue assay designed to replicate the endothelium of a blood vessel--the barrier that cells must cross so they can spread from a primary tumor to distant sites. (medindia.net)
to efficiently isolate and research human neuronal nuclei (NeuN+) populations from frozen archival tissue, thereby avoiding issues related to dealing with recent tissue. (aetox.com)
Adult stem cells are classified as pluripotent and are undifferentiated cells that remain quiescent in tissues until stimulated, when they can create cell types that are compatible with the tissue in which they reside. (bvsalud.org)
It's important to determine whether the mutation is specific to one type of vascular cell, for example, endothelial cells that line the lumen of vessels and regulate exchanges between tissue and blood and help prevent clotting, or vascular smooth muscle cells in the vessel wall that regulate the vessel diameter and adjust the blood flow like a faucet would. (medscape.com)

Background: Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. (researchgate.net)
Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. (researchgate.net)
Transcriptomic analyses confirmed that PAX6+NeuN- sorted populations are robustly enriched for pan-astrocyte markers and seize astrocytes in each resting and reactive situations. (aetox.com)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)

ECFCs are named for their ability to form colonies of cells which progress rapidly to capillary-like networks in vitro when cultured in biopolymer matrix, and in vivo. (wikipedia.org)
HADSCs were induced to confirm that they can express the characteristics of endothelial cells (ECs) in vitro. (molvis.org)
Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)

The injected cells did not fuse with the retina and gathered in the central and peripheral areas, which is the lesion area of the OIR model. (molvis.org)
Genetically modified pECs were co-cultured with human peripheral blood mononuclear cells (PBMCs) for E:T ratio of 10:1 for 2 hours. (iupui.edu)
In addition, mTEC screen thymocytes for their expression of high affinity αβ-TCRs, with negative selection limiting the release of these reactive T-cells into the peripheral pool ( 4 ). (frontiersin.org)
In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)
While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)

According to the current paradigm, atherosclerosis is not a bland cholesterol storage disease, as previously thought, but a dynamic, chronic, inflammatory condition due to a response to endothelial injury. (medscape.com)
Infections and inflammatory conditions also contribute to endothelial injury and atherosclerosis. (medscape.com)

Breast cancer cells able to cross the endothelial layer in this assay were found to have higher MenaINV levels compared with the total population of patients' aspirated cells. (medindia.net)
The company has developed a calorimetry-based assay system that can monitor the total metabolic activity by measuring the heat flow in and out of a cell culture well in real time, down to the microwatt level. (genengnews.com)
SymCel's calPlate assay is independent of cell type and media conditions. (genengnews.com)
Cultures are subjected to a standard 2D viability assay to determine the health of the cells two days after treatment with the test compound. (genengnews.com)
We generated blood out-growth endothelial cells (BOECs) from wet AMD and normal control subjects, then induced angiogenic sprouting of BOECs using a fibrin gel bead assay. (ntu.edu.sg)

A significant increase in the cell apoptosis was observed across 20 µm height s-guttatas on different days. (uwaterloo.ca)
Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
Microparticles are plasma membrane vesicle fragments (between 0.1 and 1 μm in size) released from various cell types during activation by agonists or physical or chemical stress, including apoptosis [ 6 , 7 ]. (ersjournals.com)
Hematopoietic stem cells are cells isolated from blood and bone marrow that can differentiate into a variety of different specialized cells and suffer apoptosis 1 . (bvsalud.org)

To deconvolute endothelial heterogeneity, we performed single-cell transcriptomic analysis on the sprouting BOECs, revealing a spectrum of cell states. (ntu.edu.sg)

The surgical procedure for delivery of embryonic stem cell-derived endothelial cells to the ischemic hindlimb is demonstrated, with non-invasive tracking by bioluminescence imaging. (jove.com)
A stem cell is an undifferentiated unit with powerful self-renewal properties that is capable of organizing other cell types in the body. (bvsalud.org)
Stem cells can divide into two cells identical to the original stem cell or into differentiated cell types, depending on their origin and differentiation potency. (bvsalud.org)

This method was proven to be helpful for the characterization of cell type-specific transcriptome alterations in main pathological epilepsy neocortex. (aetox.com)

Many studies have shown the utility of embryonic or adult stem cells for forming teeth and for regeneration of bone and soft tissues. (bvsalud.org)
There are basically two types of stem cells: embryonic and somatic (or adult). (bvsalud.org)
Embryonic stem cells are derived from the inner cell mass of a blastocyst, which is an accumulation of primordial cells (4-5 days after fertilization). (bvsalud.org)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)

Induces upregulation of the pluripotency network genes (Klf4, Klf2, Nanog, Oct4, Myc, Sox2) and epigenetic-associated proteins (Dnmt3a, Mbd3) in mouse ES cells, and inhibits retinoic acid-induced differentiation (Adamo et al. (stemcell.com)
Promotes differentiation and mineralization of MC3T3-E1 osteoblastic cells (Kanazawa et al. (stemcell.com)
By definition, adult stem cells are capable of differentiation into at least two lineages and have the property of self-renewal. (bvsalud.org)

DetachKit for gentle and effective detachment of adherent primary human cells. (promocell.com)
At places, the cells were adherent to endothelial lining [ Figure 1c ]. (cytojournal.com)
Three-dimensional cultures, adherent or suspension cells, bacteria, yeast, and even small parasites such as malaria can be queried. (genengnews.com)

A database search curated for known matrix protease substrates and predicted signaling motifs enabled identification of 73 MWCNT-responsive peptides, which were significantly associated with an abnormal cardiovascular phenotype, extracellular matrix organization, immune-inflammatory processes, cell receptor signaling, and a MWCNT-altered serum exosome population. (cdc.gov)
Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
introduced a new concept of CKD-associated secretory phenotype (CASP), which indicates that senescent renal cells could secrete SASP components of various cytokines such as IL-1, IL-6, and TNF- α [ 19 , 20 ]. (hindawi.com)
Whether or not these new conveyors of biological information contribute to the acquisition and/or maintenance of the altered endothelial phenotype is unexplored in PH and requires further study. (ersjournals.com)
Our wet AMD BOECs share common pathways with choroidal neovascularization such as extracellular matrix remodeling that promoted proangiogenic phenotype, and our 'activated' BOEC subpopulation demonstrated proinflammatory hallmarks, resembling the tip-like cells in vivo. (ntu.edu.sg)

Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)

They are residents of adult vasculature and are also thought to migrate to areas of injury as one form of circulating endothelial cell. (wikipedia.org)

They have been identified by marker analysis as lin- (lineage negative) CD31+, CD105+, Sca-1+, CD117 (ckit)+ and thought have the ability to generate functional vasculature from single cells. (wikipedia.org)
After induction, hADSCs expressed von Willebrand Factor (vWF), the cell marker of ECs. (molvis.org)
Especially in drug discovery, most such assays have been geared toward a particular reaction-whether it is recognition of a cell surface marker, triggering endocytosis, or exciting or inhibiting a phosphorylation cascade. (genengnews.com)
Protein expression of OLIG2 , a novel marker in RMS, was investigated utilizing antibody EP112 (Cell Marque). (aetox.com)

Glyoxalase-I (GLO-I) is an enzyme critical for the detoxification of AGEs and retinal vascular cell survival. (diabetesjournals.org)
Cultured bovine retinal endothelial cells (BREC) and bovine retinal pericytes (BRP) were incubated with Ang II (100 nmol/l) or Ang II+candesartan (1 μmol/l). (diabetesjournals.org)

To determine the effects of medications on SAA-stimulated human coronary artery endothelial cells (HCAEC). (hindawi.com)
The first report in 2007, on SAA-stimulated human coronary artery endothelial cells (HCAEC), exhibited a substantial and significantly higher induction of released IL-6 protein and mRNA levels as compared to HUVEC [ 17 ], as well as increased responsiveness to IL-1 β [ 18 ]. (hindawi.com)
Journal Article] Cell-sheet Therapy With Omentopexy Promotes Arteriogenesis and Improves Coronary Circulation Physiology in Failing Heart. (nii.ac.jp)
Genetic Polymorphism of NQO1 Influences Susceptibility to Coronary Heart Disease in a Chinese Population: A Cross-Sectional Study and Meta-Anaylsis. (cdc.gov)

In contrast, other cells that fit the phenotypic profile for an ECFC but do not maintain the same level of activity are LPP-ECFCs. (wikipedia.org)
We plan in work package 1 a prospective clinical evaluation of three patient populations (suspected glioblastoma, glioma without contrast enhancement on MRI and progressive/recurrent glioma) prior to stereotactic biopsy or surgical resection. (uni-regensburg.de)

After 15-oxo-ETE treatment, Human umbilical vein endothelial cells (HUVECs) showed more attractive to monocytes, whereas monocyte adhesion is suppressed when treated with PKC inhibitor. (biomedcentral.com)
Dysfunctional endothelium leads to increased permeability to lipoproteins and up-regulation of leukocyte and endothelial adhesion molecules. (medscape.com)
Other trophic factors, such as IL-2, TNF-α, and granulocyte-macrophage stimulating factor, cause activated T cells to produce interferon-γ, TNF-α, and TNF-β, leading to stimulation of macrophages and further up-regulation of leukocyte adhesion molecules. (medscape.com)

In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. (nii.ac.jp)

Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
American Journal Of Respiratory Cell And Molecular Biology 2023, 68: 75-89. (yalemedicine.org)

Vascular endothelial cell (EC)-derived factors play an important role in endothelial-cardiomyocyte crosstalk and could save cardiomyocytes (CMs) from injury. (mdpi.com)

In order of decreasing incidence, squamous cell carcinoma (SCC), basal cell carcinoma (BCC), basosquamous cell carcinoma, and melanoma account for 90% of primary malignant tumors of the hand. (medscape.com)
Other malignant skin lesions include dermatofibrosarcoma protuberans, Kaposi sarcoma, sweat gland tumors, and Merkel cell carcinoma. (medscape.com)
The absence of inflammatory cells clearly excluded the possibility of abscess (option A). The skin adnexal tumors with clear cells which constituted the differential diagnosis include sebaceous carcinoma and clear cell hidradenomas. (cytojournal.com)
TSPO is overexpressed in primary brain tumors and has been shown to correlate with the malignancy of the tumor cells. (uni-regensburg.de)
We also demonstrated positive immunoreaction in both malignant tumors ES2 and SS1K endothelial and parenchymal cells. (unlp.edu.ar)

During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
Our results demonstrated that these immature cells have a natural capacity to differentiate into endothelial cells in infarcted hearts. (elifesciences.org)
The key to these cells' utility is their ability to differentiate into many different cell types depending on the stimulus received and they have been used in treatments for diseases such as cancer and neural degeneration, in rehabilitation of tetraplegic and paraplegic patients and even in dentistry 1 . (bvsalud.org)

These macrophages, in addition to smooth muscle cells, activate T cells by presenting antigens, including oxidized LDL. (medscape.com)

The MICA gene is located in the MHC class I region and is expressed by monocytes, keratinocytes, and endothelial cells. (nih.gov)

Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
Medullary epithelial cells (mTEC), in conjunction with dendritic cells, then take over control of developing thymocytes. (frontiersin.org)
In the with underlying diseases of various origins the lungs to translocate to epithelial cells study by Lehnert et al. (cdc.gov)

Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)

In addition, the number and the migratory activity of these cells are inversely correlated with risk factors such as hypertension, hypercholesterolemia, diabetes, and metabolic syndrome. (intechopen.com)

We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
We have ordered Brain derived Endothelial Cells or BECs. (neuromics.com)

These well-regulated processes to transfer information between cells occur through direct cell-cell contact, various soluble bioactive factors and through cellular microparticles [ 6 , 7 ]. (ersjournals.com)

Thereafter, a distinct subpopulation of endothelial cells lining the cardinal vein starts differentiating by expressing the TF PROX1, the master regulator of lymphatic endothelial cell (LEC) identity, via the TFs SOX18 and COUPTFII. (nature.com)

NK cell tolerance occurs naturally in utero where human leukocyte antigen (HLA)-E and HLA-G are present. (iupui.edu)

Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells. (nii.ac.jp)
Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice with rapidly rising prevalence and incidence predominantly due to advancing age in Western populations. (bham.ac.uk)

RA patients have a higher incidence of cardiovascular diseases compared to the general population. (hindawi.com)

The manipulation of endothelial cells to secrete protective factors could enhance cardioprotection. (mdpi.com)

Transfected cells were stained with HLA-E and/or HLA-G antibody. (iupui.edu)
reported a significant and sustained regression of neuroblastoma with the use of low dose of vinblastine and an antibody against the vascular endothelial grown factor receptor (VEGFR). (scirp.org)

A study combining tumor cells from breast cancer patients with a laboratory model of blood vessel lining provides the most compelling evidence so far. (medindia.net)

Stem Cells, Dentistry, Regeneration. (bvsalud.org)
Stem cells are nonspecific cells with powerful self-regeneration properties and they are capable of organizing other cell types in the body. (bvsalud.org)

These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)

Stromal cells are a mixed population that can create bone, cartilage and fat and also fibrous and connective tissues. (bvsalud.org)

Our hypothesis was that maybe it's a somatic genetic disease" or due to a mutation in the genes of a single cell. (medscape.com)

d) smears showing cells forming acini with nuclei showing fine chromatin, small nucleoli, clear cytoplasm and occasional atypical mitotic figure (arrow) (May-Grunwald-Giemsa, ×40). (cytojournal.com)
The cells showed mild pleomorphism, abundant pale cytoplasm with vacuolation and nuclei having coarse chromatin, and a few with prominent nuclei. (cytojournal.com)

Anatomy54

Organisms10

Diseases10

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes45

Disciplines and Occupations2

Information Science3

Dysfunction11

VEGF4

Inflammation4

Progenitor9

Mean endothelial cell2

Proliferation9

Precursor cells3

Blood vessels8

Angiogenesis3

Methods2

Pluripotent stem1

Corneal9

Colony formi3

Tissue6

Markers5

Vitro3

Peripheral5

Atherosclerosis2

Assay5

Apoptosis4

Heterogeneity1

Stem cell3

Characterization1

Embryonic5

Differentiation3

Adherent3

Phenotype5

Mesenchymal2

Adult1

Marker4

Retinal2

Coronary4

Contrast2

Adhesion3

Induces1

Biology2

Cardiomyocytes1

Tumors5

Differentiate3

Antigens1

Monocytes1

Epithelial Cells3

Coagulation1

Hypertension1

BECs2

Bioactive1

Subpopulation1

Leukocyte1

Atrial2

Incidence1

Secrete1

Antibody2

Tumor cells1

Regeneration2

Distinct1

Stromal1

Disease1

Nuclei2