Poorly water soluble drug. Medical search. Frequent questions

The combinatorial chemistry and high throughput screening increases the solubility of poorly water soluble compounds. (scialert.net)
4. Kwon G.S. Polymeric micelles for delivery of poorly water-soluble compounds // Crit. (medline.ru)
The situation remains challenging: About 60% of compounds in development are poorly soluble. (pharmtech.com)
Amorphous pharmaceutical formulations are an increasingly common strategy for dissolution and bioavailability enhancement of poorly soluble drug compounds. (aiche.org)
The finished product specifications include tests for description, identification of the APIs (HPLC and TLC), water content, average mass, uniformity of dosage units (by content uniformity), dissolution, related compounds (HPLC), assay (HPLC), microbiological examination and XRPD (for detection of API crystalline forms). (who.int)
The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants, antihistamines, quinidine, amantadine, antipsychotics (e.g. butyrophenones, phenothiazines), disopyramide and other anticholinergics (e.g. tiotropium, ipratropium, atropine-like compounds) may be intensified by Buscopan. (janusinfo.se)
Arsenic and arsenic compounds as a contaminant of drinking-water adult offspring in C3H/HeNCr mice together with various metals, spe- (IARC, 2004 ). (who.int)
In addition, in a study of CD1 beryllium compounds, cadmium senic is now drinking-water, where mice with "whole-life" exposure to and cadmium compounds, chromi- it is found primarily as the inorgan- multiple levels of sodium arsenite in um(VI) compounds, and nickel and ic forms of arsenite and arsenate. (who.int)

Lipid-based drug delivery systems are one of the emerging technologies designed to address challenges such as the solubility and bioavailability of poorly water-soluble drugs. (mdpi.com)
Amorphous ternary solid dispersion has become one of the strategies commonly used for improving the solubility and bioavailability of poorly water soluble drugs. (intechopen.com)

Other than the dissolution enhancement of poorly water-soluble drug, BAY 12-9566, on formation of dispersion granules, drug dissolution was further enhanced upon storage at 40°C/75% RH. (uconn.edu)
Cyclodextrins (CDs) are natural pharmaceutical ingredients for the solubility-enhancement of poorly soluble drugs for over half century. (hindawi.com)

Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. (pharmatext.co.in)
Myriad drug delivery systems (DDS) have emerged to boost the absorption of certain drugs via amending their release profile and therefore enhancing the biodistribution of these drugs throughout the body and minimizing the adverse effects arising following administration [6,7]. (pharmaexcipients.com)
Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. (scialert.net)
For the BCS class II drugs, the oral absorption is limited by the solubility or dissolution in gastrointestinal (GI) tract. (scialert.net)
Studies have shown that twice-daily dosing with this drug has negligible systemic absorption and adverse effects. (aao.org)
This novel structure demonstrates excellent performance in targeting delivery of the drug and improving the dissolution and absorption of poorly water-soluble drugs," says Yu. (materialstoday.com)
Two factors govern the total oral absorption of drug i.e. drug's solubility and permeability across intestine. (omicsonline.org)
For usual absorption of drug it is soluble then it will reach intestinal wall in dissolved state and later absorbed in gut membranes combining all above transport mechanisms. (omicsonline.org)
Nanoscale drug carriers can improve the solubility and absorption of poorly water-soluble drugs, increasing their bioavailability and reducing the required dosage. (popherald.com)
Overview of Pharmacokinetics Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body-the time course of its absorption, bioavailability, distribution. (msdmanuals.com)
If the drug does not dissolve readily or cannot penetrate the epithelial membrane (eg, if it is highly ionized and polar), time at the absorption site may be insufficient. (msdmanuals.com)
Etonogestrel (ENG), ethinyl estradiol (EE), and islatravir (ISL) were loaded into the silicone poly(urethane) IVR in a controlled single step drug loading process driven by absorption. (cdc.gov)

These suggested that mPEG-PLA polymeric micelle nanoparticles had great potential as nanocarriers for effective solubilization of poorly soluble ethaselen and further reducing side effects and toxicities of the drug. (springer.com)
Exploring the systemic delivery of a poorly water-soluble model drug to the retina using PLGA nanoparticles. (mpg.de)
Strategies have been advised that nanoparticles can be used to deliver drug/gene to targeted tissues [ 4 ]. (hindawi.com)
While core-shell nanoparticles have been widely reported for drug delivery, similar fibers have received much less attention. (materialstoday.com)
Nanoparticles can be engineered to selectively deliver drugs to specific cells or tissues, improving therapeutic efficacy while minimizing side effects. (popherald.com)
Nanotechnology enables the encapsulation of drugs within nanoparticles, protecting them from degradation and improving their shelf life. (popherald.com)
Nanoparticles can be designed to release drugs in response to specific stimuli, such as pH, temperature, or enzyme activity, allowing for controlled drug release at the target site. (popherald.com)

There is renewed interest in using solid dispersions to enhance the dissolution rate of poorly water-soluble drugs. (uconn.edu)
Numerous drug formulation strategies were embraced for SOL to yield highly bioavailable products, such as solid dispersions (SDs), nanosuspensions, nanomicelles, and nanoemulsions. (pharmaexcipients.com)
Various outstanding reviews have been issued about the technologies in the dissolution enhancement of drugs using certain DDSs, such as micelles, solid dispersions (SD), nanosuspensions, and nanoemulsions. (pharmaexcipients.com)

The aim of this study was to develop pellet formulations that could be used to improve the dissolution and bioavailability of a poorly water-soluble model drug, cisapride. (ewha.ac.kr)
Likewise, the resulting formulations are supposed to improve drugs' physical stability and solubility in biological fluids. (pharmaexcipients.com)
This review recapitulates the most recent literature showing the diversity of the current application of SOL in the different pharmaceutical formulations, highlighting the prospective, current drug delivery systems, and applied preparation strategies. (pharmaexcipients.com)
Nevertheless, several SOL-based formulations are promising for boosting drug solubility and have been developed based on the SD technique [13]. (pharmaexcipients.com)
Cyclodextrins are widely used for the solubilisation of poorly soluble drugs in the formulations. (hindawi.com)
Therefore, drug release profiles are exhibited by such formulations for poorly soluble drugs to improve the solubility of such poorly soluble drugs. (scialert.net)
Water is the solvent of choice for liquid pharmaceutical formulations. (scialert.net)
This article reviews various methods used for improving the solubility of hydrophobic drugs and improve the drug release profiles which are exhibited by such formulations for poorly soluble drugs. (scialert.net)
This made it possible to overcome several challenges for drug formulations (e.g., solubility and bioavailability weakness, physical instability under stress conditions, complexation efficiency of cyclodextrin molecules). (intechopen.com)
Prepared formulations were also evaluated for % drug permeation using non-everted rat intestinal sac method which showed that Pluronic was not involved in permeability enhancement of Cefixime. (omicsonline.org)
thus, knowing whether drug formulations are equivalent is essential. (msdmanuals.com)

Most of drugs which are weakly acidic and basic show poor aqueous solubility hence various methods like, salt formation, co-solvency, micronization, addition of agent, solid dispersion, complexation etc., are some of the vital approaches routinely employed to enhance the solubility of poorly soluble drugs. (scialert.net)
In accordance with mixed solvency concept, various solid solubilizers in small quantities were dissolved in propylene glycol to enhance the solubility of drug. (scholarsresearchlibrary.com)

The topical application of drug-loaded particles has been explored extensively aiming at a dermal, follicular or transdermal drug delivery. (researchgate.net)
However, the microsized particles could only stay in blood circulation and penetrate poorly into tumor tissues, so that the wide application of the particles for in vivo tumor therapy is limited [ 3 ]. (hindawi.com)
This document signifies increasing attention to evaluating and mitigating risks of emerging hazards in the workplace before adverse health effects occur in workers and could proactively be used for how other poorly soluble, low toxicity (PSLT) particles are controlled in the workplace. (cdc.gov)

Therefore, active principals classified by the Biopharmaceutics Classification System (BCS) as class-II and class-IV drugs suffer from inadequate bioavailability because they lack appropriate water solubility. (pharmaexcipients.com)
Laboratoria Smeets has developed, in collaboration with Ghent University, a technique to produce water-soluble granules containing poorly water soluble drugs of Class II (poorly soluble, highly permeable) or Class IV (poorly soluble, poorly permeable) of the Bio Classification System (BCS). (pharmaceutical-technology.com)

A significant percentage of drugs are poorly water-soluble which affects its pharmacological properties for instance bioavailability, stability and dose dependent toxicity. (umass.edu)
Delivery vehicles, specifically nanocarriers improve the physiochemical properties of conventional drugs like water solubility, biodistribution, reduce dose dependent toxicity, bioavailability and help in targeting. (umass.edu)
Metal toxicity may complicate some forms of drug abuse. (medscape.com)
More recently, a parkinsonian syndrome among Latvian injection drug users of methcathinone was linked to manganese toxicity. (medscape.com)

The major challenge in the oral drug delivery of poorly permeable drug is their transport across intestine [ 1 , 2 ]. (omicsonline.org)

In most cases, oral drug delivery is most preferred as it is convenient, non-invasive, and easy to incorporate into a patient's lifestyle. (mdpi.com)
Poor oral bioavailability of BCS class 4 drug is due to poor aqueous solubility and poor permeability across intestine. (omicsonline.org)
Present work was undertaken to increase oral bioavailability of BCS class 4 drug i.e. (omicsonline.org)
For oral delivery of drugs, the intestinal environment is key, and consequently, a thorough structural understanding of what happens at this material-biology interface is required to understand in vivo performance and tailor improved delivery vehicles. (bvsalud.org)
Low bioavailability is most common with oral dosage forms of poorly water-soluble, slowly absorbed drugs. (msdmanuals.com)

This proof-of-concept study explores the feasibility of using a drug-loaded hydrophilic polymeric layer sandwiched between two hydrophobic layers for improving film drug load while achieving sustained release of poorly water-soluble drug. (njit.edu)
We were also interested to tackle the issue of poor drug loading capacity of nanocarriers and designed a core crosslinked polymer and designed methods to quantify drug loading in crosslinked polymeric systems where we were also curious in studying the structure property relationship of different drugs with varying LogP values. (umass.edu)
Polymeric PEG-b-PLA nanopartic les (NPs) were developed for delivery of poorly water-soluble drugs via blood brain barrier into brain parenchyma. (nel.edu)
Stabilization against crystallization during storage as well as during dosing is usually achieved by dispersing amorphous drug in a polymeric matrix and has been well studied. (aiche.org)

However, below CMC, SOL is used for drug precipitation inhibition via restraining the drug nucleation and crystal growth and providing steric stabilization in a supersaturated state [10]. (pharmaexcipients.com)

Soluplus® (SOL), a unique water-soluble graft copolymer introduced by BASF Corporation, is constructed from hydrophilic and lipophilic portions. (pharmaexcipients.com)
Among all newly discovered chemical entities about 40% drugs are lipophilic and these drugs are rejected by the pharmaceutical industry and will never benefit a patient because of its poor bioavailability due to low water solubility and/or cell membrane permeability. (scialert.net)

These traits can assist SOL in ameliorating the dissolution behavior and bioavailability of drugs loaded in self-nanoemulsifying drug delivery systems (SNEDDSs). (pharmaexcipients.com)

As an example, the team produced a pH-sensitive polymer fiber with a lipid core loaded with the anti-inflammatory drug diclofenac. (materialstoday.com)
To the best of our knowledge, this is the first time that a 'hard' polymer and 'soft' lipid-drug core/shell fiber nanocomposite has been investigated," says Deng-Guang Yu from Shanghai. (materialstoday.com)

Hot melt extrusion technology was considered an effective way of manufacturing tablets for poorly soluble APIs and hence it was selected by the manufacturer to obtain the APIs in the solid dispersible form. (who.int)

Nanocarriers for drug delivery into and through the skin - Do existing technologies match clinical challenges? (researchgate.net)
Label-free detection of core-multishell (CMS) nanocarriers and the anti-inflammatory drug dexamethasone is reported. (researchgate.net)
Furthermore, the drug loading efficiency into CMS nanocarriers is determined by X-ray spectroscopy. (researchgate.net)
With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. (hindawi.com)
As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. (hindawi.com)
Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. (hindawi.com)
In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers. (hindawi.com)
Ultrasonic drug and gene delivery from nanocarriers have tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly noninvasive means [ 7 ]. (hindawi.com)
Furthermore, as targeted delivery carriers, gene/drug-loaded nanocarriers can release their associated payload upon insonation. (hindawi.com)
Besides, nanocarriers decorated with targeting moiety can adhere to targeted tissues, which can promote intracellular uptake of drug delivery vehicles. (hindawi.com)
Although the system of ultrasound-mediated drug delivery with nanocarriers has many advantages, there are still many challenges. (hindawi.com)

Ethaselen was efficiently encapsulated into the micelles by the dialysis method, and the solubility of ethaselen in water was remarkably increased up to 82 μg/mL before freeze-drying. (springer.com)
In previous work, our group has prepared micellar ethaselen formulation employing PLA-based copolymers and characterized its drug loading contents and stability (data not shown), which have demonstrated the compatibility between the core of micelles and the ethaselen molecules. (springer.com)
Drug loading of polymer micelles can have a profound effect on their particle size and morphology as well as their physicochemical properties. (bvsalud.org)

Electrospun nanofibers can be obtained through different methods asides from the conventionalone, such as coaxial, multi-jet, side by side, emulsion, and melt electrospinning.In general, the application of an electric potential to a polymer solution causes a charged liquid jet that moves downfield to an oppositely charged collector, where the nanofibers are deposited.Plenty of polymersthat differ intheir origin, degradationcharacterand water affinityare used during the process. (una.ac.cr)
Therefore, this review summarizes the recent progress in electrospun nanofibers for their use as a nanotechnological tool for dissolution optimizationand drug deliverysystems forpoorly water-soluble drugs. (una.ac.cr)
Schematic of the modified tri-axial electrospinning process and its use for preparing core-shell drug-loaded nanofibers. (materialstoday.com)

Such films having total thickness in range ~ 146-250 μm were prepared by slurry-based casting using hydrophilic hydroxypropyl methylcellulose (HPMC) as matrix layer containing fenofibrate (FNB) as the model drug, encased between two very thin rate-limiting layers of 10 μm each of hydrophobic poly-ɛ-caprolactone (PCL). (njit.edu)
Ibuprofen, Probucol, Gliclazid, Fenofibrate, Ibrutinib and Naproxen) and this was correlated to the synergy of multiple factors (hydrophilicity enhancement, particle size reduction, drug-carrier interactions, anti-plasticizing effect and complexation efficiency). (intechopen.com)

From the search of Web of Science, there are over 700 research papers about theoretical calculations on cyclodextrins complexation with various drugs until 2014. (hindawi.com)
For example, cyclodextrins increase water solubility of poorly soluble drugs to improve bioavailability, taste mask bitter actives for use in chewable and orally disintegrating tablet applications, and stabilize drug actives to inhibit light and oxidative degradation. (ashland.com)

Unfortunately, ethaselen is poorly soluble in water (2.57 μg/mL) and in commonly used organic solvents such as methanol, ethanol, ether and chloroform. (springer.com)
The API produced is soluble in organic solvents like methanol, ethanol, dichloromethane and DMF, but practically insoluble in water and in aqueous buffers across the physiological pH range, and is hygroscopic. (who.int)

This involves research spanning basic research of drug delivery systems, and their optimal use in patients. (otago.ac.nz)
Polyvinylpyrrolidone (PVP) has proven to be a highly versatile material, as evidenced by its long history as multifunctional biomaterial with a wide range of high-performance applications (e.g., tissue engineering, drug delivery systems, and ophthalmologic applications). (intechopen.com)
The core/shell fibers have ideal characteristics for advanced drug delivery systems, believe the researchers. (materialstoday.com)
In relation to the idea to use magnetic nanopartic les in development of new delivery systems suitable for targeted drug administration, the toxicological profile of five types of magnetic fluids was assessed in mice. (nel.edu)
The production and scale-up of nanoscale drug delivery systems pose challenges, including regulatory requirements, quality control, and cost-effectiveness. (popherald.com)

It was possible to convert the drugs to their amorphous states, which showed good physical stability on storage. (uconn.edu)
The most challenging task in development of a formulation is the solubility of drug, availability at the site of action and stability of drug. (scialert.net)
Protein drug physical stability and analytical methods to study interactions between protein drugs and formulation excipients. (otago.ac.nz)
PVP was frequently used in medical and pharmaceutical field due to its several interesting properties (higher glass transition temperature, water solubility, biocompatibility, biodegradability, chemical stability, very good adhesive, and emulsifying agent). (intechopen.com)
We have shown that PVP enhanced physical stability of amorphous indomethacin under stress conditions (at RH: 75% and T = 40°C for three months), leading to the improvement of drug aqueous solubility by suppressing kaolin adsorption effect. (intechopen.com)

A drug that is weakly water soluble is dissolved in a non-volatile solvent and then absorbed into the carrier material's internal structure. (scholarsresearchlibrary.com)

ENG/EE/ISL IVR promoted sustained release of drugs for 150 days in vitro and 14 days in sheep. (cdc.gov)

Overall, these results suggest that the dual layered pellets have potential as a sustained release dosage form for poorly water-soluble drugs. (ewha.ac.kr)
Bioavailability of a drug is largely determined by the properties of the dosage form, which depend partly on its design and manufacture. (msdmanuals.com)

Physicochemical propertiesof the drug, polymer(s),and solvent systems need to be addressed to guarantee successful manufacturing. (una.ac.cr)
Recently, polymer-based DDSs have been designed to rapidly release drugs to improve their limited bioavailability. (pharmaexcipients.com)
This amphiphilic polymer can be used above the critical micelle concentration (CMC) to dissolve certain drugs via micelle formation. (pharmaexcipients.com)
Using a pH sensitive polymer as the fiber shell prevents drug release in the low-pH conditions of the stomach. (materialstoday.com)
Comparative study was carried out using Pluronic as solid dispersion and beta cyclodextrin as inclusion complexation in different drug to polymer ratios through physical mix, kneading, solvent evaporation and spray drying technique. (omicsonline.org)
However, during dissolution it is possible to generate drug-rich amorphous interfaces that are not intimately mixed with polymer. (aiche.org)
The work presented herein utilizes experimental and modeling tools to characterize and model solid-state crystallization at the amorphous-water interface as well as the impact on crystallization from polymer and surfactant species in solution. (aiche.org)
The loading-dependent behavior found in this study deviates from previous work on a different drug substance highlighting the need for further studies including different drug molecules and polymer types to improve the understanding of events on the molecular level. (bvsalud.org)

On the other hand, dermal/transdermal drug delivery candidates have increased in recent years in response to the development of new and optimized approaches to improve local and systemic drug delivery. (mdpi.com)

The amounts of crystalline and amorphous drug in co-precipitates, as determined by MDSC, and HPLC quantification of the total amount of drug in co-precipitates were used to determine the amount of drug incorporated into solid solution. (ku.dk)
It was found that dissolution rate and extent was correlated to the amount of drug incorporated into amorphous solid solution for the 1:9 to 5:5 drug-HPMCP ratio co-precipitates. (ku.dk)
Amorphous drug alone and physical mixtures of drug and HPMCP showed very little and no significant improvement in dissolution rate or extent, respectively, above crystalline drug alone. (ku.dk)
Amorphous drug alone re-crystallized to a large extent within 1 min of contact with the dissolution medium, whereas 4:6 drug-HPMCP co-precipitate showed a lower degree of re-crystallization and 2:8 drug-HPMCP co-precipitate showed very little re-crystallization. (ku.dk)
It was concluded that the likely mechanisms of improved dissolution of low drug-HPMCP ratio co-precipitates were improved wetting or increased surface area for mass transfer, thermodynamically enhanced dissolution of a higher energy amorphous form and inhibition of re-crystallization, when drug was incorporated into solid solution. (ku.dk)
Conversion of the crystalline drug to the amorphous Neusilin-bound state appeared to increase dissolution, whereas, Ostwald ripening can be used to explain the decrease in drug dissolution upon storage. (uconn.edu)
In fact, PVP acted as a stabilizing agent for various amorphous drug molecules by minimizing their molecular mobility. (intechopen.com)
Solid-state crystallization at this amorphous drug-water interface is not well understood, nor is the role played by excipients in influencing this crystallization phenomenon. (aiche.org)

Soluble wild-type ACE2 molecules inhibit newer SARS-CoV-2 variants and are a potential antiviral strategy to mitigate disease severity in COVID-19. (otago.ac.nz)

This enhanced pharmacokinetic properties and bioavailability of these drug molecules (1.49 to 15-folds increase in plasma drug concentration). (intechopen.com)

Ternary solid-dispersion granules incorporating a drug, dispersion carrier, and surface adsorbent were prepared using hot-melt granulation. (uconn.edu)
Two competing mechanisms underlie the complex changes observed in drug dissolution upon storage of solid dispersion granules. (uconn.edu)

Intestinal wall is made up of tight-fitting single layer of epithelial cell where drug is transported by active transport or passive transport. (omicsonline.org)
They include formation of a complex (eg, between tetracycline and polyvalent metal ions), hydrolysis by gastric acid or digestive enzymes (eg, penicillin and chloramphenicol palmitate hydrolysis), conjugation in the intestinal wall (eg, sulfoconjugation of isoproterenol ), adsorption to other drugs (eg, digoxin to cholestyramine ), and metabolism by luminal microflora. (msdmanuals.com)

Overall, the application of middle layer thickness could be used as a tool to manipulate drug load without the need for altering its formulation or precursor preparation by changing its thickness, hence achieving relatively high drug loading yet having sustained release of drug. (njit.edu)

3D printers can fabricate intricate drug structures with precise geometries, allowing for the controlled release of drugs and improved therapeutic outcomes. (popherald.com)
Therapeutic equivalence indicates that drug products, when given to the same patient in the same dosage regimen, have the same therapeutic and adverse effects. (msdmanuals.com)
In contrast, for drugs with a relatively narrow therapeutic index, bioavailability differences may cause substantial therapeutic nonequivalence. (msdmanuals.com)
Research on therapeutic drug targets and vaccines for these viruses is limited because biosafety level 4 containment is required for handling them. (cdc.gov)

These strategies are widely pursued because of their favorable drug-loading characteristics, nature, and low excipients concentration. (pharmaexcipients.com)

The combinatorial screening programs employed by the pharmaceutical companies identified that about 40% of active New Chemical Entities (NCEs) are poorly water soluble. (scialert.net)
Large and small pharmaceutical companies as well as emerging companies that may operate as virtual companies strive to shorten drug-development times. (pharmtech.com)
The ability to hasten drug development is particularly important for virtual pharmaceutical companies, which focus on drug discovery and development but rely heavily on outsourced services to perform the functions necessary to move a drug through development to commercial manufacture. (pharmtech.com)
Outsourcing early formulation development and clinical trial material manufacturing is an important strategy for virtual pharmaceutical companies and for larger pharmaceutical companies that seek to reduce cost and time in early drug development. (pharmtech.com)
Our graduates are often highly sought after by the pharmaceutical industry for their expertise in drug discovery and development. (ubc.ca)
n today's world of pharmaceutical research, the majority of newly developed drugs discovered are extremely water insoluble. (scholarsresearchlibrary.com)

Drug efficacy can be severely limited by poor aqueous solubility and some drugs also show side effects due to their poor solubility. (scialert.net)

Numerous strategies have been harnessed to circumvent the difficulties linked to poorly water-soluble pharmaceuticals [5]. (pharmaexcipients.com)

Biologically active agents like drugs, proteins and nucleic acids have been widely explored as therapeutics for numerous diseases and particularly for anti-cancer therapy. (umass.edu)

The biodistribution of drug carriers is monitored by imaging, so that the optimal timing for the application of external stimuli can be achieved [ 2 ]. (hindawi.com)

A great proportion of the orally administered drug dose remains unabsorbed, which limits its clinical applicability [1]. (pharmaexcipients.com)

Bioavailability refers to the extent and rate at which the active moiety (drug or metabolite) enters systemic circulation, thereby accessing the site of action. (msdmanuals.com)
both are common sites of first-pass metabolism (metabolism that occurs before a drug reaches systemic circulation). (msdmanuals.com)

The unique structure enables CDs to accommodate poorly water-soluble drugs to form drug-inclusion complexes. (hindawi.com)

The liquisolid approach is a revolutionary and improved approach for improving the dissolution and solubility of pharmaceuticals and medications that are practically water insoluble. (scholarsresearchlibrary.com)

Drug release rate was investigated using USP IV flow-through cell and surface dissolution imaging system. (njit.edu)
Ultrasound is a noninvasive and visual theranostic modality that can be used to track drug carriers, trigger drug release, and improve local drug sediment with high spatial precision [ 5 , 6 ]. (hindawi.com)
The core-shell structure of the nanocomposite fiber leads to a two-step drug release process in the body. (materialstoday.com)
This technology was used to insert water-insoluble medicines into rapid-release solid dosage forms. (scholarsresearchlibrary.com)

In passive mechanism, diffusion of drug through close junctions of epithelial cells occurs depending on its size and charge while in active transport, uptake of drug is mediated by carrier i.e. active proteins [ 3 - 5 ]. (omicsonline.org)

The reason beyond this is that drugs with poor solubility in water have poor pharmacokinetic properties and limited availability to the target site [2]. (pharmaexcipients.com)
Since 1995, more than 90% of drugs are approved as hydrophobic having poor solubility. (scialert.net)

Co-precipitates with various drug-HPMCP ratios were prepared and characterised using modulated differential scanning calorimetry (MDSC), X-ray powder diffraction, HPLC and dissolution testing. (ku.dk)
Here you will discover that liquid medications, drug solutions, drug suspension and emulsion are converted into powder, which is free-flowing [ 1 ]. (scholarsresearchlibrary.com)

For example, barium sulfate is basically nontoxic, whereas other more water-soluble barium salts are rapidly absorbed and cause profound, potentially fatal hypokalemia. (medscape.com)

Strickley, 2004 ) have been shown to improve drug solubility. (scialert.net)
We have utilized this system as the blueprint and developed it to improve and address some crucial properties of drug delivery vehicles. (umass.edu)
To improve the solubility of the drug, separate blends were created in each solvent system by dissolving various solid solubilisers (mixed solvency concept). (scholarsresearchlibrary.com)

Hernan Cuevas Brun, MBA, says biologic drugs are increasingly being investigated for delivery with inhalation therapy, which has initiated more in-depth discussions about the implications of formulation development and their pairing with adequate inhaled devices for more efficient treatment outcomes. (drug-dev.com)
Several options for dosage forms may be used in early-stage formulation development, including API in a capsule, drug in a bottle, liquid in capsule, and binary blends. (pharmtech.com)

The delivery of drugs must overcome various obstacles, including the acidic gastric environment and the presence of intestinal efflux and influx transporters. (mdpi.com)

Anatomy1

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes5

Disciplines and Occupations4

Technology, Industry, Agriculture4

Health Care3

Compounds8

Bioavailability of Poorly Water-Soluble Drugs2

Enhancement of poorly2

Absorption12

Nanoparticles7

Solid dispersions3

Formulations11

Enhance the solubility2

Particles3

Classification System2

Toxicity4

Permeable1

Oral5

Polymeric4

Stabilization1

Lipophilic2

Ameliorating the dissolution1

Lipid2

APIs1

Nanocarriers11

Micelles3

Nanofibers3

Fenofibrate2

Cyclodextrins2

Organic solvents2

Delivery systems5

Stability5

Weakly1

Vitro1

Dosage form2

Polymer8

Transdermal drug del1

Amorphous8

ACE21

Molecules1

Granules2

Intestinal wall2

Preparation1

Therapeutic4

Characteristics1

Pharmaceutical6

Aqueous solubility1

Difficulties1

Numerous1

Biodistribution1

Orally1

Systemic2

Accommodate1

Pharmaceuticals1

Release4

Uptake of drug1

Poor solubility2

Powder2

Rapidly1

Improve3

Formulation development2

Obstacles1