Equine Polysaccharide Storage Myopathy (PSSM) is a dominant autosomal hereditary condition that can cause a genetic form of tying-up with muscle damage and inability to move. (equigerminal.shop)
Draft horses are especially prone to equine polysaccharide storage myopathy (EPSM or PSSM), which results in muscle stiffness and pain. (lucernefarms.com)
Repeated tying up occurs in horses with two specific disorders characterized by cellular dysfunctions in the muscles: polysaccharide storage myopathy (PSSM) and recurrent exertional rhabdomyolysis (RER). (equisearch.com)
The panel tests for Hyperkalemic Periodic Paralysis (HYPP), Polysaccharide Storage Myopathy type 1 (PSSM 1), Malignant Hyperthermia (MH), Hereditary Epidermal Regional Dermal Asthenia (HERDA), and Glycogen Branching Enzyme Deficiency (GBED). (springhillequine.com)
Occasionally myopathy can be caused by a metabolic problem in muscle such as Polysaccharide Storage Myopathy (PSSM). (equine-vets.com)
Research has identified two specific causes of tying up: 1) Recurrent Exertional Rhabdomyolysis (RER) and 2) Polysaccharide Storage Myopathy (PSSM). (premierperformance.uk)
RER is a condition where there is a deficit in the mechanism of muscle contraction and PSSM is a disorder that results in excess storage of glycogen (a simple carbohydrate) and an abnormal form of polysaccharide (a complex carbohydrate) in muscle. (premierperformance.uk)
Horses suffering from insulin resistance due to obesity, metabolic syndrome, or equine Cushing's disease, as well as from insulin sensitivity due to polysaccharide storage myopathy (PSSM), need to be fed grass hay, free-choice, that has an acceptable NSC level of less than 12% (and ideally, below 10%) on an as-sampled basis. (haygainaustralia.com)
Teff Grass Forage Pellets for horses are a nutritional solution for horses challenged with sugar/starch sensitivities such as those diagnosed with: Equine Metabolic Syndrome (EMS), Insulin Resistance (IR), Cushing's Disease, Polysaccharide Storage Myopathy (PSSM) and Laminitis. (standleeforage.com)
NYCLASS and NY Veterinarians exposed Aysha's autopsy results that reveal her preventable death was caused by severe industry-wide neglect and an underlying, undiagnosed and untreated disease, Polysaccharide Storage Myopathy (PSSM) that is easily treated through dietary changes. (nyclass.org)
Rhabdomyolysis2
Causes of non-exercise-associated rhabdomyolysis include infectious (eg, Clostridium sp, influenza, Streptococcus equi , and Sarcocystis ) and immune-mediated myopathies, nutritional myodegeneration (vitamin E or selenium deficiency), and traumatic or compressive myopathy. (msdvetmanual.com)
C. T. Estill and Valentine, B. A. , " Severe rhabdomyolysis due to polysaccharide storage myopathy in an Arabian mare " , Equine Veterinary Education , vol. 19, no. 3, pp. 139 - 142, 2007. (oregonstate.edu)
Myosin heavy-chain my1
Quarter Horses), myosin heavy chain myopathy, and polysaccharide storage myopathy. (msdvetmanual.com)
PSSM13
DNA test for the Polysaccharide Storage Myopathy Type 1 (PSSM1). (equigerminal.shop)
PSSM1 Polysaccharide Storage Myopathy - Test results: n/n Normal horse, n/P1 Affected horse, P1/P1 Affected horse. (onlinestudbook.com)
Absence of myofibrillar myopathy in Quarter Horses with a histopathological diagnosis of type 2 polysaccharide storage myopathy and lack of association with commercial genetic tests. (cdc.gov)
What is Myofibrillar Myopathy (MFM)? (equiseq.com)
Myofibrillar Myopathy (MFM) is a subtype of PSSM2 that has a specific kind of defect in muscle revealed by a recently developed staining technique. (equiseq.com)
Abnormal3
The GSY1 mutation is associated with altered glucose metabolism (but normal glycogen metabolism), as well as accumulation of high levels of glycogen and abnormal polysaccharide in the muscles of the horse. (wikipedia.org)
In addition, abnormal expressions of Ca2+ channels led to substantial Ca2+ loss in SR and cytoplasmic Ca2+ overload, as well as Ca2+ accumulation in mitochondria, resulting in Ca2+ dyshomeostasis in PM muscle of broiler chickens with WB myopathy. (bvsalud.org)
In 1956, Andersen reported the first patient with progressive hepatosplenomegaly and accumulation of abnormal polysaccharides. (medscape.com)
Horses4
There are currently 2 subcategories of glycogen storage diseases in horses: Type 1 polysaccharide storage myopathy, glycogen branching enzyme deficiency, and Type 2 polysaccharide storage myopathy. (wikipedia.org)
Additionally, some horses have been shown to have insulin sensitivity, which improves glucose uptake by muscle cells and contributes to excessive glycogen storage that is already elevated secondary to the GSY1 mutation. (wikipedia.org)
Type 1 polysaccharide storage myopathy caused by genetic mutation in the glycogen synthase 1 gene is present in many breeds including the Noriker and Haflinger horses. (nih.gov)
Muscle Disorders in Horses Myopathies are diseases that primarily cause damage to muscles. (msdvetmanual.com)
Antigen1
The first test, serum galactomannan (GM), is a polysaccharide antigen present specifically in the cell walls of Aspergillus fungi. (labmedica.com)
Disorders3
In humans, EMG has already been used to document changes in the muscle activity patterns of patients affected by human glycogen storage disorders. (nih.gov)
The section about clinical features of neuromuscular disorders includes a brief discussion of the typical clinical presentation of myopathies and presents some information on the classic clinical presentations of a few different categories of myopathies, with some information about how these disorders are diagnosed. (medscape.com)
Glycogen storage disease (GSD) type I, also known as von Gierke disease, is a group of inherited autosomal recessive metabolic disorders of the glucose-6- phosphatase system which helps maintain glucose homeostasis. (medscape.com)
Autosomal1
It is an autosomal recessive disorder in which there is an AGL gene mutations which causes deficiency in glycogen debranchinging enzyme and limited storage of dextrin. (medscape.com)
Type1
The objective of the present study was to characterize possible variations in the quality of wooden chicken breast meat during freezing for 12 mo, in order to prove whether the shelf life recommended by the industry allows the storage of that type of meat without compromising its consumption. (bvsalud.org)
Genetic1
EPSM is a genetic disorder that prevents the storage of glycogens-starches and sugars (carbohydrates). (lucernefarms.com)
Combined, these findings indicate that WB myopathy is related to mitochondrial dysfunction, mitochondrial redox status imbalance and Ca2+ dyshomeostasis, leading to WB-affected PM muscle damage. (bvsalud.org)
Muscle damage2
Histological examination found that the occurrence of WB myopathy was accompanied by the pectoralis major (PM) muscle damage. (bvsalud.org)
Ultrastructural examination and histopathological changes suggested the occurrence of PM muscle damage in broiler chickens with WB myopathy. (bvsalud.org)
Horse1
Here is the order form for the Myopathy Panel in the United States for horse owners in the United States. (equiseq.com)
Cats2
All the cats were diagnosed with hypokalaemic myopathy caused by a range of pathologies. (bvsalud.org)
The PHT resolved along with other signs related to myopathy, such as cervical flexion and generalised weakness, after electrolyte correction in all cats. (bvsalud.org)
Form1
How can I get an Order Form for the Myopathy Panel? (equiseq.com)
Present1
RELEVANCE AND NOVEL INFORMATION: Hypokalaemic myopathy was the likely cause of PHT in the present feline cases. (bvsalud.org)
Patient1
With some exceptions, it is an essential element in the assessment of a patient with suspected myopathy. (medscape.com)