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  • gene expression
  • MiRNAs including miR-210, miR-373, and miR-21 associate with hypoxia-regulated transcripts and further modulate the levels of the encoded proteins to implement the hypoxic gene expression profile. (frontiersin.org)
  • specific
  • In response to hypoxic challenge, mammalian cells mount a well-orchestrated response that includes specific changes in the collective of expressed proteins. (frontiersin.org)
  • Isoform
  • More importantly, we identified a third protein isoform, Ly108-H1, which is absent in two lupus-prone congenic animals. (rupress.org)
  • In addition to Ly108-1 and Ly108-2, we identify a novel protein isoform, Ly108-H1, which is present only in Slamf -haplotype 1 mice and not in the lupus-prone Sle1b or B6.129chr1b strains. (rupress.org)
  • cellular
  • Although a number of cellular proteins have been shown to be involved in picornavirus RNA translation, the precise role of these factors in picornavirus internal ribosome entry is not understood. (semanticscholar.org)
  • initiation
  • Mapping of secondary structure of the spacer region within the 5′-untranslated region of the coxsackievirus B3 RNA: possible role of an apical GAGA loop in binding La protein and influencing internal initiation of translation. (microbiologyresearch.org)
  • novel
  • The expert contributors explore the isolation and characterization of RNA-protein complexes, the analysis and measurement of RNA-protein interaction, and related novel techniques and strategies. (springer.com)
  • interaction
  • RNA-Protein Interaction Protocols, Second Edition updates, complements, and expands upon the popular first edition by providing a collection of cutting-edge techniques developed or refined in the past few years along with tried-and-true methods. (springer.com)
  • Cooperates
  • in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. (abcam.com)
  • complex
  • Correction: PRAME Is a Golgi-Targeted Protein That Associates with the Elongin BC Complex and Is Upregulated by Interferon-Gamma and Bacterial PAMPs. (nih.gov)
  • splice
  • However, no effect could be detected in either the total CYP3A5 RNA, the proportion of splice variant RNA, or the protein level. (aspetjournals.org)
  • function
  • Collectively, our results indicate that a single PTB binding site can function as an inhibitor that regulates alternative splicing both in vitro and in vivo. (umassmed.edu)
  • regulators
  • Accumulating evidence suggests alternative splicing (AS) is a co-transcriptional splicing process not only controlled by RNA-binding splicing factors, but also mediated by epigenetic regulators, such as chromatin structure, nucleosome density, and histone modification. (springer.com)
  • cell
  • RNA splicing factor implicated in ovarian tumor cell growth ( An RNA-binding protein that is overprod. (bio-medicine.org)
  • Due to the vital biological importance of RNA and proteins functioning together within a cell, a protocol volume describing experimental procedures to study their interactions should find a home in many laboratories. (springer.com)
  • several
  • These abnormally spliced messengers contain several in-frame premature termination codons (PTC), explaining the low protein level. (aspetjournals.org)
  • present
  • An RNA-binding protein that is overproduced in ovarian cancer may present a new target for diagnosis or treatment of ovarian and other cancers, according to researchers at the University of Illinois at Chicago. (bio-medicine.org)