Aneuploidies were detected in 7.3% and partial chromosome abnormalities in 0.45% (n = 13), including 5 referred for maternal age, abnormal maternal serum screen, or isolated ultrasound markers. (nih.gov)
examples include aneuploidy (atypical chromosome number), deletion (loss of part of a chromosome), duplications (extra copies of a region of a chromosome), inversion (when part of a chromosome breaks off and reattaches in reverse. (schleiden-eifel.de)
Chromosome numbers vary from 2n=2x=14 in Salvia nemorosa to 2n=6x=102 in Stachys palustris L. Diversification in the Family may be attributed to the presence of polyploidy and aneuploidy. (rroij.com)
Using high-throughput sequencing technology, it can find a variety of chromosomal abnormalities such as chromosome polyploidy, aneuploidy, microdeletion/microduplication, etc. (yikongenomics.com)
demonstrated that great variations in chromosome numbers are associated with rapid species diversity due to agmatoploidy (chromosome number increases by fission without gene duplications) ( Luceño and Guerra, 1996 ) and/or aneuploidy in various linages. (e-kjpt.org)
Chromosomes9
Polyploidy is a condition in which the cells of an organism have more than one pair of (homologous) chromosomes. (wikipedia.org)
Polyploidy may occur due to abnormal cell division, either during mitosis, or more commonly from the failure of chromosomes to separate during meiosis or from the fertilization of an egg by more than one sperm. (wikipedia.org)
We tested 2,970 prenatal samples of all referral indications using a rapid BACs-on-Beads-based assay with probes for sex chromosomes, common autosomal aneuploidies, and 20 microdeletion/microduplication syndromes, designed as an alternative to microarray in low-risk pregnancies and an alternative to rapid aneuploidy testing in pregnancies also undergoing microarray analysis. (nih.gov)
Female polyploidy could not be detected, while polyploidies with Y chromosomes were suspected and confirmed through additional analysis. (nih.gov)
This article discusses the application of mathematics to the cure of cancer, the possible use of systems of smart drugs to perform simple mathematical calculations to identify and kill cancer cells, and presents a possible mechanism, developed by the author several years ago, to selectively destroy cells with abnormal numbers of chromosomes ( aneuploidy ), something common in many forms of cancer. (mathblog.com)
Polyploidy occurs in cells and organisms when there are more than two paired (homologous) sets of chromosomes . (wikipedia.org)
Aneuploidy , one or a few chromosomes more or less than the usual number in the species. (wikipedia.org)
Types of Polyploidy1
Some plant species with certain types of polyploidy do not use sexual reproduction, but survive with asexual methods. (wikipedia.org)
It will be of most use in studying the genetics of asexual organisms and cancers, where aneuploidy imposes little or no penalty on reproduction. (peercommunityin.org)
Polyploid2
Flow-cytometric and image analysis of the adrenocortical cells showed aneuploid and polyploid DNA populations, providing evidence that aneuploidy and polyploidy may occur not only in neoplastic but also in hyperplastic cells. (invisionzone.com)
[1] Some estimates suggest that 30-80% of living plant species are polyploid, and many lineages show evidence of ancient polyploidy (paleopolyploidy) in their genomes . (wikipedia.org)
Diploid1
In dysplastic 23 (77%) of 30 samples showed aneuploidy or polyploidy, whereas in non-dysplastic tissues 50 (94%) of 53 samples were diploid, the difference being statistically significant. (nii.ac.jp)
Chromosomal regions1
This allows the method to detect aneuploidy and also chromosomal regions in which multiple paralogous loci have been mistakenly assembled on top of one another. (peercommunityin.org)
Polyploidy is a fundamental mechanism in evolution, but is hard to detect in taxa with agmatoploidy or aneuploidy. (ufz.de)
In 1925 there was comparatively little systematic study of life, so we really didn't know what proportion of plant or animal taxa showed polyploidy. (stackexchange.com)
Aneuploidy is associated with genomic instability and may underlie the tumor-promoting properties of PGF 2α . (arizona.edu)
My studies of aneuploidy began as a graduate student in Dr. Mark Winey's laboratory at the University of Colorado-Boulder, where I discovered a shared localization of yeast Ndc1p to spindle poles and nuclear pore complexes and I identified NDC1 gene dosage effects - both haploinsufficiency and overexpression - that lead to genetic instability and aneuploidy in yeast. (cuanschutz.edu)
Based on these findings, we hypothesized that the phenotypes associated with altered NDC1 gene dosage and its ability to induce aneuploidy could serve as a model for understanding human diseases associated with genetic instability, including cancer and neurodegenerative disease. (cuanschutz.edu)
Pairs1
It can comprehensively investigate the genetic factors of abortion and fetal development arrest, through detecting all 23 pairs of chromosomal aneuploidies and microdeletion microduplications >100Kb. (yikongenomics.com)
Species1
There may, however, be many genetic changes in the species after polyploidy has taken place. (wikipedia.org)
Sperm6
Organophosphorous pesticide exposure increases the frequency of sperm sex null aneuploidy. (cdc.gov)
Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. (cdc.gov)
Therefore, we aimed to assess the frequency of sperm aneuploidy (X, Y, and 18) and its relationship with urinary OP metabolites in agricultural workers. (cdc.gov)
We performed multicolor fluorescence in situ hybridization on samples from nine men obtained before and during the pesticide spraying season to assess sperm aneuploidy. (cdc.gov)
Aneuploidies were found in 0.67% of total sperm nuclei. (cdc.gov)
However, Poisson regression analysis adjusted for age, alcohol intake, and sperm concentration showed significant associations between OP metabolite concentrations and increased frequency of sperm aneuploidies. (cdc.gov)
Genetic1
I have extensive experience and a long-standing interest in using cell biological and genetic approaches to uncover mechanistic links between chromosomal aneuploidy and human disease. (cuanschutz.edu)
Findings1
With these data, HMMploidy replicated previous findings of polyploidy and aneuploidy. (peercommunityin.org)
Most of the cultivated crops are developed by polyploidy method because it produces larger leaves and flowers and heavier fruits and seeds. (web-formulas.com)
Cells1
Thus, inactive p53 is not associated with a susceptible cytotoxicity of Polo-like kinase 1 inhibition and could rather foster the induction of polyploidy/aneuploidy in surviving cells. (oncotarget.com)
Proportion1
It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. (cdc.gov)
Since joining Dr. Potter's research group at the University of Colorado Alzheimer's and Cognition Center in 2015, I have been involved in the design, implementation, analysis, and publication of research projects focused on the connections between aneuploidy, Alzheimer's disease, and other forms of neurodegenerative disease, such as frontotemporal lobar degeneration (FTLD) and Huntington's disease, links between Alzheimer's disease and Down syndrome, and developing novel Alzheimer's disease therapeutics. (cuanschutz.edu)
Chen, XB & Regan, JW 2006, ' Activation of the human FP prostanoid receptor disrupts mitosis progression and generates aneuploidy and polyploidy ', Cellular and Molecular Life Sciences , vol. 63, no. 1, pp. 112-121. (arizona.edu)
Samples1
There were no differences in average aneuploidy frequency or urinary metabolite levels between samples collected before and after exposure. (cdc.gov)