Polypeptide activated leukocyte cell adhesion molecule. Medical search. Frequent questions

Members of the ADAM family contribute to various physiological and pathophysiological processes by modulation of molecules like growth factors or cytokines. (frontiersin.org)
Pancreatic acinar cell injury triggers the synthesis and release of pro-inflammatory cytokines and chemokines (32, 36, 39, 41, 82). (pancreapedia.org)
Another mechanism whereby injured pancreatic acinar cells trigger the inflammatory response is through synthesis and release of cytokines (36) and chemokines (11), and upregulation of adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) (136), which together promote neutrophil and monocyte infiltration (27, 71) and exacerbate tissue injury (10, 27, 37). (pancreapedia.org)
Chemokines (chemotactic cytokines) are positively charged polypeptides with highly conserved cysteine (C) residues within the N-terminal sequence, classifying them as 'C', 'CC', 'CXC' or 'CX3C' types (102, 143). (pancreapedia.org)
Class of pro-inflammatory cytokines that have the ability to attract and activate leukocytes. (lookformedical.com)
It is well known, that platelets have an armament of soluble molecules, factors, mediators, chemokines, cytokines and neurotransmitters in their granules, and have multiple adhesion molecules and receptors on their surface. (biomedcentral.com)
Through these pathways activated platelets are accumulated in the follicular vessels surrounding the follicle and due to its released soluble molecules (factors, mediators, chemokines, cytokines, neurotransmitters) locally increase oocyte maturation and hormone secretion. (biomedcentral.com)

In addition to killing bacteria, the products of the MPO-hydrogen peroxide-Cl system are believed to play a role in killing fungi, parasites, protozoa, viruses, tumor cells, natural killer (NK) cells, red cells, and platelets. (medscape.com)
As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. (wikidoc.org)
The first step in this interaction process is carried out by PSGL-1 interacting with P-selectin and/or E-selectin on endothelial cells and adherent platelets. (wikidoc.org)
It is a potent and selective eosinophil chemotaxin that is stored in and released from PLATELETS and activated T-LYMPHOCYTES. (lookformedical.com)
For leukocytes these are members of the β 2 integrin family, while for platelets they are members of the the β 3 integrin family. (avsconferences.org)
The signal (PAF, or other tissue/cell specific factors) comes from the stimulated (by the e.g., hypophyseal hormones, bacteria, external factors, etc.) organs or cells, and activates platelets. (biomedcentral.com)
The platelet-activating factor (PAF) is also an important secretory product of platelets mediating the platelet aggregation, inflammation and anaphylaxis[ 13 ] (Table 1 ). (biomedcentral.com)
Platelets have specialized adhesion mechanisms that make them able to take part in cell-matrix and cell-cell interactions. (biomedcentral.com)

Different fragments, released from individual components during complement activation, operate by a non-cytolytic mechanism through specific receptors present on various cell types. (dadamo.com)
The direction and intensity of the biological response depend on the state of the receptors (affinity and density) and on the function of cells bearing receptors. (dadamo.com)
Adherent receptors mediate adherence of cells and other particles with bound C3b or C4b fragments and are known as CR1 to CR5. (dadamo.com)
These receptors, present on the other cells of the immune system, are involved in a variety of immunoregulatory reactions. (dadamo.com)
The neuropeptides calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating polypeptide (PACAP) and their receptors are linked to migraine neurobiology. (bvsalud.org)
Leukocytes utilize primarily members of the selectin family of receptors and their carbohydrate ligands for this first step - often resulting in a rolling interaction. (avsconferences.org)

A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
Chemo-radio therapeutic outcomes are poor in CCA patients because the tumor is highly desmoplastic with fibrogenic connective tissue and immune cells such as T lymphocytes, natural killer (NK) cells and macrophages that infiltrate the tumor epithelium [ 4 ]. (aging-us.com)
SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. (wikidoc.org)
CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. (thermofisher.com)
CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. (thermofisher.com)
CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. (thermofisher.com)
Valmu L , Hilden T J, van Willigen G and Gahmberg C G (1999) Characterization of b2 (CD18) integrin phosphorylation in phorbol ester activated T lymphocytes. (leenavalmu.fi)
A CC-type chemokine secreted by activated MONOCYTES and T-LYMPHOCYTES. (lookformedical.com)
In a vast majority of organs, distinct epithelial tissues form the parenchyma, whereas the stroma constitutes a complex compartment composed of different cell types including fibroblasts and myofibroblasts, vessel cells, pericytes, endothelial and smooth muscle cells, as well as immune cells such as macrophages, lymphocytes and mast cells. (biomedcentral.com)
The primary immunologic abnormality resulting from infection by human immunodeficiency virus (HIV) is the progressive depletion and functional impairment of T lymphocytes expressing the CD4 cell surface glycoprotein. (justia.com)
For lymphocytes and monocytes, the integrin α 2 β 1 is also capable of mediating primary adhesion under some flow conditions via its ligand vascular cell adhesion molecule (VCAM). (avsconferences.org)

Li R, Nortamo P, Valmu L , Tolvanen M, Huuskonen J, Kantor C and Gahmberg C G (1993) A peptide from ICAM-2 binds to the Leu-kocyte Integrin CD11a/CD18 and inhibits endot-helial cell adhesion. (leenavalmu.fi)
Hilden T J, Valmu L , Kärkkäinen S and Gahmberg C G (2003) Threonine phosphorylation sites in the beta2 and beta7 leukocyte integrin polypeptides. (leenavalmu.fi)
The methods include contacting a cell with an effective amount of an agent that interferes with the interaction of gp120 and α4 integrin, such as a α4β1 or α4β7 integrin antagonist. (justia.com)
It is disclosed herein that the HIV-1 envelope protein gp120 binds to α4β7 integrin on CD4+ T-cells, natural killer (NK) cells and CD8+ T-cells. (justia.com)
Secondary or firm adhesion is mediated by members of the integrin family on the cell surface, often after activation, in concert with their ligands on the solid. (avsconferences.org)

AREAS COVERED: The emerging drugs that will be discussed in this review include zavegepant, lasmiditan, delta opioid receptor agonists, neuronal nitric oxide synthase inhibitors, monoclonal antibodies targeting pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor, dual orexin receptor antagonists, metabotropic glutamate receptor 5 antagonists, and inducers of ketosis. (bvsalud.org)
Primary adhesion or tethering of the flowing cells requires very special properties of the cell surface receptor and its ligand on the solid structure because of the very short contact times available for bond formation and the forces on those bonds due to fluid drag. (avsconferences.org)
The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

ICAM-)1, vascular cell adhesion molecule- (VCAM-)1, elargestcollectinglymphaticvessel,thethoracicduct,con- and E-selectin on activated blood vascular endothelial cells, nects the lymphatic system with the cardiovascular system. (sagepub.com)

Vermot-Desroches C, Wijdenes J, Valmu L , Roy C, Pigott R, Nortamo P and Gahmberg C G (1995) A CD44 monoclonal antibody differentially regulates CD11a/CD18 binding to intercellular adhesion molecules CD54, CD102 and CD50. (leenavalmu.fi)

Kinin increase vascular permeability by acting on vascular endothelial cells to cause cell contraction. (wikipedia.org)
esides the increased in�amma- tory cell in�ltration into the in�amed tissue, it has become In vertebrates, there are two vascular systems: the cardio- clearintherecentyearsthatacuteandchronicin�ammatory vascular and the lymphatic system. (sagepub.com)
e lymphatic blood vascular endothelial cells are activated by several in�ammatory mediators (e.g., vascular endothelial growth capillariestakeupthisprotein-rich�uid,therebymaintaining factor- (VEGF-)A, tumor necrosis factor (TNF-) , inter- not only tissue �uid homeostasis but also exerting immune leukin (IL)-6, and IL-1), leading to the typical signs of surveillance. (sagepub.com)
Human vascular endothelial cells (EC) 3 display both class I and class II MHC molecules and are directly recognized by CD8 + and CD4 + alloreactive T cells, respectively ( 12 , 13 , 14 , 15 ). (aai.org)

In response to cerulein (a CCK-8 ortholog widely used to elicit early pancreatitis responses in isolated acini an ex-vivo pancreatitis model), murine pancreatic acinar cells upregulate mRNA expression of both CXCL1 and CXCL2 within 90 min, with a supramaximally stimulating cerulein concentration of 0.1 mM producing 8 fold increase in CXCL1 and 10 fold increase in CXCL2 expression (87). (pancreapedia.org)
This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. (medicineindia.org)
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F: Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)

Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. (lookformedical.com)
BST2 bone marrow stromal cell antigen 2 (Tetherin): Candida albicans enhanced the production of the CCR5-interacting chemokines CCL3, CCL4, and CCL5, and stimulates the production of interferon-a and the restriction factors APOBEC3G, APOBEC3F, and tetherin (BST2) in macrophages Rodriguez et al, 2013 . (polygenicpathways.co.uk)

CD11, along with CD18, form a heterodimer adhesion molecule. (thermofisher.com)
Valmu L , Autero M, Siljander P, Patarroyo M and Gahmberg C G (1991) Phosphorylation of the ß-subunit of CD11/CD18 in-tegrins by protein kinase C correlates with leukocyte adhesion. (leenavalmu.fi)
Valmu L and Gahmberg C G (1995) Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies. (leenavalmu.fi)
Valmu L , Fagerholm S, Suila H and Gahmberg C G (1999) The cytoskeletal association of CD11/CD18 leukocyte integrins in phorbol ester activated cells correlates with CD18 phosphorylation. (leenavalmu.fi)

Together with acinar cell death releasing damage-associated molecular patterns (DAMPs), such as histones, high-mobility group box1 protein (HMGB1) and ATP (60), this initiates an acute, sterile (43) inflammatory response, in a manner that shares similarities with the molecular/signaling events observed in sepsis (113). (pancreapedia.org)
Kovanen P E, Junttila K, Takaluoma K, Saharinen P, Valmu L , Li W and Silvennoinen O (2000) Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentation of IL-3-dependent myeloid progenitor cell. (leenavalmu.fi)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
a protein required for the asymmetric division of vulval blast cells. (embl.de)
Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
Vertebrate paxillin, a cytoskeletal focal adhesion protein. (embl.de)
Zyxin is a low-abundance adhesion plaque protein which has been shown to interact with CRP. (embl.de)
Saccharomyces cerevisiae (Baker's yeast) rho-type GTPase activating protein RGA1/DBM1. (embl.de)
A monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. (lookformedical.com)
We will also discuss some of the important techniques employed (using in vitro and in vivo models) to assess the hemocompatibility of any new material, including the measurement of platelet preservation, platelet and protein adhesion, the effect of flow rates on thrombosis, and the ultimate surface clot area. (springer.com)
is to generate an antibody-like molecule by combining framework sequences from a human mAb with sequences from a human protein that carries a target-recognition function. (coek.info)
C-reactive protein,mannose-binding lectin, and serum amyloid P component activate complement and act as opsonins. (msdmanuals.com)

AT-hook transcription factor AKNA is accounted to coordinately regulate the expression of CD40 and its ligand, which is significant for homotypic cell interactions. (neuromics.com)
P-selectin glycoprotein ligand-1 ( PSGL-1 ) is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet ), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). (wikidoc.org)
1997). "Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin" . (wikidoc.org)

This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
The complement system influence the activity of numerous cells, tissues and physiological mechanism of the body. (dadamo.com)
The structure and structure-based modulation of ADAM17 are also described for better understanding of the various ADAM17 regulatory pathways in different cell types or tissues. (frontiersin.org)
We identified 96 differentially expressed genes (DEGs), including 13 upregulated and 83 downregulated genes, in CCA tissues as regulatory T cells were significantly higher and the proportions of activated natural killer cells and monocytes were significantly lower in CCA tissues than the precancerous tissues. (aging-us.com)
CCA patients with a higher proportion of neutrophils and T-regulatory cells (Tregs) and lower proportion of CD8 + T cells in the tumor tissues are associated with poor prognosis [ 5 ]. (aging-us.com)
However, only limited types of tumor-infiltrating immune cells have been analyzed in CCA tissues and the mechanisms regulating the tumor infiltration of immune cells are poorly understood. (aging-us.com)
Under physiological conditions, the major 4.TheRoleofBloodandLymphaticVessels functions of blood vessels include the supply of gases, �uid, in�n�ammation nutrition, and signaling molecules to the tissues with the Boththebloodandthelymphaticvascularsystemcontribute capillaries as the actual sites of exchange. (sagepub.com)
These interactions begin during the early stages of embryonic development and coordinate events such as cell proliferation and differentiation in complex tissues, crucial processes for the functional maintenance of whole organs [ 10 ]. (biomedcentral.com)
The results displayed that LINC00659 is upregulated in IVC tissues and isolated endothelial group cells (EPCs) of patients with LEDVT. (biomedcentral.com)
internal or external triggers and/or stimuli may complement and connect regulatory pathways aimed towards target tissues and/or cells. (biomedcentral.com)

Platelet activation means their aggregation, sludge formation, furthermore the release of the for-mentioned biologically very powerful factors, which can locally amplify and deepen the tissue specific cell reactions. (biomedcentral.com)
High shear stress in stenotic atherosclerotic arteries cause platelet adhesion leading to the development of arterial thrombosis and cardiovascular events[ 15 ]. (biomedcentral.com)
The initial biological response of blood to a foreign surface is the rapid adsorption of plasma proteins, which is followed by platelet adhesion and activation, and ultimately thrombus formation. (springer.com)

CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. (thermofisher.com)
Cellular interactions lie at the core of metazoan physiology and encompass an effective and elegant signaling repertoire that integrates up to trillions of cells in a single organism. (biomedcentral.com)
Understanding the molecular mechanisms of cell-solid surface interactions is crucial for developing specific therapeutic strategies to control or modulate processes such as thrombosis, inflammation and cancer metastasis. (avsconferences.org)

however, significant amounts are also produced by monocytes, macrophages, and epithelial cells in the gastrointestinal and genitourinary tracts. (dadamo.com)

A kinin is any of various structurally related polypeptides, such as bradykinin and kallidin. (wikipedia.org)

Lymphoid cells concerned with humoral immunity. (lookformedical.com)
Cyclosporine is a cyclic polypeptide that suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions such as delayed hypersensitivity, allograft rejection, experimental allergic encephalomyelitis, and graft versus host disease for a variety of organs. (medscape.com)
The loss of CD4 helper/inducer T cell function probably underlies the profound defects in cellular and humoral immunity leading to the opportunistic infections and malignancies characteristic of the acquired immunodeficiency syndrome (AIDS) (Lane et al. (justia.com)

New strategies including monoclonal antibodies and tyrosine kinase inhibitors explore molecular targets that are normally deregulated in cancer cells, and represent a new hope for patients. (biomedcentral.com)

When neutrophils become activated during phagocytosis, they undergo a process referred to as a respiratory burst. (medscape.com)
The effect of specific chemical functionalities on the attachment of neutrophils, one of the cells responsible for host response to biomaterials, was investigated using self-assembled monolayers (SAMs) containing different terminal groups. (avsconferences.org)

CD40 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 196 amino acids (21-193a.a) and having a molecular mass of 21.6kDa. (neuromics.com)
Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)

The complement system consists of more than 35 soluble and cell-bound proteins, 12 of which are directly involved in the complement pathways. (dadamo.com)
however, animal and cell models remain critical in furthering our understanding of molecular mechanisms, signaling pathways, and new drug targets. (pancreapedia.org)
Methods for dissecting the specific molecular pathways involved for each step in the adhesion process for several cell types are given and the current state of our knowledge and potential applications are discussed. (avsconferences.org)

Concomitantly they induce local expression of adhesive molecules. (wikipedia.org)

The survival outcomes of CCA patients were associated with the TP53 gene mutation status, levels of Oncostatin M (OSM) expression, and the proportions of tumor-infiltrating immune cell types, including dendritic cells, monocytes, and T follicular helper cells. (aging-us.com)
N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer. (thermofisher.com)

Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
In living organisms, if the temperature exceeds the normal range (thermo-neutral zone), it disturbs the normal physiological functioning and induces cell injury. (frontiersin.org)

Most individuals with partial or total myeloperoxidase (MPO) deficiency have no increased frequency of infections, probably because MPO-independent mechanisms in the polymorphonuclear leukocytes (PMNs) can take over. (medscape.com)
Methylprednisolone exerts anti-inflammatory effects by suppressing the migration of polymorphonuclear leukocytes and reversing increased capillary permeability. (medscape.com)

A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. (thermofisher.com)
Immunoadhesins: principles and applications Steven M. Chamow and Avi Ashkenazi The prototypic immunoadhesin is an antibody-like molecule that fuses the Fc region of an immunoglobulin molecule. (coek.info)
An antibody is a Y-shaped molecule, composed of two identical light chains (grey) and two identical heavy chains (white). (coek.info)
The same antibody molecule can cross-react with related antigens if their epitopes are similar enough to those of the original antigen. (msdmanuals.com)

The aim of the present study is to replicate the effects of the plasma levels of MHC class I polypeptide-related sequence B (MICB) and cluster of differentiation 209 (CD209) proteins reported in a previous hypothesis-free MR study. (plos.org)
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation. (mcw.edu)

MONOCYTES and a variety of other immune cells. (lookformedical.com)

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)
In this study, we used bioinformatics tools to analyze transcriptome data from cholangiocarcinoma (CCA) patients in multiple datasets (Sun Yat-sen University, TCGA and GSE32225 cohorts) to identify mechanisms that regulate tumor infiltration by immune cells and survival outcomes. (aging-us.com)
During the past decades, an increasing body of work has shed light on the cellular and molecular mechanisms involved in the transformation of normal cells into cancerous cells. (biomedcentral.com)

This interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue. (wikidoc.org)

Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
In the case of melanoma, circulating cells may find a suitable microenvironment in the first draining lymph node, known as the sentinel lymph node, in other lymphnodes or in distant organs, leading to secondary tumor growth (Figure 1 ). (hindawi.com)

CR1 on erythrocytes may bind circulating immune complexes (that had activated complement) and transport them to the liver where the immune complexes are partially degraded and thus become more soluble. (dadamo.com)

However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood vessel wall. (wikidoc.org)
Corticosteroids are immunosuppressive and affect the replication, movement, and activity of virtually all cells involved with inflammation. (medscape.com)
Hydrocortisone decreases inflammation by suppressing migration of PMN leukocytes and reversing increased capillary permeability. (medscape.com)
It is constitutively expressed in the skin and may play a role in T-CELL trafficking during cutaneous INFLAMMATION. (lookformedical.com)

They are polypeptides containing approximately 75 amino acid residues and meet all the criteria which characterize local hormones. (dadamo.com)
abstract： BACKGROUND AND OBJECTIVE:Fibronectin (FN) is an important cell adhesion molecule that is used widely to characterize cell behavior. (shengsci.com)

Cells grown in vitro from neoplastic tissue. (lookformedical.com)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
PSGL-1 is expressed on all white blood cells and plays an important role in the recruitment of white blood cells into inflamed tissue: White blood cells normally do not interact with the endothelium of blood vessels. (wikidoc.org)
2. Tissue injury and inflammatory cell recruitment. (pancreapedia.org)
Stenman M, Ainola M, Valmu L , Bjartell A, Ma G, Stenman U-H, Sorsa T, Luukkainen R and Konttinen Y T (2005) Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. (leenavalmu.fi)
It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. (lookformedical.com)

In this sense, the lack of technologies that would allow for molecular screening of individual stromal cell types poses a major challenge for the development of therapies targeting the tumor microenvironment. (biomedcentral.com)

The process of metastasis is the consequence of migration of melanoma cells from the primary lesion, to locoregional and distant body sites via the lymphatic circulation and the bloodstream. (hindawi.com)
They function as CHEMOTACTIC FACTORS for CELL MIGRATION and AXON GUIDANCE, acting as chemoattractants for some cell types, and as chemorepellents for others. (bvsalud.org)

The dimeric structure of the expressed and purified molecule can be contirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresir (SDS-PAGE), in the presence of a reducing agent to separate the polypeptide chains (Fig. 2a). (coek.info)

Cell adhesion was increased on the hydrophobic CH 3 and the anionic COOH terminated surface. (avsconferences.org)
In this chapter, we will review some of the current and most promising strategies that have been used over the years to develop polymeric materials with improved hemocompatibility, including highly hydrophilic or hydrophobic surfaces, albumin coated surfaces, zwitterionic polymers, attached endothelial cells, patterned surfaces, immobilized heparin, and nitric oxide (NO) releasing/generating surfaces. (springer.com)

TP53 mutations are also associated with the infiltration of immune cells into the tumor microenvironment [ 10 - 12 ]. (aging-us.com)
In this way, tumor microenvironment cells could represent an extremely attractive therapeutic target either along the course of the disease or during the first steps of malignant transformation. (biomedcentral.com)

It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation. (lookformedical.com)
Human CMV infection is controlled by T cell-mediated immunity and in immunosuppressed transplant patients it is associated with acute allograft rejection as well as chronic allograft vasculopathy. (aai.org)
Studies of HIV-1 infection of fractionated CD4 and CD8 T-cells from normal donors and AIDS patients have revealed that depletion of CD4 T-cells results from the ability of HIV-1 to selectively infect, replicate in, and ultimately destroy this T lymphocyte subset (Klatzmann et al. (justia.com)
This stimulates yeast hyphal formation, is immunomodulatory and causes cell damage during infection Ells et al, 2012 . (polygenicpathways.co.uk)

Adhesion was studied on surfaces preadsorbed with fibrinogen or albumin, under well defined flow conditions using a radial flow chamber and automated videomicroscopy. (avsconferences.org)

Gingival fibroblasts were isolated, and outward K+ currents were detected by whole-cell patch-clamp analysis, transmembrane potential was determined by flow cytometry. (shengsci.com)

A growing body of evidence points to the importance of the functional diversity of immune and structural cells during tumor development. (biomedcentral.com)

At the same time follicular cells enhance PAF production. (biomedcentral.com)

Advances in immunotherapy have shed greater focus on the role of tumor-infiltrating immune cells, which are vital components of the tumor immune microenvironment (TIME). (aging-us.com)
This lack of success may result in part from the fact that most studies focus on tumor cells as potential therapeutic targets and neglect the complex microenvironment that undergoes profound changes during tumor development. (biomedcentral.com)
Progress in microenvironment genetic studies represents a formidable opportunity for the development of new selective drugs because stromal cells have lower mutation rates than malignant cells, and should prove to be good targets for therapy. (biomedcentral.com)
Unresponsiveness may result, at least in part, because these therapies only target cancer cells and neglect the complex microenvironment around tumors that undergo drastic changes during disease development [ 7 ]. (biomedcentral.com)

and, in response to antigen, are subsequently secreted by plasma cells. (msdmanuals.com)

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)

Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
2~). In the absence of light chains, deletion of the C,,l domain improves assembly and secretion of immunoadhesins by the host cell. (coek.info)

The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)
ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. (frontiersin.org)
A Disintegrin and Metalloproteases (ADAM), originally named metalloproteinases disintegrin cystein-rich (MDC), are membrane-anchored cell surface proteins containing both disintegrin and metalloproteinase domains. (frontiersin.org)
Takata K, Matsuzaki T, Tajika Y. Aquaporins: water channel proteins of the cell membrane. (benthamscience.com)
The lipid envelope surrounding the nucleocapsid is derived from the host cell plasma membrane during the budding process. (fortunejournals.com)

It is estimated that as much as 10% of the cell surface proteins undergo ectodomain shedding. (frontiersin.org)

BACKGROUND AND OBJECTIVE:Activated potassium channels were found to be strongly correlated with gingival overgrowth (GO) phenotype as we reviewed syndromic hereditary gingival fibromatosis (HGF). (shengsci.com)
The aim of the present study was to explore the pathogenic role of aberrantly activated potassium channel in Hereditary Gingival Fibromatosis (HGF). (shengsci.com)

In vitro, CD4 + T cells from CMV-positive donors (but not CMV-negative donors) are readily activated by CMV-infected allogeneic EC, although it is unclear how allogeneic CMV-infected EC activate self-class II MHC-restricted memory CD4 + T cells. (aai.org)
In this study, we confirm that purified CD4 + T cells from CMV + donors are activated by allogeneic CMV-infected EC, but find that the response is dependent upon copurified APC expressing class II MHC that are autologous to the T cells. (aai.org)

AQP4 is prevalently distributed in the central nervous system, and mainly regulates water flux in brain cells under normal and pathological conditions. (benthamscience.com)

At present, with the in-depth understanding of endothelial progenitor cells (EPCs) and the increase of research, it has become the focus of medical research [ 6 ]. (biomedcentral.com)

The result of cytotoxic complement reaction may be beneficial for the body (elimination of the infectious agent or damaged cells) or harmful (damage to autologous normal cells by immunopathological reactions). (dadamo.com)

Anatomy1

Diseases1

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes1

Cytokines7

Platelets8

Receptors6

Lymphocytes14

Integrin5

Receptor5

VCAM1

Intercellular1

Vascular4

MRNA3

Chemokines2

CD114

Protein12

Ligand3

Tissues10

Platelet3

Interactions3

Macrophages1

Structurally1

Humoral immunity3

Antibodies1

Neutrophils2

Amino acids2

Pathways3

Adhesive1

Dendritic2

Physiological2

Polymorphonuclear leukocytes2

Antibody4

Differentiation2

Monocytes1

Mechanisms3

Endothelial cell1

Lymph2

Bind1

Inflammation4

Characterize2

Tissue6

Stromal cell1

Migration2

Sodium1

Hydrophobic2

Tumor microenvironment2

Infection4

Fibrinogen1

Transmembrane1

Functional1

Follicular1

Microenvironment4

Antigen1

Lymphocyte1

Secretion2

Membrane5

Proteins1

Potassium2

Donors2

Regulates1

Progenitor1

Complement1