• In most of the clinics, antibody for the anti-large T antigen of Simian virus 40 (SV40) is used. (biomedcentral.com)
  • Viral antigens in permissive cells infected with JC virus, K virus and SA12 virus were reactive in immunofluorescence tests to antisera against sodium dodecyl sulfate disrupted simian virus 40 capsids and polyoma VP1. (johnshopkins.edu)
  • The major capsid polypeptides of all papovaviruses of the simian virus 40-polyoma subgroup are immunologically related. (johnshopkins.edu)
  • In some polyomaviruses - such as the well-studied SV40, which natively infects monkeys - STag is unable to induce neoplastic transformation in the host cell on its own, but its presence may increase the transforming efficiency of LTag. (wikipedia.org)
  • These are believed to bind zinc in the SV40 STag and confer improved protein stability, but in Merkel cell polyomavirus STag, they have been reported to bind iron-sulfur clusters. (wikipedia.org)
  • In SV40 and JC virus, STag is not required for viral proliferation, but does improve efficiency. (wikipedia.org)
  • SV40 and murine polyomavirus STags appear to have a role in promoting host cell expression of genes under the control of certain types of promoters. (wikipedia.org)
  • All these biopsy samples were evaluated with routine renal biopsy stains as well as IHC for SV40 (Simvian Virus 40) antigen. (biomedcentral.com)
  • These tubular cells also stained positive by an antibody against SV40 large T antigen, confirming the presence of polyomavirus cytopathic effects. (cytopathology.ca)
  • [ 1 ] It is a small non-enveloped double-stranded DNA virus that was identified as the etiological agent in 1967 and was named JC virus in 1971 after John Cunningham, from whom it was first isolated. (medscape.com)
  • John Cunningham polyomavirus (JC Virus) T-antigen was identified in MB cells, suggesting a role of this viral infection in tumor physiopathology. (surgicalneurologyint.com)
  • The JC virus, or John Cunningham virus, is a ubiquitous, typically harmless polyomavirus that can cause PML (progressive multifocal leukoencephalopathy) in immunocompromised individuals. (hbot-india.com)
  • The John Cunningham virus (JCV) is the established etiological agent of the polyomavirus-associated nephropathy among renal transplant recipients. (biomedcentral.com)
  • The John Cunningham virus (JCV) is an ubiquitous human polyomavirus that was first discovered in 1971 from patients with progressive multifocal leukoencephalopathy (PML) [ 1 ]. (biomedcentral.com)
  • Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infection in infants and children and the second most common viral cause of pneumonia in adults. (medscape.com)
  • Influenza pneumonia: Amantadine hydrochloride and rimantadine hydrochloride are approved for the prevention and treatment of influenza A virus infection. (medscape.com)
  • It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. (mdpi.com)
  • For each type of virus, what is known about the roles of DNA methylation, histone modifications, nucleosome positioning, and regulatory RNA in epigenetic regulation of the virus infection will be discussed. (mdpi.com)
  • Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) characterized by widespread lesions due to infection of oligodendrocytes by JC virus, a ubiquitous human polyomavirus estimated to latently infect the kidneys of 50% of adults. (medscape.com)
  • Infection with the BK virus (BKV): In 1971, a renal transplant recipient suffering from ureteric stenosis had the BK virus isolated from his urine. (openpr.com)
  • The innate immune response to JCPyV infection has not been studied, and little is known about the initial host response to polyomavirus infection. (elsevierpure.com)
  • After primary infection of urothelial cells, virus DNA will be integrated into the host's genome. (biomedcentral.com)
  • It is noted that only a few tubules are showing cytopathic effects, which is common for JC virus infection as opposed to the more diffuse tubular cell changes related to BK virus infection. (cytopathology.ca)
  • A review on JC virus infection in kidney transplant recipients. (cytopathology.ca)
  • The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
  • At last follow-up, all patients were enjoying functioning grafts without recurrence of BK virus infection. (ectrx.org)
  • 10,11 Only 1% to 10% affected patients change from reactivated infection to histologically confirmed BK virus nephropathy, usually at mean 10 to 13 months after transplant (range, 6 days to 5 years). (ectrx.org)
  • 18 Although immunosuppressive agents are essential for therapy after organ transplant, these agents increase the incidence and deteriorate the severity of BK virus infection. (ectrx.org)
  • 2017, Jul).Rhodiolae kirliowii radixet rhizoma and crataegus pinnatifida fructus extracts effectively inhibit BK virus and JC virus infection of host cells. (ccu.edu.tw)
  • Adult X-linked immunodeficiency (XID) mice, IGM-/- single knockout and IGM-/- CD8-/- double knockout mice do not clear polyomavirus infection. (ictv.global)
  • The ubiquitous human polyomavirus JC (JCV) is a small double-stranded DNA virus that establishes a persistent infection, and it is often transmitted from parents to children. (ox.ac.uk)
  • 14 Primary and renally-activated BK virus infection may manifest as hemorrhagic and nonhemorrhagic cystitis. (uic.edu)
  • JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants. (cdc.gov)
  • In other polyomaviruses, such as Merkel cell polyomavirus, which causes Merkel cell carcinoma in humans, STag appears to be important for replication and to be an oncoprotein in its own right. (wikipedia.org)
  • In Merkel cell polyomavirus, it appears to play a significant role in oncogenesis, a function performed primarily by LTag in other polyomaviruses. (wikipedia.org)
  • Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes. (ictv.global)
  • Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma. (ictv.global)
  • The influenza viruses are the most common viral cause of pneumonia. (medscape.com)
  • DNA and RNA viruses are involved in the etiology of viral pneumonia. (medscape.com)
  • STag is expressed early in the infectious cycle and is usually not essential for viral proliferation, though in most polyomaviruses it does improve replication efficiency. (wikipedia.org)
  • In most well-studied polyomaviruses, STag improves the efficiency of viral proliferation but is not essential. (wikipedia.org)
  • Because polyomavirus genome replication relies on the DNA replication machinery of the host cell, the cell must be in S phase (the part of the cell cycle in which the host cell's genome is normally replicated) in order to provide the necessary molecular machinery for viral DNA replication. (wikipedia.org)
  • As many as 90% of healthy individuals have serum antibodies to this virus, but less than 10% show any evidence of ongoing viral replication. (medscape.com)
  • In HIV-negative controls, no lymphocyte or plasma samples harbored JC viral DNA. (medscape.com)
  • HIV gene products, such as Tat, may be able to transactivate the JC viral promoter directly. (medscape.com)
  • Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)
  • Viral architecture is very complex, but every virus contains at least a genome and a capsid. (unboundmedicine.com)
  • Diagnosis of BK virus nephropathy is based on histologic appearance characterized by lymphocytic interstitial infiltrates, nuclear reaction to the anti-SV-40T antibody as evidence of viral replication, and positive PCR for BK virus DNA. (ectrx.org)
  • GenBank currently has automatic prokaryotic and eukaryotic genome annotation pipelines but has no viral annotation pipeline beyond influenza virus. (biomedcentral.com)
  • Surprisingly, other than for influenza virus, NCBI GenBank does not currently have an automatic viral genome annotation pipeline. (biomedcentral.com)
  • Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, BK virus infections pipeline constitutes 4+ key companies continuously working towards developing 4+ BK virus infections treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. (openpr.com)
  • BK virus infections Pipeline Insight, 2023" report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the BK virus infections Market. (openpr.com)
  • The BK virus infections Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. (openpr.com)
  • Companies across the globe are diligently working toward developing novel BK virus infections treatment therapies with a considerable amount of success over the years. (openpr.com)
  • Emerging BK virus infections therapies in the different phases of clinical trials are- BK virus antiviral therapy, AIC 468, AntiBKV antibody, Brincidofovir, MAU868, ALVR 105, and others are expected to have a significant impact on the BK virus infections market in the coming years. (openpr.com)
  • BK virus infections pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. (openpr.com)
  • Viruses are also responsible for the common cold, childhood exanthems (such as chickenpox, measles, rubella), latent infections (such as herpes simplex), some cancers or lymphomas (such as Epstein-Barr virus), and diseases of all organ systems. (unboundmedicine.com)
  • The virus is harmless to macaques or may cause only a herpetic rash in macaques, but in humans it often produces fatal infections of the brain and meninges. (unboundmedicine.com)
  • Overview of JC polyomarvirus, BK polyomavirus and other polyomavirus infections. (cytopathology.ca)
  • I knew on inspecting my birds that this was not Dec 5, 2007 We show that nestlings of a songbird acquire polyomavirus infections from common nest ectoparasites of cavity-nesting birds, while breeding Polyomavirus in Birds. (web.app)
  • Comparison of polyomavirus (BK virus and JC viruses) viruria in renal transplant recipients with and without kidney dysfunction. (ac.ir)
  • JC polyoma viruria associates with protection from chronic kidney disease independently from apolipoprotein L1 genotype in African Americans. (wakehealth.edu)
  • Increased Prevalence of Human Polyomavirus JC Viruria in Chronic Inflammatory Rheumatic Diseases Patients in Treatment with Anti-TNF a: A 18 Month Follow-Up Study. (cdc.gov)
  • Diagnostic Value of JC Polyomavirus Viruria, Viremia, Serostatus and microRNA Expression in Multiple Sclerosis Patients Undergoing Immunosuppressive Treatment. (cdc.gov)
  • Classification of viruses is principally according to their genome sequence taking into consideration nature and structure of their genome and their method of replication, but not according to the diseases they cause (see International Committee on Taxonomy of Viruses (ICTV), 2021 release ). (msdmanuals.com)
  • In October 2021, Posoleucel (ViralymM, ALVR105) was given Orphan Drug Designation (ODD) by the US Food and Drug Administration (FDA) to treat virus-associated hemorrhagic cystitis (HC). (openpr.com)
  • In March 2021, In order to assess ALVR105 (Viralym-M), an allogeneic, commercially available multi-virus specific T cell treatment, AlloVir started a Phase III trial. (openpr.com)
  • 2021) Suppression of bone metastatic castration-resistant prostate cancer cell growth by a suicide gene delivered by JC polyomavirus-like particles. (ccu.edu.tw)
  • 2021). Peptide-guided JC polyomavirus-like particles specifically target bladder cancer cells for gene therapy. (ccu.edu.tw)
  • Concentrations of bacteria (16S rRNA gene), viruses (human adenovirus and JC polyomavirus), and antibiotic resistance genes (sul1 and bla TEM ) were assessed via quantitative PCR following the concentration of large sample volumes by dead-end ultrafiltration. (stanford.edu)
  • Adenovirus, JC polyomavirus, and bla TEM genes were reduced below the limit of detection (∼10-2 gene copies per mL) by microfiltration. (stanford.edu)
  • Routine immunohistochemistry study for polyomavirus BK nephropathy in transplanted kidney biopsies, is it recommended? (biomedcentral.com)
  • Early diagnosis and treatment of Polyomavirus BK Nephropathy (PVBKN) is a challenging issue in the management of patients with kidney transplantation. (biomedcentral.com)
  • Polyomavirus BK nephropathy (PVBKN) is an important cause of allograft dysfunction in patients with kidney transplantation [ 1 ]. (biomedcentral.com)
  • BK virus is associated with nephropathy and ureteral stenosis in kidney transplant patients. (cytopathology.ca)
  • Although both BK and JC viruses can cause nephropathy in kidney transplant patients, there are many differences between the two. (cytopathology.ca)
  • Firstly, JC virus nephropathy is not as frequent and not as well studied as the BK virus-related nephropathy in the literature. (cytopathology.ca)
  • Secondly, JC virus nephropathy seems to be associated with a less aggressive and more protracted clinical course when compared with BK virus with lower rate of graft rejection and better survival. (cytopathology.ca)
  • A third difference is the lower level of viremia in JC virus nephropathy in comparison to BK virus. (cytopathology.ca)
  • In addition, the extent of the histological changes in JC-virus nephropathy is lower with more patchy tubular involvement and more focal cytopathologic changes. (cytopathology.ca)
  • Given the results of qPCR performed on the patient's blood, a diagnosis of JC virus nephropathy was established. (cytopathology.ca)
  • After being diagnosed with JC virus-associated nephropathy, one of the patient's immunosuppressive agents was changed and the patient's creatinine returned to the baseline. (cytopathology.ca)
  • Polyomavirus BK versus JC replication and nephropathy in renal transplant recipients: a prospective evaluation. (cytopathology.ca)
  • JC polyoma virus interacts with APOL1 in African Americans with nondiabetic nephropathy. (wakehealth.edu)
  • Nephropathy from BK virus is an increasing problem in renal transplant recipients and has been correlated with newer immuno-suppressive agents and the decline in acute rejection rates. (ectrx.org)
  • 9,12-17 In other reports, it has been concluded that the median time to detect BK virus nephropathy after kidney transplant is 9.5 months, but the duration until graft failure is only 4 months after incidence of BK virus nephropathy. (ectrx.org)
  • It is difficult to make a clear differential diagnosis between BK virus nephropathy and acute cellular rejection. (ectrx.org)
  • Therefore, a decrease or discontinuation of immunosuppressive agents is essential as initial treatment for BK virus nephropathy. (ectrx.org)
  • Factors that may be associated with the risk of BK virus nephropathy include older age, male sex, white ethnicity, diabetes, renal tissue injury from ischemia, presence of cytomegalovirus, acute rejection, and treatment with high-dose steroid pulses. (ectrx.org)
  • The BK virus nephropathy is 1 of the major causes of allograft dysfunction or graft loss in patients in an overly immunosuppressed state. (ectrx.org)
  • It has been showed that 45% patients with BK virus nephropathy progressed to irreversible graft failure with tubular atrophy and interstitial fibrosis. (ectrx.org)
  • Despite the high incidence of reactivation of the JC virus in recipients of renal transplantation, a small fraction of patients eventually show JC virus-associated nephropathy, which may lead to rejection of the transplant [ 11 ]. (biomedcentral.com)
  • Progressive multifocal leukoencephalopathy (PML) is caused by reactivation of the endemic JC polyomavirus. (medscape.com)
  • JC virus is associated with progressive multifocal leukoencephalopathy in immunocompromised patients. (cytopathology.ca)
  • The C-terminal region of STag contains a protein phosphatase 2A binding region, followed in mammalian polyomaviruses by a metal ion binding region at the C-terminus with conserved cysteine-containing sequence motifs. (wikipedia.org)
  • Among polyomaviruses that infect birds - classified in the genus Gammapolyomavirus - the conserved cysteines characterizing these metal-binding regions are not present and there is no detectable sequence homology between the avian and mammalian STag C-termini. (wikipedia.org)
  • New viruses are then released either by destroying their host cell or by forming small buds that break off and infect other cells. (unboundmedicine.com)
  • Both BK and JC viruses can infect urothelial cells and renal tubular cells and give rise to characteristic cytopathic effects (DeCoy cells) that can sometimes exhibit overlapping features with high-grade urothelial carcinoma. (cytopathology.ca)
  • JC virus (JCV) is a polyomavirus that can infect brain glial cells causing a fatal disease, but may also be found throughout the normal gastrointestinal tract. (elsevierpure.com)
  • JC is a member of the polyomavirus genus of the Papovaviridae family. (bmj.com)
  • 5 This DNA virus, so labelled after the initials of the patient whose tissue was used to isolate it, is a member of the genus Polyomavirus in the family Papovaviridae , which also includes BK virus and SV 40 virus. (bmj.com)
  • Polyomavirus is a non-enveloped double stranded DNA virus which exists latently in the human body. (biomedcentral.com)
  • Avian polyomavirus (APV) causes a fatal, multi-organ disease among several bird species. (rcsb.org)
  • A longitudinal study on avian polyomavirus-specific antibodies in captive Spix's macaws ( Cyanopsitta spixii ). (ictv.global)
  • Avian polyomavirus (APV) is one of the most significant pathogens of domestically raised psittacine birds (parrots). (web.app)
  • 2017-03-01 Avian polyomavirus is a very serious disease in birds causing depression, dehydration, and haemorrhaging under the skin. (web.app)
  • It can cause a wide range of illnesses in pet birds, from benign wart Budgerigar fledgling disease (BFD), caused by an avian polyomavirus, was first Although mortality rates vary with the age of the exposed birds, polyomavirus HISTORY: Flock had high mortality in birds less than 15 days of age. (web.app)
  • Polyoma virus appears to be most prevalent in: Avian polyomavirus is a very serious disease in birds causing depression, dehydration, and haemorrhaging under the skin. (web.app)
  • Objective: To determine safety, immunogenicity, and efficacy of an inactivated avian polyomavirus vaccine in nonbudgerigar psittacine birds that varied in age, species, and immunologic status. (web.app)
  • Avian polyomavirus (APV) primarily affects young birds. (web.app)
  • MuPyV, murine polyomavirus. (cdc.gov)
  • The LTag gene is usually encoded in two exons, of which the first overlaps with the gene for STag (and sometimes other tumor antigens as well, such as the murine polyomavirus middle tumor antigen). (wikipedia.org)
  • The C-terminal portion of the STag protein is distinct from LTag but shares an additional ~100 residues with middle tumor antigen in those viruses that express it, such as murine polyomavirus. (wikipedia.org)
  • In oncogenic polyomaviruses, the tumor antigens are responsible for the transformation activity, although the exact molecular mechanisms vary from one virus to another. (wikipedia.org)
  • The common influenza viruses have antigens that mutate or combine readily, requiring new vaccines with each mutation. (unboundmedicine.com)
  • Polyoma tumor development in neonatally polyoma-virus-infected CD4-/- and CD8-/- single knockout and CD4-/-8-/- double knockout mice. (ictv.global)
  • Variations in polyoma virus genotype in relation to tumor induction in mice. (ictv.global)
  • The Avian polyoma virus (also known as Budgerigar Fledgling Disease) causes high levels of mortality in young psittacine birds. (web.app)
  • We postulate that the terminal β-hairpin locks other polyomavirus capsids in a stable conformation and that absence of the hairpin leads to the observed capsid size variation in APV. (rcsb.org)
  • Polyomavirus STag proteins are usually around 170-200 residues long and consist of two distinct regions as a result of this genetic encoding. (wikipedia.org)
  • Proteins found in any species of virus. (lookformedical.com)
  • AAVs are nonenveloped single-stranded DNA viruses used in gene therapy to insert copies of missing genes into host cells. (unboundmedicine.com)
  • Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses. (lookformedical.com)
  • Gene therapy for castration-resistant prostate cancer cells using JC polyomavirus-like particles packaged with a PSA promoter driven-suicide gene. (ccu.edu.tw)
  • Gene therapy for human lung adenocarcinoma using a suicide gene driven by a lung-specific promoter delivered by JC virus-like particles. (ccu.edu.tw)
  • The small tumor antigen (also called the small T-antigen and abbreviated STag or ST) is a protein encoded in the genomes of polyomaviruses, which are small double-stranded DNA viruses. (wikipedia.org)
  • However, the plug density is more prominent in APV and may include VP4, a minor capsid protein unique to bird polyomaviruses. (rcsb.org)
  • Alternatively, latent reactivation of the virus can occur in the brain itself in this setting. (medscape.com)
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
  • The genes for both the small and the large tumor antigen are encoded in the "early region" of the polyomavirus genome, so named because this region of the genome is expressed early in the infectious process. (wikipedia.org)
  • Positive-sense RNA viruses possess a single-stranded RNA genome that can serve as messenger RNA (mRNA) that can be directly translated to produce an amino acid sequence. (msdmanuals.com)
  • Negative-sense RNA viruses possess a single-stranded negative-sense genome that first must synthesize a complementary positive-sense antigenome, which is then used to make genomic negative-sense RNA. (msdmanuals.com)
  • the genome of RNA viruses ranges from 3.5 kilobases (some retroviruses) to 27 kilobases (some reoviruses), and the genome of DNA viruses ranges from 5 kilobases (some parvoviruses) to 280 kilobases (some poxviruses). (msdmanuals.com)
  • This manageable size together with the current advances in nucleotide sequencing technology means that partial and whole virus genome sequencing will become an essential component in epidemiologic investigations of disease outbreaks. (msdmanuals.com)
  • The 400 known viruses are classified in several ways: by genome core (RNA or DNA), host (animals, plants, or bacteria), method of reproduction (such as retrovirus), mode of transmission (such as enterovirus), and disease produced (such as hepatitis virus). (unboundmedicine.com)
  • With sequencing technologies becoming cheaper and easier to use, more groups are able to obtain whole genome sequences of viruses of public health and scientific importance. (biomedcentral.com)
  • We have created a portable, lightweight, user-friendly, internet-enabled, open-source, command-line genome annotation and submission package to facilitate virus genome submissions to NCBI GenBank. (biomedcentral.com)
  • Studies on community-acquired pneumonias consistently demonstrate viruses to be the second most common etiologic cause (behind Streptococcus pneumoniae ), ranging from 13-50% of diagnosed cases. (medscape.com)
  • An accurate and early etiologic diagnosis is important because specific therapies are used against certain viruses. (medscape.com)
  • Potential therapies would target and neutralize its etiologic agent, JC polyomavirus (JCPyV). (elsevierpure.com)
  • Certain single-strand, (+) sense RNA viruses termed retroviruses use a very different method of replication. (msdmanuals.com)
  • ABBR: AAV A genus in the parvovirus family whose members cannot replicate without the presence of another virus. (unboundmedicine.com)
  • A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. (lookformedical.com)
  • Polyoma BK viruses are widespread, double-stranded, nonencapsulated DNA viruses comprising BK and JC strains that are pathogenic in humans. (ectrx.org)
  • A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. (lookformedical.com)
  • We aimed to evaluate the effect of BK virus-positive kidney donors on the outcome of kidney transplant recipients after mean follow-up 21 months. (ectrx.org)
  • Among 18 kidney donors with BK virus in blood and urine, 5 donors were fit for donation. (ectrx.org)
  • Polyoma BK virus-positive people can be accepted safely for kidney donation, especially with a possible protective role of human leukocyte antigen Cw7. (ectrx.org)
  • Potent immunosuppression is believed to be the cause of the resurgence of BK virus in kidney transplant patients. (ectrx.org)
  • Astrocytes that are infected by the virus enlarge and take bizarre appearance (distortion of the nuclei with enlargement or multiple nuclei) and resemble the tumor cells in giant cell astrocytomas. (medscape.com)
  • WHEREAS, Institute has conducted certain research and development, and possesses certain expertise relating to the research and development of, among other things, allogeneic and autologous cytotoxic T-lymphocytes ("CTL"), including in relation to the development of novel therapies targeting tumor and other cells infected with certain viruses, for use in oncology and autoimmune indications. (justia.com)
  • Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)
  • We have also implemented commercial tests for HIV RNA, hepatitis C RNA, hepatitis C genotyping, hepatitis B DNA, and have developed molecular tests for the detection of resistance of human cytomegalovirus and hepatitis B virus to antiviral drugs. (wustl.edu)
  • Molecular epidemiology of JC polyomavirus in HIV-infected patients and healthy individuals from Iran. (cdc.gov)
  • 16 According to the 2009 American Society for Blood and Marrow Transplantation (ASBMT) guidelines for preventing infectious complications among hematopoietic cell transplant recipients, evidence is lacking for support of universal prophylactic treatment of BK virus with quinolones or cidofovir, as well as routine testing of HSCT recipients or donors for BK virus antibodies. (uic.edu)
  • The fates of viruses, bacteria, and antibiotic resistance genes during advanced wastewater treatment are important to assess for implementation of potable reuse systems. (stanford.edu)
  • The virus infects other cells from a central nidus in a circumferential manner, leading to the expansion of the demyelinating lesion. (medscape.com)
  • In adult birds, polyomavirus can cause lethargy, lack of appetite, regurgitation, diarrhea, dehydration, and sometimes death, but in general the disease is not as severe when it infects mature birds. (web.app)
  • Wild birds are believed to constitute the natural reservoir for influenza A virus. (web.app)
  • After DNA extraction, the simultaneous detection and quantification of JCV and BK polyomavirus (BKV) were conducted using a Real-time quantitative PCR method. (biomedcentral.com)
  • Increased frequency of JC-polyomavirus detection in rheumatoid arthritis patients treated with multiple biologics. (cdc.gov)
  • New approach for JC virus detection and its application for PML diagnosis]. (cdc.gov)
  • The aetiological agent of PML is the JC virus, named for the initials of the patient from whom it was initially isolated. (bmj.com)
  • According to a study of HIV-negative controls and HIV-positive patients with or without PML, a third of individuals from all subgroups had JC virus DNA in the urine. (medscape.com)
  • Some of the most virulent diseases are caused by viruses, e.g., the hemorrhagic fever caused by Ebola virus. (unboundmedicine.com)
  • State and federal public health laboratories have built capacity such that they now sequence more than 6000 influenza virus genomes and more than 5000 enteropathogenic bacterial genomes each year [ 11 ]. (biomedcentral.com)
  • Rearrangement in the Hypervariable Region of JC Polyomavirus Genomes Isolated from Patient Samples and Impact on Transcription Factor-Binding Sites and Disease Outcomes. (cdc.gov)
  • BK virus reactivation has been described as significant and often severe complications occur, especially in patients with hematopoietic stem cell transplantation (HSCT). (uic.edu)
  • After immunosuppression, following transplantation, the virus activates, replicates, and damages urothelial cells as well as renal parenchymal tubules. (biomedcentral.com)
  • Genomic characterization of a novel virus found in papillomatous lesions from a southern brown bandicoot ( Isoodon obesulus ) in Western Australia. (ictv.global)
  • Polyomavirus can cause benign feather lesions in budgies. (web.app)
  • Little is known, although the virus has been found in preneoplastic lesions. (sv40.org)
  • Viruses with lipid envelopes have a greater ability to adhere to cell membranes and to avoid destruction by the immune system. (unboundmedicine.com)
  • An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination. (ictv.global)
  • Hyperbaric oxygen therapy may help improve immune response and reduce inflammation, potentially contributing to the management of JC virus-related conditions. (hbot-india.com)
  • When the immune system is compromised, the virus may reactivate, taking on a virulent, pathologic course. (uic.edu)
  • Approximately 80-90% of individuals worldwide have BKV antibodies, indicating that they have already been infected or exposed to the virus. (openpr.com)
  • Parainfluenza virus (PIV) is second in importance only to RSV as a cause of lower respiratory tract disease in children and pneumonia and bronchiolitis in infants younger than 6 months. (medscape.com)
  • Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod. (cdc.gov)