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  • hemorrhagic
  • CONTEXT: Distinct human polyomavirus genotypes cause different diseases in patients with renal transplants: BK virus (BKV) causes tubulointerstitial nephritis and ureteral stenosis, whereas both JC virus (JCV) and BKV are responsible for hemorrhagic cystitis. (uniupo.it)
  • urinary
  • DESIGN: Samples from kidneys (n = 80), renal pelvis (n = 20), ureter (n = 40), and urinary bladder (n = 30) obtained from 10 consecutive autopsies were investigated by means of multiplex nested polymerase chain reaction to detect polyomavirus DNA and to distinguish different species of the Polyomavirus genus. (uniupo.it)
  • immunosuppression
  • To address the possibility that MCV seroreactivity could be a marker of immunosuppression, antibodies to another human polyomavirus known to reactivate among immunosuppressed individuals ( 12 ), JC virus (JCV), were also measured. (aacrjournals.org)
  • An increased risk of MCC has been linked with immunosuppression related to UV radiation, viral infections, organ transplantation, and chronic lymphocytic leukemia ( 2-6 ). (aacrjournals.org)
  • samples
  • No correlation was found between the presence or type of polyomavirus and immune status, but red blood cells were found more frequently in the positive than in the negative samples. (unimi.it)
  • patients
  • WU polyomavirus is a recently described polyomavirus found in patients with respiratory infections. (cdc.gov)
  • We plan to study patients with suspected or confirmed PML with different underlying conditions including patients on immune-modulatory therapies for multiple sclerosis (MS), rheumatologic diseases or other autoimmune diseases, as well as patients with HIV infection or other conditions leading to a compromised immune system. (clinicaltrials.gov)
  • Blood and cerebrospinal fluid (CSF) will also be collected at these time points to evaluate the behavior and biology of the JCV and the patients immune responses to the infection. (clinicaltrials.gov)
  • induces
  • We propose a model where JCV infection induces both overexpression of Rad51 protein and activation of the nucleus to cytoplasm NF-κB signaling pathway, which then act together to enhance JCV gene expression. (biomedcentral.com)
  • diseases
  • To assess MCV infection and its association with human diseases, we developed a monoclonal antibody that specifically recognizes endogenous and transfected MCV large T (LT) antigen. (blogspot.com)
  • found
  • In preliminary studies, we found that the magnitude of the Q9-restricted antiviral CD8 T cell response progressively inflates over the course of infection. (jimmunol.org)
  • years ago
  • JC and BK polyomaviruses were discovered over 40 years ago and have become increasingly prevalent causes of morbidity and mortality in a variety of distinct, immunocompromised patient cohorts. (hindawi.com)
  • cases
  • Polyomavirus DNA (predominantly BKV) is more common in UBC, but still only detectable in 7% of cases and in many of these cases at low copy number. (urotoday.com)
  • response
  • This Q9:VP2.139-specific CD8 T cell response exhibits inflationary kinetics in MHC class Ia-deficient mice - a gradual expansion in the first three months post-infection with minimal contraction thereafter. (jimmunol.org)